Holly Springs, North Carolina, United States · Hybrid
$95k–$177k/yr
Principal Automation Engineer - Warehouse Automation (Holly Springs) Welcome to Holly Springs, North Carolina— home to Roche/Genentech's largest-ever investment: a $2B greenfield start-up where next-generation technology…
Skills: PLC Troubleshooting, SAP EWM, Körber K.One.X, AS/RS Systems, AGV Fleet Management
Holly Springs, North Carolina, United States · On-site
Company Overview FUJIFILM Biotechnologies is building the future of bioproduction in Holly Springs, North Carolina. By end of 2025, we’ll open North America’s largest end-to-end CDMO biopharmaceutical manufacturing facil…
Skills: Technology Transfer, Process Validation, Root Cause Analysis, CAPA, cGMP
Holly Springs, North Carolina, United States · On-site
Purpose Primary responsibilities for this position include performing tasks associated with release testing and reviewing laboratory data. The analyst will be responsible for ensuring that CSL Seqirus samples are collect…
Skills: Immunology Testing, Biochemistry Testing, GMP Compliance, ELISA, BCA
Holly Springs, North Carolina, United States · On-site
Do you want to work with a company that tackles fascinating problems and find solutions to complex challenges? Seqirus has an exciting opportunity to join our expanding team in Holly Springs, NC. With an advanced manufac…
Skills: Quality Assurance, GMP, FDA Regulations, Aseptic Processing, Biotechnology
Holly Springs, North Carolina, United States · On-site
Primary responsibilities for this position include performing tasks associated with release testing and reviewing laboratory data. The analyst will be responsible for ensuring that CSL Seqirus samples are collected, test…
Skills: Immunology, Virology, Release Testing, GMP, Mammalian Cell Culture
Holly Springs, North Carolina, United States · On-site
The incumbent will be a member of the Team at the Holly Springs Influenza Vaccine manufacturing facility, supporting Fill/Finish Operations. The 24/7 Manufacturing Engineering function provides technical support and trou…
Skills: Technical Support, Troubleshooting, Process Improvement, Documentation Authoring, Quality Records Management
Holly Springs, North Carolina, United States · On-site
Together We Build – Partnership, Innovation, Excellence, and Safety At Kelso Industries, 3,500+ employees across 30+ companies work together to deliver exceptional HVAC, mechanical, plumbing, refrigeration, and electrica…
Skills: Equipment Setup, Chemical Handling, Flushing Operations, Passivation, Jobsite Maintenance
Holly Springs, North Carolina, United States · On-site
$71k–$97k/yr
Career CategoryCollege JobJob DescriptionJoin Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious…
Skills: Analytical Skills, Decision-making, Leadership, Project Management, Problem-solving
Holly Springs, North Carolina, United States · On-site
Company Overview FUJIFILM Biotechnologies is building the future of bioproduction in Holly Springs, North Carolina. By end of 2025, we’ll open North America’s largest end-to-end CDMO biopharmaceutical manufacturing facil…
Skills: Emerson DeltaV, PI Data Historian, Automation Engineering, Code Configuration, User Requirements Specification
Holly Springs, North Carolina, United States · On-site
PSC Biotech provides the life sciences with essential services to ensure that health care products are developed, manufactured, and distributed to the highest standards, in compliance with all applicable regulatory requi…
Skills: Technical Project Management, Operational Readiness, Facility Start-up, GMP Operations, Risk Mitigation
Holly Springs, North Carolina, United States · On-site
$108k–$146k/yr
Career CategoryManufacturingJob Description HOW MIGHT YOU DEFY IMAGINATION? If you feel like you’re part of something bigger, it’s because you are. At Amgen, our shared mission—to serve patients—drives all that we do. It…
Skills: Root Cause Analysis, CAPA Development, Technical Writing, Project Management, Veeva QMS
Holly Springs, North Carolina, United States · On-site
$106k–$144k/yr
Career CategoryManufacturingJob Description Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with seri…
Skills: Frontline Leadership, Upstream Manufacturing, Cell Culture Operations, cGMP Compliance, Facility Startup
Holly Springs, North Carolina, United States · On-site
Career CategoryManufacturingJob Description HOW MIGHT YOU DEFY IMAGINATION? If you feel like you're part of something bigger, it's because you are. At Amgen, our shared mission—to serve patients—drives all that we do. Be…
Skills: People Leadership, GMP Manufacturing, Process Stewardship, Operational Readiness, CAPA Implementation
Holly Springs, North Carolina, United States · On-site
$115k–$156k/yr
Career CategoryEngineeringJob DescriptionJoin Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious…
Skills: Bioprocessing, Downstream Purification, Technology Transfer, Process Validation, Process Optimization
Holly Springs, North Carolina, United States · On-site
The incumbent will be a shop floor employee in the manufacturing organization. The incumbent will provide (be trained in) the technical skill-sets necessary to manufacture high-quality biologicals safely in a compliant, …
Skills: cGMP Compliance, Production Equipment, Cleaning, Disinfecting, Assembly
Holly Springs, North Carolina, United States · On-site
Career CategoryManufacturingJob Description HOW MIGHT YOU DEFY IMAGINATION? If you feel like you’re part of something bigger, it’s because you are. At Amgen, our shared mission—to serve patients—drives all that we do. It…
