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Skills: GMP Regulations, Flow Cytometry, Cell-Based Assays, LIMS, GDP
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San Francisco, California, United States · Remote OK
Senior+$9.4B raised
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$75k–$85k/yr
Full-time
bachelor degree, postgraduate degree
Medical Insurance, Dental Insurance, Vision Insurance, Flexible Spending Account, Life Insurance, AD&D Insurance
Posted 28d ago
~40 hrs/week
Responsibilities
Perform cell-based release and stability assays, including flow cytometry and lentiviral vector testing. Support method transfer, validation, and maintain GMP compliance through deviations and CAPAs.
Requirements
Requires a Bachelor's or Master's degree in Biology or a related field with 3-5 years of GMP laboratory experience. Proficiency in cell-based and flow cytometry assays is required, along with the ability to work a fixed Wednesday-Saturday shift.
Full job description
Using living cells to treat – and sometimes even cure – cancer is one of the most dramatic advances in modern medicine. Patients with hematologic malignancies have been successfully treated with cell therapies. However, these profound results have not yet been achieved in patients with solid tumors, representing approximately 90% of all cancers. And for patients with hematologic malignancies, there is a need for next-generation cell therapies that can deliver increased response rates and longer duration of response. We are a clinical-stage company advancing a pipeline of next-generation CAR T-cell therapies for patients with solid tumors or hematologic malignancies. Lyell’s product candidates are enhanced with novel technology designed to generate T cells that resist exhaustion and have qualities of durable stemness in order to drive durable tumor cytotoxicity and achieve consistent and long-lasting clinical response. We were founded by cell therapy pioneers whose decades of research elevated the broader understanding of T-cell biology and its interaction with cancer. In our quest to advance next-generation CAR T-cell therapies, we have built a fully integrated company capable of discovering new technologies, translating science into therapies, manufacturing cell therapy products, and clinically evaluating them in patients. Our culture is based on Science, Respect, Collaboration, and Courage and reflects who we are, the environment we create, and our mission's urgency.
We are seeking a highly motivated and detail-oriented QC Associate IIto join our dynamic team at the Lyell Manufacturing Facility, LyFE in Bothell, WA. The ideal candidate will have hands-on experience in a GMP-regulated facility and be proficient in conducting cell-based and flow cytometry-based assays. Experience in cell therapy is highly desirable.
This role requires working a Wednesday through Saturday shift, 10 hours per day, and involves routine laboratory work supporting ongoing preclinical and clinical development programs. This is an onsite role with no remote option.
Key Responsibilities:
Perform cell-based release and stability assays for cell count, viability and cytotoxicity.
Execute release lentiviral vector assay to determine titer and potency
Perform flow cytometry in-process, release and stability testing
Support and execute method transfer, qualification and validation
Participate in authoring test methods and developing and validating blueprints for testing in LIMS
Maintain compliance with GMP regulations and internal SOPs and methods during all QC operations.
Initiate, lead and participate in deviations, Change Controls and CAPAs. Experience with MasterControl is a plus.
Perform preventative maintenance of QC equipment, and ensure clean and organized, laboratories. Experience with BMRAM is a plus.
Perform other QC support duties as assigned.
Requirements:
3-5 years of experience in a GMP-regulated pharmaceutical, biotech, or related industry.
Prior experience in cell therapy environments is a plus.
Working knowledge of LIMS systems is strongly preferred.
Detail-oriented with strong organizational and GDP skills.
Ability to work independently on a fixed schedule (Weds-Sat, 10 hours/day).
Overtime may be required occasionally, based on business needs.
Ability to stand for extended periods and work in a laboratory environment wearing personal protective equipment.
Work involves repetitive tasks and occasional lifting (up to 25 lbs).
Qualifications:
Bachelor’s or Master’s degree in biology, Immunology, Cell Biology, or related field.
3–5+ years of experience working in a GMP-regulated laboratory environment.
Experience with cell and flow cytometry-based assays is required.
Familiarity with software tools for flow cytometry data analysis (e.g. FCS Express).
Strong attention to detail, organizational skills, and ability to work independently on a fixed schedule (Weds-Sat.).
Additional Information:
This is an onsite role with no remote option.
Candidates must be authorized to work in the U.S. without sponsorship.
Shift: Weds– Saturday, 10 hours/day
The salary range for this position is $75,000 to 85,000 per year with the opportunity to earn an annual bonus. The salary range is an estimate, and the actual salary may vary based on Lyell’s compensation practices and an applicant’s qualifications and experience. Employees are also eligible to participate in Lyell’s Equity Incentive Plan.
Our Employee Benefits program is extensive and includes subsidized medical, dental and vision plans from your first day of employment, FSA, Company provided Life and AD&D Insurance as well as STD and LTD Insurance, ESPP, a 401(k) Plan with Company match, mass transit commuter benefits, cell phone reimbursement and a range of supplemental benefits that you may choose to elect. Our paid time-off benefits currently include 18 days’ vacation, 9 day’s sick leave, 8 observed holidays as well as a floating holiday. We also have a summer and a winter office shutdown.
At Lyell, we believe that highest performing teams include people from a wide variety of backgrounds and experiences who respectfully challenge each other. We are committed to building an open, diverse and inclusive culture for all employees. Lyell is proud to be an equal opportunity employer and does not discriminate on the basis of race, color, citizenship status, national origin, ancestry, sex, sexual orientation, age, religion, creed, physical or mental disability, medical condition, marital status, veteran status or any other characteristics protected under applicable federal, state and local laws.
We’ve learned from experience that some of the best people don’t always match our requirements perfectly - if you’re interested and think you could fit, please don’t hesitate to apply.
Related keywords
CAR T-cell TherapyGMPLIMSFlow CytometryCytotoxicityLentiviral VectorMasterControlBMRAMFCS ExpressGDPCAPAChange ControlCell TherapyBiotechnologyPharmaceuticalsQuality Control
At Lyell, we are advancing next-generation CAR T-cell product candidates for patients with cancer.
Industry
Biotechnology Research
Company size
201-500 employees
Headquarters
South San Francisco, CA
LinkedIn followers
21,600
Total funding
$543M
Lyell is a late-stage clinical company advancing a pipeline of next-generation CAR T-cell therapies for patients with cancer. Lyell’s product candidates are enhanced with novel technology designed to generate T cells that resist exhaustion and have qualities of durable stemness in order to drive durable tumor cytotoxicity and achieve consistent and long-lasting clinical response. We were founded by cell therapy pioneers whose decades of research elevated the broader understanding of T-cell biology and its interaction with cancer. We have built a fully integrated company capable of discovering new technologies, translating science into therapies, manufacturing cell therapy products, and clinically evaluating them in patients. Our culture is based on Science, Respect, Collaboration, and Courage and reflects who we are, the environment we create, and our mission's urgency.
Offices: 201 Haskins Way, South San Francisco, CA 94080, US · 500 Fairview Ave N, Suite 560, Seattle, Washington 98109, US · 2525 223rd St SE, Bothell, Washington 98021, US
Based on 5460 listings with disclosed salaries, most engineering jobs in Washington pay between $100k–$237k per year. Individual offers vary with seniority, company size, and specialization.
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