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Redwood City, California, United States · On-site
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Redwood City, California, United States · Hybrid
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Redwood City, California, United States · On-site
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Redwood City, California, United States · Hybrid
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Redwood City, California, United States · Hybrid
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Redwood City, California, United States • On-site
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Lead the analytical strategy for drug substance and drug product for a small molecule autophagy program. Oversee outsourced QC activities and perform hands-on laboratory work to support development and regulatory submissions.
Requires 7+ years of experience in small molecule analytical development within a regulated environment and an advanced degree in a scientific discipline. Must have expertise in UPLC/HPLC and experience managing external CDMOs/CROs.
Retro develops therapies for diseases driven by the biology of aging. We focus on cellular reprogramming and autophagy to broadly improve tissue function by targeting mechanisms of aging with the ultimate aim of adding 10 years to healthy human lifespan.
We’re building a mission-driven team of accomplished and kind individuals who embrace our startup culture of rapid iteration, transparency, and versatility.
\nAbout the Role:We are seeking a new member of the Quality and Analytical team to support Retro’s clinical-stage autophagy program through Analytical Development (AD) and Quality Control (QC) as it advances from Phase I toward Phase II development.
As the primary AD/QC scientist for our small molecule program, you will lead the analytical strategy for drug substance and drug product, working closely with the Program Lead, CMC Lead, QA, and external CDMOs and CROs. You will help ensure product quality, support manufacturing and regulatory activities, and strengthen the analytical foundation needed for continued clinical development.
Your responsibilities will include analytical method development, qualification, validation, transfer, specification setting, stability studies, impurity characterization and control, formulation support, regulatory documentation, and oversight of outsourced analytical and QC activities. You will also perform targeted hands-on laboratory work to support development, characterization, troubleshooting, and comparability assessments. Experience with LC-MS and other mass spectrometry-based techniques will be valuable.
This role reports to the Head of Quality & Analytical and partners closely with the CMC Lead to execute the analytical and quality strategy for Retro’s small molecule program.
You are a rigorous, curious, small-molecule analytical development professional who seeks to understand the underlying science and regulatory framework, not just execute against it. You stay current by engaging directly with guidelines, literature, and data, and pair scientific depth with practical judgment. You are confident yet humble in evolving areas and enjoy sharing knowledge and exchanging ideas openly. You are comfortable in a lean environment, balancing hands-on work with oversight of external partners. You communicate clearly across internal and external partners, and are excited to thoughtfully incorporate new tools, including AI, into analytical and CMC workflows.
Drive analytical control strategy development for Retro’s small molecule autophagy program, including drug substance and drug product methods, specifications, stability, impurity control, and regulatory support.
Oversee outsourced QC and characterization methods, including method development, validation, release testing, stability testing, analytical investigations, and data package review.
Support formulation development by using analytical data to help evaluate solubility, dissolution, stability, manufacturability, and overall product performance.
Identify analytical, formulation, vendor, or regulatory risks early and drive practical remediation plans in partnership with Q&AD, CMC, Quality, Regulatory, Research, and external partners.
Author and review analytical sections of regulatory submissions, including Module 3 content related to analytical methods, specifications, validation, stability, and control strategy.
Support identity testing strategy for critical raw materials, including method selection, vendor coordination, data review, and targeted in-house analytical work where appropriate.
Provide UPLC-based analytical support for research activities where appropriate, helping generate data that informs analogue characterization, compound selection, and progression decisions.
Have 7+ years of experience in small molecule analytical development, or related pharmaceutical development work in a regulated environment.
Understand phase-appropriate analytical control strategy, including specifications, stability strategy, impurity control, reference standards, method validation, and regulatory documentation.
Have experience developing, validating, transferring, or overseeing analytical methods for drug substance and drug product release, stability, dissolution, and impurity testing.
Have experience working with CDMOs, CROs, or external laboratories to manage analytical development, validation, release testing, stability testing, investigations, and data review.
Bring hands-on expertise with UPLC/HPLC method development, troubleshooting, and data interpretation for small molecule assay, purity, impurities, degradation products, and related substances.
Can operate independently in a lean environment, prioritize across internal hands-on work and external partner oversight, and communicate analytical recommendations clearly to cross-functional partners.
Hold an advanced degree in analytical chemistry, chemistry, pharmaceutical sciences, medicinal chemistry, or a related scientific discipline, or bring equivalent industry experience.
Have experience with small molecules that present solubility, dissolution, bioavailability, manufacturability, or product performance challenges.
Have experience designing or overseeing forced degradation studies, degradation pathway characterization, and stability-indicating method development.
Have experience with extractables and leachables assessments, container closure compatibility, administration-device compatibility, or material compatibility studies.
Have supported or authored analytical sections of CTD Module 3 regulatory submissions.
Have experience applying analytical methods to research-stage small molecule analogue screening, compound characterization, or compound progression decisions.
Have hands-on experience with LC-MS or other mass spectrometry-based approaches for compound characterization, impurity identification, degradation pathway assessment, or analytical comparison of small molecule analogues.
Have worked in a startup or resource-constrained environment where scientific independence, adaptability, and strong judgment were essential.
At Retro, we do not use internal job titles. New hires join as a “Member of X Team.” For external calibration, this role may map to different market-equivalent levels depending on experience, independence, and scope.
Total compensation includes competitive base salary, generous equity, and benefits including medical, dental, and vision insurance; 401(k) with 4% matching; flexible time off; paid parental leave; an annual learning & development stipend; and daily Retro-sponsored lunch and snacks.
We take pride in cultivating an environment that fosters collaboration, open communication, and authenticity. We believe that great results are best delivered by a highly creative team working in concert. We are an equal opportunity employer; we do not discriminate based on race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status. We are diverse in background and singular in mission.
We're Adding 10 Years to Healthy Human Lifespan
Retro develops therapies for diseases driven by the biology of aging. We focus on cellular reprogramming and autophagy to rejuvenate cell and tissue function with the ultimate aim of adding 10 years to healthy human lifespan.
Offices: Redwood City, US
Based on 202 listings with disclosed salaries, most engineering jobs in Redwood City, CA pay between $117k–$250k per year. Individual offers vary with seniority, company size, and specialization.
There are currently 260 open engineering positions in Redwood City, CA listed on Clera. New openings are added daily as companies post roles.
Companies currently hiring include Revolution Medicine, Luma, Delinea, BKF Engineers, Box, among others. Browse the listings above to see every active employer.
Yes — 144 of the 260 open engineering positions offer remote or hybrid work (29 remote, 115 hybrid).
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