AI/ML startups in San Francisco

Attune

San Francisco

Attune builds developer tools for a post-AI world, delivering tooling for developers operating in a post-AI context and positioning itself as a provider in the evolving developer tools market. It prepares developers for the next era of soft

Verge Genomics

San Francisco

Verge Genomics uses AI and human tissue data in its CONVERGE platform to map disease biology, identify targets, and de-risk drug development, with two drugs in clinical trials, 282 targets discovered, and partnerships worth $1.6B.

Everest

San Francisco

The company builds AI employees for IT services, aiming to transform the $300B IT services industry from 10–20% margins to software margins by turning outsourced IT support into a software business and building a $100B company that changes

Mosaic

San Francisco

Mosaic is developing an agentic video editing paradigm to build an agentic video editor. Its ex-Tesla engineering team has won the Google Gemini Kaggle grand prize ($25,000) from 6,400 entrants and the SaaStr AI Pitch competition.

Ridecell

San Francisco

Ridecell leads the digital transformation of fleet operations in Europe and North America, serving fleet operators and governments for clients such as Penske, Toyota, Ford, Daimler, BMW, BNP Paribas and Arval, including San Francisco and Ne

Raindrop

San Francisco

Raindrop provides monitoring and alerting for AI applications. Backed by Y Combinator, it counts investors including James Tamplin, Guillermo Rauch, Balaji Srinivasan, Matt MacInnis, and backers from OpenAI, Apple, Figma, Scale.

Canvas

San Francisco

Canvas, a small team, is building AI Operating System for B2B sales, backed by Y Combinator, to automate boring parts of outbound so humans can focus on finding and connecting with prospects, via AI research agents and on-demand human SDRs.

Rescale

San Francisco

Rescale is a cloud-based platform for computational engineering and R&D that democratizes access to HPC, simulation, AI/ML, and digital twins, serving leading automotive and life sciences firms and operating the largest network of hyperscal

Phind

San Francisco

Phind reinvents AI search with rich, interactive answers. Based in San Francisco with a small team, led by co-founder and CEO Michael Royzen, a UT Austin Turing Scholar ’22 with prior NLP and ML roles at Lyft, Cloudflare and Microsoft.

Spellbrush

San Francisco

Spellbrush positions itself as the world's leading generative AI studio and creator of niji・journey project, develops anime-style games with balanced gameplay and a strong focus on visual arts, and researches AI-assisted artistry in videoga

Sample

San Francisco

Sample Healthcare is a profitable San Francisco-based healthcare AI company backed by notable investors including Kulveer Taggar, Zack Kanter, Homebrew Ventures, Y Combinator, and alumni from Retool, Stripe, Ambience Healthcare, and Watersh

Reprompt

San Francisco

Reprompt builds AI Agents for location-based mapping, helping Radar and TomTom keep maps current with live POI data. It runs an AI agents platform (Web, Vision, Doc Reading; upcoming self-driving browser agents) led by Mapbox, Facebook, and

Relace

San Francisco

Relace focuses on models and infrastructure for coding agents, defining its core offerings around coding-agent technology.

Julius

San Francisco

Julius is San Francisco AI lab aiming to enable one billion people to become software creators. It writes 1 million lines of code every 36 hours and generates 3 million visualizations for more than 1 million users.

Relari

San Francisco

Relari is building infrastructure for trustworthy AI agents in the Software 3.0 era, behind Nuvi.dev, and has developed open-source frameworks Agent Contract and continuous-eval to help ensure AI systems behave as intended.

Openlayer

San Francisco

Openlayer, founded by three former Siri engineers, builds sustainable, high-performing, ethical machine learning for enterprise clients; backed by Y Combinator and investors from Instagram, Voyage, Instacart, Sendbird, and Mercury, and work

Lucid

San Francisco

Lucid is a small team building real-time interactive video models, whose work is described as sparking joy, and it seeks an engineer to build the infrastructure enabling real-time video generation at scale across cloud and bare metal enviro

Candle

San Francisco

Candle operates a consumer app that improves communication for Gen Z couples and aims to expand to friends and family; with 250k+ users and targeting 1M by end-2025, it uses a React Native/SwiftUI frontend and Convex backend with AI agents.

