San Diego, California, United States · On-site
$270k–$367k/yr
JOB SUMMARY We are seeking a Senior or Executive Medical Director to provide medical and clinical development leadership for our early-stage oncology portfolio. This individual will own the clinical strategy and executio…
Skills: Clinical development, Oncology, Medical monitoring, Regulatory affairs, IND submissions
San Diego, California, United States · Hybrid
$55/hr–$85/hr
JOB SUMMARY The Contract Senior Talent Acquisition Partner provides full-cycle recruiting support across key hiring priorities at Iambic Therapeutics. This role partners closely with hiring managers and the Talent Acquis…
Skills: Full-cycle recruiting, Sourcing, Candidate screening, Interview coordination, Offer negotiation
San Diego, California, United States · Remote OK
$209k–$288k/yr
JOB SUMMARY We are seeking an experienced Associate Director or Director of Alliance Management to support AI discovery collaborations. In this role, you will serve as the primary relationship lead for external partnersh…
Skills: Alliance Management, Relationship Management, Program Leadership, Stakeholder Management, Cross-functional Coordination
San Diego, California, United States · Remote OK
$180k–$250k/yr
JOB SUMMARY We are seeking an experienced Director of Alliance Management to support strategic drug discovery collaborations. In this role, you will serve as the primary relationship lead for external partnerships, drive…
Skills: Alliance Management, Drug Discovery, Relationship Management, Program Leadership, Cross-functional Coordination
Dublin, Leinster, Ireland · Hybrid
JOB SUMMARY Iambic Therapeutics is seeking a Biological Structures Data Engineer to join the NeuralPLexer team and own the data pipelines for acquiring, curating, and transforming experimental and synthetic data to train…
Skills: Python, Structural Biology Data, Data Pipeline Design, Software Engineering, Bioinformatics
Bristol, England, United Kingdom · Hybrid
JOB SUMMARY Iambic Therapeutics is seeking a Biological Structures Data Engineer to join the NeuralPLexer team and own the data pipelines for acquiring, curating, and transforming experimental and synthetic data to train…
Skills: Python, Structural Biology Data, Data Pipeline Design, Software Engineering, Bioinformatics
Boston, Massachusetts, United States · Hybrid
$130k–$190k/yr
JOB SUMMARY Iambic Therapeutics is seeking a Biological Structures Data Engineer to join the NeuralPLexer team and own the data pipelines for acquiring, curating, and transforming experimental and synthetic data to train…
Skills: Python, Structural Biology Data, Data Pipeline Design, Bioinformatics, Computational Biology
Boston, Massachusetts, United States · Hybrid
$168k–$210k/yr
JOB SUMMARY We are seeking a talented and motivated Cloud Security Engineer to join the tightly integrated technology and drug discovery operation at Iambic Therapeutics. You’ll work in the Software organization and work…
Skills: Python, Ansible, Aws, Terraform, Iso 27001
Dublin, Leinster, Ireland · Hybrid
$168k–$210k/yr
JOB SUMMARY We are seeking a talented and motivated Cloud Security Engineer to join the tightly integrated technology and drug discovery operation at Iambic Therapeutics. You’ll work in the Software organization and work…
Skills: Python, Ansible, Aws, Terraform, Iso 27001
San Diego, California, United States · Remote OK
$180k–$225k/yr
JOB SUMMARY We are hiring a Director of Equity Administration & Corporate Compliance to join the growing Legal Team at Iambic, an innovative biotech company redefining drug discovery and development by applying industry-…
Skills: Equity Administration, Corporate Compliance, Cap Table Management, SEC Reporting, Corporate Governance
San Diego, California, United States · On-site
$184k–$250k/yr
JOB SUMMARY Iambic is seeking a Sr Corporate Counsel to join its growing legal team. Reporting to the VP, Legal, this attorney will serve as a key generalist business partner – displaying leadership in the company’s comm…
Skills: Commercial Contracting, Corporate Governance, Securities Law, Public Company Compliance, Legal Drafting
San Diego, California, United States · On-site
$88k–$128k/yr
JOB SUMMARY We are seeking a highly motivated and experienced Senior Associate Scientist I/II to join the GPCR Biology group and advance our core mission of accelerating small molecule drug discovery programs at Iambic T…
Skills: Cell biology, In vitro assays, Cell culture, HTRF, Reporter gene assays
San Diego, California, United States · Remote OK
$144k–$180k/yr
JOB SUMMARY We are hiring a Senior Manager – Discovery R&D to join the growing Finance Team at Iambic, an innovative biotech company redefining drug discovery and development by applying industry-leading AI and Machine L…
Skills: Financial Planning And Analysis, Financial Modeling, Budgeting, Forecasting, Strategic Decision-Making
Boston, Massachusetts, United States · Hybrid
$148k–$186k/yr
JOB SUMMARY We are seeking a Machine Learning Scientist to join the Enchant team at Iambic Therapeutics. In this role, you will design and implement clinical fine-tuning of Enchant, our multimodal transformer model train…
Skills: Python, Deep Learning, Fine-tuning Transformer Models, Clinical Data Analysis, Data Sourcing
San Diego, California, United States · On-site
$146k–$204k/yr
JOB SUMMARY We are seeking skilled scientists to join our Discovery Machine Learning group at Iambic Therapeutics. In this role, you will be a key player in applying advanced ML techniques to support our drug discovery e…
Skills: Python programming, Statistics, Drug discovery, Machine learning, Statistical analysis
Dublin, Leinster, Ireland · Hybrid
JOB SUMMARY Iambic is building a secure, cloud-based platform for running our ML-driven drug-discovery workflows. You'll own and evolve our web application - the primary surface through which scientists interact with our…
Skills: Python, FastAPI, HTMX, PostgreSQL, AWS
Dublin, Leinster, Ireland · Hybrid
JOB SUMMARY Iambic is building a secure, cloud-based platform for running our ML-driven drug-discovery workflows. You'll build and own the platform that lets us run our drug-discovery ML workloads reliably and reproducib…
Skills: Terraform, OpenTofu, AWS, Containerization, ECS
Dublin, Leinster, Ireland · Hybrid
JOB SUMMARY Iambic is building a secure, cloud-based platform for running our ML-driven drug-discovery workflows. You'll turn machine-learning workflows into reliable, repeatable production services - giving models and d…
Skills: Python, FastAPI, Machine Learning Productionization, Backend Engineering, Secure-by-Design
San Diego, California, United States • On-site
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The Medical Director will lead clinical development strategy for early-stage oncology assets from IND through Phase 1 trials. This includes overseeing study design, safety monitoring, and cross-functional collaboration with regulatory, translational, and AI/ML platform teams.
