Holly Springs, North Carolina, United States · On-site
Career CategoryEngineeringJob Description Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with seriou…
Skills: Emerson DeltaV, Distributed Control System (DCS), Process Automation, Computerized Systems Validation, Data Integrity Assessments
Holly Springs, North Carolina, United States · On-site
$109k–$147k/yr
Career CategoryMaintenanceJob Description HOW MIGHT YOU DEFY IMAGINATION? You’ve worked hard to become the professional you are today and are now ready to take the next step in your career. How will you put your skills, …
Skills: Technical Leadership, Utility Operations, Maintenance Management, cGMP Compliance, Budget Management
Holly Springs, North Carolina, United States · On-site
Career CategoryManufacturingJob Description HOW MIGHT YOU DEFY IMAGINATION? If you feel like you’re part of something bigger, it’s because you are. At Amgen, our shared mission—to serve patients—drives all that we do. It…
Skills: Root Cause Analysis, Deviation Investigations, CAPA Development, Regulatory Inspection Readiness, GMP Compliance
Holly Springs, North Carolina, United States · On-site
Career CategoryManufacturingJob Description HOW MIGHT YOU DEFY IMAGINATION? If you feel like you’re part of something bigger, it’s because you are. At Amgen, our shared mission—to serve patients—drives all that we do. It…
Skills: Root Cause Analysis, Quality Risk Management, CAPA Management, GMP Regulations, Technical Writing
Holly Springs, North Carolina, United States · On-site
$154k–$209k/yr
Career CategoryManufacturingJob Description HOW MIGHT YOU DEFY IMAGINATION? If you feel like you’re part of something bigger, it’s because you are. At Amgen, our shared mission—to serve patients—drives all that we do. It…
Skills: People Leadership, Deviation Management, Root Cause Analysis, CAPA Management, Investigation Leadership
Holly Springs, North Carolina, United States · On-site
$108k–$146k/yr
Career CategoryManufacturingJob Description HOW MIGHT YOU DEFY IMAGINATION? You’ve worked hard to become the professional you are today and are now ready to take the next step in your career. How will you put your skills…
Skills: Upstream Manufacturing, Downstream Manufacturing, GMP Documentation, Root Cause Analysis, CAPA Implementation
Holly Springs, North Carolina, United States · On-site
$109k–$147k/yr
Career CategoryManufacturingJob DescriptionJoin Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serio…
Skills: Technical Leadership, GMP Maintenance, Planning and Scheduling, Troubleshooting, Reliability Improvement
Holly Springs, North Carolina, United States · On-site
Company Overview FUJIFILM Biotechnologies is building the future of bioproduction in Holly Springs, North Carolina. By end of 2025, we’ll open North America’s largest end-to-end CDMO biopharmaceutical manufacturing facil…
Skills: Sap, Erp Systems, Gmp Compliance, Cleanroom Operations, Inventory Control
Holly Springs, North Carolina, United States · On-site
$137k–$185k/yr
Career CategoryEngineeringJob DescriptionJoin Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious…
Skills: Emerson DeltaV, Process Control Network Design, Virtual Infrastructure, System Integration, OPC
Holly Springs, North Carolina, United States · On-site
$108k–$146k/yr
Career CategoryManufacturingJob Description HOW MIGHT YOU DEFY IMAGINATION? You’ve worked hard to become the professional you are today and are now ready to take the next step in your career. How will you put your skills…
Skills: Project Management, Biologics Manufacturing, Downstream Processing, Technical Writing, Lean Manufacturing
Holly Springs, North Carolina, United States · On-site
$108k–$146k/yr
Career CategoryManufacturingJob Description HOW MIGHT YOU DEFY IMAGINATION? You’ve worked hard to become the professional you are today and are now ready to take the next step in your career. How will you put your skills…
Skills: Project Management, Biologics Manufacturing, Technical Writing, Lean Manufacturing, Root Cause Analysis
Holly Springs, North Carolina, United States · On-site
$108k–$146k/yr
Career CategoryManufacturingJob Description HOW MIGHT YOU DEFY IMAGINATION? You’ve worked hard to become the professional you are today and are now ready to take the next step in your career. How will you put your skills…
Skills: Project Management, Biologics Manufacturing, Technical Writing, Lean Manufacturing, Cross-functional Communication
Holly Springs, North Carolina, United States · On-site
Company Overview FUJIFILM Biotechnologies is building the future of bioproduction in Holly Springs, North Carolina. By end of 2025, we’ll open North America’s largest end-to-end CDMO biopharmaceutical manufacturing facil…
Skills: Continuous Improvement, 5S Methodology, Lean Manufacturing, cGMP Compliance, Process Troubleshooting
Holly Springs, North Carolina, United States · On-site
Overview The Lead Warehouse Associate position is responsible for storage, handling, and distribution of materials and products. This role leads and supports the Warehouse operations team in receiving, shipping, and/or l…
Skills: SAP ERP, Inventory Management, cGMP, Logistics, Cycle Counting
Holly Springs, North Carolina, United States · On-site
Reporting to the Manager of Validation, the Validation Specialist III is responsible for validation lifecycle activities for equipment and computer systems using an integrated commissioning and qualification approach. Ex…
