Boston, Massachusetts, United States · On-site
$155k–$223k/yr
Position Summary We are seeking an experienced medicinal chemist to lead our Targeted Protein Degradation (TPD) chemistry strategy. This individual will bring prior leadership experience advancing TPD programs and will b…
Skills: Medicinal Chemistry, Targeted Protein Degradation, SAR Analysis, Linker Design, Bifunctional Molecule Optimization
Hartford, Connecticut, United States · Remote OK
$187k–$311k/yr
The territory for this role includes New England and Upstate New York. GSK ONCOLOGY GSK is a place to build a career in Oncology where purpose, science and growth come together. As a focused, global biopharma company, we…
Skills: Account Management, Oncology Clinical Science, Healthcare Economics, C-Suite Engagement, Market Access Strategy
Northborough, Massachusetts, United States · Hybrid
$115k–$147k/yr
At LifeStance Health, we believe in a truly healthy society where mental and physical healthcare are unified to make lives better. Our mission is to help people lead healthier, more fulfilling lives by improving access t…
Skills: Evidence-Based Treatment, Trauma-Informed Care, Clinical Psychology, Telehealth, Case Management
Needham, Massachusetts, United States · Hybrid
$258k–$280k/yr
• Location: Hybrid (3 days/week in Needham, MA; 2 days remote) • Type: Individual contributor (no direct reports) • Salary: 258,333 - $280,000 + 25% bonus Why Work With Us? At Candel, our people drive our success. We val…
Skills: GxP Systems Management, Computer System Validation, Vendor Oversight, Quality Assurance, 21 CFR Part 11 Compliance
Boston, Massachusetts, United States · Hybrid
$115k–$147k/yr
At LifeStance Health, we believe in a truly healthy society where mental and physical healthcare are unified to make lives better. Our mission is to help people lead healthier, more fulfilling lives by improving access t…
Skills: Evidence-Based Treatment, Trauma-Informed Care, Anxiety Treatment, Mood Disorder Treatment, Impulse-Control Treatment
Woods Hole, Massachusetts, United States · On-site
$68k–$75k/yr
Job Summary Job Description Job Description:. This is a postdoctoral position that will refine the development of isotope measurements using a hollow-core fiber. This role is expected to end Oct 2026 Essential Functions …
Skills: Fiber Optical Systems Alignment, Isotope-based Measurements, Hollow-core Fibers, Oceanography
Pittsfield, Massachusetts, United States · Hybrid
$101k–$110k/yr
Basic Qualifications Requires a Bachelor’s or Technology degree in Engineering or a related specialized area/field, or equivalent (4 years job-related experience). Requires an additional 5+ years of job-related experienc…
Skills: Systems Engineering, Test & Integration, Requirements Analysis, Model-Based Systems Engineering, Hardware-Systems Engineering
Pittsfield, Massachusetts, United States · Hybrid
$113k–$125k/yr
Basic Qualifications Requires a Bachelor’s degree in Systems Engineering, or a related Science, Engineering, Technology or Mathematics field. Also requires 5+ years of job-related experience, or a Master's degree plus 3 …
Skills: Systems Engineering, Test & Integration Engineering, Requirements Engineering, Model-Based Systems Engineering, Hardware-Systems Engineering
Lowell, Massachusetts, United States · On-site
$20/hr–$24/hr
Position Overview Now Hiring: Food Quality Technician 📍 Lowell, MA💲 $20.00–$24.00 per hour (DOE)🕒 Full-Time | Monday–FridayShift Options: 8:00 AM – 5:00 PM or 10:00 AM – Close Help Deliver Safe, High-Quality Food Ever…
Skills: Quality Control, Quality Assurance, Brix Testing, pH Testing, Viscosity Testing
Boston, Massachusetts, United States · On-site
$28/hr–$33/hr
Work Schedule First Shift (Days) Environmental Conditions Adherence to all Good Manufacturing Practices (GMP) Safety Standards Job Description At Thermo Fisher Scientific, you’ll discover meaningful work that makes a pos…
Skills: Microbiology, Good Manufacturing Practices, Sample Quality Analysis, Data Entry, Specimen Storage
Melrose, Massachusetts, United States · On-site
$20/hr–$27/hr
Labcorp is a global leader in laboratory services, providing the insights and answers that help healthcare providers, patients, researchers, pharmaceutical companies and health systems make confident decisions and improv…
Skills: Venipuncture, Capillary Techniques, Specimen Collection, Data Entry, Billing Processing
Newton, Massachusetts, United States · On-site
$127k–$174k/yr
Site: Newton-Wellesley Hospital Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-f…
Skills: Patient Assessment, Surgical Care, Physical Examinations, Diagnostic Interpretation, Treatment Planning
Cambridge, Massachusetts, United States · On-site
$116k–$174k/yr
Join AstraZeneca's Biologics Engineering (BE) team, where we turn ideas into life-changing medicines. We are looking for a highly motivated scientist to join our Biomolecular Interactions Group (BmIG) within the multidis…
