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TreeFrog Therapeutics logoTreeFrog Therapeutics

Senior Bioprocess Specialist/Engineer

Cambridge, Massachusetts, United States · On-site

Mid level$121M raised

SENIOR BIOPROCESS SPECIALIST/ENGINEER About TreeFrog Therapeutics TreeFrog Therapeutics is an innovative, international biotechnology company aiming to bring cell therapies to millions of patients using our C-STEM encaps…

Skills: Bioprocess Engineering, Perfused Bioreactor Systems, Pluripotent Stem Cells, Stirred Tank Bioreactor, Experimental Design (DOE)

TreeFrog Therapeutics logo

Senior Bioprocess Specialist/Engineer

TreeFrog Therapeutics

Cambridge, Massachusetts, United States • On-site

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Mid level

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  • Full-time
  • Medical Insurance, Dental Insurance, Vision Insurance, HSA Plan, 401(k) With Employer Match, Generous PTO And Leave Policies
  • Posted 46d ago
  • ~40 hrs/week

Responsibilities

Lead a team of bioprocess technicians and engineers to execute experiments and develop scaled biomanufacturing solutions. Act as the primary interface between stem cell biology, cell differentiation, and process development to drive clinical programs forward.

Requirements

Requires at least 3 years of experience with perfused bioreactor systems and pluripotent stem cell expansion in stirred tank bioreactors. Must have expertise in flow cytometry, DOE, and working within a GMP environment.

Full job description

SENIOR BIOPROCESS SPECIALIST/ENGINEER



About TreeFrog Therapeutics

TreeFrog Therapeutics is an innovative, international biotechnology company aiming to bring cell therapies to millions of patients using our C-STEM encapsulation technology, enabling large-scale amplification of iPS and differentiated cell products for patients. Using our C-STEM format, TreeFrog Therapeutics is currently developing multiple cell therapy programs for disease indications including Parkinson’s disease and acute liver failure. Our US team is located in Cambridge, MA and supports a combination of internal R&D programs as well as collaborations with external partners.

Find out more at our website: https://treefrog.fr

Description of Position

TreeFrog Therapeutics is seeking an experienced bioprocess specialist/engineer to join our discovery and innovation team in Cambridge, MA. TreeFrog is using our proprietarly C-Stem microencapsulation technology to develop advanced manufacturing solutions to enable the production of pluripotent stem cell (PSC) derived therapeutics for the treatment and cure of multiple diseases (Parkinson’s, Type 1 Diabetes, and others). The laboratory in Cambridge consists of field experts in multiple complementary technical disciplines (stem cell biology, cell differentiation, physics, microfluidics, etc.) who collaborate rapidly identify problems in the manufacturing space and develop novel solutions.

We are seeking an experienced bioprocess engineer to lead a team dedicated to integrating our existing technologies and expertise and applying it to scaled biomanufacturing.

Responsibilities

  • Lead a small team of bioprocess technicians/engineers to execute on experiments and foster their career development
  • Work with group leaders within the Cambridge site, as well as cross-functional teams in the Bordeaux main site to develop a cohesive strategy to solve critical problems
  • Execute on bioprocess experiments both internally and with external collaborators to move clinical programs forward
  • Act as interface between stem cell biology, cell differentiation, and process development to design and execute on handoff strategy and clinical development program.



Necessary qualifications

  • Bioprocess engineer with at least 3 years of demonstrated experience with perfused bioreactor systems in the 1 and 10 liter scale. Familiarity with the Eppendorf bioreactor systems desired but not necessary.
  • At least 3 years demonstrated experience with pluripotent stem cells (either Embryonic or induced) and growth within a stirred tank bioreactor. Minimally must have experience with pluripotent stem cell expansion, but ideally with both expansion and differentiation.
  • Experience with proper experimental design (DOE or similar) and implementation within a perfused bioreactor environment
  • Experience in testing and developing novel in-process controls (capacitance sensors, metabolite sensors, etc).
  • Strong experience in multiple analytical assays. Experience in flow cytometry a must.
  • Experience in working in a Good Manufacturing Practice (GMP) environment, and understanding the technical constraints
  • Excellent documentation skills
  • Fluent in English with excellent communication skills
  • Ability to simplify complex technical information and communicate to non-experts
  • Ability to work limited weekend hours

