Cambridge, Massachusetts, United States · On-site
$179k–$236k/yr
Reporting to the Chief Scientific Officer, this role leads DMPK and bioanalytical strategy across nonclinical and clinical programs, operating as a hands-on scientific leader. We are looking for an accomplished DMPK and …
Skills: DMPK Strategy, Bioanalytical Method Development, PK Study Design, Translational Biomarker Strategy, CRO Management
Cambridge, Massachusetts, United States · On-site
$115k–$165k/yr
What if… you could help build a life sciences company developing breakthrough technologies to transform how disease is detected, monitored, and treated? Liquid biopsies have opened the possibility of understanding diseas…
Skills: Computational Biology, Proteomics, Transcriptomics, Machine Learning, Bioinformatics
Cambridge, Massachusetts, United States · Hybrid
Make your mark for patients We are seeking a Senior Principal Scientist to join the US Neuromuscular group based in Cambridge, MA and help drive translational biology drug discovery efforts with an emphasis on muscle bio…
Skills: Muscle Biology, Translational Research, Drug Discovery, Assay Development, Cell Culture
Cambridge, Massachusetts, United States · On-site
$290k–$315k/yr
The Company Flagship Labs 110 Inc. (FL110) is a privately held, early-stage technology company developing a fully integrated, end-to-end platform to enable next generation proteomics. Our platform integrates groundbreaki…
Skills: Scientific Strategy, Platform Development, Nanopore Science, Protein Translocation, Molecular Engineering
Cambridge, Massachusetts, United States · Hybrid
$85k–$105k/yr
Iterative Health is a healthcare technology and services company powering the acceleration of clinical research to transform patient outcomes. We built a leading performance-driven network of 100+ sites across the US, Eu…
Skills: Accounts Receivable, Billing Operations, Financial Reporting, Data Analysis, Reconciliation
Cambridge, Massachusetts, United States · Hybrid
Iterative Health is a healthcare technology and services company powering the acceleration of clinical research to transform patient outcomes. We built a leading performance-driven network of 100+ sites across the US, Eu…
Skills: Clinical Trial Budgeting, Contract Negotiation, Clinical Trial Agreements, Financial Performance Management, International Contracting
Cambridge, Massachusetts, United States · On-site
Company Description By working at Harvard University, you join a vibrant community that advances Harvard's world-changing mission in meaningful ways, inspires innovation and collaboration, and builds skills and expertise…
Skills: Conservation Treatment, Preventive Care, Condition Reporting, Project Management, Technical Examination
Cambridge, Massachusetts, United States · On-site
$120k–$150k/yr
MORSE Corp is an employee owned, small business based in Cambridge, MA, Arlington, VA, and Seattle, WA with a history of fielding cutting-edge technology. MORSE boasts a specially selected team of scientists, engineers, …
Skills: SolidWorks, 3DEXPERIENCE, GD&T, Lean Manufacturing, Root Cause Analysis
Cambridge, Massachusetts, United States · On-site
$143k–$215k/yr
COMPANY DESCRIPTION Founded through Flagship Pioneering’s venture creation engine, Terrana Biosciences is a cutting-edge agricultural biotechnology company developing innovative RNA-based products to address global agric…
Skills: Next-Generation Sequencing, Assay Development, RNA Biology, Experimental Design, Laboratory Automation
Cambridge, Massachusetts, United States · On-site
COMPANY DESCRIPTION Founded through Flagship Pioneering’s venture creation engine, Terrana Biosciences is a cutting-edge agricultural biotechnology company developing innovative RNA-based products to address global agric…
Skills: Next-Generation Sequencing, Assay Development, RNA Biology, Experimental Design, Laboratory Automation
Cambridge, Massachusetts, United States · On-site
$143k–$215k/yr
