South San Francisco, California, United States · Hybrid
About Deep Origin Led by Michael Antonov, a co-founder of Oculus, and well-funded by Formic Ventures, Deep Origin is poised to reinvent the way scientists work and life science innovations come to life. We see a future l…
Skills: NodeJS, React, TypeScript, JavaScript, Postgres
South San Francisco, California, United States · On-site
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Analytical Skills, Problem Solving, Spreadsheets, Data Analysis, Written Communication
South San Francisco, California, United States · On-site
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Python, SQL, C++, Rust, Data Analysis
South San Francisco, California, United States · On-site
$170k–$210k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Rust, C++, Safety-Critical Software, Embedded Systems, CI/CD
South San Francisco, California, United States · On-site
$145k–$205k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: RF Engineering, Manufacturing Test, Design Validation, System Performance Characterization, Python
South San Francisco, California, United States · On-site
$185k–$255k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: People Leadership, Scientific Python, Pandas, NumPy, SciPy
South San Francisco, California, United States · On-site
$125k–$170k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Design for Manufacturability, PFMEA, 3D CAD, Siemens NX, Lean Manufacturing
South San Francisco, California, United States · On-site
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: 2D CAD, 3D CAD, Structural Analysis, Prototyping, Root Cause Analysis
South San Francisco, California, United States · On-site
$225k–$280k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Rust, C++, C, Trajectory Optimization, MPC
South San Francisco, California, United States · On-site
$200k–$270k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Full Stack Development, Frontend Development, Backend Development, System Design, API Design
South San Francisco, California, United States · On-site
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Data Analytics, Strategy Design, Market Intelligence, Digital Transformation, SQL
South San Francisco, California, United States · On-site
$200k–$270k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Full Stack Development, Frontend Development, Backend Development, System Design, API Design
South San Francisco, California, United States · On-site
$185k–$255k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: People Leadership, Scientific Python, Pandas, NumPy, SciPy
South San Francisco, California, United States · On-site
$160k–$220k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Quantitative Risk Analysis, Fault Tree Analysis, FMEA, Hazard Analysis, Systems Engineering
South San Francisco, California, United States · On-site
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: CAD, Embedded Software, Mechanical Engineering, Prototyping, Sensor Integration
South San Francisco, California, United States · On-site
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Flight Algorithms, Dynamic Modeling, Linear Control Analysis, Optimal Control, C
South San Francisco, California, United States · On-site
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Supplier Performance Tracking, Data Analysis, Sourcing, Cost Benchmarking, Procurement
South San Francisco, California, United States · On-site
$120k–$247k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Supplier Industrialization, DFM, Lean Methodologies, Statistical Process Control, PPAP
South San Francisco, California, United States · On-site
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Material Planning, Data Analysis, Excel, SQL, Python
South San Francisco, California, United States · On-site
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Technical Program Management, Hardware Project Delivery, Strategic Roadmapping, Systems Thinking, Risk Management
South San Francisco, California, United States • Hybrid
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The Staff Engineer will lead the architectural design and implementation of key software features and integrations. They will collaborate with cross-functional teams to build robust applications that enhance the productivity of biologists and researchers.
Requires over 10 years of experience in scalable distributed systems and 5+ years of hands-on experience with React, TypeScript, and NodeJS. Candidates must have a strong background in system design, database management, and Kubernetes, with a history of scaling platforms in startup environments.
About Deep Origin
Led by Michael Antonov, a co-founder of Oculus, and well-funded by Formic Ventures, Deep Origin is poised to reinvent the way scientists work and life science innovations come to life. We see a future largely free of diseases, with a 150-year lifespan being the norm. To get there, we are building an operating system for science, enabling scientists to be more productive and to bring tomorrow's ideas to life quickly and at a reasonable cost.
Role Description
We are seeking a talented and experienced Staff Engineer to join our dynamic team. You will be a key member of the software engineering team, building our key functionality and integrating with key partners. You will have ownership in key software feature areas and their architectural design, as well as software implementation with a high level of independence and impact. You will work closely with cross-functional teams to create robust, user-friendly applications that drive the efficiency and effectiveness of biologists and researchers in their scientific endeavors.
Applicants must be authorized to work for any employer in the U.S. We are unable to sponsor or take over sponsorship of an employment Visa at this time.
Accelerating R&D to untangle the complexity of life and discover drugs
We help scientists solve disease, develop drugs, and extend healthspan by building tools that simplify R&D, simulate biology, and untangle the complexity of life. Streamline computational analysis today. Discover drugs tomorrow.
Offices: 486 Cabot Road, South San Francisco, California 94080, US · Yerevan, AM
Based on 212 listings with disclosed salaries, most engineering jobs in South San Francisco, CA pay between $120k–$250k per year. Individual offers vary with seniority, company size, and specialization.
There are currently 276 open engineering positions in South San Francisco, CA listed on Clera. New openings are added daily as companies post roles.
Companies currently hiring include Zipline, Roche, MSD, Xaira Therapeutics, Cellares, among others. Browse the listings above to see every active employer.
Yes — 26 of the 276 open engineering positions offer remote or hybrid work (2 remote, 24 hybrid).
Each listing links directly to the employer's application page. Apply early — fresh listings get the most recruiter attention in the first two weeks.
