AI/ML startups in San Francisco

Lapel

San Francisco

Lapel builds data infrastructure and tools that help customer-facing teams understand every customer and act on insight at scale, pursuing hospitality at scale by unifying context and coordinating action.

Roforco

San Francisco

Roforco builds viral AI consumer apps and games, with seven titles reaching over 100 million users and 10.2 million peak MAU. It maintains a community (100k+ TikTok followers, 64k+ Discord) and is founded by two ex-YC founders with Meta/Sna

ZeroEntropy

San Francisco

ZeroEntropy is a B2B software and services infrastructure company focused on AI-driven information retrieval over complex unstructured data. With a two-person founding team and Y Combinator Winter 2025 participation, it combines mathematics

Embedder

San Francisco

Embedder develops a coding agent for firmware development in embedded systems, enabling writing and testing firmware on real hardware with connections to physical tools. It indexes hardware documentation to provide hardware-specific context

Emergent

San Francisco

Emergent enables anyone to build production software by describing requirements in natural language. Founded by Mukund Jha and Madhav Jha, it attracted 700,000 users and $10M ARR in two months, among fastest-growing AI companies, serving en

Synth

San Francisco

Synth helps agent developers maintain and improve their AI software by identifying problems and fixing them with changes to scaffolding code, prompts, and models. It builds Research Engineering Agents and focuses on advancing AI agent devel

Woz

San Francisco

Woz helps non-technical founders turn ideas into scalable software by combining expert engineering, business tools, and go-to-market support, bridging AI-generated code with real-world growth and accelerating the path from concept to market

Relling

San Francisco

Relling develops data and infrastructure for world models, building advanced datasets to power world-models for humanoid robots and AR systems.

Bunkerhill Health

San Francisco

Bunkerhill Health translates AI algorithms from leading research institutions (Stanford, Harvard, Johns Hopkins) into clinical use, bridging academic innovation and patient care. It markets a scalable AI healthcare solution and invites cust

Artificial Analysis

San Francisco

Artificial Analysis is an AI benchmarking and insights firm that helps labs and enterprises understand AI capabilities and shape strategies, serving as go-to authority for labs, enterprises, media, and policymakers; benchmarks are trusted b

ThirdLayer

San Francisco

ThirdLayer, behind Dex, reimagines the browser as an intelligent workspace with Dex, the AI Browser Copilot. Backed by seven-figure funding from top-tier investors, it has a small, fast-moving team and aims to solve how humans and computers

Conductor

San Francisco

Conductor, based in San Francisco, has a three-person in-person team including Omid and is building the first AI orchestrator; backed by Silicon Valley investors to sustain operations through rough patches.

RunRL

San Francisco

RunRL (X25) is a San Francisco–based reinforcement learning as a service provider delivering on-demand RL capabilities to B2B software and services infrastructure companies, operated by a three-person team led by founders Andrew Gritsevskiy

Zensors

San Francisco

Zensors is a fast-growing tech startup recruiting a Sales and Biz Ops Lead to streamline go-to-market operations and deliver consistently excellent customer experiences for a growing business.

Apten

San Francisco

Apten is an omni-channel AI agent that automates sales and marketing conversations across SMS, voice, and email, personalizing follow-ups and leveraging CRMs; profitable with 30%+ MoM growth, serving healthcare, education, and home services

Candid Health

San Francisco

Candid Health uses data science and machine learning to automate medical billing and reduce costs in the US healthcare system. A Y Combinator W20 alum with strong investor backing and rising demand from potential customers.

Polymath Robotics

San Francisco

Polymath Robotics develops software to safely control all industrial vehicles and quickly bring autonomous vehicles to various industries. With about 20 employees, its engineering is based in SF Mission office three days a week as part of a

DeepAware AI

San Francisco

DeepAware AI is a YC-backed startup delivering AI-powered infrastructure management and autonomous robotics for data centers, aiming to improve security, uptime, and energy efficiency by up to 30% for operators and AI infrastructure provide

Event Horizon Labs

San Francisco

Event Horizon Labs is building the Post-Human Trader, an autonomous system that turns raw compute and data into alpha, designed to trade without the friction or bias of human emotion.

Proven Group

San Francisco

PROVEN is a technology-first skincare company that uses data and machine learning to tailor skincare decisions for individuals, anchored by the Beauty Genome Project, which analyzes 8 million reviews, more than 100,000 products, 20,000 ingr

Godela

San Francisco

Godela, a San Francisco-based, three-person B2B software startup founded by Abhijit Pranav Pamarty and Cinnamon Sipper, builds AI models for engineers and scientists, including first Physics Foundation Model that learns from simulation, exp

Arnata

San Francisco

Arnata develops AI Workers, autonomous agents for logistics teams designed to operate within their workflows.

Vooma

San Francisco

Vooma builds an AI agent and automation platform for logistics, leveraging AI research and autonomous-vehicle expertise. Founded by Jesse Buckingham and Mike Carter, it has seed funding from Tier 1 investors and enterprise contracts with le

Text.ai

San Francisco

Text.ai is a consumer-first, AI-native company building first AI-native group chat platform where every conversation is intelligent, collaborative, and effortless. Backed by Y-Combinator, it aims to make multiple humans happy through true g

Wafer

San Francisco

Wafer provides a GPU optimization platform for AI model training and inference, plus infrastructure for inference and GPU optimization, focused on optimized AI inference tailored to each stack.

OfOne

San Francisco

OfOne uses voice AI to transform drive-thru experiences for top-50 restaurant chains, automating tens of thousands of orders weekly during an active rollout. Backed by Gaia Ventures, SignalFire, Correlation Ventures, and Y Combinator, it is

BrowserOS

San Francisco

BrowserOS develops an open-source agentic browser to host a generalist AI agent that performs tasks in the browser. It invites collaboration on building browser agents and training Large Action Models, positioning itself as a developer of b

AgentHub

San Francisco

AgentHub is an early seed-stage startup building a simulation and evaluation engine for AI agents, providing the infrastructure layer for agent-driven products. Its team includes the former Apple Foundation Model Evaluation lead and CMU/MIT

Rebolt

San Francisco

Rebolt is building a no-code platform that lets companies create and deploy custom full-stack applications in minutes, enabling both technical and non-technical teams to replace spreadsheets and generic SaaS with their own internal tools.

Ultra

San Francisco

Ultra is a life-planning platform that helps students navigate college admissions and life decisions. Founded by Oliver Zou, it serves the US and China and is backed by Y Combinator and General Catalyst, with Uber and Lyft angel investors.