Rochester, Minnesota, United States · On-site
$67k–$79k/yr
Why Mayo Clinic Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our em…
Skills: Translational Genomics, Proteomics, Variant Interpretation, Multi-omics Integration, AI/ML
Rochester, Minnesota, United States · On-site
Why Mayo Clinic Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our em…
Skills: Outpatient Consultative Care, Psychiatric Evaluation, Complex Illness Management, Neuropsychiatry, Geriatric Psychiatry
Rochester, Minnesota, United States · On-site
Why Mayo Clinic Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our em…
Skills: Patient Care, Nursing Coordination, Patient Education, Critical Care Nursing, Leadership
Rochester, Minnesota, United States · On-site
$39/hr–$62/hr
Why Mayo Clinic Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our em…
Skills: Patient Education, Moderate Sedation, Airway Management, Physiologic Monitoring, ECG Interpretation
Rochester, Minnesota, United States · On-site
$39/hr–$62/hr
Why Mayo Clinic Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our em…
Skills: Patient Care, Patient Education, Nursing Coordination, Critical Thinking, Mentoring
Rochester, Minnesota, United States · On-site
$131k–$183k/yr
Responsibilities Caring for 75,000 patients per year, the Saint Marys Hospital Emergency Department at Mayo Clinic is a regional level 1 trauma center and is also the base of operations for nationally regarded Air and Gr…
Skills: Comprehensive Assessment, Diagnosis, Pharmacological Prescription, Patient Education, Laceration Repair
Rochester, Minnesota, United States · On-site
$20/hr–$27/hr
Why Mayo Clinic Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our em…
Skills: Specimen Processing, Inventory Management, Clinical Laboratory Operations, Patient Identification, Reagent Preparation
Rochester, Minnesota, United States · Hybrid
$87k–$121k/yr
Why Mayo Clinic Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our em…
Skills: Technology Licensing, Intellectual Property Management, Market Research, Business Development, Contract Negotiation
Rochester, Minnesota, United States · On-site
$27/hr–$41/hr
Why Mayo Clinic Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our em…
Skills: Molecular Cloning, Virology, Mammalian Cell Culture, Animal Models, Viral Vector Generation
Rochester, Minnesota, United States · On-site
$67k–$79k/yr
Why Mayo Clinic Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our em…
Skills: Advanced Imaging, Single-cell Transcriptomics, Spatial Transcriptomics, Mouse Physiological Studies, Molecular Biology
Rochester, Minnesota, United States · On-site
$28/hr–$48/hr
Why Mayo Clinic Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our em…
Skills: Electroencephalography, Evoked Potentials, Autonomic Testing, Nerve Conduction Studies, Patient Preparation
Rochester, Minnesota, United States · On-site
$60k–$95k/yr
Our team is growing, and we’re looking for top-caliber Occupational Therapists to join us in Rochester, Kasson and surrounding locations in Minnesota. This position is primarily staffed in our senior living community par…
Skills: Occupational Therapy, Geriatric Care, Patient Outcome Management, Autonomous Interventions, Computer Literacy
Rochester, Minnesota, United States · On-site
$60k–$105k/yr
Our team is growing, and we’re looking for top-caliber Physical Therapists to join us in Rochester, Kasson and surrounding locations in Minnesota. This position is primarily staffed in our senior living community partner…
Skills: Physical Therapy, Geriatric Care, Patient Outcome Management, Autonomous Intervention, Interdisciplinary Collaboration
Rochester, Minnesota, United States · On-site
$67k–$79k/yr
Why Mayo Clinic Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our em…
Skills: Molecular Cloning, Mutagenesis, Cell Culture, Transfection, Immunoblotting
Rochester, Minnesota, United States · On-site
$28/hr–$48/hr
Why Mayo Clinic Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our em…
Skills: MEG Data Acquisition, EEG, Evoked Potentials, Autonomic Testing, Nerve Conduction Studies
Rochester, Minnesota, United States · On-site
Why Mayo Clinic Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our em…
Skills: Cleaning, Disinfection, Sterile Processing, Medical Equipment Preparation, Quality Monitoring
Rochester, Minnesota, United States · On-site
Why Mayo Clinic Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our em…
Skills: Molecular Biology, DNA Isolation, RNA Isolation, Cell Culture, Experimental Design
Rochester, Minnesota, United States · On-site
$39/hr–$59/hr
Why Mayo Clinic Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our em…
Skills: Diagnostic Ultrasound Imaging, Abdominal Ultrasound, OB/GYN Ultrasound, Vascular Ultrasound, Pediatric Ultrasound
Rochester, Minnesota, United States · Hybrid
$29/hr–$39/hr
Why Mayo Clinic Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our em…
Skills: Hospital Inpatient Coding, DRG Assignment, Medical Terminology, Disease Processes, Provider Queries
Rochester, Minnesota, United States · On-site
$43/hr–$66/hr
Why Mayo Clinic Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our em…
Skills: Cardiovascular Nursing, ECG Monitoring, Patient Education, Discharge Planning, Critical Thinking
Rochester, Minnesota, United States • On-site
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Lead translational research projects to integrate genomic and proteomic data for diagnosing and treating rare and complex diseases. Collaborate with clinical teams to move molecular findings into clinical follow-up and publish results in scientific manuscripts.
