Holly Springs, North Carolina, United States · On-site
$137k–$185k/yr
Career CategoryEngineeringJob DescriptionJoin Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious…
Skills: PLC Programming, Automation Engineering, Process Control, Rockwell Platforms, GMP Compliance
Holly Springs, North Carolina, United States · On-site
$115k–$156k/yr
Career CategoryEngineeringJob DescriptionJoin Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious…
Skills: Process Engineering, Commissioning & Qualification, GMP Compliance, Tech Transfer, Root Cause Analysis
Holly Springs, North Carolina, United States · On-site
Company Overview FUJIFILM Biotechnologies is building the future of bioproduction in Holly Springs, North Carolina. By end of 2025, we’ll open North America’s largest end-to-end CDMO biopharmaceutical manufacturing facil…
Skills: Preventative Maintenance, Troubleshooting, GMP Compliance, PLC, Mechanical Systems
Holly Springs, North Carolina, United States · On-site
Company Overview FUJIFILM Biotechnologies is building the future of bioproduction in Holly Springs, North Carolina. By end of 2025, we’ll open North America’s largest end-to-end CDMO biopharmaceutical manufacturing facil…
Skills: Preventative Maintenance, Troubleshooting, Equipment Installation, GMP Compliance, PLC
Holly Springs, North Carolina, United States · On-site
Company Overview FUJIFILM Biotechnologies is building the future of bioproduction in Holly Springs, North Carolina. By end of 2025, we’ll open North America’s largest end-to-end CDMO biopharmaceutical manufacturing facil…
Skills: MES Configuration, Data Historians, Electronic Batch Records, cGMP Compliance, CSV Validation
Holly Springs, North Carolina, United States · On-site
Company Overview FUJIFILM Biotechnologies is building the future of bioproduction in Holly Springs, North Carolina. By end of 2025, we’ll open North America’s largest end-to-end CDMO biopharmaceutical manufacturing facil…
Skills: Current Good Manufacturing Practice, Aseptic Qualifications, Training Facilitation, SAP, Change Management
Holly Springs, North Carolina, United States · On-site
Company Overview FUJIFILM Biotechnologies is building the future of bioproduction in Holly Springs, North Carolina. By end of 2025, we’ll open North America’s largest end-to-end CDMO biopharmaceutical manufacturing facil…
Skills: Manufacturing Operations, Troubleshooting, Batch Planning, Commissioning And Qualification, Continuous Improvement
Holly Springs, North Carolina, United States · On-site
Company Overview FUJIFILM Biotechnologies is building the future of bioproduction in Holly Springs, North Carolina. By end of 2025, we’ll open North America’s largest end-to-end CDMO biopharmaceutical manufacturing facil…
Skills: Root Cause Analysis, Technical Writing, Causal Analysis, Quality Management System, Corrective and Preventive Action
Holly Springs, North Carolina, United States · On-site
$71k–$96k/yr
Career CategoryManufacturingJob Description Join Amgen’s Mission of Serving Patients Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therap…
Skills: cGMP, Aseptic Techniques, Buffer And Media Preparation, Electronic Batch Records, Equipment Sanitization
Holly Springs, North Carolina, United States · On-site
$71k–$96k/yr
Career CategoryManufacturingJob Description Join Amgen’s Mission of Serving Patients Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therap…
Skills: cGMP, Aseptic Techniques, Buffer And Media Preparation, Electronic Batch Records, Equipment Sanitization
Holly Springs, North Carolina, United States · On-site
Company Overview The work we do at FUJIFILM Biotechnologies has never been more important—and we are looking for talented candidates to join us. We are growing our locations, our capabilities, and our teams, and looking …
Skills: SIMCA-online, TIBCO Statistica, Windows Server Administration, SQL Server, Oracle Database
Holly Springs, North Carolina, United States · On-site
Company Overview FUJIFILM Biotechnologies is building the future of bioproduction in Holly Springs, North Carolina. By end of 2025, we’ll open North America’s largest end-to-end CDMO biopharmaceutical manufacturing facil…
Skills: Drug Product Filling, cGMP, FAT, PQ, SOP Documentation
Holly Springs, North Carolina, United States · On-site
$86k–$116k/yr
Career CategoryManufacturingJob DescriptionJoin Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serio…
Skills: Continuous Improvement, Project Management, Lean Principles, Technical Writing, Bioprocessing
Holly Springs, North Carolina, United States · On-site
Company Overview FUJIFILM Biotechnologies is building the future of bioproduction in Holly Springs, North Carolina. By end of 2025, we’ll open North America’s largest end-to-end CDMO biopharmaceutical manufacturing facil…
Skills: Commissioning, Qualification, Validation, Root Cause Analysis, Statistical Process Control
Holly Springs, North Carolina, United States · On-site
Company Overview FUJIFILM Biotechnologies is building the future of bioproduction in Holly Springs, North Carolina. By end of 2025, we’ll open North America’s largest end-to-end CDMO biopharmaceutical manufacturing facil…
Skills: Commissioning, Qualification, Validation, P&ID Reading, Protocol Drafting
Holly Springs, North Carolina, United States · On-site
Purpose: The Process Engineer III will provide engineering support and leadership for Drug Substance Manufacturing operations, including cell culture, purification, and/or preparation operations for process buffers and s…
