South San Francisco, California, United States · On-site
$103k–$192k/yr
The Department of Discovery Oncology is seeking a creative, intellectually curious, and motivated Scientist 3 to help pioneer a new frontier in cancer drug discovery: harnessing induced proximity to reprogram protein fun…
Skills: Cancer Cell Culture, Cell Line Engineering, CRISPR, Lentiviral Delivery, Proximity Labeling
South San Francisco, California, United States · Hybrid
$157k–$198k/yr
The Position Genentech, Inc. seeks a Data Scientist at its South San Francisco, CA location. Duties: Within a biotechnology organization, apply statistical concepts such as p-values, rates and proportion, frequencies, co…
Skills: Statistical Modeling, SAS, R, R Shiny, FDA Guidelines
South San Francisco, California, United States · Hybrid
$129k–$239k/yr
Why Genentech We’re passionate about delivering on Our Promise to improve the lives of patients and create healthier communities for all. We foster a culture of inclusivity, integrity and creativity while boldly p…
Skills: Omnichannel Marketing, Customer Insights, Content Creation, Campaign Execution, Market Positioning
South San Francisco, California, United States · On-site
$150k–$170k/yr
About Xaira Therapeutics Xaira is an innovative biotech startup focused on leveraging AI to transform drug discovery and development. The company is leading the development of generative AI models to design protein and a…
Skills: Protein Engineering, Antibody Design, Protein Purification, Biophysical Assays, Developability Assessment
South San Francisco, California, United States · Hybrid
$139k–$169k/yr
Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic condition…
Skills: Pre-formulation, Formulation Selection, Manufacturing Process Development, Solid Oral Dosage Form Development, HPLC/UPLC
South San Francisco, California, United States · Hybrid
$97k–$184k/yr
Company Description About AbbVie AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a r…
Skills: R Programming, Interactive Dashboards, Agentic AI Development, Retrieval-Augmented Generation, Statistics
South San Francisco, California, United States · On-site
$182k–$346k/yr
Company Description About AbbVie AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a r…
Skills: Clinical Trial Design, Clinical Development Planning, Regulatory Compliance, Pharmacovigilance, Good Clinical Practices
South San Francisco, California, United States · On-site
$161k–$305k/yr
Company Description About AbbVie AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a r…
Skills: HEOR Strategy, Clinical Research, Cross-functional Leadership, Health Economics, Outcomes Research
South San Francisco, California, United States · Hybrid
$230k–$300k/yr
The Role: Your primary mission as the VP of Discovery Biology is to captain and pace our target discovery engines across multiple therapeutic areas, treating early drug discovery as a team race to beat conventional indus…
Skills: Target Discovery, Drug Discovery, People Management, Portfolio Strategy, Disease Biology
South San Francisco, California, United States · On-site
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Machine Learning, Deep Learning, PyTorch, JAX, TensorFlow
South San Francisco, California, United States · On-site
$161k–$305k/yr
Company Description About AbbVie AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a r…
Skills: Global Regulatory Strategy, Oncology Drug Development, Health Authority Interaction, Project Management, Regulatory Submission
South San Francisco, California, United States · On-site
$75k–$143k/yr
Company Description About AbbVie AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a r…
Skills: Flow Cytometry, Bioinformatics, R, Python, Spectral Flow Cytometry
South San Francisco, California, United States · On-site
$75k–$143k/yr
Company Description About AbbVie AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a r…
Skills: Flow Cytometry, Bioinformatics, R Programming, Python, Spectral Flow Cytometry
South San Francisco, California, United States · On-site
$155k–$175k/yr
SR. CLINICAL TRIAL MANAGER Sutro Biopharma, Inc. is seeking a driven and talented individual to join our Clinical Operations team as we change the future of oncology. While collaborating with cross-functional departments…
Skills: Clinical Trial Management, ICH/GCP Compliance, Vendor Management, Budget Management, Study Start-up
