SaaS startups in San Francisco

Altara

San Francisco

Altara is a San Francisco startup building an AI co-scientist for the physical world to accelerate breakthroughs in semiconductors, batteries, materials, chemicals, and aerospace, aiming to define a new AI-for-science category; backed by Gr

Vmax

San Francisco

Vmax is an applied research lab at the frontier of reinforcement learning, developing techniques to leverage RL with Large Language Models.

Runloop

San Francisco

Runloop focuses on infrastructure and orchestration for AI agents, aiming to power the Agentic Web. With a small team of engineers formerly from Google and Stripe, it tackles productionizing AI for software engineering at scale.

Abacus

San Francisco

Abacus builds AI agents to automate tedious accounting workflows, redefining how accounting firms operate. It serves large enterprise clients, generates meaningful revenue, and is led by a two-person founding team backed by top-tier investo

Statics

San Francisco

Statics is building Context OS for AI agents to optimize context and improve LLM performance. Backed by Tier 1 VCs, including a16z, it works with a portion of Forbes AI 50 and is an early-stage company led by Johnny Wang.

Lumena

San Francisco

Lumena empowers domain experts to build AI-powered enterprise applications, enabling humans and AI to collaborate across systems such as Salesforce, NetSuite, and HubSpot. Its design partners include mid-market and enterprise companies in f

Onos Health

San Francisco

Onos Health is a San Francisco-based early-stage startup building an AI-powered platform to reduce waste in U.S. healthcare spending by aligning providers and payers, with a $6M seed round, live partnerships with major health plans, and exp

Assert

San Francisco

Assert.dev is building a modern code-review interface for AI-enabled development, guided by the slogan "Code is meant to be run, not read." It operates the assert.dev website and aims to modernize code review for the AI era.

Infinite

San Francisco

Infinite is a stablecoin payment processor whose founding team previously built and scaled products at Coinbase and Sardine, bringing category-leading fintech experience to deliver stablecoin payments backed by recognized fintech leadership

Turgon

San Francisco

At Turgon, a San Francisco and New Delhi startup founded by serial entrepreneurs, combines AI agents with human-in-the-loop solutions to build, integrate, and run the enterprise IT stack, tapping into a $1.5 trillion IT services market.

Crustdata

San Francisco

A VC-backed data company delivering real-time company and people data enrichment via APIs, founded by Chris Pisarski, Abhilash Chowdhary, and Manmohit Grewal, with 15 engineers and offices in New York City and San Francisco, building reliab

XOXO AI

San Francisco

XOXO AI is a stealth research lab building consumer social AI that predicts user needs and fulfills them without prompts, aiming to democratize intelligent interfaces. It is assembling engineers, designers, and researchers to lead the next

Infilla

San Francisco

Infilla is a startup aiming to accelerate housing by fixing the permit process, the slowest part of building. It has raised $5 million from investors and reports demand, supported by a team with experience at Dropbox, Discord, Affirm, and M

Muro

San Francisco

Muro AI provides AI agents for Architectural, Engineering and Construction firms to automate pre-construction activities such as scoping and bid leveling, aiming to transform $2 trillion construction industry; led by CEO Kalyan Gautham, CTO

Magic Patterns

San Francisco

Magic Patterns is a fast-moving startup with an office in San Francisco and additional offices across North America, known for its small yet mighty team and rapid growth as it aims to transform the future of software building.

Variant

San Francisco

Variant is building a code generation platform that aims to bring generative creativity to design tools, and it is well-capitalized and backed by notable investors.

Carma (YC W24)

San Francisco

Carma is a fastest-growing fleet management software company powering large US fleets, including Fortune 500 clients. It raised a $5.5 million seed round from Soma Capital, Y Combinator, and Superhuman founders, claiming to save thousands o

Artifact

San Francisco

Artifact is a collaborative IDE for hardware engineers that accelerates the entire lifecycle, from design to sustainment, by building a verifiable AI copilot with an intuitive UI that mirrors how hardware is actually built. It has raised $3

Mesa

San Francisco

Mesa builds next-generation developer tools focused on code review, quality, and productivity. Backed by Innovation Endeavors, Essence VC, South Park Commons, and leaders like Thomas Wolf of Hugging Face, it aims to reshape software develop

Reflex

San Francisco

Reflex is an open-source framework and hosted platform that helps Python developers build, deploy, and manage web apps, backed by an ecosystem of tools and services to speed development while preserving flexibility; founded by open-source m

Roger Healthcare

San Francisco

Roger uses generative AI to alleviate staffing shortages in home health care, with full deployment at agencies serving tens of thousands of patients daily.

