All startups in San Francisco

SmithRx

San Francisco

Our mission is to reduce the cost and complexity of pharmacy benefits for America’s employers and patients. Pharmacy benefits are broken. The overly complex monopolies built by big PBMs only serve their bottom lines. SmithRx is a transparent, pass-through pharmacy benefits manager for self-insured employers. We operate independently from insurance companies and pharmacies so that our incentives are 100% aligned with our customers. Our modern technology and innovative cost savings programs connect our members to the lowest cost drugs. Get in touch with us to today to learn how to save on your pharmacy spend!

OODA Health

San Francisco

Founded in 2017 by a team of experienced digital health and technology executives, OODA Health is transforming the administration of healthcare. Today, the US healthcare system wastes $400 billion every year on an outdated and broken claims adjudication process that creates friction and frustration for payers, providers and patients alike. Patients wrestle with surprise bills that arrive months after care is received and are impossible to understand. Providers suffer unexpected denials and delays for reimbursement, and chase patients for payment rather than focus on delivering care. Payers are locked in zero sum negotiations with providers, unable to advance care management goals. OODA Health is transforming the administrative experience in healthcare by enabling collaborative, real-time interactions between providers, members and payers. With the OODA Health solution, claims adjudication will be instantaneous, and providers will be paid upon patient checkout. Payers will assume responsibility for patient collections, guaranteeing immediate payment to the provider and relieving physicians from chasing patients for money. Care management strategies will be based on real-time patient risk models, rather than retrospective claim reviews. Critical interactions will occur at the point of care, rather than months after an encounter. We are a passionate, growing team looking for dedicated teammates to make a major impact on the healthcare system. We are committed to living our company values to provide a positive and dynamic working environment for our team members.

Ikigai

San Francisco

Built upon years of MIT research, Ikigai is a generative AI platform for tabular and time series data. It helps operational teams make faster, better decisions under uncertainty and works with any data: structured or unstructured, clean or dirty, small or big. Unlock the power of AI within a few clicks to: - Prep your data with aiMatch - Predict with aiCast - Do scenario analysis with aiPlan.

Polly

San Francisco

Polly is a mortgage technology company that drives ROI through innovation enabling configurability, flexibility, granularity, and scalability in mortgage capital markets, serving banks, credit unions, and mortgage lenders; named to Forbes America's Best Startup Employers in 2025 and 2026.

Aven

San Francisco

Our mission is to provide the lowest cost, most convenient, and most transparent access to capital.

Ubiquity6 Inc. (acquired by Discord)

San Francisco

The future of communication. Acquired by Discord in 2021. Backed by $50M+ from Benchmark, Index, Kleiner, First Round, Disney.

Fuzzy

San Francisco

We're building the future of pet health care. Members pet parents get 24/7 access to exceptional virtual veterinary care in less than 1 minute, with pet health & wellness products for their pets' health needs.

WeTravel

San Francisco

At WeTravel, we believe managing multi-day travel should be seamless—so you can focus on delivering unforgettable experiences, not juggling tools. Our all-in-one platform powers the complete traveler journey, trusted by thousands of travel businesses worldwide. From custom, bookable itineraries to automated pre-departure tasks, global payment processing, and supplier payouts—we give you everything you need to run your business, grow revenue, and wow travelers at every step.

Mekonos

San Francisco

Mekonos is a Silicon Valley Venture-backed Life Sciences company — creating a proprietary cell-engineering platform based on scalable silicon technology for our partners engaged in cell & gene therapies and cell line development.

