SaaS startups in San Francisco

Kalos

San Francisco

Kalos is an early-stage, high-growth startup in San Francisco, currently in stealth mode, that has built Blue, an AI agent.

Domu Technology Inc. (YC S24)

San Francisco

Domu Technology Inc. automates debt-collection calls for banks and insurers, serving six Fortune 500s and major firms including MetLife, BBVA, and BNP Paribas Cardif. A YC alum with a female-led team, it reduces costs and improves recovery

Trellis AI

San Francisco

Trellis provides an AI agent that automates healthcare administrative workflows—such as intake, prior authorizations, and appeals—positioning itself as a solutions-focused partner to increase provider revenue while reducing administrative b

Chima

San Francisco

Chima helps leading institutions customize and scale generative AI by integrating and analyzing private and public data to privately leverage commercial LLMs; it builds infrastructure for enterprises to customize LLMs and automate functions

Dalus

San Francisco

Dalus develops AI-powered software that makes hardware design feel like software development, targeting aerospace, robotics, and defense. Founded in 2024 by Eliot and Sebastian, it has revenue and completed YC W25.

Promptless

San Francisco

Promptless builds AI teammates that integrate with users’ existing workflows, serving startups and Fortune 500 enterprises. It ranked among the top W25 by revenue; small founding team has led startups, published LLM research, and graduated

Sepal AI

San Francisco

Sepal AI provides PhD-level experts for AI model development, backed by YC-backed founders from Vercel and Turing. Since 2024, it has raised millions and counts Fortune 500s and top AI labs as customers, building the largest global talent g

Novoflow

San Francisco

Novoflow deploys AI employees for medical clinics, building computer agents to modernize healthcare and automate front- and back-office tasks across a fragmented 400+ EHR ecosystem; contracts secured, backed by YC advisers and top investors

Additive AI

San Francisco

Additive AI, founded in San Francisco, builds AI-powered tools to automate document-heavy tax and accounting workflows; acquired by Thomson Reuters in 2025, it operates as part of a global leader to help professionals make faster, more info

Pearson Labs

San Francisco

Pearson Labs presents itself as a small, high-impact, lean team focused on delivering meaningful results, emphasizing impact over scale; no information is available about its mission, products, services, or market position.

Archon

San Francisco

Archon develops automated, full-stack systems to secure critical public infrastructure and advance national cybersecurity at the intersection of national security and infrastructure protection. The company is rapidly growing, signaling mome

Dream

San Francisco

Dream is an AI platform that automates residential architecture and construction planning, transforming a slow, expensive process into an instantaneous, affordable one by enabling AI-driven design and planning for homes.

Relixir

San Francisco

Relixir is an autonomous search share maximization platform serving 40+ B2B clients. Founded by Berkeley alumni, it participated in Y Combinator's X25 batch and ranks as one of its fastest-growing companies.

Strada

San Francisco

Strada provides AI agents that handle sales and service calls 24/7 for insurance brokers, MGAs, and carriers, enabling them to scale operations. Based in San Francisco and backed by Y Combinator, it serves carriers and MGAs, engaging thousa

Kato

San Francisco

Kato builds an AI-powered servicing platform that automates critical workflows across channels with full compliance and best-in-class recoveries, in production with major fintech lenders including Bilt Rewards and Parafin, emphasizing a com

Midcentury Labs

San Francisco

Midcentury is building a next-generation platform for audio AI that enables secure onboarding of private data and expert-labeled data services from global contributors to tackle multimodal AI with massive data pipelines; it recently raised

StackAI

San Francisco

Stack AI provides a no-code drag-and-drop platform to design, test, and deploy AI workflows that leverage large language models to automate business processes. Its visual interface lets users connect data sources with different AI models to

Aravolta

San Francisco

Aravolta develops software to monitor, optimize, and control data centers, with a focus on data center infrastructure management (DCIM) software. Its mission is to build the next generation of DCIM solutions.

Veritus Agent

San Francisco

Veritus is a YC-backed AI-native platform for loan servicing and debt collection that operates its own collections agency on the platform, acquires charged-off debt to service it with in-house AI agents, and owns the full stack from acquisi

NOSO LABS

San Francisco

NOSO LABS builds agents for the trades to help technicians diagnose accurately and sell 10x better, providing tools that improve diagnostic precision and sales performance for trade professionals.

