Gaithersburg, Maryland, United States · On-site
$116k–$174k/yr
About AstraZeneca Do you have a passion for science and a desire to translate ideas into life-changing medicines? At AstraZeneca, we put patients first and foster a collaborative, inclusive environment where diverse pers…
Skills: Cell therapy process development, CAR-T, Mammalian cell culture, Aseptic processing, Flow cytometry
Gaithersburg, Maryland, United States · On-site
$67k–$85k/yr
Welcome! Under minimal supervision, performs diagnostic and service work on residential and/or light commercial HVAC equipment and accessories. Communicates with customer to answer questions, resolves problems, and ens…
Skills: HVAC Diagnostics, Heating and Cooling Repair, Ventilation Systems, Refrigeration Equipment, Electrical Troubleshooting
Gaithersburg, Maryland, United States · On-site
$112k–$168k/yr
Senior Scientist, Allogeneic T-Cell Therapy Process Development: Cell Therapy CMC Do you have a passion for science? Would you like to apply your expertise to impact a company that follows the science and turns ideas int…
Skills: T-cell culture, Flow cytometry, Process development, Cell therapy, Gene editing
Gaithersburg, Maryland, United States · On-site
$87k–$157k/yr
Leidos is seeking a Reliability, Maintainability and Availability (RMA) Engineer to join a dynamic engineering team supporting the Federal Aviation Administration’s (FAA) En Route Automation Modernization (ERAM) program.…
Skills: Reliability engineering, Maintainability analysis, Availability modeling, Systems engineering, Failure analysis
Gaithersburg, Maryland, United States · On-site
$108k–$185k/yr
Overview Senior Systems Engineer Gaithersburg, MD Active TS (SCI eligibility) clearance and eligibility to obtain a CI poly At Bcore, our strength comes from how we deliver impact to the mission. Whether it’s architectin…
Skills: Systems Engineering, Requirements Analysis, Architecture Development, Agile Frameworks, DevSecOps
Gaithersburg, Maryland, United States · On-site
$87k–$155k/yr
Overview Mid-Level DevSecOps Engineer Gaithersburg, MD Active TS (SCI eligibility) clearance and eligibility to obtain a CI poly At Bcore, our strength comes from how we deliver impact to the mission. Whether it’s archit…
Skills: CI/CD Pipelines, Docker, Kubernetes, OpenShift, Terraform
Gaithersburg, Maryland, United States · On-site
***This job requires active TS/SCI clearance. Please apply only if you have an active TS/SCI clearance. *** North Point Technology is looking to hire a Full Stack Software Engineer to support a mission-critical GEOINT pr…
Skills: Python, Java, JavaScript, TypeScript, Docker
Gaithersburg, Maryland, United States · On-site
Elevate Your Craft. Shape What’s Next You’ve built a strong foundation in civil design; now it’s time to take your expertise further. At Bohler, you’ll play a key role in creating the sites that define Maryland's communi…
Skills: Civil design, Land development, AutoCAD Civil 3D, Grading, Drainage design
Gaithersburg, Maryland, United States · On-site
$108k–$195k/yr
Leidos is seeking a Systems Integration & Test Engineer to be based out of Gaithersburg, MD. This position will support the United Kingdom National Airspace System Replacement Product Delivery Team - UK NASR PDT. This ef…
Skills: Systems Integration, Test Engineering, Requirements Verification, Automated Test Scripts, HP ALM
Gaithersburg, Maryland, United States · Hybrid
$87k–$157k/yr
Leidos is seeking a Systems Integration & Test Engineer to be based out of Gaithersburg, MD This position will support the United Kingdom National Airspace System Replacement Product Delivery Team - UK NASR PDT. This eff…
Skills: Systems Integration, Test Planning, Requirements Traceability, Automated Test Scripts, HP ALM
Gaithersburg, Maryland, United States · On-site
$146k–$234k/yr
Gaithersburg, US | full time | Job ID: 11547 About the Role: As the Associate Director AS&T Lifecycle Management, you will be making a meaningful contribution to the ongoing product development and regulatory submission …
Skills: Analytical Method Validation, Method Transfer, ADC Analysis, CMC Activities, Regulatory Filings
Gaithersburg, Maryland, United States · Hybrid
$138k–$230k/yr
Together, we own our company, our future, and our shared success. As an employee-owned company, our people are Black & Veatch. We put them at the center of everything we do and empower them to grow, explore new possibili…
Skills: Water engineering, Wastewater design, Civil engineering, Project management, Technical design
Gaithersburg, Maryland, United States · On-site
$146k–$234k/yr
Gaithersburg, US | full time | Job ID: 11546 About the Role: As the Associate Director AS&T Lifecycle Management, you will be making a meaningful contribution to the ongoing product development and regulatory submission …
Skills: Method Validation, Method Transfer, CMC Activities, GMP Standards, Regulatory Filings
Smithers - Materials and ComponentsGaithersburg, Maryland, United States · Hybrid
$50k–$75k/yr
