Senior Scientist, In Vitro and In Vivo Pharmacology
Lexington, Massachusetts, United States · On-site
$167k–$174k/yr
Senior$400M raised
Kiniksa Pharmaceuticals is a commercial‑stage biopharmaceutical company developing and commercializing novel therapies for diseases with unmet need, with a focus on cardiovascular indications. With deep expertise in immu…
Skills: In Vitro Pharmacology, In Vivo Pharmacology, Immunology, Biologic Drug Development, Mechanistic Assays
Kiniksa Pharmaceuticals is a commercial‑stage biopharmaceutical company developing and commercializing novel therapies for diseases with unmet need, with a focus on cardiovascular indications. With deep expertise in immu…
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Lexington, Massachusetts, United States · On-site
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Lexington, Massachusetts, United States · On-site
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Senior Scientist, In Vitro and In Vivo Pharmacology
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$167k–$174k/yr
Full-time
postgraduate degree
Posted 35d ago
~40 hrs/week
Responsibilities
Design and execute in vitro and in vivo pharmacology studies to characterize the mechanism of action and pharmacodynamic activity of biologic drug candidates. Collaborate with cross-functional teams and external partners to advance therapies for immune-mediated and inflammatory diseases.
Requirements
Requires a PhD in Pharmacology, Immunology, or a related biomedical science with typically 5+ years of industry experience in biotechnology or pharmaceuticals. Must have demonstrated expertise in the translational development of biologic therapeutics and the optimization of mechanistic assays.
Full job description
Kiniksa Pharmaceuticals is a commercial‑stage biopharmaceutical company developing and commercializing novel therapies for diseases with unmet need, with a focus on cardiovascular indications. With deep expertise in immunology and inflammation, Kiniksa is advancing a growing portfolio of approved and investigational medicines, anchored by its lead product, ARCALYST®, the first and only FDA‑approved therapy for recurrent pericarditis. Grounded in rigorous science and bold innovation, the company fosters a highly collaborative, patient‑first culture led by accomplished life sciences leaders. At Kiniksa, talented individuals are trusted and empowered to make a real impact—shaping the future of medicine while improving the lives of patients who need it most.
Kiniksa is seeking a highly motivated Senior Scientist, In Vitro and In Vivo Pharmacology reporting to GVP, Research & Non-Clinical Development to join our Research organization. This individual will play a key role in advancing biologic drug candidates from discovery through clinical development by designing and executing in vitro and in vivo studies that characterize mechanism of action, target engagement, pharmacodynamic activity, and biomarker responses.
The successful candidate will serve as a scientific expert across multidisciplinary project teams and will contribute to the development of innovative therapies for immune-mediated and inflammatory diseases. Particular emphasis will be placed on the characterization of biologics, development of pharmacology assays, and understanding disease biology relevant to protease biology, inflammation, and immune dysregulation.
This is an ideal opportunity for a creative, hands-on scientist who thrives at the intersection of pharmacology, immunology, translational medicine, and therapeutic development. The role will collaborate closely with Clinical Development, Clinical Pharmacology, Bioanalysis, and CMC.
This role is based in our Lexington, MA office. Our office-based employees follow an onsite schedule of 5 days in the office (Mon-Fri)
Responsibilities (including, but not limited to):
Design, execute, and interpret in vitro pharmacology studies to support target validation, lead characterization, and clinical-stage development programs.
Establish and optimize cell-based and biochemical assays using primary cells, immortalized cell lines, co-culture systems, and in vivo disease-relevant models.
Generate data packages that support candidate selection, indication prioritization, dose selection rationale, and clinical biomarker strategies.
Identify emerging targets and pathways associated with protease driven and immune-mediated disease.
Serve as a scientific representative on project teams, contributing to research strategy, development plans, and decision-making.
Collaborate with external CROs, academic investigators, and clinical collaborators.
Present scientific findings to senior leadership and project governance teams.
Author technical reports, study protocols, scientific publications, regulatory support documents, and presentations.
Standout Skills for Impact:
Strong experience with in vitro and in vivo pharmacology studies.
Expertise in immunology, inflammation, and biologic drug development.
Hands-on experience developing and optimizing cell-based and mechanistic assays.
Ability to analyze complex scientific data and translate findings into actionable insights.
Strong collaboration and communication skills within cross-functional drug development teams.
Qualifications and Experience:
PhD in Pharmacology, Immunology, Cell Biology, Molecular Biology, Biomedical Sciences, or related discipline.
Typically 5+ years of relevant biotechnology or pharmaceutical industry experience.
Demonstrated experience supporting discovery and translational development of biologic therapeutics.
Experience working within cross-functional drug development teams from early research through clinical development.
Compensation decisions are based on objective criteria including role responsibilities, experience/qualifications, internal equity, geographic location, and external market benchmarks.
Pay Range
$166,738—$174,397 USD
Kiniksa is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, transgender status, age, genetics, national origin, protected veteran status, or disability status, or any other legally protected category. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.
Kiniksa does not accept unsolicited resumes from staffing agencies or search firms. Any resumes submitted without a signed agreement will be considered property of Kiniksa, and no fees will be paid.
Related keywords
BiopharmaceuticalsCardiovascular IndicationsImmunologyInflammationBiologicsPharmacologyMechanism Of ActionTarget EngagementPharmacodynamicsBiomarkersProtease BiologyImmune DysregulationTranslational MedicineCMCBioanalysisClinical Pharmacology
Kiniksa is a biopharmaceutical company dedicated to improving the lives of patients suffering from debilitating diseases by discovering, acquiring, developing, and commercializing novel therapies for diseases with unmet need, with a focus on cardiovascular indications. Kiniksa’s portfolio of assets is based on strong biologic rationale or validated mechanisms and offers the potential for differentiation.
At Kiniksa, patients are at the heart of everything we do. Our Every Second Counts! mindset reflects our commitment to making a difference for people who are navigating the uncertainty and challenges of life-altering diseases. This is why our team is relentless in pursuing treatments that bring us closer to a better future for patients, every second of every day.
We rely on an exceptional team to drive our mission of building a global, generational company. If you're passionate about making a meaningful impact, we’d love to hear from you.
Kiniksa offers competitive benefits and dynamic career opportunities across our organization. We foster a culture of passion, innovation, and rapid execution to help fulfill our mission.
Offices: 100 Hayden Ave, Lexington, Massachusetts 02421, US · 105 Piccadilly, Second Floor, London, England W1J 7NJ, GB · Grafenaustrasse 5, Zug, ZG 6300, CH · 3366 N Torrey Pines Ct, #320, San Diego, California 92037, US