Habu

San Francisco

Collaborative Intelligence for Decentralized Data

Bullish

San Francisco

The Bullish digital asset exchange offers market-leading order depth and consistently tight spreads all in a regulated environment. Bullish is regulated by the German Federal Financial Supervisory Authority (BaFIN ID 10162355/ BakNr 162355), the Hong Kong Securities and Futures Commission (CE No BUQ956) and the Gibraltar Financial Services Commission (DLT license: FSC1038FSA). Geographic restrictions apply. In the UK our services are available solely for HNW Companies and Professional Investors, and no other UK persons. Availability in the US is limited. Important info and risk warnings here: bullish.com/legal

Intercept Music

San Francisco

Intercept Music, a Sanwire Corporation $SNWR (OTC PINK:SNWR) provides new power tools to distribute your music directly to the masses and major streaming platforms. We are here to empower independent artists and labels across the globe. Independence Empowered. After you’ve created your music with the help of band members, songwriters, engineers, producers, and graphic artists, you need to master social media marketing, distribution, playlists, press releases, reviews, online advertising, licensing, and merchandising. This can be overwhelming, and many artists settle for doing only a few of the things that they need to break out. Our goal is to change this paradigm. All the technologies an artist needs to distribute and market their craft should exist in one place. We believe in leveraging technology to do the majority of the work to keep it simple. The music industry is a fragmented marketplace. Many services must come together for your success. If you have a label backing you, that’s easy. The label does everything, and you focus on your music in exchange for a big chunk of profit. However, if you're on your own the learning curve is steep. Our software and services are built on proven processes utilized by established acts and key industry leaders. They will continue to evolve as the music industry does. Intercept Music is an unbeatable suite of artist-focused services backed by people responsible for millions of dollars in record sales. Intercept Music is here for you!

Neuromation

San Francisco

Neuromation is a leading Enterprise AI solutions and platform provider recently recognized by Gartner as a "Cool Vendors in AI Core Technologies."​ The company's Neuro platform is a best-in-class machine learning development tool enabling rapid model iteration with an unparalleled developer experience.

ixlayer

San Francisco

ixlayer is the leading provider of cloud-based platforms empowering greater operational efficiency, patient access, and improved outcomes. Seamlessly integrating with all systems, ixlayer’s platforms empower biopharma organizations to accelerate speed to market and drive engagement and compliance, while improving brand loyalty. To learn more, visit www.ixlayer.com.

Two Chairs

San Francisco

We’re building a world where everyone has access to exceptional mental health care. Two Chairs is setting a new care standard with seamlessly integrated therapy and psychiatry that’s delivered by highly trained clinicians, powered by smart technology, and measured for real impact. We combine fast access, personalized care, and proven outcomes to create a system that actually works — for patients, providers, health plans, and clinicians alike. Learn more at twochairs.com.

Notion

San Francisco

Notion blends your everyday work tools into one. Product roadmap? Company wiki? Meeting notes? With Notion, they're all in one place, and totally customizable to meet the needs of any workflow. It's the all-in-one workspace for you, your team, and your whole company. We humans are toolmakers by nature, but most of us can't build or modify the software we use every day — arguably our most powerful tool. Our team at Notion is on a mission to make it possible for everyone to shape the tools that shape their lives.

VGM Group

San Francisco

Welcome to the VGM Group page where you can learn more about what makes our company a little different. The first thing you should know is VGM Group is more than one company. As you get to know us, you’ll notice names like VGM & Associates,

Qualio

San Francisco

Qualio provides quality management solutions for life sciences, serving medical device, pharmaceutical, biotech, and contract organizations. It enables GxP, FDA, and ISO compliance, unites teams and data, and helps 650+ companies in 80 coun

Gradle

San Francisco

Gradle Inc. is the award-winning maker of the Gradle Build Tool, one of the world’s most used build systems, and the Develocity developer toolchain observability platform. Its Develocity platform is used by Netflix, LinkedIn, ASML, Airbnb,

Peek

San Francisco

Peek.com operates software and a marketplace that lets consumers book experiences; with $2 billion in bookings, it serves thousands of operators who boost revenue and automate operations, and its award-winning marketplace features Museum of

Ironclad

San Francisco

Ironclad is an SF-based software company offering a digital contracting platform to streamline legal workflows. Founded in 2014 and a YC Summer 2015 alum, it has 400 employees and investors Accel, Greylock, SV Angel, Formation 8, serving Gu

Verge Genomics

San Francisco

Verge Genomics uses AI and human tissue data in its CONVERGE platform to map disease biology, identify targets, and de-risk drug development, with two drugs in clinical trials, 282 targets discovered, and partnerships worth $1.6B.

