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Jnana Therapeutics is seeking a highly motivated Preclinical Translational Scientist to help advance innovative small molecule programs from discovery into early clinical development. This role will focus on building and applying translational human tissue and cellular models to evaluate novel compounds, interrogate disease biology, and identify biomarkers that inform clinical strategy and patient selection. The successful candidate will work closely across pharmacology, translational sciences, and chemistry teams in a fast-paced biotech environment, contributing to the design and execution of studies that directly shape program direction and decision-making. Candidates should bring strong scientific curiosity, hands-on experimental expertise, and a collaborative, problem-solving mindset.

Responsibilities

• Develop and apply in vitro and ex vivo assays using patient-derived samples, primary cells, organoids and disease-relevant models.

• Isolate and culture primary cells from a broad range of tissues, leveraging experience working with human and murine-derived tissues.

• Convert primary cell systems into suitable med chem assays

• Investigate disease mechanisms and identify biomarkers to guide drug discovery and clinical translation from whole blood, skin and kidney tissues.

• Leverage omics approaches to select biomarkers to inform patient selection and stratification

• Collaborate with cross-functional teams—discovery biology, pharmacology, computational biology, preclinical and clinical—to support target validation and therapeutic advancement.

• Become a subject matter expert on target biology and disease area.

• Analyze complex biological data and clearly communicate findings to internal stakeholders.

• Contribute to regulatory documentation and strategic planning for IND-enabling studies

Desired Qualifications & Past Experience

• PhD in Biology, Cell Biology, or relevant discipline with 2-5 years of industry experience or equivalent

• Experience working in dermatological, immunological or renal disease research with an interest in inflammation and fibrosis

• Familiarity with a variety of translational models (e.g., primary cells, organoids, tissue explants)

• Exposure to biomarker discovery, omics data, or early clinical translation.

• Experience in cellular readouts transcriptional/translational reporters, flow cytometry, ELISA, MSD and qPCR/RNAseq

• Experience with primary cell engineering (CRISPR, expression systems) a plus

• Hands-on experience overcoming challenges in assay development.

• Must be a committed, collaborative self-starter with a passion for learning and problem-solving.

• Able to integrate data from multiple sources in vitro, ex vivo, in vivo and clinical to inform next steps.

Minimum $98,400.00 - Maximum $141,450.00, plus incentive opportunity: The range shown represents a typical pay range or starting pay for individuals who are hired in the role to perform in the United States. Other elements may be used to determine actual pay such as the candidate’s job experience, specific skills, and comparison to internal incumbents currently in role. Typically, actual pay will be positioned within the established range, rather than at its minimum or maximum. This information is provided to applicants in accordance with states and local laws.

Company benefits:  Comprehensive medical, dental, vision, prescription drug coverage, company provided basic life, accidental death & dismemberment, short-term and long-term disability insurance, tuition reimbursement, student loan assistance, a generous 401(k) match, flexible time off, paid holidays, and paid leave programs as well as other company provided benefits.

Statement Regarding Job Recruiting Fraud Scams

At Jnana Therapeutics we take security and protection of your personal information very seriously. Please be aware individuals may approach you and falsely present themselves as our employees or representatives. They may use this false pretense to try to gain access to your personal information or acquire money from you by offering fictitious employment opportunities purportedly on our behalf.

Please understand, Jnana Therapeutics will never ask for financial information of any kind or for payment of money during the job application process. We do not require any financial, credit card or bank account information and/or any payment of any kind to be considered for employment. We will also not offer you money to buy equipment, software, or for any other purpose during the job application process. If you are being asked to pay or offered money for equipment fees or some other application processing fee, even if claimed you will be reimbursed, this is not Jnana Therapeutics. These claims are fraudulent, and you are strongly advised to exercise caution when you receive such an offer of employment. 

 

Jnana Therapeutics will also never ask you to download a third-party application in order to communicate about a legitimate job opportunity. Scammers may also send offers or claims from a fake email address or from Yahoo, Gmail, Hotmail, etc, and not from an official Jnana Therapeutics email address. Please take extra caution while examining such an email address, as the scammers may misspell an official Jnana Therapeutics email address and use a slightly modified version duplicating letters.

To ensure that you are communicating about a legitimate job opportunity at Jnana Therapeutics, please only deal directly with Jnana Therapeutics through its official Jnana Therapeutics Career website https://www.jnanatx.com/join-us/. 

 

Jnana Therapeutics will not be held liable or responsible for any claims, losses, damages or expenses resulting from job recruiting scams. If you suspect a position is fraudulent, please contact Jnana Therapeutics call center at: 800-363-5670. If you believe you are the victim of fraud resulting from a job recruiting scam, please contact the FBI through the Internet Crime Complaint Center at: https://www.ic3.gov, or your local authorities. 

Jnana Therapeutics, Inc. does not accept unsolicited assistance from search firms for employment opportunities. All CVs/resumes submitted by search firms to any Jnana employee directly or through Jnana’s application portal without a valid written search agreement in place for the position will be considered Jnana’s sole property. No fee will be paid if a candidate is hired by Jnana as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.