SaaS startups in San Francisco

Nabis

San Francisco

Nabis is the largest licensed cannabis wholesale platform connecting brands with retailers and handling logistics and distribution, building one of the first software cannabis logistics platforms with a modern JavaScript stack (React, Node,

Tydo

San Francisco

Tydo builds AI-powered personalization for ecommerce brands, helping them translate data into trusted, personalized shopping experiences; backed by Tier 1 investors like YC, Greylock, Alt Capital, and Manresa Ventures, and serving retailers

MDalgorithms

San Francisco

MDalgorithms is a remote, AI-driven dermatology and hair care company building custom deep learning models, native apps, and e-commerce APIs. It runs MDacne, a dermatology app with millions of downloads, and MDhair, a regrowth kit, backed b

People.ai

San Francisco

People.ai is a San Francisco-based AI-powered foundational data platform that maps people, companies, and the information flowing between them within a global business activity and identity graph, fueling enterprise growth through real-time

Swayable

San Francisco

Swayable is a Delaware Public Benefit Corporation that measures how media content changes minds. Its cloud data product empirically measures ad impact to double effectiveness, backed by Y Combinator and partners including Amazon, Meta, IBM,

Collectly

San Francisco

Collectly is a profitable healthcare tech startup that uses proprietary EHR interfaces to simplify billing, accelerate cash flow, and enhance the patient financial experience, serving 300k+ patients daily across U.S. practices with AI-drive

Attune

San Francisco

Attune builds developer tools for a post-AI world, delivering tooling for developers operating in a post-AI context and positioning itself as a provider in the evolving developer tools market. It prepares developers for the next era of soft

Joy

San Francisco

Joy is a platform that helps people organize, share, and remember life events, with a viral network that has signed 4% of American weddings and yields about seven new weddings per wedding. It serves millions globally, is YC-backed, and prod

Clipboard

San Francisco

Clipboard connects workplaces with nearby professionals to turn extra time and ambition into career growth and financial opportunity. It is a Y Combinator W17 company founded by Wei Deng, a Yale and Yale Law School graduate.

Nova Credit

San Francisco

Nova Credit is a credit infrastructure and analytics company operating as a Consumer Reporting Agency that helps lenders grow responsibly with alternative data, turning fragmented data into compliant, actionable risk insights via a platform

Ironclad

San Francisco

Ironclad is an SF-based software company offering a digital contracting platform to streamline legal workflows. Founded in 2014 and a YC Summer 2015 alum, it has 400 employees and investors Accel, Greylock, SV Angel, Formation 8, serving Gu

Verge Genomics

San Francisco

Verge Genomics uses AI and human tissue data in its CONVERGE platform to map disease biology, identify targets, and de-risk drug development, with two drugs in clinical trials, 282 targets discovered, and partnerships worth $1.6B.

Everest

San Francisco

The company builds AI employees for IT services, aiming to transform the $300B IT services industry from 10–20% margins to software margins by turning outsourced IT support into a software business and building a $100B company that changes

Y Combinator

San Francisco

Y Combinator is a leading startup accelerator founded in 2005 by Jessica Livingston that runs programs to support startups, including the YC Program, Startup School, and Co-Founder Matching, and provides resources, deals, and ongoing guidan

ClassDojo

San Francisco

ClassDojo is a San Francisco-based education platform that connects teachers, children and families through a communication app, serving 51 million+ users in 180 countries and reaching 95% of US pre-K–8 schools, making it one of the fastest

Mosaic

San Francisco

Mosaic is developing an agentic video editing paradigm to build an agentic video editor. Its ex-Tesla engineering team has won the Google Gemini Kaggle grand prize ($25,000) from 6,400 entrants and the SaaStr AI Pitch competition.

Ridecell

San Francisco

Ridecell leads the digital transformation of fleet operations in Europe and North America, serving fleet operators and governments for clients such as Penske, Toyota, Ford, Daimler, BMW, BNP Paribas and Arval, including San Francisco and Ne

Raindrop

San Francisco

Raindrop provides monitoring and alerting for AI applications. Backed by Y Combinator, it counts investors including James Tamplin, Guillermo Rauch, Balaji Srinivasan, Matt MacInnis, and backers from OpenAI, Apple, Figma, Scale.

Canvas

San Francisco

Canvas, a small team, is building AI Operating System for B2B sales, backed by Y Combinator, to automate boring parts of outbound so humans can focus on finding and connecting with prospects, via AI research agents and on-demand human SDRs.