Candidates must hold an M.D. or D.O. degree with board eligibility or certification in hematology/oncology. Significant experience in drug development, specifically in executing IND submissions and early-phase oncology clinical trials, is required.
We are seeking a Senior or Executive Medical Director to provide medical and clinical development leadership for our early-stage oncology portfolio. This individual will own the clinical strategy and execution for one or more assets from IND-enabling activities through first-in-human and early efficacy studies. You will serve as the clinical and scientific lead on cross-functional program teams, working closely with our discovery, translational, regulatory, and clinical operations groups — and directly alongside our AI/ML platform teams — to translate novel candidates into well-designed clinical programs.
This position will be based in our San Diego Headquarters.
Title and scope will be calibrated to the successful candidate's experience.
Serve as the clinical/medical lead for early-stage oncology programs, owning the clinical development strategy from IND through Phase 1 and early proof-of-concept.
Author and drive the clinical components of IND submissions, including protocols, investigator's brochures, and clinical sections of regulatory documents; support and participate in health authority interactions (e.g., pre-IND, EOP1).
Design first-in-human and early-phase oncology trials, including dose-escalation and dose-optimization strategies, biomarker and translational plans, and eligibility criteria.
Provide ongoing medical monitoring and safety oversight for active trials, including review of emerging safety data, dose decisions, and management of study conduct in partnership with Clinical Operations and Pharmacovigilance.
Partner with translational science and the AI/ML platform teams to define patient selection strategies, pharmacodynamic endpoints, and data-driven development hypotheses.
Engage key opinion leaders, investigators, and study sites; represent programs to internal governance, partners, and, as appropriate, external stakeholders.
Collaborate cross-functionally with Regulatory Affairs, CMC, Clinical Operations, Biostatistics, and Program Management to keep programs on strategy and on timeline.
Contribute to portfolio-level decisions, candidate selection input, and business development / due diligence as needed.
M.D. or D.O. (or international equivalent); board eligibility/certification in hematology/oncology or medical oncology strongly preferred; exceptional candidates with PharmD and relevant oncology and clinical experience will be considered
Meaningful drug-development experience in biotech or pharma. We anticipate roughly 5+ years for a Senior Medical Director and 8–10+ years for an Executive Medical Director; strong candidates across this range are encouraged to apply.
Direct, hands-on experience authoring and executing IND submissions.
Direct experience designing and running Phase 1 / early-phase oncology clinical trials.
Demonstrated experience with oncology assets and a strong understanding of the oncology therapeutic and drug-development landscape.
Working knowledge of GCP, ICH guidelines, and the global regulatory environment for oncology development.
Experience with small-molecule oncology programs and targeted therapies.
Experience taking a program from candidate nomination or IND through clinical proof-of-concept.
Comfort working in a fast-paced, data-rich, technology-forward environment and collaborating with computational and platform teams.
Prior experience presenting to health authorities and/or supporting BD due diligence
Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.
MISSION & CORE VALUES
Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.
We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.
Better technology for better medicines
Iambic is a clinical-stage life sciences & technology company developing novel medicines using its AI-driven platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with industry-leading speed and across multiple target classes and mechanisms of action. Iambic is advancing a disease-agnostic pipeline of potential best-in-class and first-in-class medicines to address urgent unmet patient need. Learn more at iambic.ai
Offices: San Diego, California 92121, US
Better technology for better medicines
Iambic is a clinical-stage life sciences & technology company developing novel medicines using its AI-driven platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with industry-leading speed and across multiple target classes and mechanisms of action. Iambic is advancing a disease-agnostic pipeline of potential best-in-class and first-in-class medicines to address urgent unmet patient need. Learn more at iambic.ai
Offices: San Diego, California 92121, US
