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Research Postdoctoral Fellow - Craniofacial Development and Gene Therapy
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$21k–$110k/yr
Full-time
postgraduate degree
Posted 37d ago
~40 hrs/week
Responsibilities
Conduct independent scholarly research on craniofacial developmental biology and genetics to innovate new diagnoses and treatments. Responsibilities include project planning, data evaluation, supervising junior lab members, and communicating results through manuscripts and national presentations.
Requirements
A doctorate degree is required along with a strong experimental foundation in mouse genetics and computational analysis using R, Python, or MATLAB. Experience with human cell culture, iPSC analysis, and recombinant DNA methods is highly desirable.
Full job description
SHIFT:
Day (United States of America)
Seeking Breakthrough Makers
Children’s Hospital of Philadelphia (CHOP) offers countless ways to change lives. Our diverse community of more than 20,000 Breakthrough Makers will inspire you to pursue passions, develop expertise, and drive innovation.
At CHOP, your experience is valued; your voice is heard; and your contributions make a difference for patients and families. Join us as we build on our promise to advance pediatric care—and your career.
CHOP does not discriminate on the basis of race, color, sex, national origin, religion, or any other legally protected categories in any employment, training, or vendor decisions or programs. CHOP recognizes the critical importance of a workforce rich in varied backgrounds and experiences and engages in ongoing efforts to achieve that through equally varied and non-discriminatory means.
A Brief Overview Under the direction/guidance of a mentor (principal investigator), assumes responsibility for a specific, on-going research project. The experience will serve to extend, refine and enhance skills necessary for professional and career development, and will enable the individual to broaden his/her scientific background by acquiring new research capabilities. It is expected that this individual will conduct independent scholarly research, and will contribute directly to the overall research goals of the project and the research group.
This role will be expected to participate in project planning, recording and interpretation/evaluation of data, and communication of results. This position will also be expected to acquire technical, lab management, and manuscript/grant writing skills; and participate in seminars, lectures, poster sessions and presentations at national meetings. This role also may be required to supervise junior lab members, develop new methods and protocols for research, and assist with the development of other research projects in the lab.
About the Laboratory
The Center for Craniofacial Innovation at Children’s Hospital of Philadelphia Research Institute is seeking a highly motivated research fellow interested in craniofacial developmental biology and genetics, at the intersection of fundamental discovery and gene therapy. We are specifically interested in seeking a candidate with expertise in mouse models, human cell lines and computational biology. We have a pipeline of studying human subjects and animal models of craniofacial conditions, working with human embryonic stem cells and new disease models. Experiments will involve leveraging direct human cell culture, human iPSC, mouse and zebrafish models to dissect the developmental genetic basis of craniofacial malformations and innovate new diagnosis and treatments.
The fellow will join a collaborative group of scientists who study the basic and translational biology of craniofacial biology, morphogenesis, cell specification and development. Additionally, the fellow will join and initiate studies to develop novel diagnosis and therapies. In this instance, the fellow’s work will have a direct bearing on discovery of drugs and gene therapy approaches to mitigate malformation phenotypes and target delivery to disease-driving cells in craniofacial malformations and disease.
We integrate the approaches of stem cell and computational biology and use these to explore human tissue regeneration and disease. We apply the latest technology in genetics with routine use of multi-omics, CRISPR, iPSC, single cell RNAseq, Cut&Run transcriptional analysis, cell transplants, FACS, live confocal labeling and imaging, transgenics, chemical screening, and many other experimental approaches. Our laboratories are fully integrated with the Center for Computational and Genomic Medicine which develops and implements state-of-the-art computational techniques and methods in bioinformatics: long read single cell/nuclei RNA sequencing, ChIP-X, Hi-C/3C chromosome conformation, and AI-assisted data harmonization. Our Center is also intergrated with the Center for Gene and Cell Therapy, to leverage advances in base editing and vectors to change the molecular trajectory of craniofacial conditions. Our laboratory has dedicated human cell, organoid, mouse and zebrafish facilities outfitted with the latest imaging, injection and cell manipulation instruments. We will extrapolate human studies to vertebrate models, specifically with mice for their advantages in generating human disease models, and zebrafish for higher throughput gene expression and function studies. Researchers work in open format laboratory space that foster interactions with other stellar researchers working in the Center, with ample opportunities to participate in scientific seminars and professional development.
A major focus of this position is the development of next-generation gene therapies for congenital craniofacial disorders. The successful candidate will leverage sophisticated genetic mouse models to study disease mechanisms and evaluate therapeutic strategies for conditions including craniosynostosis, fibrous dysplasia, cleft lip and palate, and related craniofacial developmental disorders. This work will integrate developmental biology, mouse genetics, genome engineering, and translational gene therapy to bridge fundamental discovery with preclinical therapeutic development.
Job Expectations
A strong experimental foundation in mouse genetics, development, cell, developmental, and computational analyses (R/Python and/or MATLAB) are mandatory. Additional experience with human neuron/cell culture, iPSC derivation, iPSC analysis, cell culture, animal models, are desirable. Working knowledge of recombinant DNA methods, genomics and microscope are welcome. Outstanding oral and written communication skills are required.
What you will do
Conduct independent scholarly research and develop new methods and protocols
Participate in project planning, recording and evaluation of data
Acquire technical, lab management and grant writing skills
Participate in seminars, lectures, poster sessions and presentation at national meetings
Supervise junior lab members
Assist with other research projects
Education Qualifications
Doctorate Required
Skills and Abilities
Ability to wear a respirator device
To carry out its mission, CHOP is committed to supporting the health of our patients, families, workforce, and global community. As a condition of employment, CHOP employees who work in patient care buildings or who have patient facing responsibilities must receive an annual influenza vaccine. Learn more.
At CHOP, we are committed to fair and transparent pay practices. Factors such as skills and experience could result in an offer above the salary range noted in this job posting. Click here for more information regarding CHOP's Compensation and Benefits.
Since its start in 1855 as the nation's first hospital devoted exclusively to caring for children, The Children's Hospital of Philadelphia has been the birthplace for many dramatic firsts in pediatric medicine. The Hospital has fostered medical discoveries and innovations that have improved pediatric healthcare and saved countless children’s lives.
Today, The Children's Hospital of Philadelphia is one of the leading pediatric hospitals and research facilities in the world. Our 150 years of innovation and service to our patients, their families and our community reflect an ongoing commitment to exceptional patient care, training new generations of pediatric healthcare providers and pioneering significant research initiatives.
Offices: 34th St. and Civic Center Blvd., Philadelphia, PA 19104, US · 3401 Civic Center Blvd, Philadelphia, PA 19104, US
Since its start in 1855 as the nation's first hospital devoted exclusively to caring for children, The Children's Hospital of Philadelphia has been the birthplace for many dramatic firsts in pediatric medicine. The Hospital has fostered medical discoveries and innovations that have improved pediatric healthcare and saved countless children’s lives.
Today, The Children's Hospital of Philadelphia is one of the leading pediatric hospitals and research facilities in the world. Our 150 years of innovation and service to our patients, their families and our community reflect an ongoing commitment to exceptional patient care, training new generations of pediatric healthcare providers and pioneering significant research initiatives.
Offices: 34th St. and Civic Center Blvd., Philadelphia, PA 19104, US · 3401 Civic Center Blvd, Philadelphia, PA 19104, US