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Full-time
Posted 58d ago
~40 hrs/week
Responsibilities
Define and lead the antibody discovery strategy, translating somatic genomics outputs into therapeutic drug discovery programs. Lead cross-functional matrix teams from early conception through development candidate nomination and IND submission.
Requirements
Requires proven experience advancing protein therapeutics through drug discovery phases and expertise in structure-based protein engineering using AI/ML and in silico approaches. Must have a track record of project leadership within a pharmaceutical R&D environment.
Full job description
Position Summary:
Quotient is seeking a Director or Senior Director of Antibody Discovery. This role will define and lead Quotient’s antibody discovery strategy; leading the delivery of therapeutic antibody projects in addition to Quotient’s antibody drug discovery platform build through the deployment of cutting-edge technologies. This role will require close involvement in the end-to-end process of translating Somatic Genomics screening outputs (i.e. candidate genes and potential drug targets) into initiation of drug discovery programs. This role will also involve senior project leadership, steering drug discovery matrix teams from early conception through to key inflection points such as development candidate nomination and IND submission.
Responsibilities:
Provide balanced expert advice on the feasibility of antibody tractable targets and the conception of high-value drug molecules
Present antibody discovery strategies to internal R&D committees to justify capital commitment in new programs
Drive decision making on construct design, format and developability for new antibody programs according to Target Product Profile specifications
Independently carry out lead sequence and format optimizations utilizing rational, structure-based and in silico/AI/ML design approaches
Drive rapid optimization of novel antibody and protein therapeutics through iterative design, build, test, and learn cycles
As a drug discovery project leader, develop efficient and balanced project plans for one or more biologic drug discovery programs and lead a cross-functional team to execute through lead generation, development candidate nomination and IND submission
Model best matrix leadership behaviours and support an emphasis on enterprise leadership across the company
Identify, select, and manage external CROs/vendors, consultants, and academic collaborators to deliver a virtual/outsourced state-of-the-art drug antibody discovery platform for the identification of high-quality mAb molecules at pace
Build and maintain networks of external experts to pressure-test hypotheses and refine strategies
Serve as a specialist antibody discovery expert within Quotient’s drug discovery team and across the company.
Contribute to broader corporate strategy, BD evaluations, and exploratory platform initiatives
Qualifications:
Essential
Proven experience advancing protein therapeutics through drug discovery phases to development.
Expertise in structure-based protein engineering and design of antibodies including (multispecifics, Fc engineering, fusion proteins etc)
Skilled in antibody engineering, including use of in silico, structure-based, and AI/ML approaches to sequence/CDR design, use of display technologies, humanization techniques, sequence liability remediation, analytics, and developability (biophysical) assessment and improvement
Project leadership experience in pharmaceutical industry R&D environment across multiple therapeutic areas, with a deep understanding of lead identification and optimization through preclinical development of antibody therapeutics
Track record of advocating for acquisition or creation of new technologies for accelerated antibody design, expression, and characterization
Desirable
Experience in early-stage or start-up biotech environments
Experience working with genetic and genomics platform-driven drug target discovery
Broader understanding of protein sciences (expression, developability, and analytical purification and analysis)
Experience managing the design and validation of cellular assays for the functional characterization of engineered biologics
Values and Behaviors:
Encourage respectful disagreement and cultivate open-minded, ego-free interactions to continuously push each other towards excellence
Seek out diverse perspectives; practice active listening and genuine curiosity to ensure all contributions are valued, regardless of source
Recognize the impact of your behavior, language and attitudes, and strive for balanced, meaningful exchanges that enhance mutual growth and understanding in all interactions
Use a company-first mindset to guide decision-making; prioritize team over individual success
Take calculated risks and challenge convention in the quest for exceptional outcomes
About Quotient:
Quotient Therapeutics is a privately-held, early stage company developing breakthrough medicines informed by natural somatic genetic diversity present in patients. Through our work in somatic genomics, we are forging a new status quo for biopharma research and development across a broad pipeline of internal and partnered programs.
The company was founded by Flagship Pioneering, an innovative enterprise that conceives, creates, resources, and grows first-in-category life sciences companies. Flagship Pioneering has created over 100 groundbreaking companies over the past twenty years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Generate Biomedicines, Sana Biotechnology (SANA), Tessera Therapeutics, Evelo Biosciences (EVLO), Indigo Agriculture, Seres Therapeutics (MCRB), and Syros Pharmaceuticals (SYRS).
Quotient Therapeutics and Flagship Pioneering are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
Recruitment & Staffing Agencies:
Quotient Therapeutics (“Quotient”) and Flagship Pioneering (“FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Quotient, FSP or their employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.
Privacy Notice for Applicants: When you apply for a role at Flagship Pioneering or one of its portfolio companies, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact [email protected].
We are a biotechnology company that invents and builds platform companies that change the world.
Industry
Biotechnology Research
Company size
501-1,000 employees
Founded
2000
Headquarters
Cambridge, MA
LinkedIn followers
155,633
Total funding
$9.1B
Flagship Pioneering is a biotechnology company that invents and builds platform companies, each with the potential for multiple transformative human health and sustainability products. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures.
The current Flagship ecosystem comprises over 40 companies, including Denali Therapeutics, Foghorn Therapeutics, Generate:Biomedicines, Inari, Indigo Agriculture, and Tessera Therapeutics.
Offices: 55 Cambridge Parkway, Suite 800E, Cambridge, MA 02142, US
life sciencesbiotechtherapeuticsdiagnosticssustainabilityclimate changeartificial intelligencemachine learningagtechmedicines
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