Skills: Contamination Control, Microbiology, Sterility Assurance, Root Cause Analysis, Quality Risk Management
Holly Springs, North Carolina, United States · On-site
Career CategoryManufacturingJob Description HOW MIGHT YOU DEFY IMAGINATION? If you feel like you’re part of something bigger, it’s because you are. At Amgen, our shared mission—to serve patients—drives all that we do. It…
Skills: Root Cause Analysis, Deviation Investigations, CAPA Development, Regulatory Inspection Readiness, GMP Compliance
Holly Springs, North Carolina, United States · On-site
Career CategoryManufacturingJob Description HOW MIGHT YOU DEFY IMAGINATION? If you feel like you’re part of something bigger, it’s because you are. At Amgen, our shared mission—to serve patients—drives all that we do. It…
Skills: Root Cause Analysis, Quality Risk Management, CAPA Management, GMP Regulations, Technical Writing
Holly Springs, North Carolina, United States · On-site
Career CategoryEngineeringJob Description Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with seriou…
Skills: Emerson DeltaV, Distributed Control System (DCS), Process Automation, Computerized Systems Validation, Data Integrity Assessments
Holly Springs, North Carolina, United States · On-site
Career CategoryManufacturingJob Description HOW MIGHT YOU DEFY IMAGINATION? If you feel like you’re part of something bigger, it’s because you are. At Amgen, our shared mission—to serve patients—drives all that we do. It…
Skills: People Management, Root Cause Analysis, CAPA Development, Environmental Monitoring, GMP
Holly Springs, North Carolina, United States • Hybrid
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Responsible for the technical integrity and optimization of automated material handling systems, including AS/RS and AGV fleets. Acts as the primary technical escalation point for warehouse control systems and ensures seamless IT/OT data integration.
Requires a Bachelor's degree with 8 years or a Master's degree with 6 years of automation experience, preferably in drug product manufacturing. Strong proficiency in PLCs, SAP EWM, and pharmaceutical regulatory standards like GAMP5 is highly preferred.
Principal Automation Engineer - Warehouse Automation (Holly Springs)
Welcome to Holly Springs, North Carolina— home to Roche/Genentech's largest-ever investment: a $2B greenfield start-up where next-generation technology, high-performing teams and Operational Excellence converge to create the global standard for high-volume, highly-efficient Drug Product manufacturing.
The facility's core is defined by Innovation - leveraging advanced automation, robotics, digital tools, real-time data analytics, and simple, streamlined processes to produce the highest quality medicines. This plant meets today’s demand for CVRM (Cardiovascular, Renal, and Metabolism) medicines and is scalable to grow with the portfolio, which focuses on next-generation metabolic medicines specifically targeting the global obesity epidemic and Type 2 diabetes. This is a fast-paced, entrepreneurial environment with a high-level of accountability, with planned launch in 2028.
ITOT supports Pharma Technical Manufacturing (PTM), PTM is responsible for managing all aspects of end-to-end drug substance and drug product manufacturing and supply. From the raw material to the final medicine, we contribute to deliver Roche’s ground-breaking therapies to more than 120 million patients around the world. We make our medicines at 9 sites around the world and coordinate all aspects of production of Roche medicines in all disease areas and dosage forms. To ensure readiness for a step-change in the standard of care that Roche delivers in the area of Cardiovascular, Renal and Metabolism (CVRM), PTM will construct a new manufacturing site in the U.S. in Holly Spring, North Carolina. ITOT will own and operate Manufacturing Technology stack at the site working with Global IT. The new site will focus on large volume low-cost Drug Product manufacturing (Component Prep & Compounding, Liquid PFS Filling, Automated Inspection, Autoinjector Assembly, Packaging/Finished Products).
Principal Automation Engineer is being hired to participate in Greenfield Project execution and then support the facility after going live.
Initially, you will perform a mix of remote and onsite work (first at the General Planner’s office, later at construction site/plant). You will transition to local full-time on-site work once the site buildings are built and equipment delivered. Travel of up to 30% of the time is expected during the project phase.
The Principal Automation Engineer - Warehouse Automation is responsible for the technical integrity, reliability, and optimization of the automated material handling systems within the Holly Springs facility. This role serves as the subject matter expert for the Körber K.One.X (Warehouse Control System), high-density Automated Storage and Retrieval System (AS/RS systems), and the Automated Guided Vehicle (AGV) fleet. You will bridge the gap between physical hardware and the digital warehouse layer, ensuring that pharmaceutical stock moves seamlessly and safely through the production lifecycle while maintaining strict GxP compliance. The role will also have responsibilities for Robotics Fleet management System that may be shared with Site Robotics Engineer. Leading automation impacting projects with large and/or complex scope and Driving strategic initiatives to improve business processes are also expected.
