SaaS startups in San Francisco

GovDash

San Francisco

GovDash enables businesses to win and deliver government contracts that advance American interests. Its customers won over $5B in government contracts in 2025, and GovDash has raised $42M in funding.

Poka Labs

San Francisco

Poka Labs, a San Francisco-based startup founded in 2023, builds AI agents that automate commercial operations for chemical manufacturers, led by Andrew Bass and Malay Shah; it is backed by Y Combinator, Flybridge, Pioneer Fund, and Beat Ve

Heliux

San Francisco

Heliux provides an all-in-one software platform to optimize enterprise-wide operations for manufacturers by unifying teams, processes, and data into one system. It’s based in San Francisco and has raised funding from New Stack Ventures, Amp

Vantara

San Francisco

Vantara positions itself as an AI product engineer that monitors user sessions and feedback from support, sales, and channels, identifies patterns, prioritizes what to build, and enables PRs and A/B tests to close the loop between user inpu

Runway

San Francisco

Runway is a collaborative business planning platform that replaces spreadsheets with a modern planning solution, democratizing planning across the organization. Its customers include AngelList, Superhuman, ConvertKit, Lambda Labs, and Sandb

Confident AI

San Francisco

Confident AI is the leading LLM evaluation platform behind the open-source DeepEval framework; its cloud product brings DeepEval to enterprises, backed by 600k+ monthly downloads, 5.3k+ GitHub stars, 40 million evaluations, and hundreds of

Numeral

San Francisco

Numeral automates sales tax compliance for ecommerce and SaaS merchants, focusing on Shopify stores. Founded around Kevin, a California-licensed CPA, and Sam, co-owner of $10M+ Shopify brand with roles at Airbnb and Teespring, it helps stor

Opal Security

San Francisco

Opal provides enterprise identity and access management solutions. It is based in New York City and San Francisco and backed by Greylock, Battery Ventures, and Silicon Valley CISO Investments, serving hypergrowth startups and Fortune 500 co

TrueClaim

San Francisco

TrueClaim provides an AI-enabled platform for health plans, focused on advancing health-plan technology and modern operations.

Rulebase

San Francisco

Rulebase delivers visibility and confidence to modern support teams, helping them understand and improve the customer experience in real time. Its technology stack includes Python, React, and Electron JS.

InspectMind AI

San Francisco

InspectMind AI delivers AI-powered documentation and reporting tools for construction and design professionals, simplifying paperwork and streamlining on-site workflows to help workers spend less time at a desk and more time building.

Uiflow

San Francisco

Y Combinator is a leading startup accelerator founded in 2005 by Jessica Livingston that runs programs to support startups, including the YC Program, Startup School, and Co-Founder Matching, and provides resources, deals, and ongoing guidan

Runway Financial

San Francisco

Runway is a collaborative business planning platform that replaces spreadsheets with a modern planning solution, democratizing planning across the organization. Its customers include AngelList, Superhuman, ConvertKit, Lambda Labs, and Sandb

Sylvan Labs

San Francisco

Sylvan Labs specializes in post-sales enablement for enterprise software, aiming to become the category-defining platform and a billion-dollar business by product- and GTM-led growth, not headcount. It pursues expansion through private equi

Helium

San Francisco

Helium automatically generates and tests paywalls to improve app conversion. Backed by Y Combinator, Google, and leaders from OpenAI and Uber, the company is positioned in the paywall automation space for apps.

Hadrius

San Francisco

Hadrius automates and consolidates securities compliance for investment firms, serving over 500 institutions and more than $5 trillion AUM. A YC W23 alum with over $10M ARR, it’s described as fastest-growing company in its space and an emer

Luminade

San Francisco

Founded by Sriram (ex-Luminade) and Mikhail (ex-Google, four-time competitive skydiving world champion); the two-person team builds a conversational voice layer for work that delivers actions in-chat, with ownership over product direction a

Resonate AI

San Francisco

An AI-driven platform that helps healthcare practices capture new patients by converting missed calls into patient inquiries, led by a founder with 10+ years of AI experience and five patents who previously built 0-to-1 ventures at Microsof

LedgerUp

San Francisco

LedgerUp is an AI-driven operations teammate for billing and accounts receivable that automates contract-to-cash workflows, reducing busywork for teams and driving growth.

