SaaS startups in San Francisco

Gigs

San Francisco

Gigs is building the operating system for mobile services, enabling tech companies to embed connectivity and automate phone-plan provisioning for fintechs and HRIS platforms. Backed by nearly $100 million from Ribbit Capital, Google, and Y

DayDream

San Francisco

Daydream is a SaaS platform that automates the entire programmatic SEO workflow, aiming to streamline programmatic SEO engines. Despite being pre-launch, it has reported rapid ARR growth month over month and plans a GA product, with LLMs in

Alex (formerly Apriora)

San Francisco

Alex AI builds the future of hiring with an autonomous recruiter that conducts real-time video interviews, asking employer-selected or job-based questions and personalized follow-ups to speed hires and improve signals; it supports thousands

Automat

San Francisco

Automat is a generative AI platform that creates and scales end-to-end automations, redefining Enterprise AI Agents, RPA, and Intelligent Document Processing; it serves some of the world's largest companies and claims 10x speed and lower co

Momentic

San Francisco

**The AI-native automated testing platform** Momentic is the modern alternative to Selenium, Cypress, and Playwright. We help software companies ship faster with reliable end-to-end tests that write themselves. World-class engineering team

Archil

San Francisco

Archil connects AI applications to data resources, including model training, agents, and sandboxes, enabling data access for AI development and experimentation. It positions itself as the connector between AI tools and the data they require

Toma

San Francisco

Toma provides an AI and software suite for automotive dealers, backed by top investors including Andreessen Horowitz and Y Combinator, and partnered with Lithia Motors and Cox Automotive; it has 100+ U.S. dealers and seven-figure ARR within

FleetWorks

San Francisco

FleetWorks builds voice agents to modernize freight booking, creating a more efficient marketplace for brokers and forwarders. With Series A funding, it is led by Paul Singer and Quang Tran and based in SOMA.

ComfyUI

San Francisco

ComfyUI is a San Francisco-based, open-source, node-based engine for generating visual AI content, billed as the world’s leading visual AI platform with a modular system and a community of millions of users, 60k GitHub stars, and thousands

Phonely

San Francisco

Phonely develops voice AI technology to improve customer support and enable doctors to see more patients, while reducing hold times. It positions itself as a leader in intelligent, scalable customer communication and aims to redefine how bu

Artie

San Francisco

Artie enables real-time data streaming and database replication between databases and data warehouses, launched about a year ago and now processing over 10 billion rows per month, backed by Pathlight and General Catalyst.

Eigen

San Francisco

Eigen is building a consumer social company focused on peer-like connections rather than an assistant, aiming to redefine social experience with intuitive product design and human-centered interactions.

Artificial Intelligence Underwriting Company (AIUC)

San Francisco

The company underwrites superintelligence and evaluates, certifies, and insures agents, focusing on assessing and supporting agents within the realm of advanced intelligence.

Hark

San Francisco

Hark builds an end-to-end AI automation system—from workflow ingestion to production monitoring—plus services that accelerate deployment 10x; founded by Obaid Khan and Tim Lee, bringing operator credibility from Motive, Miso Media, and Code

Quanta

San Francisco

Quanta is the accounting service for software businesses who want to get their finances right, without delay. We’re the only service that can provide critical business metrics up to date daily, and will close your books as fast as the data

Simple AI

San Francisco

Simple AI builds enterprise-grade voice AI agents to automate customer conversations at scale, handling millions of calls for brands like Doordash, xAI, and Omaha Steaks. Backed by Y Combinator and notable investors, the lean startup aims t

Tamarind Bio

San Francisco

Tamarind provides access to AI-powered drug discovery for scientists, used by thousands from pharma, biotech, and academia, serving a broad, cross-industry research community.

Mandolin

San Francisco

Mandolin is building last-mile delivery infrastructure to speed development and delivery of cutting-edge drugs (cell/gene therapies, biologics), aiming to extend healthy lifespans by shortening time to patient access; backed by SignalFire,

ZeroPath

San Francisco

ZeroPath, founded by security researchers formerly from Tesla and Google, helps developers ship secure code faster with a developer-friendly solution that changes how teams approach application security.

Textla

San Francisco

Textla democratizes SMS for businesses with a lowest-price guarantee, delivering hard-dollar/time savings, and grew from $0 to $13M in revenue in 18 months with under 50 employees.