Magnetic

San Francisco

Magnetic is building an AI tax preparer for CPA firms, publicly launched in 2025, with $5.2M in funding and ARR in the hundreds of thousands across dozens of firms, aiming to automate tax prep with higher accuracy and better workflow.

Radical Healthcare

San Francisco

Radical, a San Francisco-based company, aims to give every cancer patient access to the world’s best oncologist and holds exclusive access to a 400+ million-note, 8 million-record cancer dataset, backed by an elite advisory board and top-ti

Continue

San Francisco

Continue is a San Francisco–based startup (YC S23) backed by Heavybit and notable angels; Siemens is rolling out Continue, which has 26k+ GitHub stars and 2M+ downloads, and focuses on amplifying developers at the intersection of AI and dev

CloudCruise

San Francisco

CloudCruise offers a platform to design once and ship fast, reliable browser agents, triggerable via API, with automatic issue repair to keep agents running smoothly.

Blockit

San Francisco

Blockit is a Series A, Sequoia-backed AI time agent that learns user preferences and coordinates meetings across time zones and group calendars. It underpins AI agents with access to the world's time, growing stronger as calendars are linke

Crescent

San Francisco

Crescent is a US fintech building the future of business financial services, serving startups to $1B+ enterprises. It has raised over $10M from JP Morgan Chase, BNY Mellon executives and unicorn leaders, with an Elon Musk company as a custo

Tomex.ai

San Francisco

Tomex AI builds AI for enterprise supply chains, helping Fortune 500 organizations enforce negotiated terms and prevent tens of millions in annual losses. It is rapidly scaling and will engage Fortune 500 firms across CPG, retail, and healt

Vals AI

San Francisco

Vals AI is building the standard for evaluating real-world performance of large language models, originating from Stanford NLP evaluation research. Its $5 million seed round and its evaluations are used by major foundation model labs, enter

Pax

San Francisco

Pax is the first AI-powered duty drawback broker that automates and optimizes duty refunds, delivering 15% more refunds and a 99% reduction in processing time, founded by experts from Charter Brokerage, MIT, Google, Amazon, and Flexport.

Amari AI

San Francisco

The company provides AI-powered automation for customs clearance processes tailored to customs brokers, freeing them from repetitive work to focus on relationships and growth; it has helped brokers clear over $150 million in goods.

Klarity

San Francisco

Klarity Health provides high-quality, worry-free and low-cost telehealth services, ensuring comprehensive care is within reach. Whether you're seeking mental health support, weight management, or counseling and therapy, Klarity is your trusted marketplace for health and well-being. We have facilitated over 350,000 telehealth visits and are trusted by 80,000+ patients and 400+ medical specialists. Check out our 5-star ratings: https://www.reviews.io/company-reviews/store/helloklarity

Thunder Compute

San Francisco

Thunder Compute, backed by Y Combinator, raised a $4.5 million seed round and aims to revolutionize GPU utilization, with over $500,000 in revenue in six months and rapid scaling.

Willow

San Francisco

Willow is building a voice operating system that enables computer control via voice, writes for you today, takes actions for you tomorrow, and anticipates needs before you ask. It has Uber adoption; backed by Y Combinator and Box Group.

Remy

San Francisco

Remy builds autonomous AI product teams, beginning with design agents, to provide a 24/7 visual exploration and brainstorming partner for software teams, with the aim of becoming an autonomous teammate that ideates, designs, and ships softw

Latent

San Francisco

Latent develops AI-driven medical intelligence software to optimize hospital and clinic workflows, speed medication access for patients, and boost provider revenues, collaborating with major healthcare systems to expand fast, affordable pro

Secureframe

San Francisco

Secureframe provides seamless cybersecurity compliance software for thousands of businesses, aiming to revolutionize the field; recognized as a trusted leader by Forbes, TechCrunch, and The Wall Street Journal, and backed by Kleiner Perkins

Slope

San Francisco

Slope partners with large companies to offer AI-enabled credit to businesses via strategic financing partnerships; it has raised $252M from notable investors including Sam Altman, JP Morgan Chase, Union Square Ventures, and Y Combinator to

Theta

San Francisco

Theta translates real-world workspaces into simulation environments and trains expert-level agents that deeply understand those environments.

Weave

San Francisco

Weave applies machine learning to engineering data, scanning every pull request to estimate its duration and evaluate review quality and work type, enabling teams to gain visibility and improve predictability in software delivery.