South San Francisco, California, United States · On-site
$32/hr–$40/hr
Work Schedule Standard (Mon-Fri) Environmental Conditions Laboratory Setting, Some degree of PPE (Personal Protective Equipment) required (safety glasses, gowning, gloves, lab coat, ear plugs etc.) Job Description This i…
Skills: HPLC-UV, HPLC-CAD, LC-MS, PSD, ELN
South San Francisco, California, United States · On-site
$155k–$185k/yr
Associate Director, EH&S and Facilities Sutro is seeking an Associate Director, EH&S and Facilities to lead EH&S compliance and equipment service management at our South San Francisco headquarters. Responsibilities: Deve…
Skills: EH&S Compliance, Equipment Service Management, Safety Training, Job Hazard Assessments, SOP Development
South San Francisco, California, United States · On-site
$146k–$166k/yr
At InterVenn, our technology enables and empowers the understanding of glycoproteomics, a new clinical layer of biology beyond the genome, using a simple blood draw. InterVenn’s powerful solutions will broaden humankind’…
Skills: Business Development, Strategic Partnerships, Contract Negotiation, Lead Generation, Market Analysis
South San Francisco, California, United States · On-site
$230k–$270k/yr
Corvus Pharmaceutical is a clinical-stage biopharmaceutical company developing novel therapies with the potential to significantly improve the treatment of immune diseases and cancer. Our lead program, Soquelitnib, is a …
Skills: CMC Regulatory Strategy, Small Molecule Development, IND/CTA Submissions, NDA/MAA Compilation, Module 2.3 and 3 Authorship
South San Francisco, California, United States · On-site
About Breeze Bio Breeze Bio is a rapidly-growing, early-stage company pioneering a proprietary delivery platform with the potential to transform genetic medicine. Our interdisciplinary team collaborates across chemistry,…
Skills: HR Operations, Full-cycle Recruiting, Payroll Processing, Labor Law Compliance, Employee Relations
South San Francisco, California, United States · Remote OK
Senior Embedded Software Engineer - Contract Cytovale | Software & Data Systems Department: Software & Data Systems Reports To: Senior Engineering Manager, Software & Data About Cytovale Cytovale is a medical diagnostics…
Skills: C++, Python, Embedded Linux, CI/CD, Multi-threading
South San Francisco, California, United States • On-site
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Design and execute experiments to discover novel oncology targets and proximity-based mechanisms of action to modulate protein function. Collaborate with multidisciplinary teams to translate biological discoveries into therapeutic strategies using AI/ML and proteomics.
Requires a Ph.D. in a relevant biological field with at least 3 years of research experience and a proven track record of publications. Must possess expertise in cancer cell engineering, protein interaction measurements, and a broad range of molecular biology techniques.
The Department of Discovery Oncology is seeking a creative, intellectually curious, and motivated Scientist 3 to help pioneer a new frontier in cancer drug discovery: harnessing induced proximity to reprogram protein function in cancer cells. This is a role for a scientist who is energized by open-ended biological problems and wants to translate mechanistic insight into medicines for patients who need them.
Induced proximity has transformed how we think about what is "druggable," but our ambitions reach well beyond degradation and enzymatic inhibition. We are exploring the broader pharmacology of target engagement that produces novel functional outcomes—stabilizing or disrupting complexes, redirecting localization, altering post-translational modification, rewiring signaling, and inducing gain-of-function activities that simply don't exist in nature. In this role, you'll have the freedom—and the world-class tools—to ask what's possible when we can place any two biomolecules in deliberate proximity inside a living cancer cell.
You will work as part of multidisciplinary project teams, translating early biological discoveries into novel therapeutic strategies in close partnership with drug discovery groups across Genentech.
Design and execute creative, hypothesis-driven experiments to discover and validate novel oncology targets and proximity-based mechanisms of action that go beyond inhibition or degradation.