Skills: Commissioning, Qualification, Validation, DeltaV, GMP Systems
Holly Springs, North Carolina, United States · On-site
Overview The Weigh and Dispense Associate position is responsible with assisting and executing in the set-up, and weighing of raw materials, solvents, and solutions used in GMP manufacturing at FDBN. This role will inter…
Skills: GMP Manufacturing, Weighing and Dispensing, Material Transport, Powered Industrial Trucks, IBC Assembly
Holly Springs, North Carolina, United States · On-site
We are looking for a reliable and experienced Cleaner to maintain cleanliness and hygiene standards within the pharmaceutical manufacturing environment. They ensure that all areas comply with regulatory requirements and …
Skills: GMP Cleaning, Cleanroom Maintenance, Hygiene Standards, Regulatory Compliance, Attention To Detail
Holly Springs, North Carolina, United States · On-site
Company Overview FUJIFILM Biotechnologies is building the future of bioproduction in Holly Springs, North Carolina. By end of 2025, we’ll open North America’s largest end-to-end CDMO biopharmaceutical manufacturing facil…
Skills: Tech Transfer, cGMP Manufacturing, Process Validation, PPQ, Change Management
Holly Springs, North Carolina, United States · On-site
Company Overview FUJIFILM Biotechnologies is building the future of bioproduction in Holly Springs, North Carolina. By end of 2025, we’ll open North America’s largest end-to-end CDMO biopharmaceutical manufacturing facil…
Skills: Analytical Instrumentation, GMP Compliance, Data Integrity, Equipment Qualification, SOP Authoring
Holly Springs, North Carolina, United States · On-site
Overview The Planner 2, Maintenance ensures the reliability and efficiency of the equipment and systems at the facility. This role uses knowledge of maintenance processes and regulatory requirements to plan, schedule, an…
Skills: Maintenance Planning, Scheduling, CMMS, Data Analysis, KPI Monitoring
Holly Springs, North Carolina, United States • On-site
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Develop and maintain process control systems using Emerson DeltaV DCS to support GMP Drug Substance Plant Operations. Collaborate with stakeholders to deliver robust automation solutions and ensure compliance through validation and documentation.
Requires a minimum of a High School Diploma with 8 years of experience, or a Bachelor's degree with 2 years of engineering experience. Preferred candidates have a degree in Electrical, Computer, Chemical, or Biotech Engineering and direct experience with DeltaV and biopharmaceutical production systems.
Join Amgen’s Mission of Serving Patients
At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.
Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.
Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lie within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.
Be part of Amgen's newest and most advanced drug substance manufacturing plant. When completed, the Amgen FleX Batch facility will combine the latest in disposable technologies with traditional stainless-steel equipment to allow for maximum flexibility in operations. The FleX Batch facility will not only feature the best in-class drug substance manufacturing technologies with embedded industry 4.0 capabilities, but it will also integrate sustainability innovations to reduce carbon and waste, as part of Amgen's plan to be a carbon-neutral company by 2027.
Manufacturing Systems Engineer: Automation - Delta V
What you will do
Let’s do this. Let’s change the world. As a Manufacturing Systems Engineer, you will work with a group of automation engineers who are responsible for building and maintaining various automation systems and platforms that support the GMP Drug Substance Plant Operations.
In this vital role as a member of the Facilities & Engineering (F&E) Automation team you will work hand in hand with the capital project team to deliver robust process automation systems to operate the new plant.
Responsibilities:
Develop and maintain the process control system on Emerson DeltaV distributed control system (DCS).
Collaborate with key stakeholders and end-users to understand and synthesize key process requirements, and to develop solutions using Amgen standard automation platform for process automation systems.
Provide clear documentation for delivered solutions and processes.
Support QA partners in performing computerized systems validation in a GxP environment.
Perform Data Integrity Assessments (DIA) in accordance with the current Amgen and industry standards.
Support process automation systems to ensure design aligns with Amgen specifications, incorporates the latest technology, and meets safety requirements.
Support vendor FAT to ensure that control strategy and software code meet Amgen requirements.
Develop and maintain engineering and maintenance documentation, and associated procedures for delivered solutions and processes.
Support commissioning and qualification efforts including Automation Installation Verification/Automation Check Out (IV/ACO) in a fast-paced environment.
Site Operations
Own and drive to completion Change Controls, CAPAs, and Deviations.
Support technical root cause analysis, incident investigations, and troubleshooting.
Support functional area projects focused on improving process equipment, utilities, and facilities as well as large capital projects to integrate new drug substance manufacturing technologies into the facility.
