AI/ML startups in San Francisco

Theta

San Francisco

Theta translates real-world workspaces into simulation environments and trains expert-level agents that deeply understand those environments.

Weave

San Francisco

Weave applies machine learning to engineering data, scanning every pull request to estimate its duration and evaluate review quality and work type, enabling teams to gain visibility and improve predictability in software delivery.

Ivo

San Francisco

Ivo develops generative AI products for legal teams and an AI-native platform that automates contract review and other legal work, helping teams reduce time, effort, and cost and accelerate time-to-close.

Fay Nutrition

San Francisco

Fay is a healthtech company using AI-powered preventative care to empower people and care teams to avert deterioration, with thousands achieving measurable improvements and $75 million raised from notable investors including General Catalys

11x

San Francisco

11x builds fully autonomous digital workers that automate specific jobs end-to-end, aiming to sell work, not software; a pioneer in digital workers with hundreds of customers including Brex, Otter AI, and Hasura, and millions in revenue in

Fieldguide

San Francisco

Fieldguide offers a vertical AI platform for assurance and advisory firms, founded by ex-Big Four practitioners and tech leaders; headquartered in San Francisco, remote-first, backed by notable investors, trusted by top CPA firms to improve

MERGE

San Francisco

Merge is a leading provider of customer-facing integrations and agent tools for frontier LLMs, serving thousands of customers including Fortune 500s and B2B SaaS firms, with offices in San Francisco, New York, and Berlin.

Supergood

San Francisco

Supergood combines observability data with human-in-the-loop code generation to create new integrations and fix existing ones.

DeepTrust

San Francisco

DeepTrust builds the trust layer of the internet by securing live voice and video calls across platforms and automating social-engineering detection and response, providing just-in-time assistance to boost productivity, security, and compli

ScopeAI

San Francisco

Scope develops AI-enabled software to accelerate industrial inspection workflows, from reporting to asset integrity, and works with leading TIC players to shorten field reporting to 12 minutes and onboard clients seven times faster.

Fazeshift

San Francisco

Fazeshift offers an AI-driven accounts receivable platform that automates AR processes, reduces manual work, and accelerates revenue cycles for large enterprises. Backed by Y Combinator, Gradient (Google’s AI venture arm), and founded by Ha

Nooks

San Francisco

Nooks is a platform that transforms sales reps from manual laborers to scientists by equipping teams with analytics. It grew from $0 to $5M ARR in two years, expanded 4x in 2023, led by Forbes 30 Under 30 founders.

Burnt

San Francisco

Burnt is building an AI brain for global supply chains, starting with the food sector; it already automates over $10M in monthly orders without humans, has raised $3.8M, and plans enterprise deployments across freight, manufacturing, and di

Paraform

San Francisco

Paraform is a recruiting marketplace that connects companies with a network of specialized recruiters to fill roles faster and more accurately. Backed by prominent investors and partners like Palantir and Decagon, it aims to be the first en

Tavus

San Francisco

Tavus is a human computing research lab and pioneer in human computing, building AI Humans to bridge the gap between people and machines and teach machines to be human. Founders Hassaan Raza and Quinn Favret lead Tavus, which is growing.

Unusual

San Francisco

Unusual defines Brand Engineering, a research field that measures how LLMs perceive brands and benchmarks brand performance against peers. Through applied interpretability and narrative-control experiments, it aims to let people shape their

Medra

San Francisco

Medra uses AI, robotics, and biology to accelerate life science research and eradicate disease, building a Scientific Physical AI platform to scale lab work and generate orders of magnitude more data for faster drug development and biology

AirOps

San Francisco

AirOps is the first end-to-end content engineering platform for marketing teams, helping brands get found and stay found in the AI era. With hubs in San Francisco, New York, and Montevideo, it serves marketers and is backed by prominent inv

Firebender

San Francisco

Firebender is an AI software company that develops AI coding assistance tools. Founded in 2024, it has raised $3.5 million in funding and currently has a team of three.

