The Position Welcome to Holly Springs, North Carolina— home to Roche/Genentech's largest-ever investment: a $2B greenfield start-up where next-generation technology, high-performing teams and Operational Excellence conve…
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$120k–$223k/yr
Full-time
bachelor degree, postgraduate degree
Relocation assistance, Annual bonus
Posted 31d ago
~40 hrs/week
Responsibilities
The Senior Manager will establish and lead the QC Microbiology team, overseeing laboratory start-up activities and routine commercial operations for CVRM products. They are responsible for ensuring compliance, managing QMS records, and fostering a high-performing, safety-focused laboratory culture.
Requirements
Candidates must hold a B.S. or M.S. degree in a science-related discipline with at least 8 years of experience in pharmaceutical or biopharmaceutical manufacturing. Extensive technical knowledge of microbiology methods, cGMP operations, and regulatory requirements is required, along with proven leadership and project management capabilities.
Full job description
The Position
Welcome to Holly Springs, North Carolina— home to Roche/Genentech's largest-ever investment: a $2B greenfield start-up where next-generation technology, high-performing teams and Operational Excellence converge to create the global standard for high-volume, highly-efficient Drug Product manufacturing.
The facility's core is defined by Innovation - leveraging advanced automation, robotics, digital tools, real-time data analytics, and simple, streamlined processes to produce the highest quality medicines. This plant meets today’s demand for CVRM (Cardiovascular, Renal, and Metabolism) medicines and is scalable to grow with the portfolio, which focuses on next-generation metabolic medicines specifically targeting the global obesity epidemic and Type 2 diabetes. This is a fast-paced, entrepreneurial environment with a high-level of accountability, with planned launch in 2028.
Are you a problem-solver and change-agent who thrives in a Team environment, eager to tackle the most complex manufacturing challenges? If so, this is a once-in-a-lifetime opportunity to launch a state-of-the-art facility from the ground-up and shape the culture of our organization for the next generation.
Join us in Holly Springs, where you won't just build a plant—you will build the future of medicine.
The Opportunity:
The Holly Springs Quality Control Team is seeking an experienced and dynamic leader to establish and head our QC Microbiology team.
In this critical role, you will build a highly effective and engaged organization capable of delivering safe, compliant, and efficient testing for our CVRM (Cardiovascular, Renal, and Metabolism) products manufactured at the Holly Springs site. Initially, you will focus on laboratory start-up activities—establishing core QC capabilities to support facility, utility, and process qualifications—before pivoting to routine commercial operations following site licensure.
Leadership:
You will champion a proactive quality culture built on psychological safety and transparent communication—empowering your team to speak up, simplify processes, and take personal accountability for owning quality.
You will drive a proactive safety culture by fostering Behavior-Based Safety (BBS) principles and ensuring strict compliance with site safety processes and regulatory standards.
You will foster a high-performing, engaged lab culture by practicing Lean Leadership, providing active coaching, and embedding continuous improvement into daily operations.
You will ensure appropriate staffing, resource allocation, and workload balancing to support business priorities and changing operational demands
You will partner with the global network to harmonize QC standards and ensure seamless execution and compliance across site operations.
Technical and functional tasks:
You will establish key operational performance measures (KPIs) with a focus on Compliance, Right-First-Time (RFT) execution and continuous improvement to meet business objectives.
You will author, review, and approve critical technical, scientific, and compliance documents (e.g., test methods, validation protocols, SOPs).
You will own Quality Management System (QMS) records, including investigations, deviations, CAPAs, and change controls.
You will participate in the identification, evaluation, and implementation of new technologies in alignment with business objectives or regulatory requirements.
You will use data-driven decision making to identify trends, mitigate risks, and improve operational performance.
You will have responsibility for strategic projects to support execution of QC network strategy.
You are experienced in presenting Microbiology topics during regulatory inspections and maintaining a continuous state of audit readiness across QC operations.
