South San Francisco, California, United States · On-site
$170k–$275k/yr
About Phylo Phylo is an applied research lab building agentic intelligence to accelerate discovery for every biomedical scientist. We believe AI agents will fundamentally transform how biomedical research is done. Our fa…
Skills: Computational Biology, Bioinformatics, Python, Pipeline Development, Biomedical Workflows
South San Francisco, California, United States · On-site
$20/hr–$30/hr
Work Schedule Standard (Mon-Fri) Environmental Conditions Able to lift 40 lbs. without assistance, Cleanroom: no hair products, jewelry, makeup, nail polish, perfume, exposed piercings, facial hair etc... allowed, Cold R…
Skills: RF Handheld Scanners, Inventory Control, Microsoft Office, English Communication, Stock Rotation
South San Francisco, California, United States · Hybrid
$101k–$118k/yr
Cytokinetics is a specialty cardiovascular biopharmaceutical company, building on its over 25 years of pioneering scientific innovations in muscle biology, and advancing a pipeline of potential new medicines for patients…
Skills: Accounts Payable, Vendor Reconciliation, ERP Systems, Microsoft Excel, 1099 Reporting
South San Francisco, California, United States · On-site
$142k–$263k/yr
Senior Manager, Product Public Relations Why Genentech From the beginning, Genentech has been a team of highly dedicated, passionate individuals. We are a place where people are united around a single purpose and an ambi…
Skills: Public Relations, Strategic Communications, Media Relations, Issues Management, Stakeholder Management
South San Francisco, California, United States · On-site
$110k–$135k/yr
Key Responsibilities Oversee daily operations of biology, chemistry, and engineering laboratories, including support for cleanroom activities as needed.Maintain organized, safe, and compliant laboratory environments; pro…
Skills: Laboratory Management, EH&S Leadership, Hazardous Waste Management, Compliance Coordination, Equipment Maintenance
South San Francisco, California, United States · On-site
$250k–$280k/yr
Position Summary: The Executive Director/Vice President, Finance & Controller will serve as a trusted business partner responsible for ensuring financial integrity, operational excellence, and strategic decision support.…
Skills: Financial Reporting, US GAAP, Treasury Management, Risk Management, Financial Planning and Analysis
South San Francisco, California, United States · Hybrid
$125k–$237k/yr
Company Description About AbbVie AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a r…
Skills: Clinical Study Operations Management, Stakeholder Management, Clinical Operational Strategies, Risk Management, Vendor Management
South San Francisco, California, United States · On-site
$207k–$393k/yr
Company Description AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable imp…
Skills: Clinical Trial Design, Clinical Development Planning, Regulatory Compliance, Cross-functional Leadership, Hematology
South San Francisco, California, United States · Hybrid
$201k–$234k/yr
Cytokinetics is a specialty cardiovascular biopharmaceutical company, building on its over 25 years of pioneering scientific innovations in muscle biology, and advancing a pipeline of potential new medicines for patients…
Skills: Regulatory Strategy, Health Authority Engagement, IND Submissions, CTA Submissions, NDA Submissions
South San Francisco, California, United States · On-site
$145k–$269k/yr
A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more t…
Skills: Computational Chemistry, Induced Proximity, Molecular Dynamics, AI/ML, Python
South San Francisco, California, United States · Hybrid
$275k–$280k/yr
Who We Are: Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that …
Skills: Regulatory Strategy, FDA Regulations, EMA Regulations, IND Submissions, NDA/BLA/MAA Filings
South San Francisco, California, United States · On-site
$125k–$237k/yr
Company Description About AbbVie AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a r…
Skills: Clinical Study Operations Management, Stakeholder Management, Clinical Operational Strategy, Budget Oversight, Vendor Management
South San Francisco, California, United States · On-site
$125k–$150k/yr
Essential Duties and Responsibilities Major contributor to the development and optimization of CMOS chip-based DNA synthesis workflows, including both phosphoramidite and enzymatic chemistriesDevelop and optimize electro…
Skills: Phosphoramidite Oligonucleotide Synthesis, Surface Chemistry, CMOS Chip-based DNA Synthesis, Electrochemical Synthesis, NGS Workflows
South San Francisco, California, United States · On-site
$36/hr–$45/hr