Skills: Process Engineering, Equipment Troubleshooting, Project Management, Commissioning, Root Cause Analysis
Holly Springs, North Carolina, United States · On-site
$71k–$96k/yr
Career CategoryManufacturingJob Description HOW MIGHT YOU DEFY IMAGINATION? You’ve worked hard to become the professional you are today and are now ready to take the next step in your career. How will you put your skills…
Skills: Column Chromatography, Tangential Flow Filtration, cGMP, Aseptic Techniques, Electronic Batch Records
Holly Springs, North Carolina, United States · On-site
Company Overview FUJIFILM Biotechnologies is building the future of bioproduction in Holly Springs, North Carolina. By end of 2025, we’ll open North America’s largest end-to-end CDMO biopharmaceutical manufacturing facil…
Skills: Causal Analysis, Root Cause Analysis, CAPA Development, Technical Writing, Cross-functional Collaboration
Holly Springs, North Carolina, United States · On-site
$84k–$113k/yr
Career CategoryManufacturingJob Description HOW MIGHT YOU DEFY IMAGINATION? You’ve worked hard to become the professional you are today and are now ready to take the next step in your career. How will you put your skills…
Skills: Wastewater Treatment Operations, Mechanical Maintenance, Electrical Maintenance, SCADA, PLC
Holly Springs, North Carolina, United States · On-site
$135k–$183k/yr
Career CategoryInformation SystemsJob Description Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living wit…
Skills: Computer System Validation, Regulatory Compliance, Inspection Readiness, Digital Platform Implementation, Data Integrity
Holly Springs, North Carolina, United States • On-site
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Lead technical projects and provide 24/7 operational support for PLC-based processes and utility skid equipment automation. Partner with capital project teams to design, build, and qualify new equipment for drug substance production.
Requires a combination of education and engineering experience (up to 10 years for high school diploma holders) with expertise in Rockwell platforms and GMP biopharmaceutical environments. Preferred candidates hold a degree in Electrical, Computer, Chemical, or Biotech Engineering.
At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.
Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.
Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.
Be part of Amgen's newest and most advanced drug substance manufacturing plant. When completed, the Amgen FleX batch facility will combine the latest in disposable technologies with traditional stainless steel equipment to allow for maximum flexibility in operations The FleX Batch facility will not only feature the best in-class drug substance manufacturing technologies with embedded industry 4.0 capabilities, but it will also integrate sustainability innovations to reduce carbon and waste, as part of Amgen's plan to be a carbon-neutral company by 2027.
Senior Manufacturing Systems Engineer – PLC
What you will do
In this vital role as a member of the Facilities & Engineering (F&E) group, you will lead technical projects, and drive innovation and support of PLC based processes and utility skid equipment automation needs. You will solve complex engineering problems and ensure the company's engineering efforts align with strategic objectives. You will also provide leadership and guidance to the Automation Engineering team supporting 24/7 manufacturing and facility operations.
You will partner closely with the capital project team to design, build, commission, and qualify new equipment and systems needed for drug substance production. This role will develop domain expertise to support operations upon start-up, focusing on manufacturing automation.
Job responsibilities include:
Site design, construction, start-up, and operational readiness:
Provide support to the capital project team with a strong focus on safety and on-time facility start-up.
Collaborate with the site process engineering team to understand key process requirements and develop process control automation solutions for PLC based systems.
Work with platform leads to ensure standalone PLC based systems are designed with the proper network connectivity and system-to-system communication to enable centralized monitoring and alarming.
Support commissioning and qualification efforts including Automation Installation Verification/Automation Check Out (IV/ACO).
Partner with various organizational units to support tasks including operational readiness, document reviews, deviation investigation and change controls.
Develop and maintain detailed specifications, SOPs and operating standards that impact multiple organizational units.
Provide mentoring to develop and accelerate site technical automation capabilities.
Site Operations:
Act as system owner for standalone PLC based systems.
Manage Day-to-day Operational Support including: 24 x 7 Onsite/On Call Operational Support, Troubleshooting Support to Plant and Mfg. Operations, preventive and corrective maintenance, system administration, and Automation System spare parts management
Lead and support functional area projects focused on improving equipment/utilities/facilities as well as capital projects to integrate new drug substance manufacturing technologies into the facility.