COMPANY DESCRIPTION Founded through Flagship Pioneering’s venture creation engine, Terrana Biosciences is a cutting-edge agricultural biotechnology company developing innovative RNA-based products to address global agric…
Skills: Molecular Cloning, DNA Assembly, Vector Engineering, Construct Design, High-Throughput Workflows
Cambridge, Massachusetts, United States · On-site
$143k–$215k/yr
COMPANY DESCRIPTION Founded through Flagship Pioneering’s venture creation engine, Terrana Biosciences is a cutting-edge agricultural biotechnology company developing innovative RNA-based products to address global agric…
Skills: Molecular Cloning, DNA Assembly, Vector Engineering, Construct Design, High-Throughput Workflows
Cambridge, Massachusetts, United States · On-site
$36k–$48k/yr
Summary Axoft is building the most advanced and scalable platform for implantable brain–machine interfaces. Our mission is to enable minimally invasive, long-term stable, and ultrahigh-bandwidth communication with the br…
Skills: Microfabrication, Electrochemistry, Photolithography, Thin Film Deposition, Dry Etching
Cambridge, Massachusetts, United States · On-site
$263k–$321k/yr
Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing …
Skills: Biostatistics, Clinical Data Management, Clinical Trial Design, Statistical Methodology, Regulatory Submissions
Cambridge, Massachusetts, United States · Hybrid
$141k–$171k/yr
Working with Us Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every …
Skills: Computational Biology, RNA Biology, Machine Learning, Python, R
Cambridge, Massachusetts, United States · On-site
$20/hr–$45/hr
Overview: Draper is an independent, nonprofit research and development company headquartered in Cambridge, MA. The 2,000+ employees of Draper tackle important national challenges with a promise of delivering successful a…
Skills: LabVIEW, MATLAB, SolidWorks, COMSOL, ANSYS
Cambridge, Massachusetts, United States · Hybrid
$149k–$215k/yr
Job title: Senior Principal Scientist Location: Cambridge, MA About the Job We are seeking a highly motivated Senior Principal Scientist to spearhead the execution and expansion of our mast cell disorders Research & Deve…
Skills: Hematopoietic Stem Cell Biology, Mast Cell Disorders, Rare Disease Research, Target Identification, Preclinical Strategy
Cambridge, Massachusetts, United States · On-site
$39/hr–$55/hr
When you join the growing BILH team, you're not just taking a job, you’re making a difference in people’s lives. OCCUPATIONAL THERAPIST Job Description: Principal Duties and Responsibilities Provides direct patient care,…
Skills: Patient Assessment, Treatment Planning, Psychiatric Care, Student Fieldwork Training, Medical Documentation
Cambridge, Massachusetts, United States · On-site
$100k–$275k/yr
Overview: Draper is an independent, nonprofit research and development company headquartered in Cambridge, MA. The 2,000+ employees of Draper tackle important national challenges with a promise of delivering successful a…
Skills: Program Management, Production Management, Earned Value Management (EVMS), Integrated Master Schedule (IMS), Risk Management
Cambridge, Massachusetts, United States · Hybrid
$230k–$316k/yr
About This Role: As the Sr Director of Alliance Management, you will play a crucial role in establishing and nurturing relationships with Biogen’s partners. This position offers exposure to a diverse array of cross-funct…
Skills: Alliance Management, Contract Development, Stakeholder Management, Conflict Resolution, Negotiation
Cambridge, Massachusetts, United States • On-site
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Lead the DMPK and bioanalytical strategy across nonclinical and clinical programs, focusing on PK, biomarkers, and translational PD readouts. Manage external CRO partners and author nonclinical sections of regulatory filings such as INDs.
Requires a PhD in a relevant scientific field and over 8 years of industry experience in DMPK or bioanalytical sciences. Must have expertise in bioanalytical method validation, CRO oversight, and experience with novel delivery modalities like LNPs.