Skills: Biomolecular Interaction Assays, Kinetic Characterization, Epitope Binning, Biosensor-based Platforms, Carterra LSA
Great Barrington, Massachusetts, United States · On-site
At Cleveland Clinic Health System, we believe in a better future for healthcare. And each of us is responsible for honoring our commitment to excellence, pushing the boundaries and transforming the patient experience, ev…
Skills: Medical History Taking, Physical Examination, Diagnostic Interpretation, Patient Education, Medication Prescription
Lowell, Massachusetts, United States · On-site
$105k–$125k/yr
Position Overview Now Hiring: Regulatory Compliance Manager | Food Manufacturing 📍 Lowell, MA💲 $105,000–$125,000 Annually (DOE)🕒 Full-Time🏆 Leadership Role | Food Manufacturing Lead Regulatory Excellence at PGI Foods…
Skills: Regulatory Compliance, Food Labeling, FDA Regulations, USDA Regulations, HACCP
Danvers, Massachusetts, United States · On-site
$79k–$127k/yr
At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less in…
Skills: Analytical Reasoning, Computerized Equipment Skills, Emerging Technologies, Gemba Kaizen, Issue Escalation
Danvers, Massachusetts, United States · On-site
$79k–$127k/yr
At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less in…
Skills: Analytical Reasoning, Computerized Equipment Skills, Emerging Technologies, Gemba Kaizen, Issue Escalation
Boston, Massachusetts, United States · Remote OK
$129k–$193k/yr
Job Description General Summary: The Senior Manager of Cold Chain Logistics Process is responsible for leading the development and implementation of processes and procedures to ensure the success of cold chain logistics …
Skills: Cold Chain Logistics, Cell and Gene Therapy Logistics, Good Distribution Practices, Trade Compliance, Quality Systems Management
Boston, Massachusetts, United States · Remote OK
🔗Are you being referred to one of our roles by a connection in Alira Health? If so, please apply using the referral link emailed to you. Join our global team dedicated to innovation and initiative, where physical walls …
Skills: Site Monitoring, Clinical Trial Management, ICH GCP Compliance, Source Document Verification, Regulatory Documentation
Framingham, Massachusetts, United States · On-site
Operational Excellence Associate - VIE Contract Location: United States of America, FraminghamTarget start date: 01/09/2026 iMove, the Sanofi VIE Program, is available to citizens of the European Economic Area (EU + Norw…
Skills: Kaizen, Continuous Improvement, Value Stream Mapping, 5S, Data Analysis
Boston, Massachusetts, United States • On-site
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Lead the Targeted Protein Degradation (TPD) chemistry strategy, shaping the platform and guiding multiple programs toward development candidate selection. This role involves defining design principles, managing linker strategies, and expanding capabilities into next-generation degradation modalities.
Requires a Ph.D. in Chemistry or a related field with over 8 years of industry experience in medicinal chemistry. Candidates must have a proven track record of leading TPD programs with heterobifunctional molecules to the development candidate stage.
Position Summary
We are seeking an experienced medicinal chemist to lead our Targeted Protein Degradation (TPD) chemistry strategy. This individual will bring prior leadership experience advancing TPD programs and will be responsible for shaping and executing the company’s degradation platform.
This role combines scientific leadership and strategic direction with the opportunity to both guide multiple programs and directly lead a TPD project. Importantly, this individual will play a foundational role in expanding the company’s capabilities into next-generation degradation modalities (e.g. extracellular proteins), helping define platform direction from the ground up.
Key Responsibilities:
Scientific & Strategic Leadership:
Define and implement the company’s TPD chemistry strategy, including degrader design principles, toolbox development, and platform evolution.
Work with chemistry leads and project teams to lead TPD chemistry efforts on assigned programs, contributing to platform strategy and advancing molecules toward development candidate selection..
Establish linker and building block strategies, including guiding sourcing and synthesis of E3 ligase ligands and linkers.
Partner with ADME/DMPK teams to shape property and developability strategies specific to TPD molecules.
Help define and initiate new heterobifunctional modalities beyond CRBN/VHLbased degraders, including ongoing efforts in extracellular protein degradation.
Team Leadership & Cross-Functional Collaboration:
Mentor and oversee a scientist responsible for establishing a parallel synthesis capability to accelerate lead discovery.