Nexus Intelligence

San Francisco

An a16z-backed software startup building AI-enabled industrial automation systems for Fortune 100 customers across automotive, food, energy, and other sectors, aiming to become the platform for developing and deploying modern industrial aut

Harmonic

San Francisco

Harmonic is a startup discovery engine that converts fragmented sources into structured knowledge about startups, investors, and people, mapping the ecosystem and helping the most promising founders get found and funded by the world's large

Inductive Bio

San Francisco

Inductive Bio uses data, machine learning, software, and domain expertise to rapidly solve ADMET problems with speed and precision, streamlining ADMET workflows as a focused provider in the ADMET problem space.

Greptile

San Francisco

Greptile, a San Francisco AI tooling startup with a six-person team, builds an AI expert on codebases accessible via an API, serving 1,000 software teams; raised $5.3M from Y Combinator, Initialized Capital, SV Angel, and Paul Graham, with

Stainless

San Francisco

✱ Stainless provides robust & polished SDKs for your REST API.They're idiomatic, type-safe, and engineered to feel like handwritten code.API-first companies like OpenAI, Anthropic, Meta, Cloudflare, and Scale use Stainless to generate SDKs

Conversion

San Francisco

Conversion is a modern marketing automation platform for high-growth teams, making B2B marketing faster, smarter, and more personal. Trusted by over 5,000 businesses, it serves customers like Abacum, Clay, Hockeystack, and 11x, helping team

LlamaIndex

San Francisco

LlamaIndex offers an open-source framework that lets developers build agents to parse, extract insights, and act on enterprise documents, reasoning over data and scaling for production. It has 4M+ monthly downloads and 200M+ documents proce

Column Tax

San Francisco

Column Tax democratizes access to financial help by delivering game-changing tax solutions for everyday people, highlighting gaps in financial guidance and the need for affordable tax support (over 100 million Americans can’t cover a $1,000

Speakeasy

San Francisco

Speakeasy is a developer platform for building and deploying agent tools as hosted MCPs, serving startups to Fortune 500s including LaunchDarkly, Fivetran, and Verizon; it emphasizes open development, a GitHub presence, and rapid team growt

LiteLLM

San Francisco

LiteLLM develops open-source developer tooling for the AI software space, enabling access to multiple LLM APIs. It has raised $1.6M in seed funding from Y Combinator, Gravity Fund, and Pioneer Fund, and reports $7M+ ARR while remaining mean

Delightree

San Francisco

Delightree is an all-in-one franchising tech platform for emerging franchise businesses seeking to scale while preserving brand promise, offering integrated tools to streamline launch and day-to-day operations and maintain consistency acros

Spherecast (YC S24)

San Francisco

Spherecast develops an AI-driven platform for planning and execution across supply chains, making physical flows programmable like code. It is backed by Y Combinator, has worked with AG1, and employs seven experts in operations research, co

Forge

San Francisco

Forge automates complex manual processes for the world’s largest enterprises and advances human computer interaction. Backed by Founders Fund and OpenAI, it operates globally, powering Fortune 500 workflows with 98%+ quality across half a m

Chroma

San Francisco

Chroma provides data infrastructure for AI, aiming to accelerate useful and creative AI applications, and positions itself as the leading retrieval solution trusted by developers worldwide.

Finley

San Francisco

Finley is a San Francisco-based company that simplifies debt capital raise and management. A 2021 YC Winter alum, it is backed by Y Combinator and Bain Capital Ventures, with founders from Goldman Sachs, Nova Credit, and Palantir Technologi

Standard Fleet

San Francisco

Standard Fleet develops next-generation fleet management software focused on electric vehicles and aims to become the default software layer for fleet operators, empowering them to maximize efficiency and profitability by unlocking the valu

Two Dots

San Francisco

Two Dots uses AI to reinvent consumer underwriting, starting with residential real estate. It harnesses data in consumer documents to improve lending decisions, pairing its underwriting agent with advanced document and identity anti-fraud c

OpenBlock

San Francisco

OpenBlock builds CLI coding agents; its OB-1 ranked #1 on Terminal Bench ahead of Claude Code and Codex highlights leadership in developer tooling and its aim to empower individuals and teams to create and innovate in software development f

Loop AI

San Francisco

Loop is building an enterprise co-pilot for restaurants, starting with delivery to serve the sector with an enterprise-level assistant.