Daly City, California, United States · On-site
$148k–$311k/yr
The Position A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we al…
Skills: LLM-driven Agents, Python, PyTorch, JAX, LangChain
Daly City, California, United States · On-site
$100k–$186k/yr
The Position We advance science so that we all have more time with the people we love. Genentech's Translational Medicine OMNI (TM OMNI) Department supports the entire R&D portfolio of novel therapies in Ophthalmology, M…
Skills: Bioinformatics, Wet Lab Experience, Omics Data Analysis, Assay Development, R
Daly City, California, United States · On-site
$110k–$120k/yr
The Position We advance science so that we all have more time with the people we love. The Department of Human Genetics at Genentech is seeking a highly motivated Postdoctoral Fellow (Computational) to develop and apply …
Skills: Computational Biology, Bioinformatics, Statistical Genetics, Rare-Variant Association Testing, Protein Structure Analysis
Daly City, California, United States · On-site
$129k–$239k/yr
The Position Why Genentech We’re passionate about delivering on Our Promise to improve the lives of patients and create healthier communities for all. We foster a culture of inclusivity, integrity and creativity w…
Skills: UX/UI Design, Human-Centered Design, Figma, Rapid Prototyping, Usability Testing
Daly City, California, United States · Hybrid
$162k–$301k/yr
The Position Why Genentech We’re passionate about delivering on Our Promise to improve the lives of patients and create healthier communities for all. We foster a culture of inclusivity, integrity and creativity w…
Skills: Market Strategy, Customer Journey Mapping, Competitive Analysis, Brand Positioning, Cross-functional Leadership
San Diego County, California, United States · On-site
$66k–$110k/yr
The Position We are seeking an experienced QC Associate II to support direct material (raw material) testing. This role requires technical proficiency in chemical assays and compendial testing, balancing hands-on routine…
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Daly City, California, United States · On-site
$247k–$459k/yr
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Boise, Idaho, United States · On-site
$96k–$179k/yr
The Position Surgical Device Specialist (SDS), Ophthalmology – Pacific North West An ever-transforming healthcare landscape requires a high level of agility and flexibility to navigate. At Genentech, we pride ourselves i…
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Daly City, California, United States · On-site
$148k–$320k/yr
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Skills: Machine Learning, Python, PyTorch, JAX, Tensorflow
Daly City, California, United States · On-site
$173k–$322k/yr
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San Diego County, California, United States · Hybrid
$89k–$165k/yr
The Position The Opportunity We are looking for a Finance Enterprise Partner supporting Pharma Technical (PT) Operations. This position will support the Pharma Tech Operations in Oceanside, CA as well as have the opportu…
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Hillsboro, Oregon, United States · On-site
$65k–$101k/yr
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Skills: Quality Control, Analytical Testing, cGMP, Assay Performance, Method Validation
Daly City, California, United States · Hybrid
$103k–$191k/yr
The Position Job Description: As a Procurement Manager, you will work in a dynamic global environment where you bring analytical thinking, planning, execution, and focus to the procurement sourcing and delivery capabilit…
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Daly City, California, United States · Remote OK
$173k–$321k/yr
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Skills: Data Analytics, Strategic Advisory, Stakeholder Management, Healthcare Market Analysis, Python
Daly City, California, United States · On-site
$160k–$298k/yr
The Position Senior Manager, Digital Finance Portfolio & Governance A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today an…
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Daly City, California, United States · On-site
The Position 2026 Fall Intern - Translational Medicine/Oncology Department Summary The Department of Translational Medicine leads biomarker discovery and development efforts for programs in Early Stage Research through P…
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Daly City, California, United States · On-site
$202k–$374k/yr
The Position We are seeking a visionary Senior Director of Construction Delivery to lead one of Genentech's most significant capital initiatives—a billion-dollar-plus CAPEX project at our South San Francisco campus. This…
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Philadelphia, Pennsylvania, United States · On-site
$91k–$169k/yr
The Position We advance science so that we all have more time with the people we love. The Opportunity: The Downstream Process Development (DSPD) team is seeking a highly motivated Scientist with a specialized focus on f…
Skills: Downstream Process Development, Ultrafiltration/Diafiltration, Tangential Flow Filtration, Biologics Purification, Process Optimization
Daly City, California, United States · On-site
$115k–$213k/yr
The Position The Opportunity The Federal Pricing Manager performs as well as reviews multiple complex pricing calculations to determine pricing for government agencies in compliance with strict accuracy targets, timeline…
Skills: Government Pricing, Data Analysis, Financial Reconciliation, Compliance, Regulatory Interpretation
Daly City, California, United States · Hybrid
$131k–$243k/yr
The Position A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we al…
Skills: Multimodal Data Integration, Machine Learning, R, Python, Computational Biology
Daly City, California, United States • On-site
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Develop autonomous, LLM-driven agentic workflows to orchestrate ML models and physics-based methods for small-molecule drug design. Collaborate with chemists and structural biologists to optimize hypotheses and drive scientific impact through publications and open-source releases.