Amplitude

San Francisco

Amplitude is a San Francisco-based digital analytics company founded in 2012 by Spenser Skates (CEO) and Curtis Liu (CTO). It went public in 2021, serves over 3,000 paying customers, and focuses on product analytics to help organizations bu

Webflow

San Francisco

Webflow is a professional website design and publishing platform and the leading no-code visual web development platform. It enables diverse clients—from startups to Fortune 500s like Discord, Monday.com, TED, and Dropbox—to build websites

Rescale

San Francisco

Rescale is a cloud-based platform for computational engineering and R&D that democratizes access to HPC, simulation, AI/ML, and digital twins, serving leading automotive and life sciences firms and operating the largest network of hyperscal

Phind

San Francisco

Phind reinvents AI search with rich, interactive answers. Based in San Francisco with a small team, led by co-founder and CEO Michael Royzen, a UT Austin Turing Scholar ’22 with prior NLP and ML roles at Lyft, Cloudflare and Microsoft.

Floot

San Francisco

Floot builds an AI-first software foundation enabling non-coders to build and deploy full-stack web apps. It grew to 600+ customers after Y Combinator and features founders from Retool and AWS, with a CTO who bootstrapped a SaaS to $5M+ ARR

Sample

San Francisco

Sample Healthcare is a profitable San Francisco-based healthcare AI company backed by notable investors including Kulveer Taggar, Zack Kanter, Homebrew Ventures, Y Combinator, and alumni from Retool, Stripe, Ambience Healthcare, and Watersh

Givefront

San Francisco

Givefront provides financial infrastructure for nonprofits, enabling automatic compliance and precise tracking of every dollar, backed by Y Combinator in Winter 2024. Harvard CS and statistics graduate Matt Tengtrakool founded the company,

Reprompt

San Francisco

Reprompt builds AI Agents for location-based mapping, helping Radar and TomTom keep maps current with live POI data. It runs an AI agents platform (Web, Vision, Doc Reading; upcoming self-driving browser agents) led by Mapbox, Facebook, and

14.ai

San Francisco

14.ai, founded by Michael Fester and Marie Schneegans, builds customer support solutions for 1000x teams; backed by Y Combinator and SV Angel, with backers including founders from Vercel, Slack, Dropbox, and Algolia, and Fester previously c

Middleware

San Francisco

Middleware is a fast-growing San Francisco-based startup backed by a tier-1 investor, delivering insights and visibility into complex systems for B2B software and services infrastructure. Led by founder-CEO Laduram Vishnoi, who previously b

Capy

San Francisco

Scout is an AI-native software engineering agent that operates asynchronously on its own VM and tackles long-horizon tasks on large codebases.

Relace

San Francisco

Relace focuses on models and infrastructure for coding agents, defining its core offerings around coding-agent technology.

Stacksync

San Francisco

Stacksync provides real-time, two-way data synchronization between CRMs and databases, serving engineers and RevOps teams. Founded by Ruben Burdin and Alexis Favre, the company focuses on data movement and enterprise integration.

Julius

San Francisco

Julius is San Francisco AI lab aiming to enable one billion people to become software creators. It writes 1 million lines of code every 36 hours and generates 3 million visualizations for more than 1 million users.

1stCollab

San Francisco

1stCollab is an AI-powered influencer marketing platform whose founder team previously helped scale Pinterest. YC W23 seed-stage startup backed by Y Combinator, it connects thousands of creators with top brands, delivering campaigns in hour

Relari

San Francisco

Relari is building infrastructure for trustworthy AI agents in the Software 3.0 era, behind Nuvi.dev, and has developed open-source frameworks Agent Contract and continuous-eval to help ensure AI systems behave as intended.

Openlayer

San Francisco

Openlayer, founded by three former Siri engineers, builds sustainable, high-performing, ethical machine learning for enterprise clients; backed by Y Combinator and investors from Instagram, Voyage, Instacart, Sendbird, and Mercury, and work

Berry

San Francisco

Berry is a Y Combinator-backed startup serving SaaS companies worldwide. Led by co-founder and Chief Product Officer Ann Chan and founder Yan Fu, a former startup CTO, Berry scales services for SaaS firms using React, TypeScript, Python, RE

PgDog

San Francisco

PgDog builds scaling tools for PostgreSQL, including load balancing and sharding, aiming to make PostgreSQL the database you’ll need. The Rust-based platform shows compatibility with integration tests across 7+ languages and Postgres driver

Mercoa

San Francisco

Mercoa is an embedded B2B payments platform that enables B2B fintechs to add BillPay and Accounts Payable to their products, serving accounting firms, neobanks, and vertical SaaS across construction, e-commerce, and home services.

OpenFunnel

San Francisco

OpenFunnel is a time-aware search engine for GTM teams that surfaces insights from time-based signals, delivering daily actionable findings. Trusted by over 1,000 users (including Central, Mintlify, and Everest Systems), it reveals pain poi