Reporting to the Chief Scientific Officer, this role leads DMPK and bioanalytical strategy across nonclinical and clinical programs, operating as a hands-on scientific leader. We are looking for an accomplished DMPK and bioanalytical scientist with experience in PK study design, bioanalytical method development, and translational biomarker strategy. This person will support pharmacology and nonclinical toxicology programs, providing broader context across the nonclinical development portfolio. The ideal candidate brings deep scientific expertise and a hands-on approach and thrives in the fast-paced environment of a clinical-stage biotech where both scientific and strategic contributions are expected
Lead DMPK and bioanalytical strategy across nonclinical and clinical programs, including PK, biomarker, and translational PD readouts
Lead method development, qualification, and validation for bioanalytical assays (GLP/GCP-compliant as required)
Design, execute, and oversee PK and PK-PD studies of tRNAs to evaluate delivery technologies (LNP and others) and biomarker effects
Manage and qualify CRO and external lab partners across bioanalytical and PK programs
Support nonclinical toxicology programs in collaboration with internal teams and CROs
Analyze, interpret, and present DMPK and translational biomarker data to internal leadership and external stakeholders
Author nonclinical sections of regulatory filings (e.g., IND) and briefing documents; support agency interactions and responses
Serve on the Research Leadership Team; represent DMPK and bioanalytical sciences in cross-functional program discussions
Manage and develop direct report(s); collaborate with the broader pharmacology team
PhD or equivalent in pharmacokinetics, pharmacology, biochemistry, analytical chemistry, or related field
8+ years of industry experience in DMPK, bioanalytical sciences, or closely related function
Experience with a range of bioanalytical methods and their development, qualification, and validation in both nonclinical and clinical contexts (e.g. mass spectroscopy, ELISA, NGS, etc.)
Experience with ligand binding assays and multiplex immunoassay platforms (e.g., MSD, Luminex) for cytokine, immunogenicity, and biomarker analysis
Demonstrated CRO oversight - vendor qualification, study monitoring, data review
Experience designing and overseeing PK and PK-PD studies for novel delivery modalities; LNP experience preferred
Experience in translational or clinical biomarker development, including assay strategy and fit-for-purpose qualification
Strong scientific writing skills - regulatory documents (e.g., IND nonclinical sections) and internal study reports
Experience supervising and developing scientists
Experience in rare disease, genetic medicine, or nucleic acid / RNA therapeutics
Familiarity with LNP platform biology and delivery landscape
Familiarity with GLP toxicology study design and ICH nonclinical guidelines
Experience operating in a cross-functional leadership role at a clinical-stage biotech
Experience with LC-MS/MS or related mass spectrometry platforms
Alltrna is the first clinical-stage biotech company advancing tRNA medicines to address shared disease-causing mutations across many indications. The company’s initial therapeutic programs are designed to restore full-length protein production in diseases caused by premature termination codons (PTCs), collectively referred to as Stop Codon Disease, which affects approximately 10% of people with a rare genetic disease. Alltrna’s lead program, AP003, is a chemically modified, engineered tRNA oligonucleotide encapsulated in a clinically validated, liver-directed lipid nanoparticle. AP003 is being developed for the arginine-to-TGA (Arg-TGA) PTC in patients with liver Stop Codon Disease, including phenylketonuria, organic acidemias, and urea cycle disorders. Founded in 2018 by Flagship Pioneering, Alltrna has built an integrated platform to design, optimize, and deliver engineered tRNA therapeutics.
For more information, visit www.alltrna.com
The salary range for this role is $179,000 - $236,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Alltrna currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Alltrna's good faith estimate as of the date of publication and may be modified in the future.
Privacy Notice for Applicants: When you apply for a role at Flagship Pioneering or one of its portfolio companies, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact [email protected].
We are a biotechnology company that invents and builds platform companies that change the world.
Flagship Pioneering is a biotechnology company that invents and builds platform companies, each with the potential for multiple transformative human health and sustainability products. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures. The current Flagship ecosystem comprises over 40 companies, including Denali Therapeutics, Foghorn Therapeutics, Generate:Biomedicines, Inari, Indigo Agriculture, and Tessera Therapeutics.
Offices: 55 Cambridge Parkway, Suite 800E, Cambridge, MA 02142, US
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