AI/ML startups in San Francisco

Rulebase

San Francisco

Rulebase delivers visibility and confidence to modern support teams, helping them understand and improve the customer experience in real time. Its technology stack includes Python, React, and Electron JS.

InspectMind AI

San Francisco

InspectMind AI delivers AI-powered documentation and reporting tools for construction and design professionals, simplifying paperwork and streamlining on-site workflows to help workers spend less time at a desk and more time building.

Sylvan Labs

San Francisco

Sylvan Labs specializes in post-sales enablement for enterprise software, aiming to become the category-defining platform and a billion-dollar business by product- and GTM-led growth, not headcount. It pursues expansion through private equi

Helium

San Francisco

Helium automatically generates and tests paywalls to improve app conversion. Backed by Y Combinator, Google, and leaders from OpenAI and Uber, the company is positioned in the paywall automation space for apps.

Hadrius

San Francisco

Hadrius automates and consolidates securities compliance for investment firms, serving over 500 institutions and more than $5 trillion AUM. A YC W23 alum with over $10M ARR, it’s described as fastest-growing company in its space and an emer

Luminade

San Francisco

Founded by Sriram (ex-Luminade) and Mikhail (ex-Google, four-time competitive skydiving world champion); the two-person team builds a conversational voice layer for work that delivers actions in-chat, with ownership over product direction a

Resonate AI

San Francisco

An AI-driven platform that helps healthcare practices capture new patients by converting missed calls into patient inquiries, led by a founder with 10+ years of AI experience and five patents who previously built 0-to-1 ventures at Microsof

LedgerUp

San Francisco

LedgerUp is an AI-driven operations teammate for billing and accounts receivable that automates contract-to-cash workflows, reducing busywork for teams and driving growth.

Nexus Intelligence

San Francisco

An a16z-backed software startup building AI-enabled industrial automation systems for Fortune 100 customers across automotive, food, energy, and other sectors, aiming to become the platform for developing and deploying modern industrial aut

Inductive Bio

San Francisco

Inductive Bio uses data, machine learning, software, and domain expertise to rapidly solve ADMET problems with speed and precision, streamlining ADMET workflows as a focused provider in the ADMET problem space.

Greptile

San Francisco

Greptile, a San Francisco AI tooling startup with a six-person team, builds an AI expert on codebases accessible via an API, serving 1,000 software teams; raised $5.3M from Y Combinator, Initialized Capital, SV Angel, and Paul Graham, with

LlamaIndex

San Francisco

LlamaIndex offers an open-source framework that lets developers build agents to parse, extract insights, and act on enterprise documents, reasoning over data and scaling for production. It has 4M+ monthly downloads and 200M+ documents proce

Speakeasy

San Francisco

Speakeasy is a developer platform for building and deploying agent tools as hosted MCPs, serving startups to Fortune 500s including LaunchDarkly, Fivetran, and Verizon; it emphasizes open development, a GitHub presence, and rapid team growt

LiteLLM

San Francisco

LiteLLM develops open-source developer tooling for the AI software space, enabling access to multiple LLM APIs. It has raised $1.6M in seed funding from Y Combinator, Gravity Fund, and Pioneer Fund, and reports $7M+ ARR while remaining mean

CommodityAI

San Francisco

CommodityAI is a San Francisco-based AI company serving the commodities industry, founded by former commodity traders and operators with deep industry expertise. Backed by Y Combinator and Rebel Fund, it aims to build intelligence at the fo

Forge

San Francisco

Forge automates complex manual processes for the world’s largest enterprises and advances human computer interaction. Backed by Founders Fund and OpenAI, it operates globally, powering Fortune 500 workflows with 98%+ quality across half a m

Chroma

San Francisco

Chroma provides data infrastructure for AI, aiming to accelerate useful and creative AI applications, and positions itself as the leading retrieval solution trusted by developers worldwide.