Lead and support technical root cause analysis, incident investigations, and troubleshooting on process control issues related to plant operations.
Lead and support new product introductions (NPI) or new technology introductions by performing automation engineering assessments, implementing automation system configuration changes and supporting engineering and process qualification runs as applicable.
Prepare and review Standard Operating Procedures (SOP) and cGMP documents.
On-site and up to 10% domestic/international travel
What we expect of you
We are all different, yet we all use our unique contributions to serve patients. The automation professional we seek is an engineer with these qualifications.
High School Diploma / GED and 10 years of Engineering experience OR
Associate’s Degree and 8 years of Engineering experience OR
Bachelor’s Degree and 4 years of Engineering experience OR
Master’s Degree and 2 years of Engineering experience OR
Doctorate Degree
Preferred Qualifications:
Degree in Electrical Engineering or Computer Science, Chemical Engineering or Biotech Engineering.
Extensive experience with process and utility skid equipment, and direct knowledge of integrating various OEM automation software and field instrumentation technologies such as Rockwell platforms.
Direct knowledge of integrating various OEM automation software and field instrumentation technologies.
Direct knowledge of Automation System design, experience in Process control engineering and troubleshooting with GMP biopharmaceutical production facility equipment/systems automation.
Experience in programming, design, installation and lifecycle management of PLC and field device/instrumentation technologies.
Extensive understanding and background in programming, design, installation and lifecycle management of manufacturing process controls, automation and field instrumentation technologies.
In-depth knowledge of industry standards such as 21 CFR Part 11, ASTM 2500, S88, S95, GAMP, GDP, and GMP.
Experience in Capital Project Lifecycle Management including conceptual design, basis of design, detailed design, implementation, and validation.
The ideal individual must be a self-directed team player ready to mentor and develop engineering staff and embrace a team-based culture that relies on collaboration for effective decision-making.
Strong leadership, technical writing, and communication/presentation skills.
As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.
In addition to the base salary, Amgen offers competitive and comprehensive Total Rewards Plans that are aligned with local industry standards.
As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.
We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.
#WeareBiotech
Amgen harnesses the best of biology and technology to fight the world’s toughest diseases, and make people’s lives easier, fuller and longer. We helped establish the biotechnology industry, and we remain on the cutting-edge of innovation, using technology and human genetic data to push beyond what’s known today. Our investment in research and development has yielded a robust pipeline that builds on our existing portfolio of medicines to treat cancer, heart disease, osteoporosis, inflammatory diseases and rare diseases. Amgen is one of 30 companies comprising the Dow Jones Industrial Average®, and part of the Nasdaq-100 Index®. In 2024, Amgen was named one of the “World’s Most Innovative Companies” by Fast Company and one of “America’s Best Large Employers” by Forbes. For more information, visit Amgen.com and follow us on X, LinkedIn, Instagram, TikTok, YouTube and Threads. 🔗 Community Guidelines: https://wwwext.amgen.com/community-guidelines 🔗Global Privacy Statement Directory: www.amgen.com/dp Special Advisory: Please be cautious of scam recruitment offers claiming to be from Amgen. Such scams may come from various sources, including fake websites and/or unsolicited emails and seek to obtain personal data or payment from victims by offering jobs that do not exist. Please be advised that Amgen would never ask for payment to progress a job application. When in doubt, please check to see if the position in question is posted on this website before applying. Additionally, please report any suspicious recruiting activity to https://complaint.ic3.gov/ and thank you for your assistance.
Offices: One Amgen Center Drive, Thousand Oaks, CA 91320, US · 1120 Veterans Blvd, South San Francisco, CA 94080, US · 34 Commerce Way, Woburn, MA 01801, US · Avenida Calle 100 7-81, Bogota, Bogota, D.C. 110221, CO · Minervum 7061, Breda, North Brabant 4817 ZK, NL
Based on 49 listings with disclosed salaries, most engineering jobs in Holly Springs, NC pay between $79k–$156k per year. Individual offers vary with seniority, company size, and specialization.
There are currently 103 open engineering positions in Holly Springs, NC listed on Clera. New openings are added daily as companies post roles.
Companies currently hiring include Amgen, FUJIFILM Electronic Materials U.S.A., Inc., CSL, Roche, FUJIFILM Biotechnologies, among others. Browse the listings above to see every active employer.
Yes — 5 of the 103 open engineering positions offer remote or hybrid work (0 remote, 5 hybrid).
Each listing links directly to the employer's application page. Apply early — fresh listings get the most recruiter attention in the first two weeks.