System Health Monitoring: Monitor the daily performance of the Körber K.One.X (WCS) and AS/RS, proactively identifying "stuck" telegrams or queue bottlenecks before they impact production output.
L2/L3 Technical Support: Act as the highest internal escalation point for complex automation failures. Troubleshoot the handshake between PLC layers and the WCS to resolve hardware-software "mismatches" in real-time.
Disaster Recovery: Maintain and periodically test the system recovery procedures for the WCS and PLC configurations to ensure rapid restoration of the warehouse flow in the event of a server or network failure.
Fleet Availability: Manage the daily operational readiness of the AGV fleet, overseeing battery health, charging station rotations, and sensor calibration to ensure 99%+ fleet availability.
Dynamic Traffic Tuning: Adjust FMS (Fleet Management System) parameters (e.g., zone blocking, speed limits, or path priorities) based on shifting daily operational volumes to prevent congestion in high-traffic corridors.
Safety Integrity: Conduct routine operational audits of AGV safety fields and emergency stop circuits to ensure the equipment continues to operate within its validated safety envelope.
Manage Site Robotics Fleet Management Systems in partnership with future Robotics functions at the site.
Interface Oversight: Monitor the SAP EWM-to-WCS (Black Box) message logs (IDocs/Web Services), resolving data discrepancies to ensure that the physical location of pharmaceutical stock always matches its digital twin in SAP.
Audit Trail Compliance: Ensure that all automated logs and event data required by 21 CFR Part 11 are accurately captured, archived, and available for regulatory inspections or quality audits.
Continuous Optimization: Analyze OEE (Overall Equipment Effectiveness) data from the WCS and AGV systems to propose small-scale logic adjustments that improve cycle times and reduce mechanical wear and tear.
Bachelor’s degree in Chemical, Mechanical, Electrical, or Computer Science or a related discipline and 8 years of applicable automation and/or instrument and control system experience preferably majority in drug product function. Or, Master's degree in Engineering or a related discipline and 6 years of applicable automation and/or instrument and control system experience preferably majority in drug product function.
5 years in the pharmaceutical/biotech industry/GMP experience is highly preferred.
24X7 on call support, participate in an on-call environment to meet business continuity requirements, including weekends and holidays as required.
Proficiency in troubleshooting PLCs (Siemens TIA Portal or Rockwell Automation) and their communication protocols (Profinet/EtherNet/IP).
Strong understanding of SAP EWM or similar WMS interfaces (IDocs, queues, and RFC calls).
Familiarity with AGV navigation technologies (Laser, Natural, or Magnetic) and FMS software.
Knowledge of GAMP5 standards and 21 CFR Part 11 requirements is highly preferred.
Analytical mindset with the ability to perform root-cause analysis under production pressure.
Excellent communication skills to translate complex technical issues for cross-functional stakeholders in Logistics and Quality.
Ability to work in a high-density warehouse environment, which may include working at heights or in proximity to moving automated machinery.
On-call support for 24/7 warehouse operations.
The expected salary range for this position based on the primary location of Holly Springs, North Carolina is $95,200 - $176,800. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
Roche is a global pioneer in pharmaceuticals and diagnostics focused on advancing science to improve people’s lives. The combined strengths of pharmaceuticals and diagnostics under one roof have made Roche the leader in personalised healthcare – a strategy that aims to fit the right treatment to each patient in the best way possible. Roche is the world’s largest biotech company, with truly differentiated medicines in oncology, immunology, infectious diseases, ophthalmology and diseases of the central nervous system. Roche is also the world leader in in vitro diagnostics and tissue-based cancer diagnostics, and a frontrunner in diabetes management. Founded in 1896, Roche continues to search for better ways to prevent, diagnose and treat diseases and make a sustainable contribution to society. The company also aims to improve patient access to medical innovations by working with all relevant stakeholders. Thirty medicines developed by Roche are included in the World Health Organization Model Lists of Essential Medicines, among them life-saving antibiotics, antimalarials and cancer medicines. Roche has been recognised as the Group Leader in sustainability within the Pharmaceuticals, Biotechnology & Life Sciences Industry ten years in a row by the Dow Jones Sustainability Indices (DJSI). For more information, please visit https://careers.roche.com Read our community guidelines here: https://www.roche.com/some-guidelines.htm #Roche #Biotechnology #Pharmaceuticals #Diagnostics #Healthcare #PersonalisedHealthcare #GreatPlaceToWork #Innovation
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Based on 52 listings with disclosed salaries, most manufacturing jobs in Holly Springs, NC pay between $79k–$156k per year. Individual offers vary with seniority, company size, and specialization.
There are currently 129 open manufacturing positions in Holly Springs, NC listed on Clera. New openings are added daily as companies post roles.
Companies currently hiring include FUJIFILM Electronic Materials U.S.A., Inc., Amgen, CSL, Roche, ABM Industries, among others. Browse the listings above to see every active employer.
Yes — 5 of the 129 open manufacturing positions offer remote or hybrid work (1 remote, 4 hybrid).
Each listing links directly to the employer's application page. Apply early — fresh listings get the most recruiter attention in the first two weeks.
