Cary, North Carolina, United States · Hybrid
$95k–$177k/yr
The Position Principal Automation Engineer - Warehouse Automation (Holly Springs) Welcome to Holly Springs, North Carolina— home to Roche/Genentech's largest-ever investment: a $2B greenfield start-up where next-generati…
Skills: PLC Troubleshooting, SAP EWM, Warehouse Control Systems, AGV Fleet Management, AS/RS Systems
San Diego County, California, United States · On-site
$120k–$224k/yr
The Position The Principal Program Manager - Environment/Sustainability will be instrumental in defining and executing the site’s environmental stewardship and sustainability initiatives. This position is responsible for…
Skills: Decarbonization, Sustainability Strategy, ESG Reporting, Environmental Compliance, Program Management
Boise, Idaho, United States · On-site
$96k–$179k/yr
The Position Surgical Device Specialist (SDS), Ophthalmology – Pacific North West An ever-transforming healthcare landscape requires a high level of agility and flexibility to navigate. At Genentech, we pride ourselves i…
Skills: Surgical Device Training, Customer Relationship Management, Consultative Selling, Lead Generation, Technical Education
Daly City, California, United States · On-site
$100k–$107k/yr
The Position A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we al…
Skills: High-Plex Imaging Assays, Computational Image Analysis, Machine Learning, Python, Single-Cell Genomics
Daly City, California, United States · On-site
$100k–$186k/yr
The Position We advance science so that we all have more time with the people we love. Genentech's Translational Medicine OMNI (TM OMNI) Department supports the entire R&D portfolio of novel therapies across Ophthalmolog…
Skills: Proteomics, Transcriptomics, Simoa, NULISA, R
Daly City, California, United States · Hybrid
$177k–$329k/yr
The Position Why Genentech We're passionate about delivering on Our Promise to improve the lives of patients and create healthier communities for all. We foster a culture of inclusivity, integrity and creativity while bo…
Skills: Generative AI, Agentic Design, RAG Architecture, LangChain, LangGraph
Oklahoma City, Oklahoma, United States · On-site
$210k–$390k/yr
The Position Director, Field Leadership & Strategic Accounts - Texoma Ecosystem From the beginning, Genentech has been a team of highly dedicated, passionate individuals. We are a place where people are united around a s…
Skills: Field Management, Account Management, Strategic Planning, Relationship Management, Negotiation
Daly City, California, United States · On-site
$142k–$263k/yr
The Position Senior Manager, Product Public Relations Why Genentech From the beginning, Genentech has been a team of highly dedicated, passionate individuals. We are a place where people are united around a single purpos…
Skills: Public Relations, Communications Strategy, Media Relations, Issues Management, Stakeholder Management
Bedford, England, United Kingdom · On-site
$138k–$255k/yr
The Position Therapeutic Area Manager (TAM), Respiratory – Eastern New England Ecosystem From the beginning, Genentech has been a team of highly dedicated, passionate individuals. We are a place where people are united a…
Skills: Account Management, Cross-functional Collaboration, Clinical Demand Generation, Patient Access Strategy, Healthcare Ecosystem Engagement
Daly City, California, United States · On-site
$148k–$274k/yr
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Skills: Product Management, Omnichannel Orchestration, Data Analytics, Audience Management, Segmentation
Daly City, California, United States · On-site
$173k–$322k/yr
The Position A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we al…
Skills: Clinical Leadership, Scientific Communication, Medical Affairs Strategy, Clinical Study Design, Health Economic Data Analysis
Daly City, California, United States · On-site
$145k–$269k/yr
The Position A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we al…
Skills: Synthetic Organic Chemistry, Process Chemistry, Chemo-catalysis, Bio-catalysis, Organometallic Chemistry
Daly City, California, United States · On-site
$100k–$186k/yr
The Position We advance science so that we all have more time with the people we love. The Translational Medicine OMNI department at Genentech provides the scientific and strategic framework to inform clinical developmen…
Skills: Biomarker Discovery, Multi-omics Analysis, Clinical Biospecimen Handling, Single-cell RNA-seq, CITE-seq
Hillsboro, Oregon, United States · On-site
$93k–$173k/yr
The Position This role is a valuable part of our Hillsboro Innovative Therapies (HIT) Quality Systems and Validation team, which is committed to achieving our mission of delivering novel and exciting biopharmaceutical te…