Eragon

San Francisco

Eragon is an AI Operating System for enterprises that serves as a reasoning engine, learning and acting across the organization, embedding into workflows to unify data, people, and processes into a context-aware workspace for billion-dollar decisions.

Brainbase

San Francisco

Brainbase Labs is building an AI Workforce by deploying AI agents that act as employees for front-line support to back-office tasks. Backed by top investors and with a multinational team, it has 150+ live deployments across automotive, hosp

Dedalus Labs

San Francisco

Dedalus Labs provides an MCP gateway and servers, unifying the AI agents ecosystem with a drop-in API. It enables users to go from idea to production in a single click, mixing models from any vendor with MCP marketplace tools.

Cogent Security

San Francisco

Cogent develops AI-powered vulnerability management solutions for enterprises, aiming to create an AI Taskforce for Vulnerability Management to boost efficiency and accelerate risk reduction. It is trusted by brands and led by executives fr

Omen.ai

San Francisco

Omen AI develops industrial diagnostics and the Digital Mechanic, an intelligent diagnostic layer for industrial machines. Backed by leading investors, its technology has been deployed with Fortune 500 fleets and the company is scaling rapi

Taxo AI

San Francisco

Taxo builds agents to automate administrative workflows in healthcare, reducing clinicians' administrative burden and enabling them to focus on patients. It provides workflow-support solutions for healthcare professionals to improve efficie

Proximal

San Francisco

Proximal builds realistic training environments that mirror software engineering work and collaborates with frontier labs and enterprises to simulate complex tasks, helping clients train and adapt the next generation of coding agents.

Crucibl

San Francisco

Proximal builds realistic training environments that mirror software engineering work and collaborates with frontier labs and enterprises to simulate complex tasks, helping clients train and adapt the next generation of coding agents.

Onyx

San Francisco

Onyx is an open-source AI assistant that aggregates company documents, apps, and people (Slack, Google Drive, Confluence, GitHub) to provide immediate answers from a single interface, with 24/7 availability and customizable assistants; foun

Lemon Slice

San Francisco

Lemon Slice is building a video foundation model for human motion and emotion, backed by a $6M seed from Y Combinator, Matrix Partners, The Chainsmokers and others; it has generated 1M+ videos and trains models as part of GenAI strategy.

Hamilton AI

San Francisco

Hamilton AI is building the operating system for business aviation, replacing fragmented communications with a fully integrated platform that uses AI to support scheduling, trip management, and operational decision-making, delivering real-t

Layer

San Francisco

Layer provides embedded, API-first accounting software and bookkeeping services for vertical SaaS platforms and neobanks that serve small and medium-sized businesses, enabling seamless integration into the platforms SMB owners already use.

Central

San Francisco

**Central Payroll, benefits, state compliance & other bullsh*t for startups** Central kills back-office work for startups. While HR/payroll platforms give you software to figure it out, Central actually does all the work using AI agents an

Dosu

San Francisco

Dosu makes engineering knowledge accessible to developers, empowering the community with AI-driven tools. A small San Francisco-based team backed by over $9M in funding, its software is used on thousands of open-source GitHub repos and supp

Fifteenth

San Francisco

Fifteenth provides tax planning and filing for individuals in the tech industry, delivering a seamless tax experience. The firm uses cutting-edge software and a team of five engineers formerly at Flexport and Rippling, positioning it as a t

Highlight

San Francisco

The company markets itself as an on-screen personal assistant and aims to make users 10x faster at their jobs, positioning its product as a tool to streamline work and speed up daily tasks through on-screen assistance.

Unsiloed AI

San Francisco

Unsiloed AI provides production-grade APIs that ingest, parse, structure, and split documents into Markdown and JSON, preserving hierarchy and domain-specific context for Finance, Legal, and Healthcare workflows, enabling reliable AI/LLM us

Subhub

San Francisco

SubHub automates construction estimating by converting blueprints into estimator-ready takeoffs, reducing a 3+ month manual process to days.

Eloquent AI

San Francisco

Eloquent AI designs autonomous AI agents for regulated industries, enabling real-time compliance and reducing hallucinations in high-stakes interactions, serving financial institutions and insurers worldwide from its San Francisco headquart

Sphinx

San Francisco

Sphinx builds AI analysts that operate inside browsers and internal systems. Its agents, used by banks and fintechs across the United States, Canada, Europe, and Latin America, handle 90% of manual work and cut costs by 4x.