San Diego, California, United States · On-site
$88k–$128k/yr
JOB SUMMARY We are seeking a highly motivated and experienced Senior Associate Scientist I/II to join the GPCR Biology group and advance our core mission of accelerating small molecule drug discovery programs at Iambic T…
Skills: Cell biology, In vitro assays, Cell culture, HTRF, Reporter gene assays
San Diego, California, United States · On-site
$75k–$110k/yr
JOB SUMMARY We are seeking a highly motivated and experienced Senior Associate Scientist to join the Biology group and advance our core mission of accelerating small molecule drug discovery programs at Iambic Therapeutic…
Skills: Cell culture, Cell proliferation assays, Cytotoxicity assays, ELISA, Western blot
Boston, Massachusetts, United States · Hybrid
$148k–$186k/yr
JOB SUMMARY We are seeking a Machine Learning Scientist to join the Enchant team at Iambic Therapeutics. In this role, you will design and implement clinical fine-tuning of Enchant, our multimodal transformer model train…
Skills: Python, Deep Learning, Fine-tuning Transformer Models, Clinical Data Analysis, Data Sourcing
San Diego, California, United States · Remote OK
$144k–$180k/yr
JOB SUMMARY We are hiring a Senior Manager – Discovery R&D to join the growing Finance Team at Iambic, an innovative biotech company redefining drug discovery and development by applying industry-leading AI and Machine L…
Skills: Financial Planning And Analysis, Financial Modeling, Budgeting, Forecasting, Strategic Decision-Making
San Diego, California, United States · On-site
$146k–$204k/yr
JOB SUMMARY We are seeking skilled scientists to join our Discovery Machine Learning group at Iambic Therapeutics. In this role, you will be a key player in applying advanced ML techniques to support our drug discovery e…
Skills: Python programming, Statistics, Drug discovery, Machine learning, Statistical analysis
San Diego, California, United States · On-site
$138k–$172k/yr
JOB SUMMARY We are seeking a skilled and highly motivated Computational Chemist to join our Computational Sciences group at the Iambic Therapeutics headquarters in San Diego. You will be a key player in the application o…
Skills: Computational Chemistry, Ligand-based Design, Structure-based Drug Design, Cheminformatics, Pharmacophore Modeling
Dublin, Leinster, Ireland · Hybrid
JOB SUMMARY Iambic is building a secure, cloud-based platform for running our ML-driven drug-discovery workflows. You'll build and own the platform that lets us run our drug-discovery ML workloads reliably and reproducib…
Skills: Terraform, OpenTofu, AWS, Containerization, ECS
Dublin, Leinster, Ireland · Hybrid
JOB SUMMARY Iambic is building a secure, cloud-based platform for running our ML-driven drug-discovery workflows. You'll turn machine-learning workflows into reliable, repeatable production services - giving models and d…
Skills: Python, FastAPI, Machine Learning Productionization, Backend Engineering, Secure-by-Design
Dublin, Leinster, Ireland · Hybrid
JOB SUMMARY Iambic is building a secure, cloud-based platform for running our ML-driven drug-discovery workflows. You'll own and evolve our web application - the primary surface through which scientists interact with our…
Skills: Python, FastAPI, HTMX, PostgreSQL, AWS
San Diego, California, United States · Remote OK
$152k–$190k/yr
JOB SUMMARY The Senior Clinical Trial Manager, Clinical Operations, serves as the operational lead for assigned early-phase oncology studies, providing end-to-end trial leadership from start-up through close-out. In clos…
Skills: Clinical Trial Management, Vendor Oversight, Risk Management, Oncology Clinical Trials, ICH-GCP
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The role involves designing and conducting in vitro studies to support hit-to-lead medicinal chemistry efforts targeting GPCRs. Responsibilities include executing weekly cell-based assays, managing CRO scientists, and collaborating with cross-functional teams to analyze and communicate data.
Candidates need a Bachelor's or Master's degree in a scientific field with 3-8 years of industry experience depending on the level. Required expertise includes hands-on experience with cell biology, routine biological assays, and GPCR screening methodologies.
We are seeking a highly motivated and experienced Senior Associate Scientist I/II to join the GPCR Biology group and advance our core mission of accelerating small molecule drug discovery programs at Iambic Therapeutics. The successful candidate will have a proven track record of supporting in vitro cell-based assays to advance pre-clinical projects. The candidate will work closely with a cross-functional team that integrates machine learning, medicinal chemistry, analytical technology and biology to revolutionize small-molecule therapeutics design and discovery. This role is based at our San Diego headquarters.
Work closely with the Biology group to independently conceptualize, design and conduct in vitro studies aimed at supporting hit to lead medicinal chemistry efforts targeting GPCRs
Independently manage CRO scientists in the design, development, and implementation of in vitro assays for the advancement of GPCR projects
Execute weekly cell-based assays to screen/evaluate small molecule compounds in coordination with Biology, Chemistry, and Compound Management groups
Interpret and analyze scientific data and work with cross functional teams to QC/communicate data in a timely manner
Present experimental results/updates at team meetings
Contribute to the management of the biology laboratory
Bachelor’s or Master’s degree in biochemistry, pharmacology, cell biology, or other related scientific areas, with a minimum of 3-5 years of industry experience (Sr. Associate Scientist I) or 6-8 years of industry experience (Sr. Associate Scientist II)
Hands-on experience in cell biology and routine biological assays, including cell culture, HTRF and reporter gene cell-signaling assays, and imaging assays
Demonstrated scientific rigor with proven ability to critically evaluate data, and think independently and creatively in developing and testing new scientific hypotheses
Excellent oral and written communication skills
Highly motivated to work in a cross-functional team setting
Flexibility and ability to quickly learn new skills and knowledge on the job
Hands-on experience with traditional and innovative screening methodologies for GPCRs, as well as concepts related to GPCR signaling and trafficking highly preferred
Familiarity with HTS screening methodology is highly desirable
Experience with design and implementation of in vivo models in coordination with CROs is highly desirable
Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.
MISSION & CORE VALUES
Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.
We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.
Iambic is a clinical-stage life sciences & technology company developing novel medicines using its AI-driven platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with industry-leading speed and across multiple target classes and mechanisms of action. Iambic is advancing a disease-agnostic pipeline of potential best-in-class and first-in-class medicines to address urgent unmet patient need. Learn more at iambic.ai
Offices: San Diego, California 92121, US
Iambic is a clinical-stage life sciences & technology company developing novel medicines using its AI-driven platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with industry-leading speed and across multiple target classes and mechanisms of action. Iambic is advancing a disease-agnostic pipeline of potential best-in-class and first-in-class medicines to address urgent unmet patient need. Learn more at iambic.ai
Offices: San Diego, California 92121, US
