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NewLimit logoNewLimit

Scientist, Functional Genomics

South San Francisco, California, United States · On-site

$130k–$170k/yr

Senior$247M raised

Company info NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to resto…

Skills: Functional Genomics, Molecular Cloning, Next-Generation Sequencing, CRISPR-Cas, Epigenetic Reprogramming

NewLimit logo

Scientist, Functional Genomics

NewLimit

South San Francisco, California, United States • On-site

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  • $130k–$170k/yr
  • Full-time
  • postgraduate degree
  • Health Insurance, Dental Insurance, Vision Insurance, 401(k) With Company Match, Paid Parental Leave, Paid Time Off
  • Posted 3d ago
  • ~40 hrs/week

Responsibilities

The role involves running large-scale reprogramming screens and developing methods for the delivery and control of epigenetic payloads in primary mammalian cells. You will design functional genomics screens to measure the effects of epigenetic reprogramming on cellular states and contribute to therapeutic molecule formulation.

Requirements

Requires a Ph.D. in molecular or cell biology or 5+ years of equivalent industry experience. Candidates must have expertise in functional genomics screening, molecular cloning, NGS, and transgenic delivery methods for mammalian cells.

Full job description

Company info

NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.

Description

NewLimit is seeking an experienced cell and molecular biologist with a background in functional genomics to join our Epigenetic Editing team. Our therapies restore cell function by reprogramming the epigenome with both natural transcription factors and programmable editors. You will be instrumental to the discovery and development process for this new class of medicines.

As a member of our team, you will:

  • Run the largest reprogramming screens in the world in collaboration with our Single Cell Genomics and Predictive Modeling teams
  • Develop methods for the construction, delivery, and control of epigenetic reprogramming payloads for single cell screens in primary mammalian cells
  • Build and deploy molecular tools at a massive scale
  • Design and implement functional genomics screens to measure the effect of epigenetic reprogramming on the molecular and functional state of primary mammalian cells
  • Contribute to the design and formulation of therapeutic molecules (e.g. mRNA synthesis and optimization, lipid nanoparticle formulation)

Requirements

  • Ph.D. in molecular biology, cell biology, or a related field or equivalent industry experience (5+ years)
  • Experience with functional genomics approaches for pooled or arrayed screening (e.g. one of: CRISPR-Cas pooled fitness screens, gene expression perturbation profiling, Perturb/CROP-seq, or similar methods)
  • Experience with molecular cloning, next-generation sequencing, and associated molecular biology methods
  • Experience with in vitro and in vivo transgenic delivery methods for mammalian cells (at least one of: lentivirus, AAV, AdV, transposition systems, lipid nanoparticles, or similar)

Nice to have

  • Experience with epigenetic reprogramming methods using transcription factors for cell fate engineering or CRISPR-Cas tools for targeted epigenetic editing
  • Experience working with primary cells and tissue samples
  • Experience with single cell genomics methods
  • Python programming and Unix workflow management skills
  • Therapeutics development experience

Benefits

NewLimit offers generous benefits to ensure our team can focus on our mission:

  • Health, dental, and vision insurance
  • 401(k) with company match
  • Paid parental leave
  • Industry-leading paid time off (PTO) — 20 days/year for all employees + holidays
  • Meals and snacks on-site

 

Salary Range: $130,000 to $170,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. NewLimit offers a competitive benefits package, which includes a 401k, healthcare coverage, and 20 days of PTO. Learn more at: https://www.newlimit.com/careers   *This compensation and benefits information is based on Company's good faith estimate as of the date of publication and may be modified in the future.

 

Related keywords

Functional GenomicsEpigenetic EditingCRISPR-CasPerturb-seqCROP-seqNext-Generation SequencingLentivirusAAVLipid NanoparticlesmRNA SynthesisSingle Cell GenomicsPythonUnixMolecular BiologyCell BiologyEpigenome Reprogramming

About NewLimit

LinkedInVisit site

NewLimit is a biotechnology company working to extend human healthspan by developing epigenetic reprogramming therapies.

Industry
Biotechnology Research
Company size
11-50 employees
Founded
2022
Headquarters
South San Francisco, California
LinkedIn followers
13,962
Total funding
$247M

NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale. All correspondence from NewLimit will come from an @NewLimit.com email address.

Offices: South San Francisco, California 94080, US

Health CareClinical TrialsBiotechnology
View all jobs at NewLimit

About NewLimit

LinkedInVisit site

NewLimit is a biotechnology company working to extend human healthspan by developing epigenetic reprogramming therapies.

Industry
Biotechnology Research
Company size
11-50 employees
Founded
2022
Headquarters
South San Francisco, California
LinkedIn followers
13,962
Total funding
$247M

NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale. All correspondence from NewLimit will come from an @NewLimit.com email address.

Offices: South San Francisco, California 94080, US

Health CareClinical TrialsBiotechnology
View all jobs at NewLimit

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