Cuyana

San Francisco

Cuyana offers timeless, well-made women's fashion built on a 'fewer, better' philosophy, using high-quality materials and global craftsmanship; the brand is notable for integrity, careful design, and driving changes in the retail landscape.

Coinbase

San Francisco

Coinbase aims to increase economic freedom by building an on-chain platform to help shape the future global financial system through crypto and blockchain technology.

Everest

San Francisco

The company builds AI employees for IT services, aiming to transform the $300B IT services industry from 10–20% margins to software margins by turning outsourced IT support into a software business and building a $100B company that changes

Y Combinator

San Francisco

Y Combinator is a leading startup accelerator founded in 2005 by Jessica Livingston that runs programs to support startups, including the YC Program, Startup School, and Co-Founder Matching, and provides resources, deals, and ongoing guidan

ClassDojo

San Francisco

ClassDojo is a San Francisco-based education platform that connects teachers, children and families through a communication app, serving 51 million+ users in 180 countries and reaching 95% of US pre-K–8 schools, making it one of the fastest

Caresyntax

San Francisco

Caresyntax provides an AI-powered, vendor-neutral platform that integrates software, devices, and clinical services to improve surgical outcomes, with deployment in 4,200+ operating rooms and support for over 3 million procedures annually.

Skycatch

San Francisco

Skycatch is a leading industrial data collection and analytics company that uses hardware, software, and AI to deliver high-precision data from the physical world. It provides turnkey enterprise solutions deployed globally for major constru

DoorDash

San Francisco

DoorDash is a San Francisco-based technology company building a local delivery platform by partnering with merchants, hiring drivers, and developing logistics software to enable real-time delivery of goods and services. It aims to be the wo

Mosaic

San Francisco

Mosaic is developing an agentic video editing paradigm to build an agentic video editor. Its ex-Tesla engineering team has won the Google Gemini Kaggle grand prize ($25,000) from 6,400 entrants and the SaaStr AI Pitch competition.

Ridecell

San Francisco

Ridecell leads the digital transformation of fleet operations in Europe and North America, serving fleet operators and governments for clients such as Penske, Toyota, Ford, Daimler, BMW, BNP Paribas and Arval, including San Francisco and Ne

Raindrop

San Francisco

Raindrop provides monitoring and alerting for AI applications. Backed by Y Combinator, it counts investors including James Tamplin, Guillermo Rauch, Balaji Srinivasan, Matt MacInnis, and backers from OpenAI, Apple, Figma, Scale.

Anagram

San Francisco

Anagram enables eye care providers to focus on running a successful practice and delivering patient care by supporting the business side of their profession.

Nylas

San Francisco

Nylas provides a single integration platform that gives developers universal access to email, calendar, and contacts providers. Hundreds of thousands of developers worldwide use Nylas.

Hivemapper

San Francisco

Hivemapper builds a continuously refreshed map from street-level imagery contributed by a decentralized network of drivers and fleets, mapping over 100 million kilometers across 90+ countries and 6 million unique roads, highlighting its glo

Humble Bundle

San Francisco

Humble began with the Humble Bundle charity bundles in 2010 and now runs regular bundles of games, books, and software to support charity via an online storefront, having raised $240 million; Humble Games acts as a publisher supporting deve

Arable

San Francisco

Arable advances sustainable agriculture by transforming agronomic decisions with technology. In 50+ countries, backed by Galvanize Climate Solutions, Qualcomm Ventures, Prelude, S2G, and Grupo Jacto, it powers irrigation optimization and ag

Canvas

San Francisco

Canvas, a small team, is building AI Operating System for B2B sales, backed by Y Combinator, to automate boring parts of outbound so humans can focus on finding and connecting with prospects, via AI research agents and on-demand human SDRs.

Aarki

San Francisco

Aarki is an AI-driven advertising company that drives mobile revenue growth, serving hundreds of advertisers and handling 5 million ad requests per second from over 10 billion devices; it is privately held with HQ in San Francisco and offic