Collaborate closely with medicinal chemistry, computational chemistry and ADME leads across programs.
Serve as the internal TPD expert, influencing multi-project direction and decision-making.
Execution & Innovation:
Drive rapid iteration cycles through efficient synthetic design and prioritization.
Incorporate emerging advances in TPD modalities, linker chemistry, and E3 biology.
Play a key role in building the next-generation degradation platform, including evaluating and implementing novel modalities (e.g., extracellular protein degradation, molecular glues, and beyond).
Help build scalable workflows and infrastructure to support platform productivity.
Qualifications:
Required:
Ph.D. in Chemistry or related field with extensive industry experience in medicinal chemistry with 8+ years of industry
Demonstrated success leading one or more targeted protein degradation programs with heterobifunctional molecules through to a development candidate.
Deep understanding of SAR, linker design, and bifunctional molecule optimization.
Strong knowledge of E3 ligase biology and degrader mechanisms
Experience working cross-functionally with ADME/DMPK, biology, and computational chemistry.
Leadership Profile:
Track record of scientific leadership and program ownership.
Ability to operate at both strategic and hands-on levels.
Strong collaborator capable of influencing across disciplines.
Experience mentoring scientists and building capabilities.
Preferred:
Experience establishing or scaling a TPD or proximity-based pharmacology platform.
Familiarity with emerging heterobifunctional modalities.
Familiarity with parallel synthesis and direct-to-biology chemistry workflows.
Application Deadline: This will be posted for a minimum of 5 business days.
Company benefits: Comprehensive medical, dental, vision, prescription drug coverage, company provided basic life, accidental death & dismemberment, short-term and long-term disability insurance, tuition reimbursement, student loan assistance, a generous 401(k) match, flexible time off, paid holidays, and paid leave programs as well as other company provided benefits.
Come discover more about Jnana and our benefit offerings; https://www.jnanatx.com/join-us/
This job description is intended to describe the general nature and level of the work being performed by the people assigned to this position. It is not intended to include every job duty and responsibility specific to the position. Jnana Therapeutics reserves the right to amend and change responsibilities to meet business and organizational needs as necessary.
Jnana Therapeutics is an equal opportunity employer. All qualified applicants are encouraged to apply and will be given consideration for employment without regard to race, color, sex, gender identity or gender expression, sexual orientation, age, disability, religion, national origin, veteran status, marital status, or any other legally protected characteristic.
If you are a qualified individual with a disability or a disabled veteran, you may request a reasonable accommodation, if you are unable or limited in your ability to apply to this job opening as a result of your disability. You can request reasonable accommodations by contacting Accommodation Request.
At Jnana Therapeutics we take security and protection of your personal information very seriously. Please be aware individuals may approach you and falsely present themselves as our employees or representatives. They may use this false pretense to try to gain access to your personal information or acquire money from you by offering fictitious employment opportunities purportedly on our behalf.
Please understand, Jnana Therapeutics will never ask for financial information of any kind or for payment of money during the job application process. We do not require any financial, credit card or bank account information and/or any payment of any kind to be considered for employment. We will also not offer you money to buy equipment, software, or for any other purpose during the job application process. If you are being asked to pay or offered money for equipment fees or some other application processing fee, even if claimed you will be reimbursed, this is not Jnana Therapeutics. These claims are fraudulent, and you are strongly advised to exercise caution when you receive such an offer of employment.
Jnana Therapeutics will also never ask you to download a third-party application in order to communicate about a legitimate job opportunity. Scammers may also send offers or claims from a fake email address or from Yahoo, Gmail, Hotmail, etc, and not from an official Jnana Therapeutics email address. Please take extra caution while examining such an email address, as the scammers may misspell an official Jnana Therapeutics email address and use a slightly modified version duplicating letters.
To ensure that you are communicating about a legitimate job opportunity at Jnana Therapeutics, please only deal directly with Jnana Therapeutics through its official Jnana Therapeutics Career website https://www.jnanatx.com/join-us/.
Jnana Therapeutics will not be held liable or responsible for any claims, losses, damages or expenses resulting from job recruiting scams. If you suspect a position is fraudulent, please contact Jnana Therapeutics call center at: 800-363-5670. If you believe you are the victim of fraud resulting from a job recruiting scam, please contact the FBI through the Internet Crime Complaint Center at: https://www.ic3.gov, or your local authorities.
Jnana Therapeutics, Inc. does not accept unsolicited assistance from search firms for employment opportunities. All CVs/resumes submitted by search firms to any Jnana employee directly or through Jnana’s application portal without a valid written search agreement in place for the position will be considered Jnana’s sole property. No fee will be paid if a candidate is hired by Jnana as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.
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