San Francisco, California, United States · On-site
$235k–$255k/yr
Olema Oncology is a clinical-stage biopharmaceutical company committed to transforming the standard of care and improving outcomes for patients living with breast cancer and beyond. It’s an exciting time to be part of Te…
Skills: Pharmacovigilance, Drug Safety, NDA/BLA Submissions, Benefit-Risk Assessment, Clinical Safety Data Integration
San Francisco, California, United States · On-site
$220k–$245k/yr
Olema Oncology is a clinical-stage biopharmaceutical company committed to transforming the standard of care and improving outcomes for patients living with breast cancer and beyond. It’s an exciting time to be part of Te…
Skills: Clinical Trial Planning, Technical Writing, Oncology Clinical Development, Regulatory Documentation, Data Analysis
San Francisco, California, United States · On-site
$150k–$165k/yr
Olema Oncology is a clinical-stage biopharmaceutical company committed to transforming the standard of care and improving outcomes for patients living with breast cancer and beyond. It’s an exciting time to be part of Te…
Skills: In Vitro Assay Development, High Throughput Screening, Mammalian Cell Culture, Western Blotting, qRT-PCR
San Francisco, California, United States · On-site
Astranis builds advanced satellites for high orbits, expanding humanity’s reach into the solar system. Today, Astranis satellites provide dedicated, secure networks to highly-sophisticated customers across the globe— lar…
Skills: Program Management, Risk Management, Stakeholder Interaction, Scheduling, Headcount Tracking
San Francisco, California, United States · On-site
About Chai Discovery Chai is a research lab working on generative models for molecular design. We are building AI infrastructure to engineer new medicines with speed and precision. The world’s largest pharmaceutical comp…
Skills: Security Engineering, Python, TypeScript, Incident Management, SOC 2
San Francisco, California, United States · Hybrid
The Division of Cardiology is one of the largest clinical, research and training divisions of the Department of Medicine (DOM) at UCSF. The Division has developed a well-established Cardiology Clinical Research Unit (CCR…
Skills: Clinical Research Coordination, Data Management, Regulatory Compliance, Patient Recruitment, Protocol Writing
San Francisco, California, United States · On-site
$176k–$209k/yr
Job DetailsJob Location: San Francisco - SAN FRANCISCO, CA 94103Position Type: Full TimeSalary Range: $176,000.00 - $209,000.00 Salary/yearHead of Operations Youth AI Safety Institute Organization Common Sense Media Prog…
Skills: Operational Leadership, Fiduciary Oversight, Governance Compliance, Strategic Partnerships, Contract Negotiation
San Francisco, California, United States · On-site
$30/hr–$35/hr
Join the Sleep Fitness Movement At Eight Sleep, we’re on a mission to fuel human potential through optimal sleep. As the world’s first sleep fitness company, we’re redefining what it means to be well-rested and building …
Skills: Electromechanical Prototyping, Hardware Troubleshooting, Failure Analysis, Multimeter Usage, Oscilloscope Usage
San Francisco, California, United States · On-site
$45/hr–$55/hr
About Mariana Minerals Mariana Minerals is a software-first, vertically integrated minerals company on a mission to supply the critical minerals powering modern energy, AI, and defense technologies. We’re reimagining the…
Skills: Preventive Maintenance, Corrective Maintenance, Troubleshooting, Fabrication, Equipment Installation
San Francisco, California, United States · On-site
$46/hr–$47/hr
The Senior Clinical Research Coordinator independently coordinates and is accountable for the overall operation of the Ibrahim El-Hefni Liver Biorepository (IELB) and its associated clinical research studies at UCSF. Req…
Skills: Biorepository Management, Clinical Research Coordination, Regulatory Compliance, IRB Application Management, Biospecimen Processing
San Francisco, California, United States · On-site
$80k–$100k/yr
The Clinical Research Coordinator (CRC) will work with a close-knit group of health services researchers and clinicians at the University of California, San Francisco and San Francisco VA Health Care System, who are focu…
Skills: Clinical Research Coordination, Patient Recruitment, Data Collection, Electronic Medical Records, Qualitative Analysis
San Francisco, California, United States · Hybrid
$116k–$157k/yr
We are rebuilding biotech for the AI era. When a breakthrough is delayed, the world waits. Getting a molecule from discovery to patients, or a crop from lab to field, involves thousands of slow, manual, disconnected step…
Skills: Project Management, Solution Design, Requirements Analysis, Data Modeling, Application Configuration
San Francisco, California, United States · On-site
$38/hr–$60/hr
Under the supervision of the Clinical Research Supervisor, Clinical Research Coordinators (CRC) support the clinical trial management of investigator-sponsored, pharmaceutical-sponsored, and/or other types of consortium …
Skills: Clinical Trial Management, Regulatory Compliance, Data Collection, Project Management, Patient Coordination
San Francisco, California, United States · On-site