Requires a PhD or equivalent research depth in machine learning, computer science, or a related quantitative field. Must be proficient in Python, modern agentic frameworks, and have a strong foundation in ML and cheminformatics toolkits.
A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That’s what makes us Roche.
Advances in AI, data, and computational sciences are transforming drug discovery and development. Roche’s Research and Early Development organisations at Genentech (gRED) and Pharma (pRED) have demonstrated how these technologies accelerate R&D, leveraging data and novel computational models to drive impact. Seamless data sharing and access to models across gRED and pRED are essential to maximising these opportunities. The new Computational Sciences Center of Excellence (CoE) is a strategic, unified group whose goal is to harness the transformative power of data and Artificial Intelligence (AI) to assist our scientists in both pRED and gRED to deliver more innovative and transformative medicines for patients worldwide.
Join the small-molecule team within AI for Drug Discovery (AI4DD), formerly Prescient Design, at Roche and Genentech’s Computational Sciences Center of Excellence as a Machine Learning Scientist / Senior Machine Learning Scientist building agents for applied small-molecule drug design. You will develop autonomous, LLM-driven agentic workflows that orchestrate ML models, physics-based methods, and cheminformatics tools to accelerate discovery, working with world-class chemists and structural biologists.
Design, build, and apply agentic workflows and ML models for key challenges in small-molecule drug design.
Fine-tune foundation models for drug discovery relevant topics using internal and external datasets and tools.
Optimize agent-derived hypotheses in close collaboration with world-class computational and medicinal chemists and structural biologists.
Drive scientific impact through publications, open-source releases, and conference talks.
Collaborate widely with computational and experimental researchers at Roche and with academic partners.
You are experienced developing LLM-driven agents for scientific workflows and you understand how to orchestrate tools and models reliably.
You bring strong machine-learning foundations in linear algebra, probability and optimization, with hands-on experience with GNNs, sequence/language models and reinforcement learning.
You are fluent in Python and modern agentic coding environments such as LangChain, ML frameworks such as PyTorch or JAX, as well as cheminformatics toolkits like RDKit or OpenEye.
You hold a PhD or equivalent research depth in machine learning, computer science, chemical engineering or a related quantitative field such as physics or statistics, with up to 2 years of industry research experience (Scientist) or 2+ years of industry research experience (Senior Scientist).
You have a record of scientific excellence evidenced by journal and conference publications or a public portfolio of relevant projects (e.g. hosted on GitHub/GitLab)..
Preferred:
Hands-on experience orchestrating multi-tool or multi-agent scientific pipelines.
Hand-on experience working along the small molecule drug discovery value chain and an excitement to engage with chemists
Familiarity with structural biology datasets
If you want to put autonomous AI to work discovering the medicines patients need next, apply now and help build the future of drug design at Roche.