Pioneer the design and implementation of induced proximity strategies to modulate protein function in cancer cells—reshaping signaling, localization, complex formation, and activity in ways that create new therapeutic openings.
Develop and test bold therapeutic hypotheses, identify robust pharmacodynamic markers, and establish practical strategies to drug the targets you uncover.
Engineer cancer cell systems to build the cellular models needed to interrogate proximity pharmacology.
Deploy and innovate on a diverse toolkit for measuring protein–protein and protein–small molecule interactions in cells (proximity labeling, FRET, BRET, and emerging approaches).
Collaborate with outstanding scientists across Genentech, including colleagues in Genomics, Transcriptomics, Proteomics, and Computational Sciences—and leverage rapidly evolving capabilities in AI/ML, proteomics, and functional genomics.
Present and discuss data in lab meetings, department forums, and cross-functional project teams.
Foster a collaborative culture by sharing expertise, learning from others, and staying current with the literature in a fast-moving field.
A Ph.D. in Cell Biology, Molecular Biology, Cancer Biology, Chemical Biology, or a related field.
At least 3 years of research experience in an academic or industry laboratory.
A creative and rigorous experimentalist with a proven track record of impactful research, demonstrated through publications.
Cancer cell culture expertise, including experience establishing and maintaining difficult-to-culture cell lines.
Cell line engineering expertise spanning lentiviral delivery, transposon-based gene insertion, and CRISPR knock-in approaches.
Hands-on experience using multiple strategies to measure protein–protein and protein–small molecule interactions in cells, such as proximity labeling, FRET, and BRET.
Proficiency in a broad range of biochemical, molecular, and cell biology techniques including flow cytometry.
Excellent problem-solving skills and the ability to independently design, execute, and interpret experiments.
Strong communication skills and a genuine enthusiasm for collaborative, team-based science.
Motivation to learn new experimental approaches and computational analyses, and the curiosity to explore unconventional ideas.
Training and a strong research record in chemical biology.
Strong background in cancer cell signaling pathways.
Experience in functional genomics, including work with barcoded/pooled libraries.
Direct experience with induced proximity modalities (e.g., PROTACs/molecular glues and related approaches), or a demonstrated interest in extending proximity pharmacology to novel functional outcomes.
Deep mechanistic understanding of the processes that drive cancer development and progression.
Relocation benefits are available for this posting.
The expected salary range for this position based on the primary location of California is $103,400 - $192,000. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
Roche is a global pioneer in pharmaceuticals and diagnostics focused on advancing science to improve people’s lives. The combined strengths of pharmaceuticals and diagnostics under one roof have made Roche the leader in personalised healthcare – a strategy that aims to fit the right treatment to each patient in the best way possible. Roche is the world’s largest biotech company, with truly differentiated medicines in oncology, immunology, infectious diseases, ophthalmology and diseases of the central nervous system. Roche is also the world leader in in vitro diagnostics and tissue-based cancer diagnostics, and a frontrunner in diabetes management. Founded in 1896, Roche continues to search for better ways to prevent, diagnose and treat diseases and make a sustainable contribution to society. The company also aims to improve patient access to medical innovations by working with all relevant stakeholders. Thirty medicines developed by Roche are included in the World Health Organization Model Lists of Essential Medicines, among them life-saving antibiotics, antimalarials and cancer medicines. Roche has been recognised as the Group Leader in sustainability within the Pharmaceuticals, Biotechnology & Life Sciences Industry ten years in a row by the Dow Jones Sustainability Indices (DJSI). For more information, please visit https://careers.roche.com Read our community guidelines here: https://www.roche.com/some-guidelines.htm #Roche #Biotechnology #Pharmaceuticals #Diagnostics #Healthcare #PersonalisedHealthcare #GreatPlaceToWork #Innovation
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Based on 330 listings with disclosed salaries, most science & research jobs in South San Francisco, CA pay between $108k–$272k per year. Individual offers vary with seniority, company size, and specialization.
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