Who We Are: Cogent Biosciences is a publicly traded biotechnology company focused on developing novel precision therapies to treat a broad range of patients with unmet medical needs. Cogent’s lead program, bezuclastinib,…
Skills: Structure-based Drug Design, Ligand-based Drug Design, Molecular Modeling, Docking, Virtual Screening
SciTec, a wholly owned subsidiary of Firefly Aerospace, is a dynamic non-traditional defense contractor that delivers advanced technologies in support of U.S. National Security and Defense. For the past forty-five plus y…
Skills: C++, Linux, Algorithm Development, Performance Optimization, Data Structures
We are seeking a highly skilled and detail-oriented Supply Chain Project Manager to join our team in a Good Manufacturing Practices (GMP) regulated environment. This role involves facilitating complex, high priority supp…
At KBI Biopharma, we are advancing science and accelerating breakthroughs. As a global leader in biopharmaceutical development and manufacturing, we empower life science companies to bring new medicines and vaccines to t…
Summary The position has responsibilities centered around the execution, planning, and management of assigned studies. The role will participate in vivo pharmacology research conducting biochemical screening models, proo…
Skills: In Vivo Pharmacology, Rodent Cardiac Survival Surgeries, Cardiac Ultrasound, Study Protocol Development, Data Management
Job DescriptionPosition Summary: This position is limited to an end date 9 months after the start date, unless a Student at Other Institution (SOI) form can be provided. The individual in this position will work remotely…
Skills: AI/ML, Data Assimilation, Python, HPC Clusters, GitHub
Minimum qualifications: PhD degree in Physics or Electrical Engineering, or equivalent practical experience. One or more scientific publication submissions for conferences, journals, or public repositories related to qua…
At KBI Biopharma, we are advancing science and accelerating breakthroughs. As a global leader in biopharmaceutical development and manufacturing, we empower life science companies to bring new medicines and vaccines to t…
Overview Rocky Mountain Cancer Centers, Colorado's largest and most comprehensive provider of cancer care has an exciting opportunity for a FT Radiation Therapist in Boulder This position includes a $20,000 sign-on bonus…
Skills: Radiation therapy, Patient care, Electronic medical records, Billing, Mu calculations
Overview Rocky Mountain Cancer Centers, Colorado's largest and most comprehensive provider of cancer care has an exciting opportunity for an experienced Clinical Research Patient Coordinator/RN in Boulder. Bring your est…
Battelle delivers when others can’t. We conduct research and development, manage national laboratories, design and manufacture products and deliver critical services for our clients—whether they are a multi-national corp…
Skills: Ecology, Environmental Science, Research Management, Data Analysis, Project Management
Sign up with Clera and we'll reach out the moment a role actually fits you — no more spraying applications into the void.
$180k–$210k/yr
Full-time
postgraduate degree
Medical Insurance, Dental Insurance, Vision Insurance, 401(k) Match, Paid Time Off, Parental Leave
Posted 74d ago
~40 hrs/week
Responsibilities
Apply structure-based and ligand-based drug design methods to support projects from hit discovery through lead optimization. Collaborate with cross-functional teams to generate hypotheses and maintain computational workflows on HPC Linux environments.
Requirements
Requires a Ph.D. in Computational Chemistry or a related field with at least 10 years of industrial experience. Expertise in MOE software, cheminformatics tools, and HPC infrastructure is essential.
Full job description
Who We Are:
Cogent Biosciences is a publicly traded biotechnology company focused on developing novel precision therapies to treat a broad range of patients with unmet medical needs. Cogent’s lead program, bezuclastinib, is designed to selectively and potently inhibit exon 17 mutations found within the KIT receptor tyrosine kinase, including KIT D816V. KIT D816V is responsible for driving a rare and serious condition called Systemic Mastocytosis, and exon 17 mutations are also found in patients with gastrointestinal stromal tumors (GIST), a type of cancer with strong dependence on oncogenic KIT signaling. Bezuclastinib has exhibited promising initial data across all three trials: APEX in AdvSM, SUMMIT in NonAdvSM, and PEAK in GIST, including an encouraging safety profile across 600+ patients in single-agent and combination dosing.
The Role:
We are seeking an Experienced Computational Chemist who thrives at the intersection of molecular modeling, data‑driven decision making, and innovative drug design. In this role, you will directly influence discovery programs by generating actionable structure‑based insights, developing predictive models, and partnering with multidisciplinary teams to guide molecular design from hits to optimized leads. This is a full-time, on-site position based at our R&D facility in Boulder, Colorado.
Responsibilities:
Apply structure‑based and ligand‑based drug design methods—including docking, protein modeling, and a range of computational techniques—to support projects from hit discovery through lead optimization.
Collaborate with project team members, engaging them in iterative structure‑based drug design cycles to generate hypotheses, evaluate targets, triage hits, and guide SAR exploration.