Relocation benefits are NOT available for this opportunity
The expected salary range for this position, based on the primary location of San Francisco, is $147,600 - $274,000 for the ML Scientist, and $167,400 - 310,800 for the Senior ML Scientist. For the primary of location of New York City, $141.100 - $262,100 for the ML Scientist, and $160,100 - 297,300 for the Senior ML Scientist. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
#ComputationCoE
#tech4lifeComputationalScience
#tech4lifeAI
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
About Genentech We're passionate about finding solutions for people facing the world's most difficult-to-treat conditions. That is why we use cutting-edge science to create and deliver innovative medicines around the globe. To us, science is personal. Making a difference in the lives of millions starts when you make a change in yours. If you’d like to join our team, view our openings at gene.com/careers. Our patient resource center is dedicated to getting patients and caregivers to the right resources. You can reach them at 1 (877) GENENTECH (436-3683) Monday-Friday, 6am-5pm PST or [email protected]. Community Guidelines: 1. We want to foster positive conversation around the issues we are passionate about. To that end, we remove profanity, content that contains threatening language, content that is aimed at private individuals, personal information, and repeated unwanted messages. 2. Don’t mention any medicines by name — ours or anyone else’s. Because of the fair balance rules governing our industry, we cannot post any comments that reference any pharmaceutical brand, product, or service. Please do not mention any specific medicines by name, or include any links to third party sites in your comments. 3. This isn’t the place to report or discuss side effects. This site is not intended as a forum for reporting side effects experienced while taking a Genentech product. Instead, you should report any side effects to Genentech Drug Safety at 1-888-835-2555. You can also report side effects of any prescription product directly to the FDA at 1-800-FDA-1088 or by visiting www.FDA.gov/medwatch. 4. Don’t pitch your product or service. Please don't use our page as a place to promote your product or pitch your services. Please also avoid posting links to external sites. We reserve the right to remove any posts that are deemed promotional.
Offices: 1 Dna Way, South San Francisco, California 94080, US · 1000 New Horizons Way, Vacaville, California 95688, US · 1 Antibody Way, Oceanside, California 92056, US · 4625 NE Brookwood Pkwy, Hillsboro, Oregon 97124, US
About Genentech We're passionate about finding solutions for people facing the world's most difficult-to-treat conditions. That is why we use cutting-edge science to create and deliver innovative medicines around the globe. To us, science is personal. Making a difference in the lives of millions starts when you make a change in yours. If you’d like to join our team, view our openings at gene.com/careers. Our patient resource center is dedicated to getting patients and caregivers to the right resources. You can reach them at 1 (877) GENENTECH (436-3683) Monday-Friday, 6am-5pm PST or [email protected]. Community Guidelines: 1. We want to foster positive conversation around the issues we are passionate about. To that end, we remove profanity, content that contains threatening language, content that is aimed at private individuals, personal information, and repeated unwanted messages. 2. Don’t mention any medicines by name — ours or anyone else’s. Because of the fair balance rules governing our industry, we cannot post any comments that reference any pharmaceutical brand, product, or service. Please do not mention any specific medicines by name, or include any links to third party sites in your comments. 3. This isn’t the place to report or discuss side effects. This site is not intended as a forum for reporting side effects experienced while taking a Genentech product. Instead, you should report any side effects to Genentech Drug Safety at 1-888-835-2555. You can also report side effects of any prescription product directly to the FDA at 1-800-FDA-1088 or by visiting www.FDA.gov/medwatch. 4. Don’t pitch your product or service. Please don't use our page as a place to promote your product or pitch your services. Please also avoid posting links to external sites. We reserve the right to remove any posts that are deemed promotional.
Offices: 1 Dna Way, South San Francisco, California 94080, US · 1000 New Horizons Way, Vacaville, California 95688, US · 1 Antibody Way, Oceanside, California 92056, US · 4625 NE Brookwood Pkwy, Hillsboro, Oregon 97124, US