Skills: Quality Assurance, Computer System Validation, cGMP, Site Qualification, Equipment Validation
Daly City, California, United States · On-site
$153k–$285k/yr
The Position This role is in Early Development Biometrics (EDB), a core function within Product Development Data Sciences (PDD) that provides strategic leadership and scientific rigor across early clinical development at…
Skills: Clinical Trial Design, Biostatistics, SAS, R, CDISC Standards
Los Angeles, California, United States · On-site
$108k–$201k/yr
The Position A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we al…
Skills: High-throughput Library Screening, Molecular Cloning, Nucleic Acid Manipulation, Mammalian Expression Vector Design, Golden Gate Cloning
Daly City, California, United States · On-site
$171k–$317k/yr
The Position Enterprise Architect - Pharma Commercial The Opportunity The Enterprise Architect - Pharma Commercial acts as the strategic bridge between the central Strategy, Portfolio & Governance (SPG) organization and …
Skills: Enterprise Architecture, Domain Architecture, Pharma Commercial Operations, Cloud-Native Ecosystems, Veeva
Louisville, Kentucky, United States · On-site
$112k–$209k/yr
The Position This role is a highly valuable part of our Enterprise Risk Management (ERM) and Business Continuity Management (BCM) team, which is committed to safeguarding Genentech’s primary US distribution network and e…
Skills: Enterprise Risk Management, Business Continuity Management, Crisis Management, Business Impact Analysis, Physical Security
Daly City, California, United States · On-site
$145k–$269k/yr
The Position A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we al…
Skills: Computational Chemistry, Induced Proximity, Molecular Dynamics, AI/ML, Python
Daly City, California, United States · On-site
$90k–$140k/yr
The Position A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we al…
Skills: Executive Support, Calendar Management, Event Coordination, Cross-functional Communication, Travel Management
Cary, North Carolina, United States • Hybrid
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Responsible for the technical integrity and optimization of automated material handling systems, including AS/RS, WCS, and AGV fleets. Acts as the primary technical escalation point to ensure seamless pharmaceutical stock movement and GxP compliance.
Requires a Bachelor's or Master's degree in Engineering or Computer Science with 6-8+ years of automation experience, preferably in drug product manufacturing. Must have proficiency in PLCs, SAP EWM interfaces, and knowledge of GAMP5 and 21 CFR Part 11 standards.
Principal Automation Engineer - Warehouse Automation (Holly Springs)
Welcome to Holly Springs, North Carolina— home to Roche/Genentech's largest-ever investment: a $2B greenfield start-up where next-generation technology, high-performing teams and Operational Excellence converge to create the global standard for high-volume, highly-efficient Drug Product manufacturing.
The facility's core is defined by Innovation - leveraging advanced automation, robotics, digital tools, real-time data analytics, and simple, streamlined processes to produce the highest quality medicines. This plant meets today’s demand for CVRM (Cardiovascular, Renal, and Metabolism) medicines and is scalable to grow with the portfolio, which focuses on next-generation metabolic medicines specifically targeting the global obesity epidemic and Type 2 diabetes. This is a fast-paced, entrepreneurial environment with a high-level of accountability, with planned launch in 2028.
ITOT supports Pharma Technical Manufacturing (PTM), PTM is responsible for managing all aspects of end-to-end drug substance and drug product manufacturing and supply. From the raw material to the final medicine, we contribute to deliver Roche’s ground-breaking therapies to more than 120 million patients around the world. We make our medicines at 9 sites around the world and coordinate all aspects of production of Roche medicines in all disease areas and dosage forms. To ensure readiness for a step-change in the standard of care that Roche delivers in the area of Cardiovascular, Renal and Metabolism (CVRM), PTM will construct a new manufacturing site in the U.S. in Holly Spring, North Carolina. ITOT will own and operate Manufacturing Technology stack at the site working with Global IT. The new site will focus on large volume low-cost Drug Product manufacturing (Component Prep & Compounding, Liquid PFS Filling, Automated Inspection, Autoinjector Assembly, Packaging/Finished Products).