Requires a PhD, MD, or equivalent in genetics, bioinformatics, or a related field with deep expertise in either molecular biology or data science. Candidates must demonstrate a strong interest in patient-focused discovery and the ability to work across computational and wet-lab domains.
The Translational Omics Program (TOP) and the DOM-led ORIGIN initiative at Mayo Clinic are seeking a postdoctoral Research Fellow to help turn molecular data into answers for patients with rare and complex disease. This is a genomics-first role for a scientist who wants to work where variant interpretation, proteomic signal, and clinical reality meet and who is drawn to the idea that the next gene–disease link or therapeutic lead may already be sitting in data that hasn’t yet been read the right way.
We are seeking talented individuals and will tailor projects accordingly to background such as a molecular biologist with some informatics training who wants to sharpen their computational skills, or a data scientist with some molecular biology training who wants to point their methods at real disease biology. What matters most is genuine depth in one of these areas, the curiosity to grow into the other, and a real pull toward patient-focused discovery. The work is translational and genomics-centered, and computational and AI-enabled methods are tools we use to get there rather than the point of the work.
ORIGIN is a bench-to-bedside translational research program built to connect multi-omics discovery with real-time clinical care across DOM divisions. It draws on deep molecular profiling, functional genomics, and collaborative translational pipelines to sharpen diagnosis, open targeted therapies, and accelerate discovery for patients with serious, complex, and rare disease. Fellows work inside an unusually complete research ecosystem including large patient-linked biobanks, genome and exome sequencing, plasma proteomics at scale, and direct access to the clinicians, genetic counselors, and laboratory scientists who care for these patients.
Projects evolve with clinical need, emerging discoveries, and collaborative opportunities across the institution, and fellows are encouraged to shape their own. Several directions are especially open right now:
Integrated omics models. Bringing genomic and proteomic data together into a single framework — including AI/ML approaches — to resolve rare and monogenic disease, rather than reading each -omic layer in isolation.
New therapies and new associations. Using that integrated view to surface novel therapeutic avenues and establish new gene–disease associations.
From the individual to the population. Developing methods and models that bridge the gap between rare monogenic diseases identified in phenotypically selected patients and the role that same variation plays across population-scale datasets connecting deep-phenotype discovery with biobank-scale validation, and back again.
This position provides advanced training in translational omics research and is designed to prepare fellows for independent careers in academia, translational medicine, or industry. Fellows are supported to publish routinely and to build the track record needed to compete for external funding.
Responsibilities are shaped to the fellow’s background and evolving project, so a given fellow will lean into some of these more than others:
Design and lead translational research projects aligned with ORIGIN priorities, spanning patient identification, precise diagnosis, targeted therapy, and discovery.
Analyze and integrate multi-omics data, especially with genomics and proteomics (e.g. Olink) at the core — to investigate disease mechanisms and surface therapeutic opportunities, extending to other -omic layers as projects require.
Perform variant classification and interpretation following ACMG/AMP guidelines in rare and undiagnosed disease as well as preventive (“healthy screen”) testing and communicate that reasoning clearly to clinical and research audiences.
Build integrated genomic–proteomic models, including AI/ML approaches, to elucidate monogenic disease, identify new gene–disease associations, and nominate therapeutic avenues.
Contribute to genotype-first and cohort-based studies that connect deeply phenotyped patients to population-scale resources such as biobanks and reverse-phenotyping pipelines.
Work with clinical data alongside molecular data to link genetic and proteomic findings to patient phenotypes and outcomes.
Collaborate with clinical teams, genetic counselors, laboratory scientists, and external partners to move findings into clinical or experimental follow-up.
Present genetic findings and variant interpretations to internal and external groups and take part in multidisciplinary case and research conferences.
Communicate results through manuscripts, presentations, case reports, and methods papers, and publish routinely.
Establish and maintain productive internal and external scientific collaborations.
Mayo Clinic has expanded and changed in many ways, but our values remain true to the vision of our founders. Our primary value – The needs of the patient come first – guides our plans and decisions as we create the future of health care. Join us and you'll find a culture of teamwork, professionalism and mutual respect, and most importantly, a life-changing career. Mayo Clinic was founded in Rochester, Minnesota by brothers Dr. William James Mayo and Dr. Charles Horace Mayo. More than 100 years later, their vision continues to evolve around a single guiding value: "The needs of the patient come first." Today we are the largest integrated, not for-profit medical group practice in the world. We are recognized for high-quality patient care more than any other academic medical center in the nation. These endorsements are very gratifying, but also humbling. They remind us of the tradition that has been entrusted to each one of us, and the legacy of excellence that we uphold every day.
Offices: 200 First St. S.W., Rochester, Minnesota 55905, US · 13400 East Shea Blvd., Scottsdale, Arizona 85259, US · 4500 San Pablo Road, Jacksonville, Florida 32224, US · 5777 E Mayo Blvd, Phoenix, Arizona 85054, US · 201 W Center St., Rochester, MN 55902, US
There are currently 1,200 open healthcare positions in Rochester, MN listed on Clera. New openings are added daily as companies post roles.
Companies currently hiring include Mayo Clinic, Rochester Regional Health, Compass Group, Olmsted Medical Center, Benedictine, among others. Browse the listings above to see every active employer.
Yes — 232 of the 1200 open healthcare positions offer remote or hybrid work (51 remote, 181 hybrid).
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