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About This Role The Head of Rare Diseases, US Medical is a critical leadership role within the US Medical organization, accountable for the strategic direction and execution of medical affairs activities across the Rare …
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Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitmen…
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Cambridge, Massachusetts, United States · On-site
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About Flagship Pioneering Flagship Pioneering invents and builds companies that change the world. We bring together the greatest scientific minds with entrepreneurial company builders and assemble the capital to allow th…
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Cambridge, Massachusetts, United States · Hybrid
$269k–$292k/yr
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Skills: Nonclinical Safety Strategy, Toxicology, Regulatory Submissions, CRO Management, Risk-Benefit Assessment
Biogen
Cambridge, Massachusetts, United States • Hybrid
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Lead the development and execution of US Medical strategy for the Rare Diseases portfolio, overseeing cross-functional teams and field medical operations. Serve as the primary medical point of contact for internal and external stakeholders while ensuring alignment with corporate goals and regulatory standards.
Requires an MD, PhD, PharmD, or DNP with at least 12 years of experience in Medical Affairs and 5 years in a leadership capacity. Candidates must demonstrate expertise in medical strategy, regulatory environments, and managing complex therapeutic portfolios.
About This Role
The Head of Rare Diseases, US Medical is a critical leadership role within the US Medical organization, accountable for the strategic direction and execution of medical affairs activities across the Rare Diseases portfolio. This includes both marketed and pipeline assets in Spinal Muscular Atrophy (SMA), Amyotrophic Lateral Sclerosis (ALS), and Friedreich’s Ataxia (FA), among other emerging indications. The portfolio spans early access programs, lifecycle management studies, and multiple launched therapies, each supporting patients with high unmet needs and representing major growth opportunities for Biogen.
As a key member of the North America Medical Leadership Team, this leader will report to the Head of Medical, North America. They will oversee a cross-functional medical team including Medical Directors, Field Director, and Medical Science Liaisons (MSLs), while collaborating closely with Global Medical teams, Regulatory, US Commercial, Market Access, and Value & Evidence Generation partners. This individual will represent the Rare Diseases medical perspective across senior leadership forums and ensure that the strategic priorities of the therapeutic area are aligned with broader corporate goals, all while advancing scientific knowledge, clinical impact, and patient outcomes.
Lead the development and execution of the US Medical strategy across the Rare Diseases portfolio, encompassing multiple marketed products and late-stage development assets.
Serve as the primary medical point of contact for Rare Diseases across US Commercial, Market Access, Global Medical, and Regulatory organizations.
Oversee field medical strategy and operations for the Rare Diseases franchise, including Field Director and MSL teams.
Provide leadership and strategic oversight for scientific content development, external stakeholder engagement, congress strategy, publications, and advisory boards.
Ensure medical input is embedded in key cross-functional activities including lifecycle management, launch planning, and field enablement.
Champion the integration of patient and HCP insights into strategic and tactical planning, ensuring a data-driven and customer-centric approach to decision-making.
Lead with a performance-driven mindset, promoting accountability, innovation, and excellence across the Rare Diseases medical team.
Mentor and develop medical affairs talent through intentional coaching, career path planning, and succession development.
Represent Rare Diseases in cross-functional governance, promotional review committees, and compliance processes, ensuring rigorous execution and alignment with regulatory expectations.
Manage and oversee the Rare Diseases medical budget, ensuring efficient resource utilization and investment in areas of highest impact.
Who You Are
You are a purpose-driven and strategic medical leader with a passion for advancing care in rare and complex diseases. You have experience leading medical teams, building collaborative relationships across stakeholders, and delivering meaningful impact for patients and the business. You thrive in complexity, operate with integrity, and create environments where high performance and empathy can co-exist.
MD, PhD, PharmD, or DNP in a clinical or scientific discipline.
12+ years of Medical Affairs experience in roles with increasing responsibility and accountability for medical affairs planning & tactical execution.
5+ years of experience leading Medical Affairs teams across multiple products or within complex therapeutic areas.
Demonstrated experience in developing and executing medical strategies for both marketed and pipeline assets.
Deep understanding of medical engagement, regulatory environment, field medical operations, and scientific communication.
Experience in Rare Diseases or Neurology strongly preferred.
Proven success launching and supporting multiple products within a portfolio-based medical model.
Comfort working in a fast-paced, matrixed environment with high strategic visibility.
Track record of building and leading high-performing teams with a focus on talent development and inclusive leadership.
Additional Information
Base salary offered is determined through an analytical approach utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity.
Regular employees are eligible to receive both short term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward recent achievements and recognize your future potential based on individual, business unit and company performance.
In addition to compensation, Biogen offers a full and highly competitive range of benefits designed to support our employees’ and their families physical, financial, emotional, and social well-being; including, but not limited to:
We are a global team with a commitment to excellence, and a pioneering spirit. As a mid-sized biotechnology company, we provide the stability and resources of a well-established business while fostering an environment where individual contributions make a significant impact. Our team encompasses some of the most talented and passionate achievers who have unparalleled opportunities for learning, growth, and expanding their skills. Above all, we work together to deliver life-changing medicines, with every role playing a vital part in our mission. Caring Deeply. Achieving Excellence. Changing Lives.
At Biogen, we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds, cultures, and perspectives make us a stronger and more innovative company, and we are focused on building teams where every employee feels empowered and inspired. Read on to learn more about Biogen.
All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E-Verify Employer in the United States.
Founded in 1978, Biogen is a leading biotechnology company that pioneers innovative science to deliver new medicines to transform patients’ lives and to create value for shareholders and our communities. We apply deep understanding of human biology and leverage different modalities, to advance first-in-class treatments or therapies that deliver superior outcomes. Our approach is to take bold risks, balanced with return on investment to deliver long-term growth. With approximately 7,000 people worldwide, we are truly a global organization, headquartered in Cambridge, Massachusetts, which is also home to our research operations. Our international headquarters are based in Baar, Switzerland and we have world-class manufacturing facilities in North Carolina and Solothurn, Switzerland. We offer therapies globally through direct affiliate presence in 30 countries and a network of distribution partners in over 50 additional countries. For more information, please visit www.biogen.com. Community Guidelines: https://www.biogen.com/community-guidelines.html Follow us on social media – LinkedIn, Instagram, Facebook, X, and YouTube.
Offices: 225 Binney Street, Cambridge, MA 02142, US · Landis & Gyr-Strasse 3, Zug, CH 6300, CH · P.O. Box 14627, 5000 Davis Drive, Research Triangle Park, NC 27709, US
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