AI/ML startups in San Francisco Bay Area

Promptless

San Francisco

Promptless builds AI teammates that integrate with users’ existing workflows, serving startups and Fortune 500 enterprises. It ranked among the top W25 by revenue; small founding team has led startups, published LLM research, and graduated

Sepal AI

San Francisco

Sepal AI provides PhD-level experts for AI model development, backed by YC-backed founders from Vercel and Turing. Since 2024, it has raised millions and counts Fortune 500s and top AI labs as customers, building the largest global talent g

Prelude AI

San Francisco

The company is building an AI-native platform that makes financial advisors more effective, transforming wealth management by advancing advisory capabilities with advanced technology. Backed by a world-class founding team from top fintech a

Andromeda Surgical

South San Francisco

Andromeda Surgical is developing autonomous surgical robots to shorten the learning curve for surgeons. By leveraging off-the-shelf hardware, it builds controls, planning, and ML algorithms to guide surgeons to perform steps more quickly an

Conductor Quantum

San Francisco

Conductor Quantum, based in San Francisco, develops software to enable fault-tolerant quantum computation. A small team of quantum physicists, hardware engineers, and machine learning experts envisions scalable operation of thousands to bil

Entangl

San Francisco

Entangl uses AI to autonomously detect design errors in data center engineering and operations, delivering targeted solutions to engineers. Founded by Shapol and Antanas, ex-reusable rocket program leaders, Entangl aims to save time, reduce

Novoflow

San Francisco

Novoflow deploys AI employees for medical clinics, building computer agents to modernize healthcare and automate front- and back-office tasks across a fragmented 400+ EHR ecosystem; contracts secured, backed by YC advisers and top investors

Additive AI

San Francisco

Additive AI, founded in San Francisco, builds AI-powered tools to automate document-heavy tax and accounting workflows; acquired by Thomson Reuters in 2025, it operates as part of a global leader to help professionals make faster, more info

Pearson Labs

San Francisco

Pearson Labs presents itself as a small, high-impact, lean team focused on delivering meaningful results, emphasizing impact over scale; no information is available about its mission, products, services, or market position.

Conduit Intelligence

San Francisco

The company develops noninvasive thought-to-text technology to bridge communication between people and devices by reducing the language barrier.

Dream

San Francisco

Dream is an AI platform that automates residential architecture and construction planning, transforming a slow, expensive process into an instantaneous, affordable one by enabling AI-driven design and planning for homes.

Relixir

San Francisco

Relixir is an autonomous search share maximization platform serving 40+ B2B clients. Founded by Berkeley alumni, it participated in Y Combinator's X25 batch and ranks as one of its fastest-growing companies.

Bindwell

San Francisco

Bindwell uses AI to discover new pesticides, replacing slow lab work and accelerating discovery by 100×. The company is a small team of Caltech and Wolfram Research alumni with drug-discovery ML experience, aiming to rebuild agrochemical R&

Kato

San Francisco

Kato builds an AI-powered servicing platform that automates critical workflows across channels with full compliance and best-in-class recoveries, in production with major fintech lenders including Bilt Rewards and Parafin, emphasizing a com

Zettascale

San Francisco

Zettascale develops reconfigurable, energy-efficient AI chips for training and inference that optimize each model’s dataflow, aiming to outperform GPUs in speed and power efficiency and to save data centers billions in cooling and energy co

Midcentury Labs

San Francisco

Midcentury is building a next-generation platform for audio AI that enables secure onboarding of private data and expert-labeled data services from global contributors to tackle multimodal AI with massive data pipelines; it recently raised

StackAI

San Francisco

Stack AI provides a no-code drag-and-drop platform to design, test, and deploy AI workflows that leverage large language models to automate business processes. Its visual interface lets users connect data sources with different AI models to

NOSO LABS

San Francisco

NOSO LABS builds agents for the trades to help technicians diagnose accurately and sell 10x better, providing tools that improve diagnostic precision and sales performance for trade professionals.