Synch

San Francisco

Synch, based in New York City, is the first AI-powered Salesforce system of engagement, backed by Y Combinator and executives from Retool, Ramp, and Superhuman. It enables enterprises to manage their Salesforce environment using natural-lan

HappyRobot

San Francisco

HappyRobot offers an AI-native operating system for real economy, starting with supply chains. It has raised $62M, including a $44M Series B in Sept 2025, from YC, Andreessen Horowitz, and Base10, led by Pablo and Javier Palafox and Luis Pa

Usul (YC S24)

San Francisco

Usul positions itself as the 'Amazon for Government,' enabling companies to sell to government quickly. With Fortune 500, U.S. Government, and NATO as customers and ARR near $5M, it is scaling a repeatable enterprise motion with internation

Conduit AI

San Francisco

Conduit builds AI-native conversational agents to automate high-touch business communications, focusing on hospitality and housing. It offers a help-desk platform for creating agents that handle text and voice conversations and escalate to

Zero Labs

San Francisco

At Zero develops a tax-forecasting engine with the goal of eliminating tax liabilities, positioning itself in the tax technology space.

Dataleap

San Francisco

Dataleap is the world's first vibe working platform, backed by $3 million in funding, aiming to be the first agentic work platform for tech-forward companies, with agents serving 2-person startups to 2,000-person unicorns; founders are Jan

Quander

San Francisco

Quander runs an applied AI product lab that automates invention, building thousands of inventions to improve humanity's future. It develops AI systems to discover, grow, and scale new ventures, driving venture creation through automated inv

Arphie

San Francisco

Arphie is building a platform for collaborative intelligence between go-to-market and product/engineering teams. Backed by top-tier VC firms and led by CEO/CTO co-founders who met at Harvard, it has posted rapid ARR growth since commerciali

Outset

San Francisco

Outset, a Y Combinator–backed startup, uses AI and ChatGPT to conduct in-depth qualitative interviews at scale, aiming to revolutionize qualitative research and deliver rich, scalable insights through innovative research tooling.

MangoDesk

San Francisco

Creates frontier data and environments to advance AI, bridging AI with the $5T knowledge-work economy and accelerating AI capabilities and adoption in knowledge work.

AthenaHQ

San Francisco

AthenaHQ provides an AI Search platform that helps global brands improve visibility, discoverability, and branding. It counts Coinbase, SoFi, and Twilio among its customers and serves over 200 clients with more than $2M ARR, underscoring ra

Cekura

San Francisco

Cekura is a Y Combinator–backed startup redefining AI voice agent reliability through testing and monitoring. Founded by IIT Bombay alumni with ETH Zurich credentials and high-stakes trading experience, it guarantees dependable performance,

Colare

San Francisco

Colare is an end-to-end hiring platform for hardtech teams in automotive, aerospace, energy, and defense. Its AI-powered simulations replicate real engineering workflows—from CAD to systems problem solving—to evaluate talent, with stack-ran

GovDash

San Francisco

GovDash enables businesses to win and deliver government contracts that advance American interests. Its customers won over $5B in government contracts in 2025, and GovDash has raised $42M in funding.

Poka Labs

San Francisco

Poka Labs, a San Francisco-based startup founded in 2023, builds AI agents that automate commercial operations for chemical manufacturers, led by Andrew Bass and Malay Shah; it is backed by Y Combinator, Flybridge, Pioneer Fund, and Beat Ve

Vantara

San Francisco

Vantara positions itself as an AI product engineer that monitors user sessions and feedback from support, sales, and channels, identifies patterns, prioritizes what to build, and enables PRs and A/B tests to close the loop between user inpu

Runway

San Francisco

Runway is a collaborative business planning platform that replaces spreadsheets with a modern planning solution, democratizing planning across the organization. Its customers include AngelList, Superhuman, ConvertKit, Lambda Labs, and Sandb

Scale AI

San Francisco

Scale AI provides data-centric infrastructure to accelerate AI development, helping organizations build strong AI models and derive business insights and operational efficiency; serving customers across tech, government, and enterprise, inc

Confident AI

San Francisco

Confident AI is the leading LLM evaluation platform behind the open-source DeepEval framework; its cloud product brings DeepEval to enterprises, backed by 600k+ monthly downloads, 5.3k+ GitHub stars, 40 million evaluations, and hundreds of

Opal Security

San Francisco

Opal provides enterprise identity and access management solutions. It is based in New York City and San Francisco and backed by Greylock, Battery Ventures, and Silicon Valley CISO Investments, serving hypergrowth startups and Fortune 500 co

TrueClaim

San Francisco

TrueClaim provides an AI-enabled platform for health plans, focused on advancing health-plan technology and modern operations.