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We advance science so that we all have more time with the people we love. The Position: The Complex in Vitro Systems (CiS) Lab within the Department of Translational Safety is seeking a highly motivated Senior Scientist …
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South San Francisco, California, United States · On-site
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Commercial HVAC Refrigeration & Cooking Equipment Apprentice Technician South San Francisco, CA Hourly rates from: $20-25/hour Overview Commercial Appliance is hiring Commercial HVAC Refrigeration & Cooking Equipment Tec…
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South San Francisco, California, United States · On-site
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Spirair, a venture capital-backed medical device company, was co-founded by two Stanford Biodesign and Innovation fellows with a shared interest in optimizing outcomes and patient experience through innovation solutions.…
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South San Francisco, California, United States · Hybrid
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The Opportunity We are seeking a highly motivated Senior Project Manager to join Stafl Systems and lead the execution of projects for next-generation battery and powertrain technologies for mobility and consumer product …
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South San Francisco, California, United States · On-site
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South San Francisco, California, United States • On-site
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Develop, characterize, and qualify advanced complex in vitro ocular models, including retinal organoids, to support drug development and safety evaluation. Collaborate with cross-functional teams to align model building with therapeutic strategies and maintain rigorous scientific documentation.
Requires a PhD in biology, bioengineering, pharmacology, or a related field with experience in complex in vitro ocular systems. Candidates must possess technical proficiency in 3D tissue modeling and quantitative characterization techniques like scRNA-seq and confocal microscopy.
We advance science so that we all have more time with the people we love.
The Position:
The Complex in Vitro Systems (CiS) Lab within the Department of Translational Safety is seeking a highly motivated Senior Scientist / Principal Scientist to develop, characterize, and qualify advanced complex in vitro models to support Genentech’s mission of delivering safe and efficacious medicines. The CiS group partners closely with colleagues across Development Sciences, Translational Medicine, and Research to establish and implement innovative platforms that enable target assessment, lead optimization, and safety evaluation across a dynamic portfolio, novel modalities, and emerging therapeutic areas.
In this lab-based role, you will provide scientific and technical expertise to support the development and implementation of human iPSC-derived ocular complex in vitro models (CIVM) including retinal organoids, for drug development. Responsibilities include culturing and characterizing state-of-the-art ocular CIVM models, designing and executing model qualification and characterization studies (e.g., advanced imaging, transcriptomics, and functional and phenotypic assays), analyzing and interpreting complex datasets; and maintaining rigorous, high-quality documentation. The Scientist will be expected to share scientific insights across functional teams, contribute to cross-disciplinary collaborations, and support internal and external publication efforts.
This position is ideal for an experienced scientist passionate about advancing disease modeling and translational safety through innovative complex in vitro and stem cell based approaches. The successful candidate will excel in a dynamic, collaborative research environment, demonstrate exceptional problem-solving skills, and effectively communicate across scientific disciplines to contribute to the development of cutting-edge ocular disease models and help shape the future of ocular drug discovery and development.
The Opportunity:
Establishing and implementing innovative in vitro ocular model systems including iPSC-derived retinal organoids and integrated retinal organoid retinal pigment epithelium (RPE) co-culture platforms to support disease modeling, mechanistic studies, and ocular risk assessment.
Designing and executing experiments to characterize retinal models, including evaluation of cell viability, morphology, photoreceptor health, and RPE barrier integrity and function, using techniques such as cytotoxicity assays, confocal and high-content imaging, transepithelial resistance/permeability assays, and transcriptomic and proteomic analyses.
Collaborating closely with cross-functional teams within and outside gRED to align ophtha complex model building with therapeutic strategies and program needs.
Analyzing, interpreting, and clearly communicating study results to collaborators and stakeholders, and contributing to internal and external scientific presentations as appropriate.
Maintaining comprehensive electronic documentation in accordance with departmental Standard Operating Procedures (SOPs) and contributing to study reports, safety assessments, and final deliverables.
PhD degree in biology, bioengineering, biomedical engineering, pharmacology, or a related field with hypothesis-driven research in industry or academia; compensation and title commensurate with experience
For Senior Scientist (0-4 years) and for Principal Scientist (5+ years) of post-PhD experience in pharmaceutical, biotechnology, academia, or research organizations, with a strong focus on complex in vitro ocular systems.
Expertise in developing, qualifying, and applying 3D ocular tissue models, retinal organoids, co-culture systems, and microphysiological or microfluidic platforms, to support drug discovery and translational research is a strong plus.
Proficiency with quantitative and qualitative characterization techniques such as qRT-PCR, scRNA-seq, proteomics, immunofluorescence and confocal microscopy, live-cell and time-lapse imaging, high-content imaging/screening, and analysis of data generated from these assays.
A collaborative, team-oriented scientist who prioritizes shared objectives and communicates effectively across disciplines, with a strong work ethic grounded in scientific rigor, attention to detail, and a commitment to excellence.
Strong scholastic record with demonstrated independent thought, creativity, and technical proficiency in the relevant discipline, as evidenced by co-authored publications.
Strong organizational and communication skills are necessary; experience writing detailed SOPs.
Ability to analyze, integrate, and clearly communicate/present data to colleagues is required.
Preferred Qualifications:
Experience with stem cell based systems and ophthalmology background is a strong plus. Additional desirable skill sets include cell engineering, application of design of experiments (DOE) methodologies, and computational data analysis and/or programming:compensation and title commensurate with experience
The expected salary range for this position based on the primary location of South San Francisco, California is $120,700- $224,100 (Senior Scientist) and $141,500- $262,900 (Principal Scientist) Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Relocation benefits are not available for this job posting.
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Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
Roche is a global pioneer in pharmaceuticals and diagnostics focused on advancing science to improve people’s lives. The combined strengths of pharmaceuticals and diagnostics under one roof have made Roche the leader in personalised healthcare – a strategy that aims to fit the right treatment to each patient in the best way possible. Roche is the world’s largest biotech company, with truly differentiated medicines in oncology, immunology, infectious diseases, ophthalmology and diseases of the central nervous system. Roche is also the world leader in in vitro diagnostics and tissue-based cancer diagnostics, and a frontrunner in diabetes management. Founded in 1896, Roche continues to search for better ways to prevent, diagnose and treat diseases and make a sustainable contribution to society. The company also aims to improve patient access to medical innovations by working with all relevant stakeholders. Thirty medicines developed by Roche are included in the World Health Organization Model Lists of Essential Medicines, among them life-saving antibiotics, antimalarials and cancer medicines. Roche has been recognised as the Group Leader in sustainability within the Pharmaceuticals, Biotechnology & Life Sciences Industry ten years in a row by the Dow Jones Sustainability Indices (DJSI). For more information, please visit https://careers.roche.com Read our community guidelines here: https://www.roche.com/some-guidelines.htm #Roche #Biotechnology #Pharmaceuticals #Diagnostics #Healthcare #PersonalisedHealthcare #GreatPlaceToWork #Innovation
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Based on 212 listings with disclosed salaries, most engineering jobs in South San Francisco, CA pay between $120k–$250k per year. Individual offers vary with seniority, company size, and specialization.
There are currently 276 open engineering positions in South San Francisco, CA listed on Clera. New openings are added daily as companies post roles.
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