Cambridge, Massachusetts, United States · On-site
Role Overview Vesalius is seeking a Senior/Executive Director-level Head of Biology to lead biological strategy and target validation across our causality-driven discovery platform. This role is responsible for translati…
Skills: Target validation, Human genetics, Functional genomics, Neurodegeneration, Parkinson's disease
Cambridge, Massachusetts, United States • On-site
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The role involves leading biological strategy and target validation by translating human genetic evidence into disease-relevant cellular phenotypes. You will oversee preclinical drug discovery programs and mentor a high-caliber biology team to advance targets toward development readiness.
Candidates must hold a PhD or MD/PhD in a relevant scientific field with over 10 years of industry or academic experience. Proven expertise in target validation, neurodegeneration, and human-relevant in vitro systems is essential for this leadership position.
Vesalius is seeking a Senior/Executive Director-level Head of Biology to lead biological strategy and target validation across our causality-driven discovery platform. This role is responsible for translating human genetic evidence (including GWAS, rare variants, Mendelian randomization, and functional genomics) into rigorous, disease-relevant biological validation and for shaping preclinical programs across multiple therapeutic areas.
The ideal candidate brings deep target validation expertise across therapeutic modalities and disease areas, with particular strength in neurodegeneration (including Parkinson’s disease), genomic perturbation tools, and the ability to contribute meaningfully to cardiovascular and immune-mediated biology. You will build and mentor a high-caliber biology team, establish standards for scientific rigor and decision-quality, and partner closely with data science, chemistry, and platform operations to advance targets toward development readiness.
At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact.
We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.
We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship.
Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.
The salary range for this role is $108,000 - $170,700. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Vesalius Therapeutics currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Vesalius Therapeutics's good faith estimate as of the date of publication and may be modified in the future.
Pioneering a revolutionary platform to generate breakthrough treatments for common diseases
Pioneering a revolutionary platform to generate breakthrough treatments for common diseases.
Offices: Cambridge, Massachusetts 02142, US
Pioneering a revolutionary platform to generate breakthrough treatments for common diseases
Pioneering a revolutionary platform to generate breakthrough treatments for common diseases.
Offices: Cambridge, Massachusetts 02142, US
