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$100k–$115k/yr
Mid level$1.2B raised
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$110k–$130k/yr
Mid level$1.2B raised
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Senior Manager, Operational Excellence and Process Engineering
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Senior+$1.2B raised
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$176k–$220k/yr
Full-time
postgraduate degree
Medical insurance, Dental insurance, Vision insurance, Life insurance, Disability plans, Free testing
Posted 8d ago
~40 hrs/week
Remote in United States
Responsibilities
Lead the design and execution of observational research strategies and prospective studies to support early cancer detection programs. Collaborate cross-functionally with clinical, medical, and data science teams to translate real-world data into actionable clinical implementation strategies.
Requirements
Requires an advanced degree such as a PhD, MPH, or PharmD in a quantitative field. Candidates must have 7+ years of experience in real-world evidence generation or observational clinical research within the life sciences industry.
Full job description
POSITION SUMMARY:
We are seeking a Principal Clinical Scientist / Associate Director of Real-World Evidence & Epidemiology to drive observational evidence strategy for our Early Cancer Detection (ECD) portfolio. Population-scale liquid biopsy screening requires robust real-world evidence demonstrating clinical utility, clinical decision-making impact, and downstream patient outcomes. This ownership role uses real-world datasets to accelerate standard-of-care implementation across oncology diagnostics. Working with a builder mindset, you will partner across Clinical Science, Medical Affairs, Market Access, and Data Science to convert population-scale observational data into actionable clinical implementation strategies.
PRIMARY RESPONSIBILITIES:
Epidemiology and Observational Research Strategy
Lead the design, protocol development, and execution of prospective observational studies, registries, and retrospective database assessments across early cancer detection programs
Shape post-market evidence generation strategies by isolating critical clinical utility and implementation hurdles that can be resolved via real-world data assets
Translate clinical and market requirements into rigorous, practical study designs, specifying target populations, clinical endpoints, and analytic frameworks
Systematically identify and mitigate sources of bias, confounding factors, and missing data variance inherent in real-world healthcare datasets
Design protocols evaluating clinical utility across diverse populations, ensuring the data generated directly supports precision interventions for individual patients and families
Cross-Functional Scientific Leadership
Partner across Clinical Science, Medical Affairs, Product Management, and Market Access to prioritize evidence generation initiatives based on regulatory and clinical urgency
Collaborate with Biostatistics and Data Science to engineer statistical analysis plans, interpret data findings, and deliver clinical contextualization
Extract empirical evidence from early commercial and Laboratory Developed Test (LDT) cohorts to isolate adoption variables, diagnostic compliance, and real-world clinical workflows
Deliver real-world data assets that dismantle payer coverage barriers and ground product positioning strictly in clinical utility metrics
Evidence Dissemination and External Engagement
Convert complex epidemiological findings into clear, high-integrity scientific narratives for internal product governance and external healthcare stakeholders
Spearhead the development of peer-reviewed abstracts, posters, presentations, and core manuscripts for major oncology and diagnostic conferences
Engage with external clinical collaborators, investigators, and key opinion leaders (KOLs) to advance the platform base for early cancer detection
QUALIFICATIONS:
Advanced degree (PhD, MPH, MS, PharmD, or equivalent scientific credential) in epidemiology, health outcomes research, biostatistics, or a highly quantitative field
7+ years of experience leading real-world evidence generation, observational clinical research, or HEOR portfolios within the life sciences industry
Documented experience executing observational studies across the entire asset lifecycle, from initial protocol drafting through statistical analysis and publication
Deep data competency across real-world data sources, including longitudinal medical claims, electronic health records (EHR), and clinical registries
Direct experience in oncology clinical trials, molecular diagnostics, or early cancer detection programs is preferred
KNOWLEDGE, SKILLS, AND ABILITIES:
Take full ownership of complex clinical portfolios as an autonomous strategist
Rigorous analytical skills with the ability to pressure-test study assumptions and ground major milestones entirely in data
Communicate with technical precision across matrixed lines to align R&D, commercial, medical, and lab operations functions
Strong ownership mindset with the capability to balance scientific rigor, speed, and trial resource constraints under tight timelines
Comfort with ambiguity and an evolving product surface as underlying genomic science advances
The pay range is listed and actual compensation packages are based on a wide array of factors unique to each candidate, including but not limited to skill set, years & depth of experience, certifications and specific office location. This may differ in other locations due to cost of labor considerations.