Septerna is a biotechnology company based in South San Francisco, CA on a mission to develop life-changing medicines for patients with the vision to become the industry-leading G protein-coupled receptor (GPCR)-focused d…
Skills: Protein Purification, FPLC, Affinity Chromatography, Ion-Exchange Chromatography, Size Exclusion Chromatography
South San Francisco, California, United States · On-site
$125k–$150k/yr
About the Role This is a unique opportunity to join a talented team of scientists and engineers focused on solving one of the most critical challenges in DNA data storage. As a Senior Scientist in Surface Chemistry, you …
Skills: Surface Chemistry, Bioconjugation, Synthetic Chemistry, Self-Assembled Monolayers, Polymer Synthesis
South San Francisco, California, United States · On-site
About NewLimit NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to res…
Skills: Executive Recruiting, Sourcing, Candidate Development, Offer Negotiation, Strategic Partnership
South San Francisco, California, United States · On-site
$160k–$200k/yr
Senior Manager / Associate Director, Process Development Department: CMC Work Location: This is an on-site position based at our corporate Headquarters in South San Francisco, CA. Position Summary: TCG Labs Soleil is see…
Skills: Biologics CMC, Process Development, CDMO Management, Project Management, Drug Substance Manufacturing
South San Francisco, California, United States · Hybrid
$108k–$133k/yr
Why Join Us? Be a hero for our rare disease patients At Ultragenyx, we fundamentally believe that taking real impactful action to care for the needs of patients and our people is always the right thing to do. To achieve …
Skills: Calendar Management, Travel Coordination, Expense Reporting, PowerPoint Presentation Design, Meeting Coordination
South San Francisco, California, United States · Hybrid
$327k–$374k/yr
The Position Genentech, Inc. seeks a Chief of Staff, Computational Center of Excellence at its South San Francisco, CA location. Duties: On behalf of global pharmaceutical company, play a critical role in planning and dr…
Skills: Program Management, Strategic Planning, Cross-functional Collaboration, Operational Strategy, Risk Mitigation
South San Francisco, California, United States · On-site
Mentor Technical Group (MTG) provides a comprehensive portfolio of technical support and solutions for the FDA-regulated industry. As a world leader in life science engineering and technical solutions, MTG has the knowle…
Skills: Maintenance Planning, Scheduling, CMMS, Resource Allocation, Regulatory Compliance
South San Francisco, California, United States • On-site
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Partner with enterprise biotech and pharma customers to translate scientific workflows into technical requirements for AI agents. Build and curate biomedical tools and databases while designing evaluation pipelines to ensure scientific rigor and accuracy.
Requires a PhD or MD/PhD in a relevant field with industry experience in computational biology or bioinformatics. Must possess strong engineering skills for building data pipelines and deep expertise in discovery, IND-enabling, or clinical/translational research.
Phylo is an applied research lab building agentic intelligence to accelerate discovery for every biomedical scientist. We believe AI agents will fundamentally transform how biomedical research is done. Our fast-growing team brings together researchers and engineers across AI and biology.
Our Scientific Solutions team is where our science meets our customers. We're hiring forward deployed scientists with industry experience to partner closely with our enterprise customers, raise the scientific bar of our agents, and make sure outputs hold up under real scientific scrutiny.
The role has two parts: One is constructing the bio environment our agents rely on: building and curating the biomedical skills, tools, databases, and data integrations that power them. The other is making sure the science holds up: designing evaluation pipelines and benchmarks, and doing direct scientific review to measure whether agents meet the standards of working scientists. You'll do both while embedded with customers: running training sessions, scoping and delivering solutions on high-stakes projects, and feeding what you learn back into the product.
We're building a team that spans the drug R&D pipeline, so we're hiring across three areas of depth: discovery, IND-enabling, and clinical/translational. You don't need all three; you need to go deep in at least one and be conversant across the rest.
Partner with enterprise customers in biotech and pharma to understand their scientific workflows and bring those needs into the product.