Desirable skills

  • Experience with microfluidics and understanding the technical advantages/disadvantages
  • Experience with alginate microencapsulation methods and instruments
  • Familiarity in common software packages and coding languages (MatLab, Python, R, etc)

Compensation and Benefits

  • Competitive salary and bonus structure
  • Medical/Dental/Vision, including HSA Plan
  • 401(k) w/ employer match
  • Generous PTO and leave policies

TreeFrog Therapeutics is an equal opportunity employer that complies with all applicable national, state, and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work in the United States.

Related keywords

Bioprocess EngineeringC-STEM TechnologyPluripotent Stem CellsiPS CellsPerfused BioreactorsStirred Tank BioreactorDOEGMPFlow CytometryMicrofluidicsAlginate MicroencapsulationMatLabPythonRBiomanufacturingCell Therapy

About TreeFrog Therapeutics

LinkedInVisit site

Cell Therapy for All

Industry
Biotechnology Research
Company size
51-200 employees
Founded
2018
Headquarters
Pessac, Nouvelle-Aquitaine
LinkedIn followers
24,929
Total funding
$121M

TreeFrog Therapeutics is a French-based biotech company aiming to unlock access to cell therapies for millions of patients. TreeFrog Therapeutics is developing a pipeline of therapeutic candidates using proprietary C-Stem technology, allowing for the mass production of induced pluripotent stem cells and their differentiation into ready-to-transplant microtissues with unprecedented scalability and cell quality. Bringing together over 150 biophysicists, cell biologists and bioproduction engineers, TreeFrog Therapeutics raised $82M in 2021 to advance its pipeline of stem cell-based therapies in the field of regenerative medicine with the lead program in Parkinson's Disease. In 2022, the company opened a technological hub in Boston, USA to drive the adoption of C-Stem and initiate co-development partnerships with leading academic, biotech and industry players in the field of cell therapy.

Offices: 30 Avenue Gustave Eiffel, Bat A, Pessac, Nouvelle-Aquitaine 33600, FR

Cell TherapyStem CellStem cell mass-productionCell therapy cGMP manufacturingbiomimetic 3D cell cultureand bioreactor stem cell cultivationBiopharmaBiotechnologyTherapeutics
View all jobs at TreeFrog Therapeutics

About TreeFrog Therapeutics

LinkedInVisit site

Cell Therapy for All

Industry
Biotechnology Research
Company size
51-200 employees
Founded
2018
Headquarters
Pessac, Nouvelle-Aquitaine
LinkedIn followers
24,929
Total funding
$121M

TreeFrog Therapeutics is a French-based biotech company aiming to unlock access to cell therapies for millions of patients. TreeFrog Therapeutics is developing a pipeline of therapeutic candidates using proprietary C-Stem technology, allowing for the mass production of induced pluripotent stem cells and their differentiation into ready-to-transplant microtissues with unprecedented scalability and cell quality. Bringing together over 150 biophysicists, cell biologists and bioproduction engineers, TreeFrog Therapeutics raised $82M in 2021 to advance its pipeline of stem cell-based therapies in the field of regenerative medicine with the lead program in Parkinson's Disease. In 2022, the company opened a technological hub in Boston, USA to drive the adoption of C-Stem and initiate co-development partnerships with leading academic, biotech and industry players in the field of cell therapy.

Offices: 30 Avenue Gustave Eiffel, Bat A, Pessac, Nouvelle-Aquitaine 33600, FR

Cell TherapyStem CellStem cell mass-productionCell therapy cGMP manufacturingbiomimetic 3D cell cultureand bioreactor stem cell cultivationBiopharmaBiotechnologyTherapeutics
View all jobs at TreeFrog Therapeutics

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