Boston, Massachusetts, United States · On-site
$138k–$224k/yr
At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headqua…
Skills: NGS, RNA-seq, scRNA-seq, Spatial Transcriptomics, Functional Genomics
Atlanta, Georgia, United States · On-site
$121k–$157k/yr
Locations: Boston | Atlanta Who We Are Boston Consulting Group partners with leaders in business and society to tackle their most important challenges and capture their greatest opportunities. BCG was the pioneer in busi…
Skills: C#, .NET, React, Node.js, JavaScript
Boston, Massachusetts, United States · On-site
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Skills: SystemVerilog, Cache-Coherent Interconnects, CHI, ACE, CXL
Boston, Massachusetts, United States · On-site
$155k–$200k/yr
About Our Company We’re a diversified financial services leader with more than $1.5 trillion in assets under management, administration and advisement as of year-end 2024. Our team of 22,000 people across 19 countries, s…
Skills: Python, LLM, Agentic AI, Anthropic Cloud Code, Claude Interpreter
Boston, Massachusetts, United States · On-site
Requirements Please note that only applications from individuals residing in the United States will be considered for this position. We appreciate your understanding and thank all applicants for their interest.
Skills: Coax Splicing, Telecommunications
Boston, Massachusetts, United States · On-site
About SiFive As the pioneers who introduced RISC-V to the world, SiFive is transforming the future of compute by bringing the limitless potential of RISC-V to the highest performance and most data-intensive applications …
Skills: SystemVerilog, Cache-Coherent Interconnects, CHI, ACE, CXL
Cambridge, England, United Kingdom · On-site
$231k–$283k/yr
About SiFive As the pioneers who introduced RISC-V to the world, SiFive is transforming the future of compute by bringing the limitless potential of RISC-V to the highest performance and most data-intensive applications …
Skills: Cache Coherency, NoC, Interconnect Fabrics, AXI, AHB
Boston, Massachusetts, United States · Remote OK
$125k–$175k/yr
DevOps Engineering Manager LiveData | Remote, United States (Eastern Time preferred) | Full-Time Why LiveData LiveData builds cloud-based surgical software that helps hospitals run operating rooms more efficiently while …
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Boston, Massachusetts, United States · Hybrid
$179k–$219k/yr
Lightmatter is leading the revolution in AI data center infrastructure, enabling the next giant leaps in human progress. The company invented the world’s first 3D-stacked photonics engine, Passage™, capable of connecting…
Skills: Photonics Design, PDK Modeling, Python, Device Physics, Compact Modeling
Boston, Massachusetts, United States · Hybrid
$100k–$150k/yr
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Costa Mesa, California, United States · On-site
$220k–$292k/yr
Anduril Industries is a defense technology company with a mission to transform U.S. and allied military capabilities with advanced technology. By bringing the expertise, technology, and business model of the 21st century…
Skills: Cryptography, Systems Security, Secure Architecture, Hardware Root-of-Trust, Key Management
Costa Mesa, California, United States · On-site
$191k–$253k/yr
Anduril Industries is a defense technology company with a mission to transform U.S. and allied military capabilities with advanced technology. By bringing the expertise, technology, and business model of the 21st century…
Skills: Cryptography, Systems Security, Hardware Root-of-Trust, C++, Rust
Boston, Massachusetts, United States · On-site
$70/hr–$80/hr
Anduril Industries is a defense technology company with a mission to transform U.S. and allied military capabilities with advanced technology. By bringing the expertise, technology, and business model of the 21st century…
Skills: Technical Sourcing, Full Cycle Recruiting, Manufacturing Recruitment, Supply Chain Recruitment, Candidate Negotiation
Boston, Massachusetts, United States · On-site
$174k–$212k/yr
This Opportunity WSP is initiating a search for a compliance-focused Senior Compliance Professional for our Boston Massachusetts office to be involved in projects with our Earth & Environment Team and be a part of a grow…
Skills: EHS Compliance, Project Management, Technical Writing, Regulatory Reporting, Site Assessments
Boston, Massachusetts, United States · On-site
$253k–$336k/yr
Anduril Industries is a defense technology company with a mission to transform U.S. and allied military capabilities with advanced technology. By bringing the expertise, technology, and business model of the 21st century…
Skills: C++, Python, Computer Vision, Sensor Fusion, SLAM
Boston, Massachusetts, United States · On-site
$191k–$253k/yr
Anduril Industries is a defense technology company with a mission to transform U.S. and allied military capabilities with advanced technology. By bringing the expertise, technology, and business model of the 21st century…
Skills: C++, Python, Computer Vision, Sensor Fusion, SLAM
Boston, Massachusetts, United States · Hybrid
$112k–$141k/yr
Who we are At CarGurus (NASDAQ: CARG), our mission is to give people the power to reach their destination. We started as a small team of developers determined to bring trust and transparency to car shopping. Since then, …
Skills: Java, Concurrency, Multi-threading, Web Applications, Event Driven Architectures
Boston, Massachusetts, United States · On-site
$120k–$145k/yr
From our nation’s earliest days, ABCorp has been a trusted force in security and innovation. In 1795, the federally chartered Bank of the United States entrusted American Bank Note Company with the mission of produ…
Skills: Backend Development, RESTful APIs, Distributed Services, React, Angular
Boston, Massachusetts, United States · On-site
$110k–$120k/yr
From our nation’s earliest days, ABCorp has been a trusted force in security and innovation. In 1795, the federally chartered Bank of the United States entrusted American Bank Note Company with the mission of produ…
Skills: React, Angular, RESTful APIs, Azure, CI/CD
Boston, Massachusetts, United States · On-site
$130k–$160k/yr
From our nation’s earliest days, ABCorp has been a trusted force in security and innovation. In 1795, the federally chartered Bank of the United States entrusted American Bank Note Company with the mission of produ…
Skills: Technical Leadership, Cloud-Native Architecture, React, Angular, RESTful APIs
Boston, Massachusetts, United States • On-site
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Design and execute NGS-based genomics experiments to support RNA therapeutics compound profiling and mechanism-of-action characterization. Collaborate with cross-functional teams to translate complex genomic data into actionable recommendations for lead optimization and program decisions.