Drive continuous improvement for process automation systems to improve operational workflows, safety, reliability, efficiency, and sustainability.
Support day-to-day operations including rotational on-call support.
Prepare/review Standard Operating Procedures (SOP) and cGMP documents.
Be constantly curious and feed your passion and interests in groundbreaking technology. Use your given time to look for new and innovative ways to do business differently, better, and more cost effectively.
What we expect from you
We are all different, yet we all use our unique contributions to serve patients. The automation professional we seek is an engineer with these qualifications.
Basic Qualifications
High School Diploma / GED and 8 years of Engineering experience OR
Associate’s Degree and 6 years of Engineering experience OR
Bachelor’s Degree and 2 years of Engineering experience OR
Master’s Degree
Preferred Qualifications
Degree in Electrical Engineering, Computer Science, Chemical Engineering, Biotech Engineering, or related field.
Direct knowledge of Automation System design, experience in process control engineering and troubleshooting with GMP biopharmaceutical production facility equipment/systems automation such as media, harvest, bioreactors, solution prep, single use mixing vessels, chromatography, TFFL/TFFX, viral filtration, viral inactivation, UF/DF, depth filtration, drug substance fill, CIP/SIP, clean utilities, and integrating various OEM automation software.
Experience in programming, installation, and lifecycle management of automation and field instrumentation technologies.
Experience in programming, design, installation and lifecycle management of manufacturing process controls, and automation and field instrumentation technologies.
Experience with Emerson DeltaV DCS system and ability to perform advanced troubleshooting, and system integration using OPC, Foundation Fieldbus, and Profibus technologies.
Ability to interpret and apply GAMPs and GMPs, and familiarity with documentation in a highly regulated environment with requirements such as 21 CFR Part 11, ASTM 2500, S88 and S95.
Self-directed team player able to work cross-functionally.
Strong technical writing and communication skills.
What you can expect from us
As we work to develop treatments that take care of others, we also work to care for our teammates’ professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.
In addition to the base salary, Amgen offers a Total Rewards Plan based on eligibility that may include:
A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
Stock-based long-term incentives
Award-winning time-off plans and bi-annual company-wide shutdowns
Flexible work models, including remote work arrangements, where possible
Apply now for a career that defies imagination
In our quest to serve patients above all else, Amgen is the first to imagine and the last to doubt. Join us.
careers.amgen.com
#AmgenNorthCarolina
.#WeareBiotech
Amgen harnesses the best of biology and technology to fight the world’s toughest diseases, and make people’s lives easier, fuller and longer. We helped establish the biotechnology industry, and we remain on the cutting-edge of innovation, using technology and human genetic data to push beyond what’s known today. Our investment in research and development has yielded a robust pipeline that builds on our existing portfolio of medicines to treat cancer, heart disease, osteoporosis, inflammatory diseases and rare diseases. Amgen is one of 30 companies comprising the Dow Jones Industrial Average®, and part of the Nasdaq-100 Index®. In 2024, Amgen was named one of the “World’s Most Innovative Companies” by Fast Company and one of “America’s Best Large Employers” by Forbes. For more information, visit Amgen.com and follow us on X, LinkedIn, Instagram, TikTok, YouTube and Threads. 🔗 Community Guidelines: https://wwwext.amgen.com/community-guidelines 🔗Global Privacy Statement Directory: www.amgen.com/dp Special Advisory: Please be cautious of scam recruitment offers claiming to be from Amgen. Such scams may come from various sources, including fake websites and/or unsolicited emails and seek to obtain personal data or payment from victims by offering jobs that do not exist. Please be advised that Amgen would never ask for payment to progress a job application. When in doubt, please check to see if the position in question is posted on this website before applying. Additionally, please report any suspicious recruiting activity to https://complaint.ic3.gov/ and thank you for your assistance.
Offices: One Amgen Center Drive, Thousand Oaks, CA 91320, US · 1120 Veterans Blvd, South San Francisco, CA 94080, US · 34 Commerce Way, Woburn, MA 01801, US · Avenida Calle 100 7-81, Bogota, Bogota, D.C. 110221, CO · Minervum 7061, Breda, North Brabant 4817 ZK, NL
Based on 52 listings with disclosed salaries, most manufacturing jobs in Holly Springs, NC pay between $79k–$156k per year. Individual offers vary with seniority, company size, and specialization.
There are currently 129 open manufacturing positions in Holly Springs, NC listed on Clera. New openings are added daily as companies post roles.
Companies currently hiring include FUJIFILM Electronic Materials U.S.A., Inc., Amgen, CSL, Roche, ABM Industries, among others. Browse the listings above to see every active employer.
Yes — 5 of the 129 open manufacturing positions offer remote or hybrid work (1 remote, 4 hybrid).
Each listing links directly to the employer's application page. Apply early — fresh listings get the most recruiter attention in the first two weeks.
