South San Francisco, California, United States · On-site
$100k–$159k/yr
Frontier Medicines is seeking a highly motivated Scientist, AI Engineer to join our AI organization. This role will play a key scientific and technical role in advancing Frontier’s AI and cheminformatics capabilities in …
Skills: Python, Machine Learning, Generative AI, Deep Learning, Cheminformatics
South San Francisco, California, United States · Hybrid
$252k–$269k/yr
Company Description AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable imp…
Skills: Data Strategy, Business Intelligence, Data Analysis, Data Management, Marketing Analytics
South San Francisco, California, United States · Hybrid
$229k–$302k/yr
The Position Genentech, Inc. seeks a Principal Software Engineer at its South San Francisco, CA location. Duties: Identify innovative and sustainable solutions to improve data management and business processes to address…
Skills: Object-Oriented Design, Microservices Architecture, Amazon Web Services (AWS), Java, Python
South San Francisco, California, United States · On-site
$136k–$170k/yr
About Xaira Therapeutics Xaira is an innovative biotech startup focused on leveraging AI to transform drug discovery and development. The company is leading the development of generative AI models to design protein and a…
Skills: Single-cell RNA sequencing, Perturb-seq, Bioinformatics Pipelines, Python, Nextflow
South San Francisco, California, United States · On-site
$165k–$245k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Rust, C++, Embedded Linux, Interprocess Communication, Concurrency
South San Francisco, California, United States · On-site
About Westmag Westmag is the American manufacturer of drone motors and robot actuators, backed by Andreessen Horowitz, Founders Fund, Lux Capital, NFDG, Menlo Ventures, and other top investors. Westmag is committed to bu…
Skills: Quality Management Systems, Root Cause Analysis, CAPA, Statistical Process Control, FMEA
South San Francisco, California, United States · Hybrid
$190k–$286k/yr
Who we are About Stripe Stripe, LLC. is a financial infrastructure platform for businesses. Millions of companies - from the world’s largest enterprises to the most ambitious startups - use Stripe to accept payments, gro…
Skills: Java, C++, Scala, Javascript, Ruby
South San Francisco, California, United States · Hybrid
About Deep Origin Led by Michael Antonov, a co-founder of Oculus, and well-funded by Formic Ventures, Deep Origin is poised to reinvent the way scientists work and life science innovations come to life. We see a future l…
Skills: NodeJS, React, TypeScript, JavaScript, Postgres
South San Francisco, California, United States · On-site
$170k–$200k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Lifecycle Marketing, CRM Execution, Customer Journey Mapping, Braze, A/B Testing
South San Francisco, California, United States · On-site
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Flight Algorithms, Dynamic Modeling, Linear Control Analysis, Optimal Control, C
South San Francisco, California, United States · On-site
$180k–$270k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Frontend Development, Backend Development, Customer Acquisition, A/B Testing, Data Analytics
South San Francisco, California, United States · On-site
$145k–$185k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: C, C++, Python, Linux Kernel, Real-time Systems
South San Francisco, California, United States · On-site
$130k–$190k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: PCBA Manufacturing, Design For Manufacturing (DfM), Supplier Quality Management, Root Cause Analysis, Statistical Process Control (SPC)
South San Francisco, California, United States · On-site
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Technical Program Management, Hardware Project Delivery, Strategic Roadmapping, Systems Thinking, Risk Management
South San Francisco, California, United States · Hybrid
$230k–$275k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Cloud Security, Application Security, Threat Modeling, Secure SDLC, IAM
South San Francisco, California, United States · On-site
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Program Management, Risk Mitigation, Cross-functional Leadership, Technical Communication, Timeline Definition
South San Francisco, California, United States · On-site
$150k–$215k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Board Level Design, Circuit Analysis, Schematic Capture, PCB Layout, Power Electronics
South San Francisco, California, United States · On-site
$155k–$225k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: C++, Rust, Python, Motor Control, Embedded Systems
South San Francisco, California, United States · On-site
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: 2D CAD, 3D CAD, Structural Analysis, Prototyping, Root Cause Analysis
South San Francisco, California, United States · On-site
$120k–$247k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Supplier Industrialization, DFM, Lean Methodologies, Statistical Process Control, PPAP
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Design and deploy multimodal AI models and agentic systems to accelerate covalent small molecule drug discovery. Collaborate with cross-functional teams to translate complex chemical and biological data into actionable scientific insights.
Requires a Bachelor's degree with 2-3 years of industry experience or a PhD with at least 1 year of experience in a quantitative discipline. Must possess strong Python programming skills and expertise in deep learning architectures for molecular design.
Frontier Medicines is seeking a highly motivated Scientist, AI Engineer to join our AI organization. This role will play a key scientific and technical role in advancing Frontier’s AI and cheminformatics capabilities in support of covalent small molecule drug discovery.
The successful candidate will design and deploy machine learning models, agentic AI systems, and multimodal foundation and generative models that leverage Frontier's large-scale covalent chemistry and chemoproteomics data to accelerate compound design, prioritization, and optimization. This role works closely with medicinal chemistry, biology, and cross-functional drug discovery teams to build AI-powered tools that translate complex, heterogeneous data into actionable scientific insight
This position is ideal for an individual contributor who thrives in scientifically uncharted territory and enjoys building novel solutions for medicinal chemistry, biology, and computational chemistry teams.
This is an exciting opportunity in our South San Francisco site to deploy AI to make a difference for patients suffering from debilitating diseases by working in a highly collaborative and energetic team in a startup environment with short communication lines across functions and departments
What we are looking for:
Traits we believe make a strong candidate:
Leveling Guidelines
Scientist I
At Frontier, we strive to build a diverse and equitable workplace. The salary range for this role is $100,000 - $158,900. Compensation for the role will depend on a number of factors, including candidates' qualifications, skills, competencies and experience. Frontier offers a competitive total rewards package which includes healthcare coverage, 401k and a broad range of other benefits.
This compensation and benefits information is based on Frontier's knowledge as of the date of publication, and may be modified in the future.
Frontier Medicines is a biopharmaceutical company that “drugs the undruggable” to transform patients’ lives.
Frontier Medicines, located in South San Francisco, CA and Boston, MA, is a precision medicine company that has pioneered a powerful discovery and development platform designed to generate medicines against disease-causing proteins previously considered undruggable. We are deploying our technologies in chemoproteomics, covalent drug discovery, and machine learning to develop a pipeline of groundbreaking medicines against the most important drivers of disease. Our lead program targets both the activated and inactive forms of KRAS G12C, a validated driver in a number of cancers that until recently has been undruggable. Our pipeline embodies our vision of bolding advancing science to defeat disease, starting with cancer.
Offices: South San Francisco, CA 94080, US · 451 D Street, Suite 207, Boston, MA 02210, US
Based on 161 listings with disclosed salaries, most technology jobs in South San Francisco, CA pay between $130k–$265k per year. Individual offers vary with seniority, company size, and specialization.
There are currently 194 open technology positions in South San Francisco, CA listed on Clera. New openings are added daily as companies post roles.
Companies currently hiring include Zipline, Roche, Xaira Therapeutics, Cellares, Eli Lilly and Company, among others. Browse the listings above to see every active employer.
Yes — 24 of the 194 open technology positions offer remote or hybrid work (2 remote, 22 hybrid).
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