South San Francisco, California, United States · On-site
$160k–$225k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Project Engineering, NPI, Cross-functional Leadership, Root Cause Analysis, Systems Engineering
South San Francisco, California, United States · On-site
$150k–$200k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Supplier Industrialization, Design For Manufacturability, Lean Methodologies, Statistical Process Control, Should-Cost Modelling
South San Francisco, California, United States · On-site
$175k–$250k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Construction Management, Strategic Planning, Contractor Management, Budgeting, Project Controls
South San Francisco, California, United States · On-site
$160k–$200k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Embedded Software Development, Rust, C++, C, Python
South San Francisco, California, United States · On-site
$170k–$210k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: CI/CD, Bazel, Github Actions, Buildkite, Datadog
South San Francisco, California, United States · On-site
$200k–$245k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Rust, C++, C, Trajectory Generation, MPC
South San Francisco, California, United States · Remote OK
$180k–$270k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Full Stack Development, Frontend Development, Backend Development, System Design, Go
South San Francisco, California, United States · On-site
$170k–$210k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Path Planning, Graph Search, Motion Planning, Optimization Algorithms, Distributed Systems
South San Francisco, California, United States · On-site
$100k–$140k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Hardware Rework, Team Leadership, Process Development, Technical Literacy, Schematic Interpretation
South San Francisco, California, United States · On-site
$160k–$225k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Multidisciplinary Design Leadership, Engineering Standardization, Basis Of Design, Civil Engineering, Structural Engineering
South San Francisco, California, United States · On-site
$200k–$245k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Rust, C++, C, Trajectory Generation, Model Predictive Control
South San Francisco, California, United States · On-site
$180k–$270k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Full-stack Engineering, System Design, Scalable Systems, Python, Go
South San Francisco, California, United States · Hybrid
$176k–$277k/yr
Job Description Position description: Our Company is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achieveme…
Skills: Adme, Biochemical Analysis, Biophysics, Cross-Functional Teamwork, Drug Metabolism
South San Francisco, California, United States · On-site
$161k–$299k/yr
Welcome to Holly Springs, North Carolina— home to Roche/Genentech's largest-ever investment: a $2B greenfield start-up where next-generation technology, high-performing teams and Operational Excellence converge to create…
Skills: Supply Chain Management, Materials Management, S&OP Process, SAP Workflows, Lean Supply Chain
South San Francisco, California, United States · On-site
Overview Accepting Applications for Hourly Hotel Positions. Explore opportunities in the following areas: Engineering Food and Beverage Front Office Housekeeping About Us HHM Hotels is proud to be an equal-opportunity em…
Skills: Engineering, Food and Beverage Service, Front Office Operations, Housekeeping
South San Francisco, California, United States · On-site
$100k–$107k/yr
We advance science so that we all have more time with the people we love. A Postdoctoral Fellow position is available for a highly motivated and independent candidate to join our Protein Sciences - Structural Biology Gro…
Skills: Protein Purification, Biophysical Characterization, X-ray Crystallography, Single-particle Cryo-EM, Protein Engineering
South San Francisco, California, United States · On-site
$84k–$156k/yr
A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more t…
Skills: Molecular Biology, Immune Cell Engineering, Single-Cell Genomics, CRISPR, Flow Cytometry
South San Francisco, California, United States · On-site
$106k–$138k/yr
Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our d…
Skills: Purification Process Development, Protein Characterization, Design of Experiments, AKTA Protein Purification Systems, TFF Systems
South San Francisco, California, United States · On-site
About Human Longevity, Inc. (HLI) Human Longevity, Inc. (HLI) is a leader in precision health, combining genomics, advanced imaging, biomarker testing, and artificial intelligence to transform the future of proactive hea…
Skills: Python, SQL, Large Language Models, Retrieval-Augmented Generation, AI Agents
South San Francisco, California, United States · On-site
$182k–$338k/yr
A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more t…
Skills: Functional Genomics, Scientific Strategy, Genome-wide Screening, Perturbation Biology, Multi-omics Data Generation
South San Francisco, California, United States • On-site
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Build and lead a multidisciplinary Project Engineering function to support ground systems deployment, construction, and launch. Coordinate the site-facing New Product Introduction process and establish feedback loops to improve upstream design and operational standards.