Construct bio environments for our agents: build and curate biomedical skills, tools, databases, and data integrations that expand what agents can do.
Evaluate agent performance across biomedical domains through internal benchmarks, structured evals, and direct scientific review.
Validate the scientific accuracy and rigor of agent outputs and drive improvements back into the product with the AI team.
Deliver in the field: run training sessions, help customers scope and solve real problems, and own delivery from first hypothesis to production.
Serve as the scientific voice in customer engagements, deployments, and feedback loops.
PhD training in a relevant field (or MD/PhD or equivalent), with strong command of common biomedical tools, databases, and analytical workflows.
Industry experience in biotech or pharma (computational biology, bioinformatics, or a closely related function).
Solid engineering skills: writing code, building pipelines, and working with biological data at scale.
Comfort working directly with enterprise customers and translating their scientific needs into technical requirements, including running training sessions.
A strong communicator who can explain complex ideas clearly to both scientists and executives.
Ability to move quickly in a fast-paced research and product environment.
Deep expertise in at least one of the following areas (and comfort collaborating across the others):
Discovery: identifying and optimizing therapeutic candidates across modalities. On the small-molecule side: screening (biochemical, cell-based, or phenotypic), hit-to-lead, and lead optimization; SAR analysis and medicinal chemistry / cheminformatics; chemical and bioactivity data (e.g. ChEMBL, PubChem). On the biologics side: protein and binder design, antibody discovery, de novo protein design, protein engineering, and affinity maturation.
IND-Enabling (preclinical): nonclinical safety and toxicology, DMPK, PK/PD modeling, exposure-response and dose selection; familiarity with the regulatory requirements and study designs that support an IND filing.
Clinical & Translational: biomarker strategy, mechanism-of-action confirmation, patient stratification, and translational PK/PD; early clinical development (Phase 1/2, first-in-human); real-world evidence and clinical data (EHR, claims, registries; RWD analysis for effectiveness and safety).
AI-native working style; fluent with modern AI coding tools and agent-based workflows.
Experience with LLMs, agents, or AI/ML systems applied to biomedical problems.
Familiarity with foundation models: genomic foundation models, protein language models, or vision models for pathology/imaging.
Depth in more than one of the three areas above, or breadth across multiple biomedical domains (genomics, proteomics, drug discovery, clinical data).
Area-specific strengths, such as: structure-based and generative design of small molecules or proteins, e.g. docking, RFdiffusion, ProteinMPNN, ESM (Discovery); PBPK or QSP modeling, e.g. Simcyp, GastroPlus, NONMEM (IND-Enabling); epidemiology / biostatistics, CDISC data standards, digital biomarkers (Clinical & Translational).
Type: Full-time
Location: In-person in South San Francisco (some travel to customer sites)
Start Date: ASAP
Competitive salary and equity share in building the future of biomedical discovery
Full medical, dental, and vision coverage, including free therapy sessions and eyewear stipend
401(k) to help you build long-term financial security (US only)
Unlimited PTO to recharge when you need it (US only)
Lunch and snacks when you're in the office
Regular team offsites and company events
A culture of excellence and speed - we move fast, think big, and support each other every step of the way
Your work will directly impact our mission to 100X biomedical discoveries through AI
Research lab studying agentic biology
Phylo is an applied research lab dedicated to studying agentic intelligence to accelerate discoveries for every biomedical scientist. Building Biomni Lab - the first integrated biology environment.
Offices: South San Francisco, California 94080, US · 701 Gateway Blvd, South San Francisco, California 94080, US
Based on 330 listings with disclosed salaries, most science & research jobs in South San Francisco, CA pay between $108k–$272k per year. Individual offers vary with seniority, company size, and specialization.
There are currently 372 open science & research positions in South San Francisco, CA listed on Clera. New openings are added daily as companies post roles.
Companies currently hiring include Roche, Allergan, MSD, Cytokinetics, Amgen, among others. Browse the listings above to see every active employer.
Yes — 96 of the 372 open science & research positions offer remote or hybrid work (8 remote, 88 hybrid).
Each listing links directly to the employer's application page. Apply early — fresh listings get the most recruiter attention in the first two weeks.