Principal Automation Engineer is being hired to participate in Greenfield Project execution and then support the facility after going live.
Initially, you will perform a mix of remote and onsite work (first at the General Planner’s office, later at construction site/plant). You will transition to local full-time on-site work once the site buildings are built and equipment delivered. Travel of up to 30% of the time is expected during the project phase.
The Principal Automation Engineer - Warehouse Automation is responsible for the technical integrity, reliability, and optimization of the automated material handling systems within the Holly Springs facility. This role serves as the subject matter expert for the Körber K.One.X (Warehouse Control System), high-density Automated Storage and Retrieval System (AS/RS systems), and the Automated Guided Vehicle (AGV) fleet. You will bridge the gap between physical hardware and the digital warehouse layer, ensuring that pharmaceutical stock moves seamlessly and safely through the production lifecycle while maintaining strict GxP compliance. The role will also have responsibilities for Robotics Fleet management System that may be shared with Site Robotics Engineer. Leading automation impacting projects with large and/or complex scope and Driving strategic initiatives to improve business processes are also expected.
System Health Monitoring: Monitor the daily performance of the Körber K.One.X (WCS) and AS/RS, proactively identifying "stuck" telegrams or queue bottlenecks before they impact production output.
L2/L3 Technical Support: Act as the highest internal escalation point for complex automation failures. Troubleshoot the handshake between PLC layers and the WCS to resolve hardware-software "mismatches" in real-time.
Disaster Recovery: Maintain and periodically test the system recovery procedures for the WCS and PLC configurations to ensure rapid restoration of the warehouse flow in the event of a server or network failure.
Fleet Availability: Manage the daily operational readiness of the AGV fleet, overseeing battery health, charging station rotations, and sensor calibration to ensure 99%+ fleet availability.
Dynamic Traffic Tuning: Adjust FMS (Fleet Management System) parameters (e.g., zone blocking, speed limits, or path priorities) based on shifting daily operational volumes to prevent congestion in high-traffic corridors.
Safety Integrity: Conduct routine operational audits of AGV safety fields and emergency stop circuits to ensure the equipment continues to operate within its validated safety envelope.
Manage Site Robotics Fleet Management Systems in partnership with future Robotics functions at the site.
Interface Oversight: Monitor the SAP EWM-to-WCS (Black Box) message logs (IDocs/Web Services), resolving data discrepancies to ensure that the physical location of pharmaceutical stock always matches its digital twin in SAP.
Audit Trail Compliance: Ensure that all automated logs and event data required by 21 CFR Part 11 are accurately captured, archived, and available for regulatory inspections or quality audits.
Continuous Optimization: Analyze OEE (Overall Equipment Effectiveness) data from the WCS and AGV systems to propose small-scale logic adjustments that improve cycle times and reduce mechanical wear and tear.
Bachelor’s degree in Chemical, Mechanical, Electrical, or Computer Science or a related discipline and 8 years of applicable automation and/or instrument and control system experience preferably majority in drug product function. Or, Master's degree in Engineering or a related discipline and 6 years of applicable automation and/or instrument and control system experience preferably majority in drug product function.
5 years in the pharmaceutical/biotech industry/GMP experience is highly preferred.
24X7 on call support, participate in an on-call environment to meet business continuity requirements, including weekends and holidays as required.
Proficiency in troubleshooting PLCs (Siemens TIA Portal or Rockwell Automation) and their communication protocols (Profinet/EtherNet/IP).
Strong understanding of SAP EWM or similar WMS interfaces (IDocs, queues, and RFC calls).
Familiarity with AGV navigation technologies (Laser, Natural, or Magnetic) and FMS software.
