Engineering Jobs in Boston, MA (Now Hiring) — 2,777 open — Page 14
Vertex Inc.
Principal Full Stack AI Engineer
Boston, Massachusetts, United States · Hybrid
$167k–$250k/yr
Senior$345M raised
Job Description Position Summary Vertex is seeking an AI Full-Stack Engineer to create the next generation of AI-powered applications and agents that deliver practical value across internal and user-facing experiences. T…
Skills: Large language model application development, Agentic workflow design, Prompt engineering, API integration, Multi-step workflow automation
Job Description Dewberry is seeking a Staff Structural (Bridge) Engineer to work in its Boston, MA office. The successful candidate will be part of a team designing simple and complex bridges (primarily of steel and conc…
Job Title2nd Class Stationary Engineer Job Description SummaryJob Description attached Cushman & Wakefield also provides eligible employees with an opportunity to enroll in a variety of benefit programs, generally includ…
Skills: Stationary engineering, Building maintenance, Equipment operation, System monitoring, Preventive maintenance
Vertex Inc.
Principal Full Stack AI Engineer
Boston, Massachusetts, United States · Hybrid
$167k–$250k/yr
Senior$345M raised
Job Description Position Summary Vertex is seeking an AI Full-Stack Engineer to create the next generation of AI-powered applications and agents that deliver practical value across internal and user-facing experiences. T…
Skills: Large language model application development, Agentic workflow design, Prompt engineering, API integration, Multi-step workflow automation
Vertex Inc.
Executive Director Quality, Cell & Gene Therapy
Boston, Massachusetts, United States · On-site
$245k–$367k/yr
Senior+$345M raised
Job Description Position Summary: The Executive Director serves as a strategic leader responsible for defining and executing the Cell & Genetic Therapies (CGT) Quality vision, operating model, and organizational strategy…
Associate Director, CMC Quality Compliance and Inspection Readiness (Hybrid)
Boston, Massachusetts, United States · Hybrid
$148k–$221k/yr
Senior+$345M raised
Job Description General Summary: The Associate Director, CMC Quality Compliance and Inspection Readiness, is responsible for inspection readiness and compliance of external sites including evaluating, improving, and moni…
Job Description Job Summary The Principal Engineer, VaiDA Mobile Experience will help bring Vertex’s AI experience tool, VaiDA, to life through intuitive, high-quality mobile experiences that make AI accessible wherever …
Skills: Mobile application development, iOS development, Android development, API integration, Secure mobile development
THIS POSTING IS INTENDED FOR THOSE REGISTERED TO ATTEND THE SOCIETY OF HISPANIC PROFESSIONAL ENGINEERS CONFERENCE, Oct 28 - 31st in Indianapolis, IN
Menlo Park, California, United States · On-site
$89k–$133k/yr
Senior+Visa sponsorship$18B raised
We anticipate the application window for this opening will close on - 2 Nov 2026 Careers that change lives start here. Medtronic is a global leader in healthcare technology with a Mission to alleviate pain, restore healt…
Skills: Software engineering, Electrical engineering, Firmware development, Hardware engineering, Research and development
Job Description General Summary: The Salesforce Technical Architecture & Strategy Lead plays a pivotal role as a cornerstone of our Data, Technology, and Engineering (DTE) team. This role is instrumental in driving the s…
2027 Future Talent Program - Protein & Structural Chemistry - Intern
South San Francisco, California, United States · On-site
$39k–$111k/yr
Entry level
Job Description The Future Talent Program features internships that last up to 12 weeks and will include one or more projects. These opportunities in our Research and Development Division can provide you with great devel…
Skills: Structural biology, Protein biochemistry, Biophysics, BioNMR, Mass spectrometry
Built on meritocracy, our unique company culture rewards self-starters and those who are committed to doing what is best for our customers. Brown & Brown is seeking a Safety Loss Control Consultant to join our growing te…
Skills: Risk Management, Loss Prevention, Safety Assessments, Property Loss Control, Hydraulic Calculations
2027 Future Talent Program - Discovery Chemistry & Process Research - Intern
South San Francisco, California, United States · On-site
$39k–$111k/yr
Entry level
Job Description The Future Talent Program features internships that last up to 12 weeks and include working on one or more specially designed projects. These opportunities in our Research & Development Division provide m…
About Wonder Everything’s on the menu at Wonder. Except compromise. Wonder is the mealtime platform built to feed every craving in one order. With Wonder, you can mix and match hundreds of dishes from 20+ exclusive resta…
Associate Director, GMP Operational Quality (Biologics and Devices)
Boston, Massachusetts, United States · Hybrid
$95k–$142k/yr
Senior+$345M raised
Job Description General Summary: The Associate Director, GMP Operational Quality Assurance is a Quality leader and advanced technical resource responsible for strategic and operational Quality oversight across multiple c…
Director, Cell & Gene Therapy Research Technology (Boston)
Boston, Massachusetts, United States · Hybrid
$198k–$297k/yr
Senior+$345M raised
Job Description General Summary: This role leads a team responsible for the architecture, delivery, security, support, and continuous evolution of enterprise laboratory technology platforms across LC1/2, Vertex's Cell & …
Job Description General Summary: Vertex is seeking an experienced scientist eager to help develop cutting-edge small molecules and the science underpinning the analytical control of their syntheses. As a member of the Dr…
Skills: Analytical development, Drug substance control strategy, Small molecule chemistry, Quality by design, Chromatography
Vertex Inc.
