AI/ML startups in San Francisco

Empathic Labs

San Francisco

San Francisco-based, engineering-first company building AI conversations that feel like real people, with real-time, native integration in FaceTime and iMessage. Backed by BoxGroup and led by a Thiel Fellow and YC alum who recently sold his

April

San Francisco

April is an AI Executive Assistant for email and calendar that is voice-first and productivity-obsessed, backed by Y Combinator; it launched in August and has shown traction as it grows, aiming to give every busy professional the assistant

Planbase

San Francisco

Planbase is a flexible AI-powered platform that embeds intelligence into operations, tailoring to each workflow to boost speed and accuracy; it serves healthcare organizations touching 100M+ patients, including $500M+ revenue leaders, with

Meridian

San Francisco

The company catalyzes the next generation of consumer experiences by redefining how people interact with products and services, driving innovation in everyday engagement and shaping how brands are experienced in modern markets.

Ohm

San Francisco

Ohm is a San Francisco-based AI-first company applying AI to battery research, validation, and manufacturing workflows. Backed by Y Combinator and other investors, it leverages a lean, multidisciplinary team of engineers, creatives, and PhD

Kalos

San Francisco

Kalos is an early-stage, high-growth startup in San Francisco, currently in stealth mode, that has built Blue, an AI agent.

Domu Technology Inc. (YC S24)

San Francisco

Domu Technology Inc. automates debt-collection calls for banks and insurers, serving six Fortune 500s and major firms including MetLife, BBVA, and BNP Paribas Cardif. A YC alum with a female-led team, it reduces costs and improves recovery

Cua

San Francisco

Cua builds infrastructure for general AI agents to safely use computers and apps. It offers an open-source framework and cloud sandboxed container platform, a seed round, 9k+ GitHub stars in four months, and a research-backed blueprint for

Trellis AI

San Francisco

Trellis provides an AI agent that automates healthcare administrative workflows—such as intake, prior authorizations, and appeals—positioning itself as a solutions-focused partner to increase provider revenue while reducing administrative b

Chima

San Francisco

Chima helps leading institutions customize and scale generative AI by integrating and analyzing private and public data to privately leverage commercial LLMs; it builds infrastructure for enterprises to customize LLMs and automate functions

Dalus

San Francisco

Dalus develops AI-powered software that makes hardware design feel like software development, targeting aerospace, robotics, and defense. Founded in 2024 by Eliot and Sebastian, it has revenue and completed YC W25.

Promptless

San Francisco

Promptless builds AI teammates that integrate with users’ existing workflows, serving startups and Fortune 500 enterprises. It ranked among the top W25 by revenue; small founding team has led startups, published LLM research, and graduated

Sepal AI

San Francisco

Sepal AI provides PhD-level experts for AI model development, backed by YC-backed founders from Vercel and Turing. Since 2024, it has raised millions and counts Fortune 500s and top AI labs as customers, building the largest global talent g

Prelude AI

San Francisco

The company is building an AI-native platform that makes financial advisors more effective, transforming wealth management by advancing advisory capabilities with advanced technology. Backed by a world-class founding team from top fintech a

Conductor Quantum

San Francisco

Conductor Quantum, based in San Francisco, develops software to enable fault-tolerant quantum computation. A small team of quantum physicists, hardware engineers, and machine learning experts envisions scalable operation of thousands to bil

Entangl

San Francisco

Entangl uses AI to autonomously detect design errors in data center engineering and operations, delivering targeted solutions to engineers. Founded by Shapol and Antanas, ex-reusable rocket program leaders, Entangl aims to save time, reduce

Novoflow

San Francisco

Novoflow deploys AI employees for medical clinics, building computer agents to modernize healthcare and automate front- and back-office tasks across a fragmented 400+ EHR ecosystem; contracts secured, backed by YC advisers and top investors

Additive AI

San Francisco

Additive AI, founded in San Francisco, builds AI-powered tools to automate document-heavy tax and accounting workflows; acquired by Thomson Reuters in 2025, it operates as part of a global leader to help professionals make faster, more info

Pearson Labs

San Francisco

Pearson Labs presents itself as a small, high-impact, lean team focused on delivering meaningful results, emphasizing impact over scale; no information is available about its mission, products, services, or market position.

