SaaS startups in San Francisco

New Lantern

San Francisco

New Lantern is a radiology software company delivering an AI-powered cloud platform to automate imaging workflows and replace on-premise radiology SaaS. It bills itself as the first AI-powered cloud radiology platform and engages radiologis

Suger

San Francisco

Suger is a Cloud GTM platform that lets software companies list, transact, and co-sell through cloud marketplaces and partner portals (AWS, Azure, GCP, Snowflake, Alibaba), automating cross-functional GTM work for faster deal closure; 250+

Parahelp

San Francisco

Parahelp offers an AI support agent for fast-moving software companies, designed to automate complex support tickets end-to-end and deployable in one day without engineers. With a five-person, founder-heavy team and rapid growth, it is seek

Cambio

San Francisco

Cambio is an AI-powered platform for commercial real estate operations, built by investors for investors, focusing on capital planning and compliance. It partners with Beacon Capital Partners and Madison International Realty and reports a 1

Mach9

San Francisco

Mach9, founded in 2021 in San Francisco, is a geospatial technology company that automates detection and analysis of urban features for transportation planning, turning geospatial data into actionable insights via machine learning and compu

Delphi

San Francisco

Delphi aims to amplify human wisdom—personalized, discoverable, and preservable—while scaling brilliance across generations. It has tripled revenue, users, and Delphi interactions in six months, backed by Sequoia Capital, Founders Fund, Abs

Dynamo AI

San Francisco

Dynamo offers end-to-end privacy, security, and compliance solutions to help organizations prepare for emerging AI regulations and productionize AI with confidence, enabling deployments aligned with evolving rules.

Evidently

San Francisco

Evidently is a Clinical Data Intelligence platform built on 12 years of advanced research in Machine Reading and Knowledge Graph, aiming to dramatically improve the efficiency and effectiveness of clinical data workflows.

Takeoff

San Francisco

A startup backed by Matrix Partners with an uncapped seed, accepted into Y Combinator; has customers and distribution and a clear path to eight-figure revenue, driven by an execution-focused team of veterans from Stripe, Microsoft, Salesfor

Diversion

San Francisco

Diversion is a well-funded, early-stage company building a modern, cloud-native SCM as the basis of the dev stack for developers worldwide, and claims to be the world's first fully cloud-based version management solution for the creative in

Onecrew

San Francisco

OneCrew is an all-in-one software platform for asphalt paving crews that centralizes estimating, scheduling, invoicing, and communication, helping contractors get more done, faster and enabling more efficient operations on paving projects.

Commenda

San Francisco

The company automates multinational compliance by indexing regulations and enabling fast querying, targeting a $200B market and challenging the Big Four as a nimble alternative; it has raised $10M seed and counts Razorpay, Pine Labs, MPL, a

Replo

San Francisco

Replo, a San Francisco-based company, builds agentic commerce for the internet and grew to 1,000+ paying customers in under a year with no sales or marketing budget, while raising over $8.4 million in seed funding from notable investors.

Poly

San Francisco

Poly provides a personal cloud storage platform for files and media, positioning itself as the most advanced in its category and aiming to replace Finder/File Explorer on the desktop, using proprietary AI to reimagine the stack.

Foundational

San Francisco

Foundational helps data teams build and deploy code more reliably, reducing fragility from code changes and downstream data impacts. Founded by three industry veterans, its team includes professionals from leading companies and addresses a

Vitalize

San Francisco

Vitalize is building an operating system for hospital operations, starting with staffing and scheduling optimization. Backed by Y Combinator and leading health systems, it reached seven-figures in ARR in under six months.

Chronicle

San Francisco

Chronicle is an AI-native presentation platform backed by Accel and SquarePeg, marketed as the modern 'Cursor for Slides' with hundreds of thousands of users; led by Mayuresh and Tejas, it earned Product Hunt's #4 Product of the Year in 202

Vitalize Care

San Francisco

Vitalize is building an operating system for hospital operations, starting with staffing and scheduling optimization. Backed by Y Combinator and leading health systems, it reached seven-figures in ARR in under six months.

Zuma

San Francisco

Zuma provides Kelsey, an AI leasing assistant for multifamily resident lifecycle, helping operators automate leasing and resident tasks. It blends agentic AI with humans-in-the-loop to preserve brand voice, accuracy, and empathy, and runs 2

Scritch

San Francisco

Scritch is building the leading AI-powered operating system for veterinary care, providing AI agents to streamline operations for veterinary clinics, including scheduling and clinical workflows.