Knowledge of GAMP5 standards and 21 CFR Part 11 requirements is highly preferred.
Analytical mindset with the ability to perform root-cause analysis under production pressure.
Excellent communication skills to translate complex technical issues for cross-functional stakeholders in Logistics and Quality.
Ability to work in a high-density warehouse environment, which may include working at heights or in proximity to moving automated machinery.
On-call support for 24/7 warehouse operations.
The expected salary range for this position based on the primary location of Holly Springs, North Carolina is $95,200 - $176,800. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
About Genentech We're passionate about finding solutions for people facing the world's most difficult-to-treat conditions. That is why we use cutting-edge science to create and deliver innovative medicines around the globe. To us, science is personal. Making a difference in the lives of millions starts when you make a change in yours. If you’d like to join our team, view our openings at gene.com/careers. Our patient resource center is dedicated to getting patients and caregivers to the right resources. You can reach them at 1 (877) GENENTECH (436-3683) Monday-Friday, 6am-5pm PST or [email protected]. Community Guidelines: 1. We want to foster positive conversation around the issues we are passionate about. To that end, we remove profanity, content that contains threatening language, content that is aimed at private individuals, personal information, and repeated unwanted messages. 2. Don’t mention any medicines by name — ours or anyone else’s. Because of the fair balance rules governing our industry, we cannot post any comments that reference any pharmaceutical brand, product, or service. Please do not mention any specific medicines by name, or include any links to third party sites in your comments. 3. This isn’t the place to report or discuss side effects. This site is not intended as a forum for reporting side effects experienced while taking a Genentech product. Instead, you should report any side effects to Genentech Drug Safety at 1-888-835-2555. You can also report side effects of any prescription product directly to the FDA at 1-800-FDA-1088 or by visiting www.FDA.gov/medwatch. 4. Don’t pitch your product or service. Please don't use our page as a place to promote your product or pitch your services. Please also avoid posting links to external sites. We reserve the right to remove any posts that are deemed promotional.
Offices: 1 Dna Way, South San Francisco, California 94080, US · 1000 New Horizons Way, Vacaville, California 95688, US · 1 Antibody Way, Oceanside, California 92056, US · 4625 NE Brookwood Pkwy, Hillsboro, Oregon 97124, US
About Genentech We're passionate about finding solutions for people facing the world's most difficult-to-treat conditions. That is why we use cutting-edge science to create and deliver innovative medicines around the globe. To us, science is personal. Making a difference in the lives of millions starts when you make a change in yours. If you’d like to join our team, view our openings at gene.com/careers. Our patient resource center is dedicated to getting patients and caregivers to the right resources. You can reach them at 1 (877) GENENTECH (436-3683) Monday-Friday, 6am-5pm PST or [email protected]. Community Guidelines: 1. We want to foster positive conversation around the issues we are passionate about. To that end, we remove profanity, content that contains threatening language, content that is aimed at private individuals, personal information, and repeated unwanted messages. 2. Don’t mention any medicines by name — ours or anyone else’s. Because of the fair balance rules governing our industry, we cannot post any comments that reference any pharmaceutical brand, product, or service. Please do not mention any specific medicines by name, or include any links to third party sites in your comments. 3. This isn’t the place to report or discuss side effects. This site is not intended as a forum for reporting side effects experienced while taking a Genentech product. Instead, you should report any side effects to Genentech Drug Safety at 1-888-835-2555. You can also report side effects of any prescription product directly to the FDA at 1-800-FDA-1088 or by visiting www.FDA.gov/medwatch. 4. Don’t pitch your product or service. Please don't use our page as a place to promote your product or pitch your services. Please also avoid posting links to external sites. We reserve the right to remove any posts that are deemed promotional.
Offices: 1 Dna Way, South San Francisco, California 94080, US · 1000 New Horizons Way, Vacaville, California 95688, US · 1 Antibody Way, Oceanside, California 92056, US · 4625 NE Brookwood Pkwy, Hillsboro, Oregon 97124, US
