Enterprise Software startups in San Francisco

Fieldguide

San Francisco

Fieldguide offers a vertical AI platform for assurance and advisory firms, founded by ex-Big Four practitioners and tech leaders; headquartered in San Francisco, remote-first, backed by notable investors, trusted by top CPA firms to improve

Merge API

San Francisco

Merge is a leading provider of customer-facing integrations and agent tools for frontier LLMs, serving thousands of customers including Fortune 500s and B2B SaaS firms, with offices in San Francisco, New York, and Berlin.

ScopeAI

San Francisco

Scope develops AI-enabled software to accelerate industrial inspection workflows, from reporting to asset integrity, and works with leading TIC players to shorten field reporting to 12 minutes and onboard clients seven times faster.

Centralize

San Francisco

Centralize is an AI-powered relationship intelligence platform for enterprise sales teams. Its founding team launched Facebook Shops, Slack Huddles, and Modern Treasury Reconciliation, and it is backed by Y Combinator, Salesforce Ventures,

Nooks

San Francisco

Nooks is a platform that transforms sales reps from manual laborers to scientists by equipping teams with analytics. It grew from $0 to $5M ARR in two years, expanded 4x in 2023, led by Forbes 30 Under 30 founders.

Burnt

San Francisco

Burnt is building an AI brain for global supply chains, starting with the food sector; it already automates over $10M in monthly orders without humans, has raised $3.8M, and plans enterprise deployments across freight, manufacturing, and di

Unusual

San Francisco

Unusual defines Brand Engineering, a research field that measures how LLMs perceive brands and benchmarks brand performance against peers. Through applied interpretability and narrative-control experiments, it aims to let people shape their

Medra

San Francisco

Medra uses AI, robotics, and biology to accelerate life science research and eradicate disease, building a Scientific Physical AI platform to scale lab work and generate orders of magnitude more data for faster drug development and biology

AirOps

San Francisco

AirOps is the first end-to-end content engineering platform for marketing teams, helping brands get found and stay found in the AI era. With hubs in San Francisco, New York, and Montevideo, it serves marketers and is backed by prominent inv

Argos

San Francisco

Argos builds the AI operating system for in-house legal teams, is based in San Francisco, California, and has $3.5M pre-seed funding as it enters an early stage with pilots launching soon.

Synch

San Francisco

Synch, based in New York City, is the first AI-powered Salesforce system of engagement, backed by Y Combinator and executives from Retool, Ramp, and Superhuman. It enables enterprises to manage their Salesforce environment using natural-lan

HappyRobot

San Francisco

HappyRobot offers an AI-native operating system for real economy, starting with supply chains. It has raised $62M, including a $44M Series B in Sept 2025, from YC, Andreessen Horowitz, and Base10, led by Pablo and Javier Palafox and Luis Pa

Usul (YC S24)

San Francisco

Usul positions itself as the 'Amazon for Government,' enabling companies to sell to government quickly. With Fortune 500, U.S. Government, and NATO as customers and ARR near $5M, it is scaling a repeatable enterprise motion with internation

Gridware

San Francisco

Gridware is a privately held technology company in San Francisco focused on protecting and enhancing the electrical grid, backed by climate-tech and Silicon Valley investors, addressing faults—especially in remote, aging infrastructure and

Dataleap

San Francisco

Dataleap is the world's first vibe working platform, backed by $3 million in funding, aiming to be the first agentic work platform for tech-forward companies, with agents serving 2-person startups to 2,000-person unicorns; founders are Jan

Arphie

San Francisco

Arphie is building a platform for collaborative intelligence between go-to-market and product/engineering teams. Backed by top-tier VC firms and led by CEO/CTO co-founders who met at Harvard, it has posted rapid ARR growth since commerciali

Circleback

San Francisco

Circleback focuses on improving how teams communicate and getting the most out of every conversation. By prioritizing effective conversations, it aims to maximize the value of team interactions and enable better collaboration.

MangoDesk

San Francisco

Creates frontier data and environments to advance AI, bridging AI with the $5T knowledge-work economy and accelerating AI capabilities and adoption in knowledge work.

Rippling

San Francisco

Rippling is a San Francisco-based workforce management platform that unifies applicant tracking, payroll, IT, and expenses, delivering a shared source of truth, automation, and insights by syncing data across apps to enable faster, better d

Pulley

San Francisco

Pulley helps construction teams break ground faster and is backed by a marquee group of investors and industry leaders, pursuing a broader mission to make it easier for anyone to start a company, believing founder-led startups succeed longe

GovDash

San Francisco

GovDash enables businesses to win and deliver government contracts that advance American interests. Its customers won over $5B in government contracts in 2025, and GovDash has raised $42M in funding.