Blaze

San Francisco

Blaze is the first AI agent that handles marketing for you, founded by Faiyam Rahman and Luc Succès and backed by Y Combinator. Its mission is to free business owners and marketing teams to focus on high-impact growth.

Syntra

San Francisco

Syntra operates in healthcare revenue cycle management, integrating with all major EHR systems. It processes hundreds of millions of dollars in charges annually and aims to increase revenue, reduce audit risk and denials, and shorten accoun

Metis

San Francisco

Metis helps enterprises build reliable AI agents for Fortune 500 enterprises and frontier AI labs; it reports six-figure monthly revenue and 150%+ MoM growth, backed by Y Combinator, CRV, and executives from OpenAI, Google, Mercor, and NVID

Reacher

San Francisco

Reacher is a San Francisco-based B2B software and services company that automates creator marketing for the world’s largest brands, positioning itself as the AI Brand Manager for ecommerce scaling through the creator economy.

Soff

San Francisco

Soff is an AI-powered supply chain hub that integrates with email and ERP systems to automate procurement workflows, leveraging years of supply chain data to save manufacturers time and money.

Saphira AI

San Francisco

Saphira AI builds tools for safety and compliance teams in hardware companies to accelerate and streamline processes, serving startups to industry leaders in semiconductors, aerospace, and robotics, delivering faster, cheaper safety and com

Roame

San Francisco

Roame is a flight search engine that uses credit card points and miles to find redemptions, positioning itself as Google Flights for points; it serves 1 million travelers and is backed by Y Combinator, Goodwater Capital, and Accel’s Starter

A0.dev

San Francisco

a0.dev is a platform generating custom React Native projects to help mobile developers build apps in days, not weeks. It has launched apps used by hundreds of thousands of users and relies on React Native, TypeScript, Node.js, Express, Next

Idler

San Francisco

Idler builds reinforcement learning coding environments that train AI to code like elite engineers using real-world scenarios. It closed a multimillion-dollar contract with a leading foundation lab and is scaling to power the training data

Attunement

San Francisco

Attunement, a YC W24 company, builds compliance infrastructure that connects clinical data pipelines, model outputs, and audit systems to make AI-assisted behavioral care traceable, explainable, and auditable. Clinics cut audit prep time by

Photonium

San Francisco

Photonium is building a next-generation design automation platform for optical systems, using AI to automate layout generation, optimization, simulation, tolerancing, and sourcing, marketed as an optics-focused alternative to Cadence or Syn

Stream

San Francisco

Stream Platforms, Ltd is a B Corporation delivering fair financial services and modernizing insurance, whose Stream platform serves three million people through 2,000 brands across UK, Europe and the US, backed by YC and investors as a fina

Complete

San Francisco

Complete provides compensation for fast-growth startups, serving elite tech teams such as Render, Linear, Vercel, and DataStax. Revenue has grown threefold this year, momentum as the company is at an inflection point and plans significant t

Simplify

San Francisco

Simplify builds AI-enabled hiring infrastructure to democratize the job search, offering an AI-powered talent agent to help users plan, manage, and achieve career goals, backed by Craft and Y Combinator, with 1M job seekers applying to 100M

Coperniq

San Francisco

**Coperniq Workflow software for solar & energy contractors ☀️😎** Coperniq is workflow software for solar & energy contractors. It cuts soft cost per installation by $3K (17% of total cost) & accelerates project completion by 45 days (30%

Zen

San Francisco

Zen develops posture-awareness software that nudges users to correct slouching, aiming to free people from physical and mental pain. With 30,000+ users and $3.5M in funding from investors including Y Combinator and Valor Equity Partners, it

HOAi

San Francisco

HOAi is a fast-growing community association management platform acquired by Vantaca in 2024; backed by Cove Hill Partners and JMI Private Equity, it achieved seven-figure ARR growth and now serves over 6 million doors, as Vantaca reached a

Infisical

San Francisco

Infisical is the #1 open-source secret management platform for developers, aiming to make security easier. Based in San Francisco with a remote team, it has raised $3M from Y Combinator and serves customers such as Hugging Face and Delivery

Agave

San Francisco

Agave is an early-stage company modernizing the construction industry. With a 10-year founding team from Graphiq/Amazon, it has raised $3M from YC, Accel, and industry leaders, serves 200+ paying customers, is cash-flow positive, and target

Velt

San Francisco

Velt SDK provides JavaScript toolkit to add collaboration features to apps. Founded by former Google engineers who built AR for Search and Maps, it is YC-backed and aims to ship collaboration experiences and boost growth across creative, an