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The actual location of this job is in Basel Stücki, Switzerland. This is a fully site‑based role. Working together in person supports close, real‑time collaboration and the technical precision needed to manufacture medic…
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Full-time
postgraduate degree
Posted 42d ago
Apply by Sep 1
~40 hrs/week
Responsibilities
Lead the strategy and execution of advanced oral formulation platforms to overcome solubility and permeability challenges for drug candidates. Act as the pCMC Drug Product lead, guiding scientific strategy from discovery through clinical proof-of-concept.
Requirements
Requires a PhD in Pharmaceutical Technology or a related field with at least 8 years of industry experience, including 3-5 years in enabling formulation technologies. Must possess deep expertise in lipid-based formulations, polymer-stabilized amorphous systems, and the use of AI/ML tools for drug performance prediction.
Full job description
At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters.
The Position
In Roche’s Pharmaceutical Research and Early Development organization (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility, and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.
Therapeutic Modalities (TMo) organization, accountable for translating disease biology into high-quality drug candidates across small molecules, large molecules, oligonucleotides, and genomic medicines. By integrating deep modality expertise with cross-disciplinary collaboration, TMo drives innovation within and across platforms to enable differentiated, sustainable therapeutic impact.
We are CMC experts and build our strength on a broad diversity of technical expertise in chemistry, formulation design, material science, and analytical chemistry, delivering and innovating in the space of small molecules, peptides, and nucleic acid based medicines.
As Subject Matter Expert (SME) in Oral Enabling Formulation Technologies. This is a high-impact, technical leadership role focused on overcoming the challenges of poorly soluble or poorly permeable drug candidates. You will lead the strategy, design, and execution of advanced formulation platforms to drive our pipeline from discovery through clinical proof-of-concep
The Opportunity
Enabling Formulation Mastery:
Establish a high-impact technical network to maintain state-of-the-art oral enabling formulation technologies for delivery of complex synthetic modalities.
Design and execute specialized formulations (e.g., lipid based-delivery systems such as SMEDDS/SNEDDS, amorphous solid dispersion spray-dried, hot-melt extrusion) to maximize exposure in PK, PD, and safety studies.
Drive the advancement of global formulation strategies by integrating novel delivery technologies to enhance absorption and therapeutic efficacy
Lead the technical profiling of NCEs and conduct rigorous Developability Assessments to identify and mitigate risks in molecular properties early in the pipeline
Internal Advisory Collaboration:
You act as subject matter expert (SME) for internal pRED scientists, advising on formulation strategies for complex synthetic molecules and foster collaborative innovation across the organization.
Portfolio Execution & Excellence:
Act as pCMC Drug Product lead within research project teams, guiding the end to end CMC scientific strategy until transfer to the Technical Development Department.
Plan, coordinate and effectively communicate with research teams, function, stakeholders and governance boards.
Master Modeling & Simulation and AI/ML tools to predict drug performance, optimize formulation selection, and bridge in vitro data to in vivo outcomes.
Ensure scientific excellence and operational efficiency while meeting dynamic portfolio needs through effective internal and external supply strategies.
Who You Are
You possess a very strong background in Pharmaceutical Research and Development, Chemistry or related field. Ideally you have obtained a PhD in Pharmaceutical Technology and got at least 8 years of industry experience in Drug Discovery/Development, with at least 3-5 years specifically focused on Enabling Formulation Technologies for Oral Drug Delivery.
A strong knowledge and experience in Enabling Formulation Technologies like Lipid Based Formulations and Polymer Stabilized Amorphous Systems from Screening to Proof of Concept and Scale-up Supplies.
Proven physical-chemical as well as biopharmaceutical understanding of complex chemical modalities, typically exhibiting Beyond rule of 5 properties.
Proficient in utilizing and developing M&S and AI tools in preformulation and formulation development.
Scientific leadership that allows you to engage as a peer with both internal research and early development project teams and external collaboration partners.
Proven ability to position ideas and drive strategic shifts in a matrix environment, influencing stakeholders across different functions and levels of seniority.
The ability to anticipate the impact of industry shifts and proactively adapt to changing priorities and manage multiple projects simultaneously. Commitment to maintaining the highest standards of scientific integrity and professionalism.
At Roche, we aim high to deliver life-changing healthcare solutions. If you’re ready to make a meaningful impact on patients and healthcare systems worldwide, this is the place for you.
Who we are
A healthier future drives us to innovate. Together, more than 100’000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact.
Let’s build a healthier future, together.
Roche is an Equal Opportunity Employer.
Related keywords
Pharmaceutical ResearchpREDCMCSmall MoleculesPeptidesNucleic Acid Based MedicinesSMEDDSSNEDDSPK/PDNCEsBeyond Rule of 5BiopharmaceuticalsMaterial ScienceAnalytical ChemistryFormulation DesignDrug Delivery
Roche is a global pioneer in pharmaceuticals and diagnostics focused on advancing science to improve people’s lives. The combined strengths of pharmaceuticals and diagnostics under one roof have made Roche the leader in personalised healthcare – a strategy that aims to fit the right treatment to each patient in the best way possible.
Roche is the world’s largest biotech company, with truly differentiated medicines in oncology, immunology, infectious diseases, ophthalmology and diseases of the central nervous system. Roche is also the world leader in in vitro diagnostics and tissue-based cancer diagnostics, and a frontrunner in diabetes management.
Founded in 1896, Roche continues to search for better ways to prevent, diagnose and treat diseases and make a sustainable contribution to society. The company also aims to improve patient access to medical innovations by working with all relevant stakeholders. Thirty medicines developed by Roche are included in the World Health Organization Model Lists of Essential Medicines, among them life-saving antibiotics, antimalarials and cancer medicines. Roche has been recognised as the Group Leader in sustainability within the Pharmaceuticals, Biotechnology & Life Sciences Industry ten years in a row by the Dow Jones Sustainability Indices (DJSI).
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How many Healthcare jobs are open in Basel, Switzerland right now?
There are currently 319 open healthcare positions in Basel, Switzerland listed on Clera. New openings are added daily as companies post roles.
Which companies are hiring for Healthcare roles in Basel, Switzerland?
Companies currently hiring include Roche, Novartis, Revolution Medicine, ZURZACH Care Unternehmensgruppe, Lonza, among others. Browse the listings above to see every active employer.
Are there remote or hybrid Healthcare jobs in Basel, Switzerland?
Yes — 111 of the 319 open healthcare positions offer remote or hybrid work (5 remote, 106 hybrid).
How do I apply for Healthcare jobs in Basel, Switzerland?
Each listing links directly to the employer's application page. Apply early — fresh listings get the most recruiter attention in the first two weeks.