GroundControl

San Francisco

GroundControl is a vertical SaaS company solving inefficiencies in regulated manufacturing, focusing on aerospace and defense, enabling high-quality parts with precision. It operates in the U.S., serves North American aerospace/defense clie

Pump.co

San Francisco

Pump is a cloud cost-savings company using group buying and AI to reduce AWS compute spend for startups; Forbes calls it the 'Costco of Cloud compute,' with 250+ customers and India expansion to save up to 60% on AWS costs.

Vapi

San Francisco

Vapi provides a configurable platform to deploy voice agents. Aiming to make voice humanity’s default interface, it's grown to 400,000 developers in 20 months and raised $20M in Series A led by Bessemer Venture Partners, Canadian founders J

Assembly HOA

San Francisco

Assembly HOA Management is a California-based HOA management firm that automates administrative tasks, enhances transparent communication, and provides online access to information, aiming to transform homeowner associations into turnkey co

Medplum

San Francisco

Medplum is an open-source, API-first electronic health record (EHR) platform that increases access to and usefulness of medical data, used by major digital health and life sciences companies to build medical applications.

Activepieces

San Francisco

Activepieces is an MIT-licensed, open-source no-code business automation platform that can be self-hosted on customers' servers, positioned as a self-hosted alternative to cloud tools like Zapier and aimed at making AI a native part of ente

Dart

San Francisco

Dart, founded in 2022 in San Francisco, positions itself as the only truly AI-native project management tool, with an AI-first, product-driven approach. With about 10 full-time staff (5 engineers) and revenue growth in 2025, it has strong f

Exa

San Francisco

Exa, a San Francisco-based startup, is building a next-generation AI search engine aimed at outperforming Google for power users, with an about 20-person team including alumni from Harvard, MIT, Apple, and Palantir, and a Series A from Ligh

Finni Health

San Francisco

Finni Health enables autism care providers to start, run, and grow their own practice with a dedicated platform, backed by General Catalyst, Greymatter, and Y Combinator, as the market expands with rising diagnoses and enabling legislation.

Nash

San Francisco

Nash builds last-mile logistics infrastructure for the internet, aiming to capture a share of the last mile; founded 2021 by MIT alumni Mahmoud Ghulman and Aziz Alghunaim in San Francisco, backed by YC and a16z, serving Walmart, 7-Eleven, a

Attain

San Francisco

Attain is a seed-stage startup that aggregates supplier inventory for convenience store owners, tackling fragmentation and antiquated procurement to cut inventory inefficiencies for over 150,000 stores. It offers price transparency, reliabi

Atlas

San Francisco

Atlas Card is a San Francisco-based fintech delivering modern spend management and concierge services. Founded in 2022 with 25 employees, its founders are Patrick Mrozowski, Sid Parihar, and Kenan Pulak; the company lists Tom Blomfield as a

Forage

San Francisco

Forage builds payment technology to expand access to government benefits, helping SNAP EBT shoppers stretch grocery budgets and feed 42 million Americans. Backed by Nyca and PayPal Ventures, it aims to become a $1B+ business in a $100B+ mar

BentoML

San Francisco

BentoML is an enterprise-grade inference platform that deploys and manages AI models at scale, serving LLMs, embeddings, and agentic pipelines across VPC, on-prem, or hybrid environments. It covers the full inference lifecycle with mission-

Datrics

San Francisco

Datrics, a San Francisco-based company with 22 employees, develops generative AI for healthcare coding automation, led by CEO Anton Vaisburd and founded by Kirill Kirykov and Volodymyr Sofinskyi, both seasoned data science and analytics exe

Sphere

San Francisco

Sphere is an AI-powered cross-border tax compliance platform that automates sales tax, VAT, and GST, building local rails into tax authorities worldwide and the world’s first AI-native tax engine; backed by Felicis Ventures and Y Combinator

Stable

San Francisco

Stable is a virtual address and mailroom platform for startups that helps manage compliant addresses and mail, including guidance for changing addresses with IRS, states, banks, and payroll; used by over 1,400 companies and expanding across

Wanderlog

San Francisco

Wanderlog is a bootstrapped startup building tools to simplify leisure travel. Its core travel-planning app, launched in 2019, is the top-ranked trip planner on iOS and Android, serving millions of travelers monthly.

Substack

San Francisco

Substack enables creators to monetize their work through direct subscriptions, granting economic autonomy, creative ownership, and direct relationships with engaged readers, positioning itself at the intersection of independent publishing a

Milo

San Francisco

Milo (W20) markets itself as The Family AI, a copilot helping parents manage the invisible load of raising a family. It is led by Avni Patel Thompson, founder/CEO of Modern Village, which uses collaborative technology to ease parenting.