Present modeling insights clearly and effectively to cross‑functional project teams, ensuring data is interpreted in the right context.
Develop, refine, and maintain robust computational workflows on HPC Linux environments, enabling scalable execution of large‑scale simulations.
Train and mentor colleagues on computational chemistry tools, cheminformatics standards, data formats, and key workflow practices.
Qualifications:
Ph.D. in Computational Chemistry or a related field, with 10 years of relevant industrial experience.
Expertise in structure‑based design, docking, virtual screening, pharmacophore modeling, and other computational approaches for lead optimization.
Expertise in MOE modeling software, with working knowledge of other commercial and open‑source computational chemistry platforms preferred.
Strong hands‑on experience with cheminformatics platforms and tools, including Spotfire.
Strong programming skills with experience in building custom scripts or automated pipelines, is a plus.
Proficiency in Linux/UNIX, shell scripting, and HPC frameworks (e.g., SLURM, LSF, PBS/Torque).
Experience optimizing large computational workloads on cluster or cloud infrastructure.
Familiarity with molecular representations and cheminformatics standards (SMILES, SDF, descriptors, fragment‑based encodings).
A solid publication record and excellent scientific communication skills.
Proven effectiveness working within cross‑functional, data‑driven scientific teams.
Salary Range:
$180k - $210k USD
Target Bonus: 15%
Exact compensation will vary based on skills, experience, and location.
Our Locations
Waltham, MA: Our headquarters is located in the Greater Boston life sciencescommunity, with an open, collaborative office environment designedto support teamwork and connection. Employees benefit from convenient on-site amenities, including free on-site parking and gym facilities in the building.
Boulder, CO: Our Boulder location is home to Cogent’s discovery research organization and a key scientific hub with strong leadership based on site. Situated in the greater Denver-Boulder biopharmaceutical corridor, this office plays a central role in advancing our discovery efforts and pipeline.
Our Offer To You
At Cogent Biosciences, we offer a competitive salary, bonus, and ongoing stock awards, alongside a benefits package that sets us apart.We cover 100% of medical, dental, and vision premiums for you and your family, and help reduce out-of-pocket costs by funding up to 75% of in-network deductibles. Our benefits also include a 401(k) match with immediate vesting, generous paid time off, 12 weeks of fully paid parental leave, paid family and medical leave for all employees regardless of location, and company-paid short-term disability coverage for up to 20 weeks.Additionalperks likewellness programs, tuition reimbursement, and inclusive family-forming support help you thrive at work and beyond.
We are proud to be an Equal Opportunity Employer. Our goal is to have a diverse workforce. We do not discriminate on the basis of race, age, color, religion, national origin, gender, sexual orientation, gender identity or expression, veteran status or disability, or any other status protected under federal, state, or local law. All employment is decided on the basis of qualifications, merit, and business need.
Precision therapeutics for genetically defined diseases. Real solutions for real challenges.
Industry
Biotechnology Research
Company size
51-200 employees
Founded
2014
Headquarters
Waltham, Massachusetts
LinkedIn followers
21,304
Total funding
$1.2B
Cogent Biosciences is a biotechnology company focused on developing novel precision therapies to treat a broad range of patients with unmet medical needs. Cogent’s lead program, bezuclastinib, is designed to selectively and potently inhibit exon 17 mutations found within the KIT receptor tyrosine kinase, including KIT D816V. KIT D816V is responsible for driving a rare and serious condition called Systemic Mastocytosis, and exon 17 mutations are also found in patients with advanced gastrointestinal stromal tumors (GIST), a type of cancer with strong dependence on oncogenic KIT signaling. Bezuclastinib has already exhibited promising early clinical activity and safety in a Phase 1/2 trial in patients with advanced GIST and also has the potential to fill an unmet need for patients living with Systemic Mastocytosis.
Offices: 275 Wyman Street, 3rd Floor, Waltham, Massachusetts 02451, US · 4840 Pearl East Circle, Suite 100, Boulder, Colorado 80301, US
How much do Science & Research jobs in Boulder, CO pay?
Based on 136 listings with disclosed salaries, most science & research jobs in Boulder, CO pay between $72k–$192k per year. Individual offers vary with seniority, company size, and specialization.
How many Science & Research jobs are open in Boulder, CO right now?
There are currently 149 open science & research positions in Boulder, CO listed on Clera. New openings are added daily as companies post roles.
Which companies are hiring for Science & Research roles in Boulder, CO?
Companies currently hiring include KBI Biopharma, Lynker, Infleqtion, Inotiv, Danaher, among others. Browse the listings above to see every active employer.
Are there remote or hybrid Science & Research jobs in Boulder, CO?
Yes — 46 of the 149 open science & research positions offer remote or hybrid work (12 remote, 34 hybrid).
How do I apply for Science & Research jobs in Boulder, CO?
Each listing links directly to the employer's application page. Apply early — fresh listings get the most recruiter attention in the first two weeks.