San Carlos, California, United States · On-site
About Us: Ridge Biotechnologies enables the development and construction of the next generation of precision medicines through enzyme and targeted therapeutic design. Using our powerful experimental and computational pla…
Skills: Antibody Discovery, ADC Development, Monoclonal Antibody Generation, Cell-Based Assays, Flow Cytometry
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Lead the development and implementation of drug discovery workflows for antibody-drug conjugates (ADCs) from initial characterization to in vitro proof-of-concept. Serve as the internal expert on antibody biology while collaborating with platform teams to connect biological insights to enzyme and linker design.
Requires a Ph.D. in immunology or a related field with over 10 years of drug discovery experience specializing in antibody development and oncology. Must have extensive hands-on experience in the full antibody life cycle, cell-based assay construction, and managing external CROs.
Ridge Biotechnologies enables the development and construction of the next generation of precision medicines through enzyme and targeted therapeutic design. Using our powerful experimental and computational platform built on large datasets generated by cell-free synthesis, biorthogonal chemistries, and ever-improving machine learning models, Ridge is pioneering the design of new medicines and scalable production methods that enable our partners to bring life-saving therapies to patients in need. In recent months, we’ve secured multiple partnerships and launched our first product lines: NativeLink enzymes that provide precise and stable bioconjugation without modification of protein sequence, glycan, or disulfide bonds; ProTrigger protease-cleavable linkers that enable selective drug release in the tumor microenvironment; and novel enzyme-based Catalytic Medicines.
Ridge Bio’s founders are industry veterans who have previously built successful biotechnology companies and academic leaders from top institutions including Stanford and Caltech with world-leading expertise in cell-free systems, therapeutic development, and protein engineering. We are backed by Sutter Hill Ventures, a quiet powerhouse that has been building successful companies since 1962 by focusing on bringing together great people to solve hard technological problems in big markets. Our company culture is dedicated to intellectual integrity, service ownership, and creative impact.
We are looking for an experienced, hands-on antibody scientist with deep expertise in antibody discovery, characterization, and antibody drug conjugate (ADC) development to join our team. In this role, you’ll develop and implement drug discovery workflows for our partners’ assets from initial characterization through in vitro proof-of-concept, and serve as our in-house expert on antibody function and ADC biology as we apply NativeLink and ProTrigger challenging targets. You’ll spend the majority of your time at the bench: building cell lines, running binding and functional assays, and generating the data packages that help our partners drive molecules to the clinic and continue to prove out and expand the applications of our technology. Your work will be highly collaborative, combining your expertise with that of top scientists across enzyme design, high-throughput experimentation, machine learning, and bioconjugation chemistry. An appetite for taking on new challenges and techniques, working flexibly across disciplines, and delivering value for our partners through a pragmatic, get-it-done approach to drug discovery are a must. As we grow, you’ll help shape our antibody and in vitro biology strategy, advance assets across a range of indications, and mentor scientists throughout the team. Level and compensation will be set by experience and previously demonstrated impact in highly related research.
We offer a strong benefits package, competitive compensation, and an opportunity to work collaboratively with a top-notch team with diverse skillsets to solve challenging problems with wide impact in therapeutics. If you’re a master at your craft of antibody and ADC development and are looking to apply your skills to solve important problems faced by therapeutic developers as part of a fast-paced, team-based, and entrepreneurial environment, then this job is for you!
Catalyzing Medicine
Ridge Biotechnologies is pioneering AI-based enzyme and targeted drug design to power the next wave of precision therapeutics. Led by a collection of established biotech entrepreneurs and faculty from top institutions, we use proprietary machine learning models informed by high-throughput cell-free experimentation for a wide range of applications in antibody-drug conjugates (ADCs), conditionally active prodrugs, in vivo CART therapies, targeted nucleic acid delivery, radiotherapies, and enzyme-based therapeutics. Our current product lines include NativeLink enzymes that enable precision bioconjugation including construction of ADCs and Antibody-oligonucleotide conjugates, ProTrigger linkers that provide tissue and disease-specific activation and release of diverse payloads and prodrugs, and new classes of enzyme-based Catalytic Medicines. We are focused on enabling our partners to build better drugs for patients.
Offices: Palo Alto, CA, US · 755 Page Mill Rd, STE A200, Palo Alto, California 94304, US
Catalyzing Medicine
Ridge Biotechnologies is pioneering AI-based enzyme and targeted drug design to power the next wave of precision therapeutics. Led by a collection of established biotech entrepreneurs and faculty from top institutions, we use proprietary machine learning models informed by high-throughput cell-free experimentation for a wide range of applications in antibody-drug conjugates (ADCs), conditionally active prodrugs, in vivo CART therapies, targeted nucleic acid delivery, radiotherapies, and enzyme-based therapeutics. Our current product lines include NativeLink enzymes that enable precision bioconjugation including construction of ADCs and Antibody-oligonucleotide conjugates, ProTrigger linkers that provide tissue and disease-specific activation and release of diverse payloads and prodrugs, and new classes of enzyme-based Catalytic Medicines. We are focused on enabling our partners to build better drugs for patients.
Offices: Palo Alto, CA, US · 755 Page Mill Rd, STE A200, Palo Alto, California 94304, US