Poka Labs

San Francisco

Poka Labs, a San Francisco-based startup founded in 2023, builds AI agents that automate commercial operations for chemical manufacturers, led by Andrew Bass and Malay Shah; it is backed by Y Combinator, Flybridge, Pioneer Fund, and Beat Ve

Heliux

San Francisco

Heliux provides an all-in-one software platform to optimize enterprise-wide operations for manufacturers by unifying teams, processes, and data into one system. It’s based in San Francisco and has raised funding from New Stack Ventures, Amp

Scale AI

San Francisco

Scale AI provides data-centric infrastructure to accelerate AI development, helping organizations build strong AI models and derive business insights and operational efficiency; serving customers across tech, government, and enterprise, inc

Uiflow

San Francisco

Y Combinator is a leading startup accelerator founded in 2005 by Jessica Livingston that runs programs to support startups, including the YC Program, Startup School, and Co-Founder Matching, and provides resources, deals, and ongoing guidan

Sylvan Labs

San Francisco

Sylvan Labs specializes in post-sales enablement for enterprise software, aiming to become the category-defining platform and a billion-dollar business by product- and GTM-led growth, not headcount. It pursues expansion through private equi

Hadrius

San Francisco

Hadrius automates and consolidates securities compliance for investment firms, serving over 500 institutions and more than $5 trillion AUM. A YC W23 alum with over $10M ARR, it’s described as fastest-growing company in its space and an emer

Resonate AI

San Francisco

An AI-driven platform that helps healthcare practices capture new patients by converting missed calls into patient inquiries, led by a founder with 10+ years of AI experience and five patents who previously built 0-to-1 ventures at Microsof

LedgerUp

San Francisco

LedgerUp is an AI-driven operations teammate for billing and accounts receivable that automates contract-to-cash workflows, reducing busywork for teams and driving growth.

Greptile

San Francisco

Greptile, a San Francisco AI tooling startup with a six-person team, builds an AI expert on codebases accessible via an API, serving 1,000 software teams; raised $5.3M from Y Combinator, Initialized Capital, SV Angel, and Paul Graham, with

LlamaIndex

San Francisco

LlamaIndex offers an open-source framework that lets developers build agents to parse, extract insights, and act on enterprise documents, reasoning over data and scaling for production. It has 4M+ monthly downloads and 200M+ documents proce

LiteLLM

San Francisco

LiteLLM develops open-source developer tooling for the AI software space, enabling access to multiple LLM APIs. It has raised $1.6M in seed funding from Y Combinator, Gravity Fund, and Pioneer Fund, and reports $7M+ ARR while remaining mean

Delightree

San Francisco

Delightree is an all-in-one franchising tech platform for emerging franchise businesses seeking to scale while preserving brand promise, offering integrated tools to streamline launch and day-to-day operations and maintain consistency acros

Spherecast (YC S24)

San Francisco

Spherecast develops an AI-driven platform for planning and execution across supply chains, making physical flows programmable like code. It is backed by Y Combinator, has worked with AG1, and employs seven experts in operations research, co

CommodityAI

San Francisco

CommodityAI is a San Francisco-based AI company serving the commodities industry, founded by former commodity traders and operators with deep industry expertise. Backed by Y Combinator and Rebel Fund, it aims to build intelligence at the fo

Forge

San Francisco

Forge automates complex manual processes for the world’s largest enterprises and advances human computer interaction. Backed by Founders Fund and OpenAI, it operates globally, powering Fortune 500 workflows with 98%+ quality across half a m

Finley

San Francisco

Finley is a San Francisco-based company that simplifies debt capital raise and management. A 2021 YC Winter alum, it is backed by Y Combinator and Bain Capital Ventures, with founders from Goldman Sachs, Nova Credit, and Palantir Technologi

Loop AI

San Francisco

Loop is building an enterprise co-pilot for restaurants, starting with delivery to serve the sector with an enterprise-level assistant.

Suger

San Francisco

Suger is a Cloud GTM platform that lets software companies list, transact, and co-sell through cloud marketplaces and partner portals (AWS, Azure, GCP, Snowflake, Alibaba), automating cross-functional GTM work for faster deal closure; 250+

Parahelp

San Francisco

Parahelp offers an AI support agent for fast-moving software companies, designed to automate complex support tickets end-to-end and deployable in one day without engineers. With a five-person, founder-heavy team and rapid growth, it is seek