GroundControl

San Francisco

GroundControl is a vertical SaaS company solving inefficiencies in regulated manufacturing, focusing on aerospace and defense, enabling high-quality parts with precision. It operates in the U.S., serves North American aerospace/defense clie

Dart

San Francisco

Dart, founded in 2022 in San Francisco, positions itself as the only truly AI-native project management tool, with an AI-first, product-driven approach. With about 10 full-time staff (5 engineers) and revenue growth in 2025, it has strong f

Exa

San Francisco

Exa, a San Francisco-based startup, is building a next-generation AI search engine aimed at outperforming Google for power users, with an about 20-person team including alumni from Harvard, MIT, Apple, and Palantir, and a Series A from Ligh

Diffuse Bio

San Carlos

Diffuse builds generative AI for protein design, with coverage from The New York Times and NBC News; it has produced the first crystal structures of AI-designed proteins and diffusion models for structure and sequence generation.

BentoML

San Francisco

BentoML is an enterprise-grade inference platform that deploys and manages AI models at scale, serving LLMs, embeddings, and agentic pipelines across VPC, on-prem, or hybrid environments. It covers the full inference lifecycle with mission-

Datrics

San Francisco

Datrics, a San Francisco-based company with 22 employees, develops generative AI for healthcare coding automation, led by CEO Anton Vaisburd and founded by Kirill Kirykov and Volodymyr Sofinskyi, both seasoned data science and analytics exe

Milo

San Francisco

Milo (W20) markets itself as The Family AI, a copilot helping parents manage the invisible load of raising a family. It is led by Avni Patel Thompson, founder/CEO of Modern Village, which uses collaborative technology to ease parenting.

Tydo

San Francisco

Tydo builds AI-powered personalization for ecommerce brands, helping them translate data into trusted, personalized shopping experiences; backed by Tier 1 investors like YC, Greylock, Alt Capital, and Manresa Ventures, and serving retailers

MDalgorithms

San Francisco

MDalgorithms is a remote, AI-driven dermatology and hair care company building custom deep learning models, native apps, and e-commerce APIs. It runs MDacne, a dermatology app with millions of downloads, and MDhair, a regrowth kit, backed b

Ambient.ai

San Jose

Ambient.ai is a computer vision company that helps large enterprises prevent security incidents, serving Fortune 500 customers; backed by a16z, SV Angel and Y Combinator with $50M raised, recognized on YC Top Companies List and Forbes Cloud

Collectly

San Francisco

Collectly is a profitable healthcare tech startup that uses proprietary EHR interfaces to simplify billing, accelerate cash flow, and enhance the patient financial experience, serving 300k+ patients daily across U.S. practices with AI-drive

Attune

San Francisco

Attune builds developer tools for a post-AI world, delivering tooling for developers operating in a post-AI context and positioning itself as a provider in the evolving developer tools market. It prepares developers for the next era of soft

Verge Genomics

San Francisco

Verge Genomics uses AI and human tissue data in its CONVERGE platform to map disease biology, identify targets, and de-risk drug development, with two drugs in clinical trials, 282 targets discovered, and partnerships worth $1.6B.

Everest

San Francisco

The company builds AI employees for IT services, aiming to transform the $300B IT services industry from 10–20% margins to software margins by turning outsourced IT support into a software business and building a $100B company that changes

Mosaic

San Francisco

Mosaic is developing an agentic video editing paradigm to build an agentic video editor. Its ex-Tesla engineering team has won the Google Gemini Kaggle grand prize ($25,000) from 6,400 entrants and the SaaStr AI Pitch competition.

Ridecell

San Francisco

Ridecell leads the digital transformation of fleet operations in Europe and North America, serving fleet operators and governments for clients such as Penske, Toyota, Ford, Daimler, BMW, BNP Paribas and Arval, including San Francisco and Ne

Raindrop

San Francisco

Raindrop provides monitoring and alerting for AI applications. Backed by Y Combinator, it counts investors including James Tamplin, Guillermo Rauch, Balaji Srinivasan, Matt MacInnis, and backers from OpenAI, Apple, Figma, Scale.

Canvas

San Francisco

Canvas, a small team, is building AI Operating System for B2B sales, backed by Y Combinator, to automate boring parts of outbound so humans can focus on finding and connecting with prospects, via AI research agents and on-demand human SDRs.

Rescale

San Francisco

Rescale is a cloud-based platform for computational engineering and R&D that democratizes access to HPC, simulation, AI/ML, and digital twins, serving leading automotive and life sciences firms and operating the largest network of hyperscal