Conduit Intelligence

San Francisco

The company develops noninvasive thought-to-text technology to bridge communication between people and devices by reducing the language barrier.

Dream

San Francisco

Dream is an AI platform that automates residential architecture and construction planning, transforming a slow, expensive process into an instantaneous, affordable one by enabling AI-driven design and planning for homes.

Relixir

San Francisco

Relixir is an autonomous search share maximization platform serving 40+ B2B clients. Founded by Berkeley alumni, it participated in Y Combinator's X25 batch and ranks as one of its fastest-growing companies.

Bindwell

San Francisco

Bindwell uses AI to discover new pesticides, replacing slow lab work and accelerating discovery by 100×. The company is a small team of Caltech and Wolfram Research alumni with drug-discovery ML experience, aiming to rebuild agrochemical R&

Kato

San Francisco

Kato builds an AI-powered servicing platform that automates critical workflows across channels with full compliance and best-in-class recoveries, in production with major fintech lenders including Bilt Rewards and Parafin, emphasizing a com

Zettascale

San Francisco

Zettascale develops reconfigurable, energy-efficient AI chips for training and inference that optimize each model’s dataflow, aiming to outperform GPUs in speed and power efficiency and to save data centers billions in cooling and energy co

Midcentury Labs

San Francisco

Midcentury is building a next-generation platform for audio AI that enables secure onboarding of private data and expert-labeled data services from global contributors to tackle multimodal AI with massive data pipelines; it recently raised

StackAI

San Francisco

Stack AI provides a no-code drag-and-drop platform to design, test, and deploy AI workflows that leverage large language models to automate business processes. Its visual interface lets users connect data sources with different AI models to

NOSO LABS

San Francisco

NOSO LABS builds agents for the trades to help technicians diagnose accurately and sell 10x better, providing tools that improve diagnostic precision and sales performance for trade professionals.

GroundControl

San Francisco

GroundControl is a vertical SaaS company solving inefficiencies in regulated manufacturing, focusing on aerospace and defense, enabling high-quality parts with precision. It operates in the U.S., serves North American aerospace/defense clie

Dart

San Francisco

Dart, founded in 2022 in San Francisco, positions itself as the only truly AI-native project management tool, with an AI-first, product-driven approach. With about 10 full-time staff (5 engineers) and revenue growth in 2025, it has strong f

Exa

San Francisco

Exa, a San Francisco-based startup, is building a next-generation AI search engine aimed at outperforming Google for power users, with an about 20-person team including alumni from Harvard, MIT, Apple, and Palantir, and a Series A from Ligh

BentoML

San Francisco

BentoML is an enterprise-grade inference platform that deploys and manages AI models at scale, serving LLMs, embeddings, and agentic pipelines across VPC, on-prem, or hybrid environments. It covers the full inference lifecycle with mission-

Datrics

San Francisco

Datrics, a San Francisco-based company with 22 employees, develops generative AI for healthcare coding automation, led by CEO Anton Vaisburd and founded by Kirill Kirykov and Volodymyr Sofinskyi, both seasoned data science and analytics exe

Milo

San Francisco

Milo (W20) markets itself as The Family AI, a copilot helping parents manage the invisible load of raising a family. It is led by Avni Patel Thompson, founder/CEO of Modern Village, which uses collaborative technology to ease parenting.

Tydo

San Francisco

Tydo builds AI-powered personalization for ecommerce brands, helping them translate data into trusted, personalized shopping experiences; backed by Tier 1 investors like YC, Greylock, Alt Capital, and Manresa Ventures, and serving retailers

MDalgorithms

San Francisco

MDalgorithms is a remote, AI-driven dermatology and hair care company building custom deep learning models, native apps, and e-commerce APIs. It runs MDacne, a dermatology app with millions of downloads, and MDhair, a regrowth kit, backed b

Collectly

San Francisco

Collectly is a profitable healthcare tech startup that uses proprietary EHR interfaces to simplify billing, accelerate cash flow, and enhance the patient financial experience, serving 300k+ patients daily across U.S. practices with AI-drive