Remote USA
$176,000—$220,000 USD
OUR OPPORTUNITY
Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.
The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.
WHAT WE OFFER
Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program!
Natera is proud to be an Equal Opportunity Employer. We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide.
All qualified applicants are encouraged to apply, and will be considered without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, veteran status, disability or any other legally protected status. We also consider qualified applicants regardless of criminal histories, consistent with applicable laws.
If you are based in California, we encourage you to read this important information for California residents.
Please be advised that Natera will reach out to candidates with a @natera.com email domain ONLY. Email communications from all other domain names are not from Natera or its employees and are fraudulent. Natera does not request interviews via text messages and does not ask for personal information until a candidate has engaged with the company and has spoken to a recruiter and the hiring team. Natera takes cyber crimes seriously, and will collaborate with law enforcement authorities to prosecute any related cyber crimes.
We are a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health.
Industry
Biotechnology Research
Company size
5,001-10,000 employees
Founded
2004
Headquarters
Austin, Texas
LinkedIn followers
230,553
Total funding
$1.2B
Natera™ is a global leader in cell-free DNA and precision medicine, dedicated to oncology, women’s health, and organ health. We aim to make personalized genetic testing and diagnostics part of the standard-of-care to protect health and inform earlier, more targeted interventions that help lead to longer, healthier lives. Natera’s tests are supported by more than 325 peer-reviewed publications that demonstrate excellent performance. Natera operates ISO 13485-certified and CAP-accredited laboratories certified under the Clinical Laboratory Improvement Amendments (CLIA) in Austin, Texas, and San Carlos, California, and through Foresight Diagnostics, its subsidiary, operates an ISO 27001-certified and CAP-accredited laboratory certified under CLIA in Boulder, Colorado.
Please be advised that Natera will only reach out to candidates with an @natera.com email domain. Email communications from all other domain names are not from Natera or its employees and are fraudulent. Natera does not request interviews via text messages and does not ask for personal information until a candidate has engaged with the company and has spoken to a recruiter and the hiring team. Natera takes cyber crimes seriously, and will collaborate with law enforcement authorities to prosecute any related cyber crimes.
https://www.natera.com/privacy/
Offices: 13011A McCallen Pass, Austin, Texas 78753, US · 201 Industrial Road, Suite 410, San Carlos, CA 94070, US
We are a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health.
Industry
Biotechnology Research
Company size
5,001-10,000 employees
Founded
2004
Headquarters
Austin, Texas
LinkedIn followers
230,553
Total funding
$1.2B
Natera™ is a global leader in cell-free DNA and precision medicine, dedicated to oncology, women’s health, and organ health. We aim to make personalized genetic testing and diagnostics part of the standard-of-care to protect health and inform earlier, more targeted interventions that help lead to longer, healthier lives. Natera’s tests are supported by more than 325 peer-reviewed publications that demonstrate excellent performance. Natera operates ISO 13485-certified and CAP-accredited laboratories certified under the Clinical Laboratory Improvement Amendments (CLIA) in Austin, Texas, and San Carlos, California, and through Foresight Diagnostics, its subsidiary, operates an ISO 27001-certified and CAP-accredited laboratory certified under CLIA in Boulder, Colorado.
Please be advised that Natera will only reach out to candidates with an @natera.com email domain. Email communications from all other domain names are not from Natera or its employees and are fraudulent. Natera does not request interviews via text messages and does not ask for personal information until a candidate has engaged with the company and has spoken to a recruiter and the hiring team. Natera takes cyber crimes seriously, and will collaborate with law enforcement authorities to prosecute any related cyber crimes.
https://www.natera.com/privacy/
Offices: 13011A McCallen Pass, Austin, Texas 78753, US · 201 Industrial Road, Suite 410, San Carlos, CA 94070, US