Smithers PDS LLC (Pharmaceutical Development Services) brings new drugs to market by providing pre-clinical and clinical services for all phases of drug development. PDS works with customers to develop and validate new m…
Skills: Quality control, Data analysis, GLP compliance, GCP compliance, Watson LIMS
Gaithersburg, Maryland, United States · On-site
***This job requires active TS/SCI clearance. Please apply only if you have an active TS/SCI clearance. *** North Point Technology is looking to hire a Full-Stack Software Engineer to support the Chinook Program, deliver…
Skills: Rest API Development, Python, Java, SQL, Django
Gaithersburg, Maryland, United States · Hybrid
$83k–$149k/yr
Build the Documentation That Powers Mission-Critical Intelligence The Maru Program is seeking a Senior Technical Writer who thrives at the intersection of technology, mission, and impact. Join a high-performing team supp…
Skills: Technical writing, GEOINT systems, Software documentation, Systems engineering, Confluence
Gaithersburg, Maryland, United States · On-site
$108k–$195k/yr
Engineering the Mission. Enabling Intelligence. Join Leidos and help shape the future of geospatial intelligence! We are seeking an experienced and innovative Senior Systems Engineer to support the Maru Program with our …
Skills: Systems Engineering, Geospatial Intelligence, Agile, DevSecOps, Requirements Analysis
Gaithersburg, Maryland, United States · On-site
$19/hr–$26/hr
Be a part of our mission! As a world leader in creating comfortable, sustainable, and efficient climate solutions for buildings, homes and transportation, it's our responsibility to put the planet first. For us at Trane …
Skills: Equipment delivery, Preventive maintenance, Customer service, Inventory management, Service ticket management
Gaithersburg, Maryland, United States · On-site
About Rivian Rivian is on a mission to keep the world adventurous forever. This goes for the emissions-free Electric Adventure Vehicles we build, and the curious, courageous souls we seek to attract. As a company, we con…
Skills: Vehicle inspection, Automotive detailing, Vehicle charging, Logistics management, 5S principles
Gaithersburg, Maryland, United States · On-site
$92k–$138k/yr
---This is a hands-on, laboratory-focused position.--- Typical Accountabilities - Conduct hands-on in vivo research and contribute independently to the planning and design of in vivo studies. Proficient in animal handlin…
Skills: In vivo research, Animal handling, Cellular therapy, Immunology, Immuno-oncology
Gaithersburg, Maryland, United States • On-site
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The Senior Scientist will lead and execute CAR-T cell therapy process development activities, focusing on autologous manufacturing workflows and process optimization. They will collaborate across cross-functional teams to support technology transfer, process characterization, and the implementation of scalable cell processing equipment.
Candidates must hold a PhD with at least 1 year of experience, an MS with 4 years, or a BS with 6 years of relevant experience in a scientific or engineering discipline. Strong hands-on expertise in mammalian cell culture, aseptic processing, and flow cytometry is required.
Do you have a passion for science and a desire to translate ideas into life-changing medicines? At AstraZeneca, we put patients first and foster a collaborative, inclusive environment where diverse perspectives, scientific rigor, and bold thinking help advance innovative therapies for patients worldwide.
Our Gaithersburg, Maryland campus is a major U.S. hub for R&D and Oncology. The site brings together multidisciplinary scientists, modern laboratories, and cross-functional development teams to advance medicines from discovery through clinical and commercial development.
We are seeking a highly motivated Senior Scientist to lead and execute CAR-T cell therapy process development activities, with an emphasis on autologous manufacturing processes. The successful candidate will apply strong scientific and technical judgment to develop robust, scalable, and transferable processes; evaluate new cell therapy processing equipment; and collaborate across research, analytical, drug product, manufacturing, quality, and regulatory functions to advance programs from preclinical development through clinical stages.
Lead the design, execution, and interpretation of laboratory studies supporting CAR-T process development, including cell selection, activation, gene modification, expansion, harvest, formulation, and cryopreservation.
Develop and optimize unit operations and integrated manufacturing workflows for autologous CAR-T products using quality-by-design and risk-based principles.
Evaluate, select, and implement commercially available cell therapy process equipment and closed or functionally closed processing technologies; assess fit for intended use, scalability, process robustness, and manufacturing readiness.
Develop equipment operating strategies, define critical process parameters, and troubleshoot cell processing platforms and associated single-use consumables.