Requires extensive experience in project, field, or systems engineering with a strong generalist background across mechanical, electrical, and civil domains. Must have a proven track record of leading technical teams and managing the transition of hardware from design to field deployment.
Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We design, build, and operate the world’s largest autonomous logistics system, delivering critical supplies quickly and reliably. Today, Zipline operates on four continents, makes a delivery somewhere in the world every 30 seconds, and has completed millions of deliveries to date, including blood, vaccines, medical supplies, food, and retail products.
Our customers include the world’s largest and most prominent healthcare systems, governments, retailers, restaurants and global businesses who rely on us to save lives, reduce emissions, increase economic opportunity, and provide delivery from point A to point B as fast as possible. The drone is only 15% of what we’ve built to enable seamless, reliable, global operations.
Our system strengthens supply chains, reduces congestion, and gives people time back. With more than 140 million commercial autonomous miles safely flown, Zipline is redefining access to healthcare, consumer products, and food across the globe.
We operate at a global scale and are looking for practical problem solvers who thrive on real-world challenges and rapid growth. Our team is motivated by building systems that have a direct, meaningful impact on people’s lives and by scaling the future of logistics. We are seeking people who sculpt from first principles, enjoy facing adversity, and can do the impossible at record breaking speeds.
Zipline is looking for a Sr Staff Engineer or Engineering Manager to build and lead a generalist engineering function for Ground Systems Deployments. Project Engineering will attack a broad set of practical technical problems across mechanical, electrical, civil, structural, site infrastructure, construction, serviceability, deployment execution, new product introduction, process improvement, and field feedback.
This role is for someone who is technically strong, highly tactical, and comfortable solving problems that do not fit neatly inside one discipline. You will lead engineers who can move from a field issue to a design improvement, from a construction blocker to a technical trade study, from a new hardware deployment to a launch-readiness plan, and from a recurring site problem to a better upstream standard or product requirement.
The function will also own the coordination needed when new hardware products are deployed on-site. Project Engineering will work across Engineering, Product, Operations, Construction, Service Operations, Launch, Supply Chain, and external partners to make sure new site hardware can be designed, built, installed, commissioned, operated, maintained, and improved successfully.
The right candidate combines technical innovation with process development and continuous improvement. This function should solve urgent project problems effectively while also making the system better over time: fewer repeated issues, clearer technical ownership, stronger design inputs, better field feedback loops, better NPI readiness, and practical engineering tools that improve speed and quality.
Zipline was founded to create the first logistics system that serves all humans equally. Our aim is to solve the world’s most urgent and complex access challenges. Leveraging expertise in robotics and autonomy, Zipline designs, manufactures and operates the world’s largest automated delivery system. Zipline serves tens of millions of people around the world and is making good on the promise of building an equitable and more resilient global supply chain. From powering Rwanda’s national blood delivery network and Ghana’s COVID-19 vaccine distribution, to providing on-demand home delivery for Walmart and enabling leading healthcare providers to bring care into the home in the United States, Zipline is transforming the way goods move. By transitioning to clean, electric, instant logistics, we can decarbonize delivery, decrease road congestion, and reduce fossil fuel consumption and air pollution, while providing equitable access for billions of people. The technology is complex but the idea is simple: a teleportation service that delivers what you need, when you need it. Zipline is inspiring people, governments, and businesses to imagine what is possible when goods can move as seamlessly as information. To join the team, check out our career page: https://flyzipline.com/careers/
Offices: 333 Corey Way, South San Francisco, California 94080, US
Based on 212 listings with disclosed salaries, most engineering jobs in South San Francisco, CA pay between $120k–$250k per year. Individual offers vary with seniority, company size, and specialization.
There are currently 276 open engineering positions in South San Francisco, CA listed on Clera. New openings are added daily as companies post roles.
Companies currently hiring include Zipline, Roche, MSD, Xaira Therapeutics, Cellares, among others. Browse the listings above to see every active employer.
Yes — 26 of the 276 open engineering positions offer remote or hybrid work (2 remote, 24 hybrid).
Each listing links directly to the employer's application page. Apply early — fresh listings get the most recruiter attention in the first two weeks.