Who you are:
You hold a B.S. or M.S. degree (Science related discipline) with a minimum of 8 years of experience in pharmaceutical or biopharmaceutical manufacturing. This includes at least 3 years of direct experience in QC operations at a finished drug product commercial manufacturing site.
You have extensive technical knowledge of Microbiology methods, laboratory instrumentation, and analytical method validation, qualification, and transfer within the pharmaceutical or biopharmaceutical industry.
You have extensive experience in contamination control strategies, environmental and utility system monitoring.
You have in-depth working knowledge of cGMP operations, ICH guidelines, and global Health Authority regulatory requirements (FDA, EMA, etc.).
You have proven technical leadership capabilities and demonstrated project management skills, with a track record of effectively managing workload distribution, timelines, and competing priorities.
You have exceptional communication skills with the demonstrated ability to inspire, motivate, and coach a team while collaborating effectively with internal cross-functional groups, global partners, suppliers, and external customers.
You have proven experience managing operational and capital budgets (OpEx/CapEx), with a track record of driving cost-efficient laboratory operations and resource optimization.
The expected salary range for this position based on the primary location for this position of Holly Springs, North Carolina is $120,100 - $223,100. Actual pay will be determined based on experience, level, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance.
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
About Genentech
We're passionate about finding solutions for people facing the world's most difficult-to-treat conditions. That is why we use cutting-edge science to create and deliver innovative medicines around the globe. To us, science is personal.
Making a difference in the lives of millions starts when you make a change in yours. If you’d like to join our team, view our openings at gene.com/careers.
Our patient resource center is dedicated to getting patients and caregivers to the right resources. You can reach them at 1 (877) GENENTECH (436-3683)
Monday-Friday, 6am-5pm PST or [email protected].
Community Guidelines:
1. We want to foster positive conversation around the issues we are passionate about. To that end, we remove profanity, content that contains threatening language, content that is aimed at private individuals, personal information, and repeated unwanted messages.
2. Don’t mention any medicines by name — ours or anyone else’s.
Because of the fair balance rules governing our industry, we cannot post any comments that reference any pharmaceutical brand, product, or service. Please do not mention any specific medicines by name, or include any links to third party sites in your comments.
3. This isn’t the place to report or discuss side effects.
This site is not intended as a forum for reporting side effects experienced while taking a Genentech product. Instead, you should report any side effects to Genentech Drug Safety at 1-888-835-2555. You can also report side effects of any prescription product directly to the FDA at 1-800-FDA-1088 or by visiting www.FDA.gov/medwatch.
4. Don’t pitch your product or service.
Please don't use our page as a place to promote your product or pitch your services. Please also avoid posting links to external sites. We reserve the right to remove any posts that are deemed promotional.
Offices: 1 Dna Way, South San Francisco, California 94080, US · 1000 New Horizons Way, Vacaville, California 95688, US · 1 Antibody Way, Oceanside, California 92056, US · 4625 NE Brookwood Pkwy, Hillsboro, Oregon 97124, US
OncologyImmunologyDisorders of Tissue Growth and RepairNeuroscience and Infectious DiseaseMetabolismand OphthalmologyElectronicsIndustrial ManufacturingBiotechnologyLife Science
Based on 171 listings with disclosed salaries, most engineering jobs in Cary, NC pay between $49k–$180k per year. Individual offers vary with seniority, company size, and specialization.
How many Engineering jobs are open in Cary, NC right now?
There are currently 328 open engineering positions in Cary, NC listed on Clera. New openings are added daily as companies post roles.
Which companies are hiring for Engineering roles in Cary, NC?
Companies currently hiring include Epic Games, Sargent & Lundy, SAS, Bright Vision Technologies, Overland Contracting Inc., among others. Browse the listings above to see every active employer.
Are there remote or hybrid Engineering jobs in Cary, NC?
Yes — 132 of the 328 open engineering positions offer remote or hybrid work (29 remote, 103 hybrid).
How do I apply for Engineering jobs in Cary, NC?
Each listing links directly to the employer's application page. Apply early — fresh listings get the most recruiter attention in the first two weeks.