Apply flow cytometry to characterize cell identity, phenotype, viability, activation, differentiation, and other process-relevant attributes; partner with analytical teams on panel strategy, assay execution, and data interpretation.
Perform statistical and multivariate data analysis to understand process performance, identify sources of variability, and inform process characterization and control strategies.
Lead cross-functional technical discussions, communicate study outcomes, and provide clear recommendations to project teams and governance forums.
Support technology transfer to internal and external GMP manufacturing sites, including process documentation, training, engineering runs, deviation investigations, and manufacturing troubleshooting.
Author and review development reports, protocols, risk assessments, technical transfer documents, regulatory submission content, scientific publications, and invention disclosures.
Mentor junior scientists and contribute to a collaborative, safe, and scientifically rigorous laboratory culture.
PhD in Chemical Engineering, Biochemical Engineering, Biomedical Engineering, Biotechnology, Biochemistry, Biological Sciences, Immunology, or a related discipline with at least 1 years of relevant experience; or MS with at least 4 years; or BS with at least 6 years of relevant industry or academic experience.
Demonstrated experience in cell therapy process development, preferably with autologous CAR-T or other genetically modified immune-cell products.
Experience leading complex experimental programs and working effectively in a matrixed, cross-functional development environment.
Strong hands-on experience with mammalian cell culture, aseptic processing, and development of cell therapy manufacturing processes.
Demonstrated ability to design experiments, analyze complex datasets, draw scientifically sound conclusions, and translate findings into process recommendations.
Experience with flow cytometry-based instruments and analysis software, including sample preparation, acquisition, gating, data review, and interpretation.
Experience operating and troubleshooting cell processing equipment and single-use systems used in cell therapy development.
Working knowledge of process scale-up, technology transfer, process characterization, and manufacturing control strategies.
Excellent written and verbal communication skills, with the ability to prepare high-quality technical documents and present conclusions to multidisciplinary audiences.
Ability to work independently, manage multiple priorities, and adapt effectively in a fast-paced development environment.
Direct experience developing autologous CAR-T processes across multiple unit operations and stages of product development.
Familiarity with available cell therapy processing platforms for cell isolation, washing, concentration, activation, expansion, formulation, and closed-system processing. Experience may include platforms such as CliniMACS Prodigy, Sepax/Sefia, LOVO/CUE, DynaCellect, G-Rex, or comparable systems.
Advanced flow cytometry experience, including multicolor panel design, compensation or spectral unmixing, gating strategy development, and analysis of T-cell phenotype and functional markers.
Knowledge of T-cell biology, immunology, cellular engineering, gene delivery technologies, and the relationship between process conditions and product quality attributes.
Experience supporting GMP manufacturing, process validation, regulatory filings, deviation investigations, and interactions across clinical development stages.
Experience with automation, digital process monitoring, data visualization, or statistical software used in bioprocess development.
Demonstrated scientific leadership through mentoring, publications, patents, regulatory contributions, or cross-functional program leadership.
At AstraZeneca, we follow the science, act with urgency, and work across boundaries to deliver medicines that can transform patients' lives. Join a team where your expertise in cell therapy process development can help shape robust manufacturing strategies and advance the next generation of cellular therapies.
AstraZeneca is an equal opportunity employer. We value diversity and inclusion and are committed to creating an environment in which all employees can contribute and thrive. Hiring decisions are based on business needs, job requirements, and individual qualifications.
Ready to join us on this mission? Apply now!
We offer a competitive Total Reward program including a market driven base salary, bonus and long-term incentive. We have a generous paid time off program and a comprehensive benefits package.
The annual base pay for this position ranges from $112,304.00 - $168,456.00. Our positions offer eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans.
Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.
We're transforming the future of healthcare by unlocking the power of what science can do for people, society and the planet. For more information, visit www.astrazeneca.com. Community Guidelines: bit.ly/2MgAcio
Offices: 1 Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge, Cambridgeshire CB2 0AA, GB · Astraallen, Sodertalje, Stockholm County 152 57, SE
Based on 98 listings with disclosed salaries, most engineering jobs in Gaithersburg, MD pay between $70k–$195k per year. Individual offers vary with seniority, company size, and specialization.
There are currently 110 open engineering positions in Gaithersburg, MD listed on Clera. New openings are added daily as companies post roles.
Companies currently hiring include Leidos, AstraZeneca, MESO SCALE DIAGNOSTICS, LLC., Asbury Communities, Inc., BioNTech SE, among others. Browse the listings above to see every active employer.
Yes — 31 of the 110 open engineering positions offer remote or hybrid work (1 remote, 30 hybrid).
Each listing links directly to the employer's application page. Apply early — fresh listings get the most recruiter attention in the first two weeks.