Associate Director, GMP Quality CGT Personalized Medicine
Boston, Massachusetts, United States · Hybrid
$148k–$222k/yr
Senior+$345M raised
Job Description Position Summary The Associate Director, GMP Quality, CGT Personalized Medicine supports strategic design of and ensures tactical execution of quality systems, risk management, and quality culture across …
Mfg Operations Associate Director - Biologics, Drug Substance
Boston, Massachusetts, United States · Hybrid
$160k–$240k/yr
Senior+$345M raised
Job Description General Summary: The Associate Director, Technical Services is accountable for the technical execution of biologics drug substance manufacturing at external manufacturing partners. This role is responsibl…
Senior Manager, Operational Area Quality (Combination Products)
Boston, Massachusetts, United States · Hybrid
$134k–$201k/yr
Senior+$345M raised
Job Description General Summary The Operational Area Quality Senior Manager provides quality leadership for assembly manufacturing operations supporting medical device and combination products. The role is responsible fo…
Senior Principal Scientist, Agentic Systems Development for Drug Discovery
Boston, Massachusetts, United States · Hybrid
$168k–$252k/yr
Senior+$345M raised
Job Description Vertex is seeking an accomplished Senior Principal Scientist with proven record of developing, testing and deploying scientific computational methods and agentic AI systems for drug discovery. In this rol…
Skills: Agentic AI, Drug discovery, Cheminformatics, Python, Machine learning
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$167k–$250k/yr
Full-time
bachelor degree
Annual bonus, Annual equity awards, Medical insurance, Dental insurance, Vision insurance, Paid time off
Posted 4d ago
~40 hrs/week
Responsibilities
Design, prototype, and productionize multi-step AI agent workflows that integrate with enterprise systems and business processes. Collaborate with cross-functional teams to iterate on agent behavior based on data, feedback, and operational metrics.
Requirements
Requires a bachelor's degree in a technical field and hands-on experience building applications powered by large language models or agentic systems. Candidates must demonstrate the ability to move from prototype to production while balancing speed, quality, and security.
Full job description
Job Description
Position Summary
Vertex is seeking anAI Full-StackEngineer to create the next generation of AI-powered applications andagents that deliver practical value across internal and user-facing experiences.This role will own solutions end to end—from user experience and application services to agent orchestration, data access, platform integration, deployment, and production operations.
The ideal candidatecombinesstrongfull-stack softwareengineeringfundamentals with hands-on experience building AI-enabled products.This individual will use a forward deployed engineering mindset to work closely with stakeholders, rapidly iterate on real-world use cases, connectapplications andagents toenterprisesystems, and continuously improve quality through measurement and feedback.The AI Full-StackEngineer willhelp shapehowsecure, reliable, and scalable AI solutionsare adopted across Vertex.
Key Responsibilities
Design,build, and productionizefull-stackAIapplications,agents,and multi-step workflows for internal and user-facing use cases
Apply a forward deployed engineering approach by working closely with end users, product teams, and business stakeholders to solve real workflow problems quickly and effectively
Build agents that can reason across steps, invoke tools, call APIs, retrieve information, and take actions within defined enterprise guardrails
Own end-to-end solution delivery across user interfaces, application services, APIs, data access, agent orchestration, and integrations with internal platforms, third-party applications, and business-critical systems
Develop reusable agent patterns, components, prompts, tools, and orchestration logic that can be scaled across use cases
Rapidly iterate on agent behavior based on usage data, qualitative feedback, evaluation results, and operational metrics
Improve agent quality through testing, experimentation, benchmarking, and structured measurement of outcomes
Partner with platform, integration, data, security, and product teams to ensure agents are secure, reliable, maintainable, and aligned with enterprise architecture
Help define best practices for agent design, tool use, fallback behavior, escalation paths, and human-in-the-loop workflows
Supportthe complete software lifecycle, including architecture, development, integration,deployment, monitoring, troubleshooting, and optimization in production environments
Contribute to observability practices for agent execution, including logging, tracing, performance tracking, and issue analysis
Ensure solutions are designed with security, compliance, and responsible AI principles in mind
Stay current on emerging patterns, frameworks, and technologies in generative AI and agentic systems, and translate them into practical applications for Vertex
Required Qualifications
Bachelor’s degree in Computer Science, Software Engineering, Artificial Intelligence, Data Science, or a related technical field; equivalent practical experience may be considered
Experience infull-stacksoftware engineering, AI engineering, machine learning engineering, or intelligent application development
Hands-on experience buildingand operating productionapplications powered by large language models, AI workflows, or agentic systems
Experiencedesigning and delivering end-to-endapplicationsacross front-end, back-end,APIs, datastores, and enterprise systems
Demonstrated experience using AI-assisted software development and autonomous coding agents to design, generate, test, review, debug, optimize, and refactor code across complex enterprise systems.