Two Dots

San Francisco

Two Dots uses AI to reinvent consumer underwriting, starting with residential real estate. It harnesses data in consumer documents to improve lending decisions, pairing its underwriting agent with advanced document and identity anti-fraud c

OpenBlock

San Francisco

OpenBlock builds CLI coding agents; its OB-1 ranked #1 on Terminal Bench ahead of Claude Code and Codex highlights leadership in developer tooling and its aim to empower individuals and teams to create and innovate in software development f

Parahelp

San Francisco

Parahelp offers an AI support agent for fast-moving software companies, designed to automate complex support tickets end-to-end and deployable in one day without engineers. With a five-person, founder-heavy team and rapid growth, it is seek

Mach9

San Francisco

Mach9, founded in 2021 in San Francisco, is a geospatial technology company that automates detection and analysis of urban features for transportation planning, turning geospatial data into actionable insights via machine learning and compu

Delphi

San Francisco

Delphi aims to amplify human wisdom—personalized, discoverable, and preservable—while scaling brilliance across generations. It has tripled revenue, users, and Delphi interactions in six months, backed by Sequoia Capital, Founders Fund, Abs

Dynamo AI

San Francisco

Dynamo offers end-to-end privacy, security, and compliance solutions to help organizations prepare for emerging AI regulations and productionize AI with confidence, enabling deployments aligned with evolving rules.

Evidently

San Francisco

Evidently is a Clinical Data Intelligence platform built on 12 years of advanced research in Machine Reading and Knowledge Graph, aiming to dramatically improve the efficiency and effectiveness of clinical data workflows.

Takeoff

San Francisco

A startup backed by Matrix Partners with an uncapped seed, accepted into Y Combinator; has customers and distribution and a clear path to eight-figure revenue, driven by an execution-focused team of veterans from Stripe, Microsoft, Salesfor

Scritch

San Francisco

Scritch is building the leading AI-powered operating system for veterinary care, providing AI agents to streamline operations for veterinary clinics, including scheduling and clinical workflows.

Blaze

San Francisco

Blaze is the first AI agent that handles marketing for you, founded by Faiyam Rahman and Luc Succès and backed by Y Combinator. Its mission is to free business owners and marketing teams to focus on high-impact growth.

Enhanced Radar

San Francisco

The company develops safer aviation systems with a focus on next-generation air traffic control, aiming to advance aviation safety by delivering modern ATC solutions and defining its work in the aviation technology sector.

Bucket Robotics

San Francisco

Bucket Robotics seeks to solve the problem that 95% of industrial robots are blind, addressing robot blindness as its core mission.

Syntra

San Francisco

Syntra operates in healthcare revenue cycle management, integrating with all major EHR systems. It processes hundreds of millions of dollars in charges annually and aims to increase revenue, reduce audit risk and denials, and shorten accoun

Metis

San Francisco

Metis helps enterprises build reliable AI agents for Fortune 500 enterprises and frontier AI labs; it reports six-figure monthly revenue and 150%+ MoM growth, backed by Y Combinator, CRV, and executives from OpenAI, Google, Mercor, and NVID

Soff

San Francisco

Soff is an AI-powered supply chain hub that integrates with email and ERP systems to automate procurement workflows, leveraging years of supply chain data to save manufacturers time and money.

Unsloth AI

San Francisco

Unsloth AI, a San Francisco–based company, makes custom AI accessible by fixing critical LLM bugs (Gemma, Llama, Phi-4) and conducting open-source RL and fine-tuning; YC S24-backed with investors such as Logan Kilpatrick and Jon Oringer, us

Idler

San Francisco

Idler builds reinforcement learning coding environments that train AI to code like elite engineers using real-world scenarios. It closed a multimillion-dollar contract with a leading foundation lab and is scaling to power the training data

Attunement

San Francisco

Attunement, a YC W24 company, builds compliance infrastructure that connects clinical data pipelines, model outputs, and audit systems to make AI-assisted behavioral care traceable, explainable, and auditable. Clinics cut audit prep time by

Photonium

San Francisco

Photonium is building a next-generation design automation platform for optical systems, using AI to automate layout generation, optimization, simulation, tolerancing, and sourcing, marketed as an optics-focused alternative to Cadence or Syn

Stream

San Francisco

Stream Platforms, Ltd is a B Corporation delivering fair financial services and modernizing insurance, whose Stream platform serves three million people through 2,000 brands across UK, Europe and the US, backed by YC and investors as a fina

Simplify

San Francisco

Simplify builds AI-enabled hiring infrastructure to democratize the job search, offering an AI-powered talent agent to help users plan, manage, and achieve career goals, backed by Craft and Y Combinator, with 1M job seekers applying to 100M

HOAi

San Francisco

HOAi is a fast-growing community association management platform acquired by Vantaca in 2024; backed by Cove Hill Partners and JMI Private Equity, it achieved seven-figure ARR growth and now serves over 6 million doors, as Vantaca reached a

Laurel

San Francisco

Laurel is the world’s first AI Time platform for professional services firms, founded in 2018. It serves many of the world’s largest accounting, consulting and law firms.