Peppr AI

San Francisco

Peppr AI builds an enterprise data and intelligence layer that enables AI agents to learn from how employees work, stitching scattered data into a self-improving, org-wide knowledge base. Deployed at 1,000+ employee enterprises (including C

Turing Labs

San Francisco

Turing Labs Inc. provides an AI-powered SaaS platform for the CPG industry to help companies create new products using data and industry-specific AI, pursuing a more sustainable world; Forbes describes it as 'the Palantir for the CPG indust

CTGT

San Francisco

CTGT Inc safeguards reputational risk from GenAI for organizations in the B2B software and services infrastructure market. Based in San Francisco as a seven-employee startup founded by Cyril Gorlla and Trevor Tuttle, Gorlla's efficient AI w

Code Four

San Francisco

Code Four is an AI-first public-safety startup applying artificial intelligence to challenges for municipal, county, state, and federal agencies, positioning itself at the forefront of public-safety technology across multiple government lev

Aden

San Francisco

Aden is an AI-native, multi-agent ERP platform unifying business systems for operations leaders. Customizable and deployable, it uses declarative solutions and AI agents to automate workflows, serving over 100 businesses, including supply c

Nozomio

San Francisco

Nozomio builds context-augmentation infrastructure for AI agents, indexing codebases, documentation, and external sources to provide agents with expanded knowledge. It claims this boosts performance by 27% and emphasizes fast shipping and r

Waypoint Transit

San Francisco

Waypoint Transit automates urban planning to help cities design sustainable, resilient, human-centric environments faster and cheaper, reducing reliance on costly consultants; led by CTO Ryan Johnston and CEO Varun Tandon, leveraging expert

Sonauto

San Francisco

Sonauto builds a platform for creating, sharing, and listening to music powered by its in-house generative model, Melodia. It aims to democratize music-making, letting beginners express themselves through cutting-edge generative music resea

Shadeform

San Francisco

Shadeform is a cloud GPU marketplace across 15+ providers, building a multi-cloud distributed compute platform to run inference and training workloads anywhere. It serves Fortune 100s, startups, and others, emphasizing capital efficiency an

Theorem

San Francisco

Theorem is an AI and programming languages research lab in San Francisco that develops scalable software correctness feedback and cryptography securing trillions of connections; it publishes at NeurIPS, ICML, POPL, and ITP, and runs educati

Pincites

San Francisco

Pincites is an AI contract negotiation assistant embedded in Microsoft Word that helps legal teams review and redline contracts faster; a YC S23 startup with unicorn customers, it doubled revenue in Q1 2024 and is led by Sona and Mariam.

FuseAI

San Francisco

FuseAI is a Y Combinator–backed enterprise GTM automation platform building an agentic OS to automate go-to-market teams with AI agents. San Francisco-based, eight-employee startup founded by Saurav Bubber and Imogen Low, who bring Deel and

Casco

San Francisco

Casco performs security reviews of web, cloud, and AI applications using supervised AI agents that think like attackers to identify vulnerabilities and provide remediation guides, pioneering AI-driven security testing designed to make softw

Overlap

San Francisco

Overlap builds multimodal video marketing AI agents for media companies, serving some of the world's largest media companies with thousands of creators using its product. Headquartered in San Francisco, it is led by CEO Jonathan Baer and CT

Paragon AI

San Francisco

Paragon AI (S22) provides AI-powered sales technology that extracts information from meetings, emails, and calls to automate tasks, deliver insights, and coach teams, addressing administrative burdens and incomplete CRM data; led by founder

DryMerge

San Francisco

DryMerge provides a platform to create AI agents that connect to apps and automate tasks via a chat interface, emphasizing near-perfect accuracy and deep integrations with Gmail and Salesforce; it is a small Rust/Javascript/Svelte engineeri

SafeBeat

San Francisco

SafeBeat Rx is a healthcare tech company developing ECG software and a take-home kit to enable at-home initiation of heart medications, backed by YC Summer 2021 and pursuing clinician-approved AI-driven dosing and faster FDA pathways to red

WAYLINE

San Francisco

Wayline provides 24/7 support for property managers, serving as a dependable, around-the-clock partner in property management.

Helicone

San Francisco

Helicone is an open-source observability platform for LLM applications, delivering monitoring, optimization, and reliability tools to productionize AI systems. With ~4,000 GitHub stars, a thriving community, 20% MoM growth, and SOC 2 and GD

Stably AI

San Francisco

Stably AI focuses on AI-powered QA testing to help teams deliver software faster. Founded by experts who built testing infrastructure at Google and ML systems at Uber, it positions itself as a leader in AI-powered QA testing.

Toothy AI

San Francisco

Toothy AI automates back-office operations for dental clinics using large language models, led by founders with proven AI-enabled B2B track records (Chen’s SoftBank-backed $1M ARR AI email solution; Kerrigan’s pre-ChatGPT LLM campaign tool)

JustAI

San Francisco

JustAI is a marketing technology company that uses AI to enable 1-to-1 hyper-personalized messaging and continuous always-on testing, reducing operational overhead and accelerating rapid marketing experimentation by moving away from traditi