Deep understanding of AI-native software engineering practices and experienceestablishingstandards, governance, and best practices for the responsible use of AI coding assistants and software engineering agents across engineering teams
Demonstrated ability to move from prototype to production while balancing speed, quality, and operational rigor
Experience working directly with users or stakeholders to iteratively refine technical solutions based on real-world needs
Strong problem-solving andsystems-thinking skills
Strong written and verbal communication skills with the ability to work effectively across technical and non-technical teams
Technical Skills Required
Full-stack application development across modern front-end and back-end technologies
Large language model application development
Agentic workflow design and orchestration
Prompt engineering and prompt iteration
Tool use and API integration for AI agents
Multi-step workflow automation
Rapid prototyping andproductionization
Evaluation, testing, and quality measurement for AI systems
Application logging, monitoring, and observability
API design, service development, data modeling, and application architecture
Distributed systems and service integration
Secure software development practices
Enterprise application integration
Cloud-based application development
Version control, CI/CD, and deployment practices
Preferred Skills
Experience using a forward deployed engineering or similar embedded delivery model
Experience building internal copilots, assistants, or task-oriented AI agents
Familiarity with orchestration frameworks, agent runtimes, tool-calling architectures, and retrieval patterns
Experience integrating with enterprise collaboration tools, workflow systems, document platforms, or knowledge repositories
Familiarity with evaluation frameworks for AI quality,groundedness, task completion, and reliability
Experience designing human-in-the-loop workflows and safe failure or escalation mechanisms
Exposure to AI observability, tracing, and operational analytics
Experience in regulated industries such as biotechnology, pharmaceuticals, healthcare, or life sciences
#LI-Hybrid
At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.
Pay Range:
$166,640 - $250,000
Disclosure Statement:
The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.
At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.
Flex Designation:
Hybrid-Eligible Or On-Site Eligible
Flex Eligibility Status:
In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility.
Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.
#LI-Hybrid
Company Information
Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com
Vertex is the Decision-to-Defense™ global indirect tax and compliance company.
We help enterprises control indirect tax and compliance across the transaction lifecycle-so outcomes can be proved and improved with confidence. Our purpose is to ensure businesses and communities thrive through trusted transactions.
Global compliance now lives inside the transaction. So does Vertex-helping enterprises prove outcomes from determination to defense.
Offices: 2301 Renaissance Blvd, King of Prussia, PA 19406, US · 40 Shuman Blvd., Suite 218, Naperville, IL 60540, US · 1 Furzeground Way, Stockley Park, Stockley Park, Uxbridge UB11 1EZ, GB · 101 Arthur Andersen Parkway, Suite 300, Sarasota, FL 34232, US · Gustav Mahlerplein, Amsterdam, North Holland 1082, NL
taxtransaction taxindirect taxtax compliancesoftwareVATvalue added taxsales and usemanaged servicesreturns outsourcing
Frequently asked questions
How much do Engineering jobs in Boston, MA pay?
Based on 2244 listings with disclosed salaries, most engineering jobs in Boston, MA pay between $80k–$212k per year. Individual offers vary with seniority, company size, and specialization.
How many Engineering jobs are open in Boston, MA right now?
There are currently 2,777 open engineering positions in Boston, MA listed on Clera. New openings are added daily as companies post roles.
Which companies are hiring for Engineering roles in Boston, MA?
Companies currently hiring include WHOOP, Amazon, State Street, Vertex Inc., Liberty Mutual Insurance, among others. Browse the listings above to see every active employer.
Are there remote or hybrid Engineering jobs in Boston, MA?
Yes — 1258 of the 2777 open engineering positions offer remote or hybrid work (292 remote, 966 hybrid).
How do I apply for Engineering jobs in Boston, MA?
Each listing links directly to the employer's application page. Apply early — fresh listings get the most recruiter attention in the first two weeks.