$24/hr–$30/hr
Job DetailsJob Location: West Portal - San Francisco, CA 94127Position Type: Part TimeEducation Level: Completed Bachelor's Degree or higherSalary Range: $24.00 - $30.00 HourlyTravel Percentage: NegligibleJob Category: E…
Skills: Biology Tutoring, Chemistry Tutoring, Physics Tutoring, Lesson Planning, Classroom Management
San Francisco, California, United States · On-site
$38/hr–$61/hr
Under the supervision of the Clinical Research Supervisor, Clinical Research Coordinators (CRC) support the management of investigator-sponsored research studies as assigned/needed. Responsibilities include communicating…
Skills: Clinical Research Coordination, Project Management, Data Collection, Regulatory Compliance, Patient Enrollment
San Francisco, California, United States · On-site
$85k–$90k/yr
About Glide GLIDE is a nationally recognized center for social justice, dedicated to fighting systemic injustices, creating pathways out of poverty and crisis, and transforming lives. Through its integrated comprehensive…
Skills: Phlebotomy, HIV/HCV/STI Testing, Clinical Supervision, Quality Assurance, Harm Reduction
San Francisco, California, United States · Hybrid
$72k–$155k/yr
Job Summary: Sr. Research Administrator uses skills as a seasoned, experienced research administrator to develop complex grant and contract applications for international projects spanning disciplines at UCSF (pre-award)…
Skills: Pre-award Administration, Post-award Administration, Grant Writing, Financial Analysis, Project Management
San Francisco, California, United States · On-site
$113k–$150k/yr
Job Summary: The Program Manager supports the Leadership Team in both Women's Health and the Department of Obstetrics, Gynecology & Reproductive Sciences Division of Reproductive Endocrinology & Infertility (REI) as well…
Skills: Program Management, Stakeholder Management, Strategic Planning, Healthcare Administration, Project Tracking
San Francisco, California, United States · Hybrid
The Department of Pharmaceutical Services provides a full range of services for patients cared for by the Medical Center at UCSF and its providers and payors. These services include, but are not limited to: drug procurem…
Skills: Pharmaceutical Care, Medication Access, Prior Authorizations, Insurance Appeals, Patient Education
San Francisco, California, United States · Hybrid
Location: Mountain View, CA (On-site) Overview Diffusion models have transformed image, video, and multimodal AI. We're applying those ideas to one of the next frontiers in machine learning. At Granica, we're building La…
Skills: Diffusion Models, Generative Learning Algorithms, Representation Learning, PyTorch, JAX
Sign up with Clera and we'll reach out the moment a role actually fits you — no more spraying applications into the void.
Lead the strategy, evaluation, and communication of clinical safety data to support global regulatory submissions and product development. Oversee the preparation of key safety deliverables for NDA/BLA filings and drive cross-functional alignment on benefit-risk assessments.
Requires an advanced degree (MD, PhD, PharmD, or RN) with 8-10+ years of pharmacovigilance experience in the biopharmaceutical industry, specifically within oncology and small molecules. Must have proven experience with late-phase clinical development, NDA/BLA submissions, and regulatory interactions with agencies like the FDA and EMA.
Olema Oncology is a clinical-stage biopharmaceutical company committed to transforming the standard of care and improving outcomes for patients living with breast cancer and beyond. It’s an exciting time to be part of Team Olema, with our transformation into a fully integrated oncology company well underway, top-line data from our lead program expected later this year, and our first potential commercial launch on the horizon.
Our lead product candidate, palazestrant, is a novel, orally available complete estrogen receptor antagonist (CERAN) and selective estrogen receptor degrader (SERD) currently in two pivotal Phase 3 clinical trials. We expect top-line data from OPERA-01, our ongoing Phase 3 trial of palazestrant as a monotherapy in patients with second- or third-line ER+/HER2- metastatic breast cancer (MBC), in the fall which, if successful, could lead to our first potential approval and commercial launch in 2027. OPERA-02, our Phase 3 trial of palazestrant in combination with ribociblib in patients with frontline ER+/HER2- MBC, is enrolling patients. Together with its mechanism of action, pharmacokinetic properties, and the potential to demonstrate activity in both ESR1 wild-type and mutant tumors, palazestrant has the potential to transform the metastatic breast cancer treatment paradigm and access a $15 billion global market opportunity.
Our follow-on product candidate, OP-3136, is a potent KAT6 inhibitor with the potential to generate further value and meaningfully impact the metastatic breast cancer treatment landscape – particularly in combination with palazestrant. We recently reported encouraging Phase 1 monotherapy data from this program across multiple solid tumor types and are advancing patient enrollment in the ongoing combination arms in MBC.