Requires a Ph.D. in genomics, molecular biology, or a related field with at least 2 years of postdoctoral or industry experience. Candidates should have a proven track record in NGS-based functional genomics and experience in a pharmaceutical or biotech research environment.
At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.
Position Overview
We are seeking an experienced scientist to join the Genomic Sciences team in Lilly Genetic Medicine’s RNA Therapeutics organization. This team leverages high-throughput approaches to generate data that drives compound selection and lead optimization decisions and enables innovative cross-functional science both within RNA therapeutics and across therapeutic areas.
The successful candidate will join a team of genomics experts who independently identify key scientific questions, design and execute functional genomics experiments to answer them, and integrate results across data modalities to advance compound programs from screening through preclinical development. This role requires close partnership with medicinal chemistry, in vitro pharmacology, in vivo pharmacology, computational genomics, lab automation, and therapeutic area teams—and a scientist who can translate experimental findings into clear recommendations that shape portfolio-facing program decisions.
Key Responsibilities
Design and execute NGS-based genomics experiments (e.g., 3’ RNA-seq, mRNA-seq, targeted panels, scRNA-seq, spatial transcriptomics, etc.) to support siRNA and ASO compound profiling, selectivity assessment, biodistribution studies, and mechanism-of-action characterization
Independently identify scientific questions and develop experimental strategies that advance portfolio programs, applying an end-to-end understanding from assay design through data interpretation
Establish and optimize functional genomics workflows at screening scale, including library preparation, multiplexing, QC, and sequencing across NGS platforms
Integrate cross-functional and external information—transcriptomic, pharmacologic, structural—to support data-driven decision-making on compound progression and lead selection
Collaborate with computational genomics colleagues on analysis design, ensuring experimental parameters (replication, power, controls) support robust statistical inference
Leverage laboratory automation systems (e.g., Hamilton, Beckman) to increase throughput and reproducibility of genomics workflows
Troubleshoot assay performance, diagnose failure modes, and implement corrective actions with minimal supervision
Present scientific findings and recommendations to project teams, governance bodies, and external collaborators; contribute to publications, patents, and conference presentations
Mentor junior scientists on experimental design, technical execution, and scientific rigor
Ph.D. in genomics, molecular biology, genetics, or a related discipline with a minimum of 2 years of postdoctoral and/or industry experience
Demonstrated track record of independently designing, executing, and interpreting NGS-based functional genomics experiments
Experience working on collaborative, cross-functional teams in a pharmaceutical, biotech, or large-scale research environment
Strong scientific communication skills with the ability to translate complex genomic data into actionable recommendations for non-specialist stakeholders
Exceptional demonstrated ability to collaborate with scientists and business leaders with diverse scientific backgrounds
Experience with high-throughput transcriptomic screening workflows in a drug discovery context (e.g., compound profiling, dose-response characterization, off-target assessment)
Familiarity with RNA therapeutics biology, including siRNA seed-mediated off-target effects and/or antisense oligonucleotide pharmacology
Hands-on experience with spatial transcriptomics (e.g., Xenium, CosMx, MERFISH) and/or single-cell genomics (e.g., 10x Chromium) applied to mechanistic questions in drug development
Genomics data analysis skills including differential expression analysis frameworks and visualization of high-dimensional data
Experience with laboratory automation platforms for NGS library preparation or sample handling at scale
Publication record demonstrating scientific contributions in genomics or functional genomics
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women’s Initiative for Leading at Lilly (WILL).
Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is
$138,000 - $224,400Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
#WeAreLilly
We're a medicine company turning science into healing to make life better for people around the world. It all started nearly 150 years ago with a clear vision from founder Colonel Eli Lilly: "Take what you find here and make it better and better." Harnessing the power of biotechnology, chemistry and genetic medicine, our scientists are urgently advancing science to solve some of the world's most significant health challenges. General Information and Guidelines: When you engage with us on LinkedIn, you're agreeing to these Community Guidelines: https://e.lilly/guidelines. If you have questions about a Lilly medicine, contact The Lilly Answers Center at 1-800-Lilly-Rx (1-800-545-5979) Monday through Friday, excluding company holidays.
Offices: Lilly Corporate Center, Indianapolis, Indiana 46285, US
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