Natick, Massachusetts, United States · On-site
Overview WuXi Biology is seeking a Bioinformatics Engineer with experience in Oligonucleotide Drug design. Responsibilities Oligonucleotide drug design Responsible for design of small nucleic acid drugs (e.g., siRNA, ASO…
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Natick, Massachusetts, United States · On-site
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Position: Engineering Drafter / SolidWorks Specialist Location: Natick, MA Join a Team Committed to a Mission! At Leidos, we deliver innovative solutions through the dedication of our diverse and talented people who are …
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Natick, Massachusetts, United States · Hybrid
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Ounce IT LLCNatick, Massachusetts, United States · Hybrid
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Natick, Massachusetts, United States · On-site
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Natick, Massachusetts, United States · On-site
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Natick, Massachusetts, United States · On-site
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Natick, Massachusetts, United States · On-site
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Natick, Massachusetts, United States · On-site
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Natick, Massachusetts, United States · On-site
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Natick, Massachusetts, United States · Hybrid
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Natick, Massachusetts, United States · On-site
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Natick, Massachusetts, United States · On-site
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Natick, Massachusetts, United States · On-site
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Natick, Massachusetts, United States · On-site
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Natick, Massachusetts, United States · On-site
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Natick, Massachusetts, United States · On-site
$28/hr–$34/hr
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Natick, Massachusetts, United States • On-site
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Design small nucleic acid drugs such as siRNA and ASO using bioinformatics tools and machine learning platforms. Perform off-target analysis and build knowledge bases using public and internal databases to accelerate drug discovery.
Requires a PhD in Bioinformatics, Computational Biology, or a related field with over 5 years of experience in bioinformatics or nucleic acid drug development. Proficiency in Python or R and experience with high-throughput sequencing analysis tools are essential.
WuXi Biology is seeking a Bioinformatics Engineer with experience in Oligonucleotide Drug design.
Responsible for design of small nucleic acid drugs (e.g., siRNA, ASO). Use bioinformatics tools and algorithms to analyse gene expression profiles, variations, and splicing isoforms in biological samples for target selection. Apply machine learning platforms for oligo sequence design. Read and run Python, R, and Bash scripts. Optimize and improve existing design algorithms. Create new design workflows and platforms including design of chemical modifications for oligo drugs. Actively participate in project discussions and reports.
Understand and apply principles and algorithms for off-target evaluation. Analyze and interpret high-throughput next-generation sequencing data, including data preprocessing, quality control, alignment analysis, differential expression analysis, and full pathway analysis. Adjust sequence alignment program parameters to meet the needs of short sequence matching.
Use bioinformatics resources from public databases (like NCBI, Ensembl, UniProt, etc.) and combine with the company's internal data to build knowledge bases and databases to accelerate oligo drug discovery.
Work closely with wet lab drug discovery team including in vitro and in vivo teams, chemistry team, etc., participate in project discussions, support bioinformatics aspects of the projects. Analyze results and obtain insights to improve the bioinformatics models and workflows.
Additional prefeerred qualifations:
Established in December 2000, WuXi AppTec (NYSE: WX) is a leading global pharmaceutical, biopharmaceutical, and medical device open-access capability and technology platform with operations in China and the United States. WuXi AppTec has successfully established a fully integrated services and technology platform during the past decade. The company built its initial capabilities around discovery chemistry and has further enhanced the integrated services with analytical services, bio-analytical services, process research, process development services, API manufacturing services, DMPK/ADME, discovery biology, pharmacology, formulation, toxicology, genomic services, biologics manufacturing services, antibody and biological research reagent manufacturing and sales, and most recently clinical research and regulatory services. WuXi AppTec has developed from four founders and a single laboratory in December 2000 to 10,000 employees and 5 million square feet of laboratory and manufacturing space, including facilities under construction. The company is actively improving its capabilities and capacity through new expansions in its global business. Capitalizing on the great advantage of conducting R&D services both in China and in the U.S., WuXi AppTec is building an alternative R&D engine to serve the global life-science industry. 药明康德新药开发有限公司于2000年12月成立，是全球领先的制药、生物技术以及医疗器械研发开放式能力和技术平台公司，在中美两国均有运营实体。 十多年来，药明康德成功打造了全方位一体化的研发服务技术平台。创建之初，药明康德凭借其在发现化学合成领域的雄厚实力实现了全面发展。近几年来，我们又新增了一系列一体化服务，包括分析服务、生物分析服务、工艺研究、工艺研发服务、API生产服务、药物代谢及其动力学服务、研发生物学、药理学、制剂、毒理学、基因组服务、生物制剂生产服务、抗体及生物诊断试剂的生产和销售服务以及临床研发和产品注册服务等。 从 2000 年 12 月创立至今，药明康德的员工数从4 人增长至 10000 人，实验室由当初仅有的一间增长到近46 万平方米已有及在建研发基地和生产厂房。与此同时，药明康德还在不断增强服务能力，拓宽服务领域，以更好地服务公司持续增长的全球业务需求。作为一家全球领先的医药研发服务公司，药明康德将继续致力于在中美两国为全球客户提供高质量的医药研发服务，帮助研发出更多造福患者的新药及产品。
Offices: Shanghai, CN
There are currently 34 open engineering positions in Natick, MA listed on Clera. New openings are added daily as companies post roles.
Companies currently hiring include Delsys, Busek, Cogeco Connexion, Exponent, Intuvie, among others. Browse the listings above to see every active employer.
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