Aspiring to transform the metastatic treatment paradigm is an ambitious endeavor that requires a resolute approach to developing better therapies and a passionate team dedicated to helping the patients we serve feel better, longer. We possess a deep commitment to our shared purpose, the sustained pursuit of excellence, cultivating the courage required to advance our programs, drive to succeed, and a collective capacity for adaptability through learning, growth, and evolution. Team Olema is made up of nimble self-starters who bring consistency in their quest for the extraordinary every single day.
If you’re ready to be part of a tenacious, courageous, agile, and growing team, join us in making a profound impact, together – for our patients, for your career, and for what’s beyond.
About the Role >>> Director, Safety Sciences
As the Director, Safety Sciences reporting to the Senior Director, Safety Science you will provide leadership for the strategy, evaluation, and communication of clinical safety data across the development lifecycle, supporting global regulatory submissions and ongoing product development. Oversee the development of key safety deliverables for NDA/BLA filings, lead integrated benefit-risk assessments, and drive cross-functional alignment on safety strategy and regulatory interactions. Ensure compliance with FDA, EMA, ICH, and other global regulatory requirements while enabling proactive risk management and informed benefit-risk decision-making.
This role is based out of our San Francisco or Boston office and will require less than 10% travel.
Your work will primarily encompass:
Ideal Candidate Profile >>>
A love of challenging, important work. We are a pragmatic team, driven to imagine and develop meaningful therapies for improving lives. All employees within our company play a unique and crucial role in our success, both in accomplishing our mission and building a positive company culture. As such, we are looking for someone with the right combination of knowledge, experience, and attributes for this role.
Knowledge:
Experience:
Attributes:
The base pay range for this position is expected to be $235,000 - $255,000 annually, however the base pay offered may vary depending on location, market, job related knowledge, skills and capabilities, and experience. The total compensation package for this position also includes equity, bonus, and benefits.
Important Information >>>
We provide equal opportunity to all employees and applicants for employment and believe that great ideas and discoveries come from a mix of expertise, background, and experience. Olema is building a culture where the value of difference is celebrated.
We offer a competitive compensation and benefits package, seeking to provide an open, flexible, and friendly work environment to empower employees and provide them with a platform to develop their long-term careers. A Summary of Benefits is available for all applicants.
Please note: Olema doesn’t accept agency resumes and is not responsible for any fees related to unsolicited resumes. Thank you.
Fraud Alert: We are aware of employment scams where individuals pose as representatives of Olema Oncology and make false use of our company name to defraud job seekers. To protect yourself, please note that Olema’s official email addresses end in @olema.com. Our official corporate website is olema.com; our careers page is olema.com/careers; our LinkedIn page is linkedin.com/company/olema-oncology. Please visit these links for official information from Olema. Communication from any other variant is fraudulent. Olema does not conduct interviews via text message/messaging platforms, will not ask you to download anything as part of your interview, will never request any form of payment, provide upfront payments of any kind, and does not make job offers without an in-person interview.
Olema Oncology is a cancer medicines company dedicated to impacting breast cancer and beyond. Our lead program, palazestrant (OP-1250), is a differentiated oral medicine known as a complete estrogen receptor antagonist (CERAN) initially in development for metastatic breast cancer. Our pipeline also includes OP-3136, a potent, selective oral inhibitor of the KAT6 pathway. At Olema, we are building a focused team committed to our mission with intention and clarity. Working alongside a talented, passionate group of leaders and advisors, we strive to create better medicines that aim to help patients feel better, longer. For more information, visit us at www.olema.com. Important Notice: Fraudulent Recruiting Activities We are aware of employment scams where individuals pose as representatives of Olema Oncology and make false use of our company name to defraud job seekers. To protect yourself, please note that Olema’s official email addresses end in @olema.com. Our official corporate website is olema.com; our careers page is olema.com/careers; our LinkedIn page is linkedin.com/company/olema-oncology. Please visit these links for official information from Olema. Communication from any other variant is fraudulent. Olema does not conduct interviews via text message/messaging platforms, will not ask you to download anything as part of your interview, will never request any form of payment, provide upfront payments of any kind, and does not make job offers without an in-person interview.
Offices: 780 Brannan St, San Francisco, California 94103, US · 101 Rogers St, 3B, Cambridge, Massachusetts 02142, US
Based on 1038 listings with disclosed salaries, most science & research jobs in San Francisco, CA pay between $90k–$295k per year. Individual offers vary with seniority, company size, and specialization.
There are currently 1,457 open science & research positions in San Francisco, CA listed on Clera. New openings are added daily as companies post roles.
Companies currently hiring include UCSF Department of Anesthesia and Perioperative Care, OpenAI, Anthropic, Sutter Health, Astranis Space Technologies, among others. Browse the listings above to see every active employer.
Yes — 589 of the 1457 open science & research positions offer remote or hybrid work (129 remote, 460 hybrid).
Each listing links directly to the employer's application page. Apply early — fresh listings get the most recruiter attention in the first two weeks.
