Senior Scientist I, Antibody Engineering
About this role
Senior Scientist I, Antibody Engineering
Department: Lab Science
Employment Type: Full Time
Location: San Mateo, CA
Description
Key Responsibilities
- Lead cross-functional project teams (including Data Science, AI/ML, Engineering, Protein Sciences, Automation) on the execution of rapid, iterative multi-objective optimization to identify high-value therapeutic antibodies through gold-standard assays.
- Deeply understand target biology to better design antibodies that meet our candidate profile.
- Contribute expertise in antibody engineering approaches (including humanization, liability remediation, affinity tuning, format engineering, etc) to generate and optimize novel antibodies that meet design requirements.
- Collaborate closely with BigHat leadership and other cross-functional team members to ensure a tight linkage between strategy, research, and development components.
- Lead in-depth data analysis of each design cycle to better leverage experimental and computational approaches to reach our design goals.
- Effectively and regularly communicate results to key decision makers, the broader BigHat team, and to external partners.
Skills Knowledge and Expertise
- Ph.D. in biochemistry, structural biology, protein engineering, or related fields.
- 5+ years of advanced research experience in an industry setting.
- Hands-on protein engineering expertise, including structure-guided design, affinity maturation, stability/developability optimization, and rational or computational approaches to antibody engineering.
- Experience working with diverse antibody formats such as complex multispecifics, T-cell engagers, antibody fragments, antibody-drug conjugates, etc.
- Expertise in mammalian cell culture, immunoassay, molecular techniques, cell-based assays, protein expression and characterization (e.g., kinetics, SEC).
- Exceptional written, verbal, and visual communication skills.
- Experience presenting and communicating strategy and results to internal and external partners.
- Scientific track record and publication record.
- Strong data analysis and interpretation skills. Experience working with agentic software tools is a plus.
Total Rewards
Company at a glance
BigHat's mission is to improve human health by making it far easier to design advanced, next-generation antibody therapeutics. The company works to accelerate the development of these therapies and positions itself at the forefront of antibody design. BigHat is backed by a notable group of investors, including Section 32, Andreessen Horowitz, 8VC, Amgen Ventures, Bristol Myers Squibb, Quadrille, Grids Capital, AME Cloud Ventures, Innovation Endeavors and Gaingels. This strong investor lineup provides credibility and support as BigHat pursues its mission in the biotech market.
Top Benefits
- Bonus
- Options
- Health Insurance
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